If mobile marketing isn't in your startup's toolkit, it should be. Photo via Getty Images

Consumer privacy is driving startups to immediately begin marketing and data collection. Google and Apple have recently stressed the importance of first-party data collection for businesses. For the last two decades, businesses have had access to cookies to advertise to people who visited their digital assets. Digital advertising has already changed with Apple’s iOS 14.5 alterations, switching the default of ad tracking from yes to no and both Google and Apple expect data privacy to increase.

For startups, when and how to begin marketing their business can feel like a cumbersome task. As a chief marketing officer, I was asked to list services and channels that I oversee, and I came up with 16. For founders of startups who must often take on the roles of CEO and COO in addition to CMO as they look to expand their teams, that time commitment is not reasonable for someone who also has a personal life.

Entrepreneurs need tools that are simple to institute and not cost prohibitive, to meet their respective milestones. First, we need to collect first party data, so that when we get to our minimum viable product we have plenty of people waiting to buy it. Next, marketing must work even when we can’t focus on it. Third, we must focus on revenue generating activities, whether they are marketing or not. Finally, we want to create an environment where successful entrepreneurs have a work and life balance.

Before doing anything else — get a virtual phone number

A virtual phone number is the first marketing tool I would use for any business. This number can be connected to your cell phone during certain hours of the day and disconnected for others. This allows people to reach you on your schedule. Put this phone number on every asset you have, so it can be integrated into future tools, such as customer relationship management and Google My Business. With proper opt-in information, it also creates an immediate list for SMS marketing in the future. A virtual phone number typically runs $1 to $2 a month plus usage fees, so it can be used by any business.

It is important that this is set up first, because without this, you can’t use the following marketing tools effectively.

Tool 1: Missed Call – Text Back

An entrepreneurs’ worst nightmare is missing an important phone call, whether it’s an investor or closing your first sale. Constant phone and email checking causes anxiety, but more importantly, it is a low revenue activity, so you are actively hurting your business.

Missed Call – Text Back, or MCTB, allows a customizable text message to be delivered to a client when you miss their phone call. It moves the caller towards resolution (sales or otherwise) immediately encouraging them to give you more information about their problem. The best part is, that once you have the system in place, it costs you zero time. Imagine walking out of a meeting and instead of 10 missed calls, you have 10 text messages that you can quickly answer. How much time did you just get back?

Pro Tip: In many cases, you can automate your emails in a similar way.

Tool 2: A funnel page

Now that we have a tool that allows us to work productively without constant phone checking, we need to increase our book of business. This is where a funnel comes in.

A funnel is a unique digital experience you would like a specific person — a client or investor — to have. When you start a business, a funnel can be your website because you only have one specific thing you want any visitor to do, like collect information.

Almost every consultant to new businesses is promoting funnel building. Why? Because a good funnel motivates people to act in a specific way. If you are raising funds, you want an investor to have a specific experience to garner interest, not hope they navigate to the correct webpage. If you have a new technology, you want early adopters to learn and then provide a simple way to collect their information, so that you can contact them when your product is ready. Finally, if you’re about to hit the market with your new product, providing customers with a simple purchase method will improve revenue during your important proof-of-concept period.

Funnels, like MCTB, can grow and adapt with your business, providing different groups of people with different experiences, with minimal effort. For instance, suppose I created a dating app and needed early adopters. Instead of creating one funnel, let’s say I created two. The only difference between the two funnels, is the first one’s headline was “The No. 1 new dating app for men” and then the second one said women. Everything else remains the same, but the experience is immediately different for the consumer. The more you can change the funnel to cater to their personal experience, the better it will be, but even simple changes can go a long way.

Pro Tip: Funnels are easiest to keep track of when they are subdomains of your website.

Tool 3: Automated SMS marketing

The final tool I recommend to start is Automated SMS Marketing. Assuming you have people properly opted in from your funnel — review Telephone Consumer Protection Act (1991) to ensure legal compliance — you can make sure they receive a welcome message in the first 5 minutes.

The most important part of text messaging marketing is allowing your customer to believe they are really having a conversation with you. If you can avoid it, never tell a customer that your digital number is automated. If you need, tell them it is automated but overseen by you. You are the owner of the business or the inventor of the technology, people want to talk to you. Customers want to pretend that they know you. Allow them this feeling. Once the customer responds, you should be picking up an organic conversation with them anyway.

Bringing it together

Using these tools, we have created a simple, repeatable method to gather customer data and start their customer journey. Your funnel may also help you gather an email list, but your most active prospects will be more than willing to communicate with you over the phone.

When you can’t take calls, whether it’s because you are in a meeting or with your kids, you can rest easier, knowing that potential customers get an immediate response that helps them get where they need to go, or at the very least, when you get back to work, you can help them quickly.

And the best part for a new entrepreneur is that this can all be done cost effectively. Personally, I recommend a service called HighLevel, a feature-rich cost-effective CRM, that includes all of the tools previously discussed. Most tech savvy entrepreneurs can figure out how to institute all these practices quickly from one platform in a no code environment. If you’d rather have assistance, there are 20,000 agencies that use the platform and just as many YouTube videos.

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Chris Romani is the chief marketing officer for illumiPure, a Houston-based medical device company.

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Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.

5 incubators and accelerators fueling the growth of Houston startups

meet the finalists

Houston is home to numerous accelerators and incubators that support founders in pushing their innovative startups and technologies forward.

As part of our 2025 Houston Innovation Awards, the new Incubator/Accelerator of the Year category honors a local incubator or accelerator that is championing and fueling the growth of Houston startups.

Five incubators and accelerators have been named finalists for the 2025 award. They support startups ranging from hard-tech companies to digital health startups.

Read more about these organizations below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled.

Get your tickets now on sale for this exclusive event celebrating Houston Innovation.

Activate

Hard tech incubator Activate supports scientists in "the outset of their entrepreneurial journey." The Houston hub was introduced last year, and joins others in Boston, New York, and Berkley, California—where Activate is headquartered. It named its second Houston cohort this summer.

This year, the incubator grew to include its largest number of concurrent supported fellows, with 88 companies currently being supported nationally. In total, Activate has supported 296 fellows who have created 236 companies. Those companies have raised over $4 billion in follow-on funding, according to Activate. In Houston, it has supported several Innovation Awards finalists, including Solidec, Bairitone Health and Deep Anchor Solutions. It is led locally by Houston Managing Director Jeremy Pitts.

EnergyTech Nexus

Cleantech startup hub EnergyTech Nexus' mission is to accelerate the energy transition by connecting founders, investors and industrial stakeholders and helping to develop transformative companies, known as "thunderlizards."

The hub was founded in 2023 by CEO Jason Ethier, Juliana Garaizar and Nada Ahmed. It has supported startups including Capwell Services, Resollant, Syzygy Plasmonics, Hertha Metals, EarthEn Energy and Solidec—many of which are current or past Innovation Awards finalists. This year Energy Tech Nexus launched its COPILOT Accelerator, powered by Wells Fargo Innovation Incubator (IN²) at the National Renewable Energy Laboratory (NREL). COPILOT partners with Browning the Green Space, a nonprofit that promotes diversity, equity and inclusion (DEI) in the clean energy and climatech sectors. Energy Tech Nexus also launched its Liftoff fundraising program, its Investor Program, and a "strategic ecosystem partnership" with Greentown Labs.

Greentown Labs

Climatetech incubator Greentown Labs offers its community resources and a network to climate and energy innovation startups looking to grow. The collaborative community offers members state-of-the-art prototyping labs, business resources and access to investors and corporate partners. The co-located incubator was first launched in Boston in 2011 before opening in Houston in 2021.

Greentown has seen major changes and activity this year. In February, Greentown announced Georgina Campbell Flatter as its new CEO, along with a new Board of Directors. In July, it announced Lawson Gow as its Head of Houston, a "dedicated role to champion the success of Greentown Houston’s startups and lead Greentown’s next chapter of impact in the region," according to Greentown. It has since announced numerous new partnerships, including those with Energy Tech Nexus, Los Angeles-based software development firm Nominal, to launch the new Industrial Center of Excellence; and Houston-based Shoreless, to launch an AI lab onsite. Greentown Houston has supported 175 startups since its launch in 2021, with 45 joining in the last two years. Those startups include the likes of Hertha Metals, RepAir Carbon, Solidec, Eclipse Energy (formerly GoldH2) and many others.

Healthtech Accelerator (TMCi)

The Healthtech Accelerator, formerly TMCx, focuses on clinical partnerships to improve healthcare delivery and outcomes. Emerging digital health and medical device startups that join the accelerator are connected with a network of TMC hospitals and seasoned advisors that will prepare them for clinical validation, funding and deployment.

The Healthtech Accelerator is part of Texas Medical Center Innovation, which also offers the TMCi Accelerator for Cancer Therapeutics. The Healthtech Accelerator named its 19th, and latest, cohort of 11 companies last month.

Impact Hub Houston

Impact Hub Houston supports early-stage ventures at various stages of development through innovative programs that address pressing societal issues. The nonprofit organization supports social impact startups through mentorship, connections and training opportunities.

There are more than 110 Impact Hubs globally with 24,000-plus members spanning 69 countries, making it one of the world’s largest communities for accelerating entrepreneurial solutions toward the United Nations' Sustainable Development Goals (SDGs).

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.



Rice University launches  engineering-led brain science and health institute

brain research

Rice University has announced the creation of a new interdisciplinary center known as the Rice Brain Institute (RBI).

The new hub will aim to use engineering, natural sciences and social sciences to research the brain and reduce the burden of neurodegenerative, neurodevelopmental and mental health disorders.

“The Rice Brain Institute reflects Rice’s strength in collaboration without boundaries,” Rachel Kimbro, dean of the School of Social Sciences, said in a news release. “Our researchers are not only advancing fundamental science but they’re also ensuring that knowledge reaches society in ways that promote human flourishing.”

RBI researchers will work in thematic clusters focusing on neurodegeneration, mental health, brain injury and neurodevelopment. The clusters will work toward goals such as significantly improving key brain health outcomes, reducing mortality and mental health disorders and improving quality of life for patients living with brain injuries and neurodevelopmental disorders, according to Rice.

The institute will focus on “engineering-driven innovation,” rather than traditional neuroscience, to design tools that can measure, model and modulate brain activity based around Rice’s expertise in soft robotics, neuroimaging, data science and artificial intelligence—making it unique among peer organizations, according to Rice.

Additionally, RBI will be structured around three collaborative Rice “pillars”:

  • The Neuroengineering Initiative, launched in 2018, brings together neuroscience, engineering, and related fields experts
  • The Neuroscience Initiative, a new initiative that brings together cell biologists, neurobiologists, biochemists, chemists and physicists to explore fundamental mechanisms of the brain and nervous system
  • The Brain and Society Initiative, also a new initiative, considers brain research within the broader social and policy landscape

Rice’s Neuroengineering Initiative has already garnered more than $78 million in research funding, according to Rice, and has established major partnerships, like the Rice-Houston Methodist Center for Neural Systems Restoration.

“Rice is uniquely equipped to bridge and connect scientific understanding of the brain and behavior sciences with the technologies and policies that shape our world,” Amy Dittmar, the Howard R. Hughes Provost and executive vice president for academic affairs, added in the news release. “By uniting faculty in neuroengineering, neuroscience and psychological sciences, this interdisciplinary hub embodies the kind of bold, nimble collaboration that allows Rice to turn discovery into societal impact to save lives and enhance human flourishing.”

The formation of the RBI coincides with recent support of the Dementia Prevention Research Institute of Texas (DPRIT), which landed voter approval earlier this week and aims to make Texas the center for dementia research via brain-health tech. According to the World Economic Forum, brain disorders and mental health disorders cost the global economy an estimated $5 trillion per year and could be as high as $16 trillion by 2030.

“Few areas of research have as direct and profound an impact on human well-being as brain health,” Rice President Reginald DesRoches added in the news release. “As rates of Alzheimer’s, dementia and other neurological diseases rise in our country and around the world, universities have a responsibility to lead the discovery of solutions that preserve memory, movement and quality of life. We all know someone who has been affected by a brain-related health issue, so this research is personal to all of us.”