Leaders across the spectrum are coming together this week to shine a spotlight on the future of tech jobs in Houston. Photo via Getty Images

This week, leaders in government, business, and academia are convening to work within the community to explore how we can leverage partnerships and new federal programs to drive investment into Houston’s burgeoning innovation ecosystem.

At AI Across America: Houston, we’ll begin forming plans and partnerships capable of sparking an innovation ecosystem, fueling AI education, training, research, development, and job creation. We’ll also examine how students, workers, businesses, and academics in the community can prepare for upcoming opportunities and challenges.

Why Houston

Besides being near Texas’ 10th District, choosing Houston was easy in its own right. According to a study by Axios and LinkedIn, between 2020 and 2021, while the traditional tech hubs bled top talent, Houston gained 10.6 percent new tech workers. Those workers arrived to a solid foundation; in 2022 the Houston metro area had net tech employment of 134,436 people. The growth is steady too. From 2010 to 2019, the Houston area tech workforce grew 12.3 percent.

Recently, Houstonians are leveraging federal programs and public-private partnerships to build innovative, collaborative environments. These include places like The Ion, East End Maker Hub, and Houston Community College.

Defining the project

The AI Across America project is a collaboration between SeedAI, a 501(c)3 nonprofit, and the Congressional AI Caucus. Working in conjunction, the organizations support efforts in the public and private sectors to expand access to AI education, training, development, testing, and job creation for communities across the country.

The AI Caucus is a group of U.S. Representatives working together to better understand their constituent's interests and those of all Americans as it pertains to AI. The organization works to explain the underlying technology and the ecosystem.

SeedAI does the groundwork to build collaboration across the private sector, government, academia, and civil society to support community-driven AI investments. The work of SeedAI focuses specifically on people who have been historically-marginalized and overlooked.

This is a critical moment for AI in America and beyond

AI is the battleground of the next great global competition. We have to be the first to build and master AI technology. Yet, because AI is a reflection of the people creating it and historical data, pursuing technology through the perspective of only a small group of people opens us to disproportionate harm and unknown risks.

Worse still, if the barrier to entry for AI is allowed to continue growing, we risk losing our most precious resource – the ingenuity waiting to be unleashed across the country. How, in those circumstances, can we succeed when faced with a nation like China with a population dwarfing the U.S. alongside an ability to spend far more agilely and extensively?

How can we succeed, and what is Houston’s role?

Fortunately, through recently-passed legislation called the Chips and Science Act, we have an opportunity to reclaim international leadership in a quintessentially American way: by leveraging the diverse strengths of communities across the country.

Houston already has a head start and an expanding tech economy – with planning and collaboration, Houstonians can be first in line to build new resources for AI education and development. When every state and community begins to realize their potential in the AI-powered future, Houston can play a leading role in guiding others to success and enabling their transformation.

If we succeed, we’ll uncover ingenuity and inventions we would’ve never anticipated. And as AI becomes easier to apply, we’ll have a real chance to build an AI-first generation of workers and builders from coast to coast.

Once we become competitive internally, we will be unbeatable internationally. If we succeed, we’ll lead the world in economic competitiveness and national security for decades to come.

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Austin Carson is the founder of SeedAI, a nonprofit established to work with a diverse group of policymakers, academics, and private sector experts to help communities across the United States access the resources they need to engage with AI. Congressman Michael T. McCaul, Republican Leader for the House Foreign Affairs Committee and Vice Chair of the Congressional AI Caucus, is currently serving his ninth term representing Texas' 10th Congressional District which stretches from the city of Austin to the Houston suburbs.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.