8 Houston companies earn spots among Fortune's most innovative for 2025

top honor

Health care companies dominated Fortune's America’s Most Innovative Companies report for 2025, with Houston’s top-rated company on the list falling into that sector. Photo via Getty Images

Eight Houston companies have been named to Fortune’s third annual list of America’s Most Innovative Companies, joining another 16 from the state of Texas.

The group of 300 companies nationwide was rated based on production innovation, process innovation, and innovation culture, according to Fortune. In partnership with Statista, the magazine considered IP portfolios, employee, expert and customer opinions; and many other factors.

While many of the top-rated companies fell into the tech sector, Fortune reports that health care companies made up the largest portion of the 2025 list. Sixty-three honorees fell into the health care category, including Houston’s top-rated company, Houston Methodist.

Here’s which Houston companies made the list and where they ranked:

  • No. 35 — Houston Methodist
  • No. 54. — ExxonMobil
  • No. 137 — NRG Energy
  • No. 158 — Hewlett-Packard Enterprise
  • No. 169 — BMC Software
  • No. 175 — Texas Children’s Hospital
  • No. 227 — Sysco
  • No. 268 — Chevron

“This award is a true credit to the culture we have created around innovation and the incredible work of Roberta Schwartz, our Chief Innovation Officer, and her team at the Center for Innovation,” Marc Boom, CEO of Houston Methodist, said in a LinkedIn post. “They have really set the tone for how we can use innovation and technology to continue to deliver the highest quality care for our patients.”

Dallas-Fort Worth claimed the largest number of Texas companies on the list, with 11 headquartered in the metroplex. Houston was home to the second-most with eight hailing from the Bayou City. Austin is home to only four of the companies on the list, however, companies from the Capital City ranked higher on average, with Oracle, Tesla and Dell Technologies claiming the top three spots for the state. Beloved Texas grocer H-E-B was the one company to represent San Antonio.

Here's how the other Texas companies fared:

  • No. 6 — Oracle
  • No. 11 — Tesla
  • No. 14 — Dell Technologies
  • No. 37 — AT&T
  • No. 59 — Texas Instruments
  • No. 89 — Charles Schwab
  • No. 91 — McKesson
  • No. 113 — Jacobs Solutions
  • No. 125 — Baylor, Scott & White Health
  • No. 165 — Frontier Communications
  • No. 201— H-E-B
  • No. 210 — CBRE Group
  • No. 219 — TTEC Holdings
  • No. 223 — GameStop
  • No. 251 — American Airlines Group
  • No. 271 — Caterpillar

California-based tech conglomerate Alphabet Inc. topped the list for the third year in a row, and California companies again represented the majority of companies on the list, according to Fortune. Alphabet, Microsoft, Apple, IBM and Salesforce made up the top five, of which three are headquartered in California.

The 2025 group had a median revenue of $22 billion over the last 12 months, according to Fortune. See the full report here.

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Apple's Houston factory will open in 2026. Getty Images

Apple announces 250,000-square-foot Houston factory as part of $500B plan

The Big Apple

As part of a more than $500 billion, four-year investment across the U.S., Silicon Valley tech giant Apple plans to build a factory in Houston that will produce servers for its data centers to support the company’s artificial intelligence (AI) business.

In a February 24 announcement, Apple says the company and its partners will build the 250,000-square-foot factory. The plant, set to open in 2026, will employ thousands of people. The announcement doesn’t mention where the plant will be located or how much the project will cost.

“Previously manufactured outside the U.S., the servers that will soon be assembled in Houston play a key role in powering Apple Intelligence, and are the foundation of Private Cloud Compute, which combines powerful AI processing with the most advanced security architecture ever deployed at scale for AI cloud computing,” according to the announcement.

Various media outlets report that Apple is shifting AI server manufacturing and other operations to the U.S. to escape President Trump’s 10% tariff on imports from China. Apple makes many of its iPhones and other tech products in China in partnership with Taiwanese electronics manufacturer Foxconn.

The New York Times says Foxconn will be involved in the Houston factory. Last year, Foxconn spent $33 million to buy 10 acres and a building north of Houston in Harris County, adjacent to one of its warehouses, that it said would be used for its AI server business, according to The Times and Focus Taiwan.

Other countries that produce Apple products include India, Japan, South Korea, Taiwan and Vietnam, according to IndustryWeek.

The Houston plant announcement comes just days after Apple CEO Tim Cook met with Trump at the White House.

“We are bullish on the future of American innovation,” Cook says in a news release, “and we’re proud to build on our long-standing U.S. investments with this $500 billion commitment to our country’s future.”

With establishment of the factory in Houston, Apple will enjoy access to a deep pool of manufacturing workers. As of December, nearly 240,000 people held manufacturing jobs in the Houston area, according to the U.S. Bureau of Labor Statistics. The Greater Houston Partnership says the Houston area is home to over 7,000 manufacturers that produce more than $75 billion worth of goods each year.

Given the region’s solid manufacturing base, Apple should be able to attract plenty of job candidates for its Houston facility.

“Apple’s announcement further solidifies Houston’s leadership as a hub for innovation and advanced manufacturing,” Steve Kean, president and CEO of the Greater Houston Partnership, says in a statement. “This is a testament to our region’s business-friendly environment, skilled workforce, strategic global positioning, and proven ability to attract world-class companies. As U.S. companies continue to onshore their manufacturing operations, we are bullish on Houston’s ability to win big.”

"I am pleased with today's announcement and would like to give a shout-out to Apple for plans to bring a state-of-the-art facility to Houston. My administration believes in collaborating with corporations to ensure they know Houston is a place of opportunity. We have the talent and a can-do attitude to get things done," said Mayor John Whitmire via an email statement.

"Last year, Chevron announced its move from California to Houston. Today, Vestas, a leading global wind turbine manufacturer, is opening a new corporate office in Houston. Apple's announcement is a powerful message to everyone that the City of Houston is recognized as a place to live and work and the best major city in America to do business."

As the use of AI continues to grow, companies like Apple need more computing power. Thus, the company is making servers — housed at an escalating number of data centers — that bolster its Apple Intelligence program. Apple describes the program as a “personal intelligence system that helps users write, express themselves, and get things done.”

Over the next four years, Apple aims to add about 20,000 employees in Houston and other U.S. locations, mostly in AI and machine learning, research and development, silicon engineering, and software development. Aside from Texas, Apple is expanding in Arizona, California, Iowa, Michigan, Nevada, North Carolina, Oregon, and Washington.

In Texas, Apple already maintains a significant presence in Austin, where it employs about 7,000 people at two corporate campuses. Elsewhere in the Austin area, it has offices in West Lake Hills and San Marcos. It also maintains an office in Dallas.

The analysis cites Amazon, Apple, and Tesla as three of the major employers in Texas pursuing AI initiatives. Photo via Getty Images

Texas ranks as top state for interest in AI-related job postings

eye on AI

If internet search volume is an accurate barometer, Texas is a hotbed for interest in artificial intelligence jobs.

An analysis by Agility Writer, whose technology helps users produce AI-generated content, shows Texas ranks second among the states with the highest monthly search volume for AI-related jobs. The analysis puts Texas’ monthly search volume at 1,300, with California sitting in first place at 1,900 monthly searches.

“As the AI revolution continues to gain momentum, the geographic distribution of interest in AI careers is likely to evolve further, with states investing in AI education and fostering supportive ecosystems poised to reap the benefits of this transformative technology,” says Adam Yong, CEO of Agility Writer.

The analysis cites Amazon, Apple, and Tesla as three of the major employers in Texas pursuing AI initiatives.

Dice.com, a search engine for tech jobs, says AI roles that are in high demand include machine learning engineer, data scientist, AI research scientist, and robotics engineer.

“Looking forward, the demand for AI professionals is expected to intensify as technologies continue to advance and integrate into everyday business processes and consumer products. AI is not just creating jobs but also transforming them, requiring workers to adapt by gaining new skills,” says Dice.com.

A January 2024 report from career platform LinkedIn found that AI consultant and AI engineer are two of the 25 fastest-growing jobs in the U.S. this year. Most of these roles are concentrated in San Francisco, New York City, Washington, D.C.-Baltimore, and Boston, according to the report.

On the flip side, some analysts predict millions of jobs will be affected by or even lost to AI. For example, research from investment banking giant Goldman Sachs indicates roughly two-thirds of U.S. occupations “are exposed to some degree of automation by AI.”

A study released in 2023 by Chamber of Commerce, a business research company, anticipates as many as 12 percent of Houston-area workers could lose their jobs by 2027 due to AI.

"AI and technology in general may be taking certain jobs away, and yet we also see how it is changing the nature of jobs and even organizations and professions. In the ever-changing arena of AI, employees, job-seekers, and students will continue to adapt and learn new job skills that align with and anticipate workforce needs,” AI expert Fred Oswald, the Herbert S. Autrey Chair in Social Sciences at Rice University and a professor of psychological sciences, said in a 2023 news release.

Temporary gatherings — like conferences and hackathons — are essential to attracting third-party developers. Photo via Getty Images

Rice expert: Why tech companies should sponsor hackathons

houston voices

Companies like Amazon, Microsoft and Apple depend on third-party developers to create applications that improve the user experience on their platforms. However, given the many options available, developers face a daunting task in deciding which platform to focus their efforts on.

“Developers are faced with imperfect information,” says Rice Business assistant professor Tommy Pan Fang. “They don’t have an overview of the entire technology landscape.”

A team of researchers, consisting of Fang, Andy Wu (Harvard University) and David Clough (University of British Columbia), set out to investigate how temporary gatherings like “hackathons” — in-person software development competitions — might influence a developer’s choice of software platform.

Hackathons like Rice University’s annual HackRice draw developers looking to pick up new skills and create applications with teammates. Many of these events are sponsored by software platform companies.

The research team conjectured that hackathon attendees are more likely to adopt a particular platform if any of the following conditions are true:

  • A high number of fellow attendees have already embraced it.
  • A fellow attendee has built an award-winning hackathon project on it.
  • The platform that sponsors the hackathon is already popular.

To test their theories, the researchers followed 1,302 software developers participating in 167 hackathons from January 2014 to May 2017. Twenty-nine different platforms sponsored the hackathons. Fang and his colleagues tracked developers’ platform choices before and after the in-person events.

The researchers found that temporary gatherings — like hackathons, conferences and trade fairs — make a difference.

Developers with greater technical expertise were more likely to use a platform widely embraced by fellow hackathon attendees. And with every 10% increase in the number of hackathon attendees already using a given platform, other attendees were 1.2% more likely to try out that platform themselves the following year.

They also found that platforms benefit from sponsoring temporary gatherings, like hackathons.

Developers who attended a hackathon sponsored by a particular platform were 20.4% more likely to adopt that platform in the following year, compared to developers who either did not attend any hackathon or attended one without a sponsor.

Part of the reason for the findings is that developers at hackathons exert social influence on each other, both during organized hackathon events like competitions and workshops, as well as informal ones including ping pong tournaments or nights playing video games.

“The social interaction and seeing their peers be successful with the tools and what’s fashionable impacts the tools they decide to adopt,” says Fang. “For developers trying to figure out what technology to adopt in a world with imperfect information and uncertainty, having a gathering can be a beacon.”

Interviews with hackathon organizers, sponsors and developers in the U.S. and Canada backed up the researchers’ findings. Interviewees shared how they learned from their interactions with fellow developers during hackathons.

“When I’m walking around, it becomes noticeable what technologies people are using,” said a veteran of 15 hackathons. Another noted that if more people use a certain application programming interface, “it’s lower risk because it will be usable.” They added, “Most people just follow others.”

The study has implications for both developers and software platform companies alike. Results suggest hackathons can be a valuable venue for developers, not only to pick up new skills, but also to help them identify which platforms to use in the first place. For software companies, the lesson is simple: Sponsoring hackathons can be good for business.

Future research could look at how other types of events like conferences, tournaments and world’s fairs might impact how people end up adopting technologies, especially emerging ones, Fang says. For example, a company like OpenAI could use these types of in-person events to garner support and build momentum for its products.

“Companies that may have taken a step back during Covid should reevaluate in-person events to get people excited and regain momentum for their platforms,” Fang says. “The take-home message is, go out there and sponsor these events.”

This article originally ran on Rice Business Wisdom. For more, see Fang, et al. “Platform diffusion at temporary gatherings: Social coordination and ecosystem emergence.” Strategic Management Journal 42.2 (2021): 233-272. https://doi.org/10.1002/smj.3230.

Apple's current facilities in North Austin. Photo courtesy of Apple

Apple announces $1 billion Texas campus

I-news

Apple is embarking on a massive expansion in the Austin area. On December 13, the Cupertino, California-based company announced it is investing $1 billion to create a North Austin campus and adding 5,000 potential new jobs.

Though an exact location was not revealed, the company said the new 113-acre campus will be located "less than a mile" from its current office on Parmer Lane near the Domain. Initially the new Austin Apple will be designed to accommodate 5,000 employees, with the possibility to grow to up to 15,000 employees, the company says.

According to a release, the new facilities will house a broad range of job functions, including engineering, R&D, operations, finance, sales, and customer support. Currently, Apple employs 6,200 Austinites, the largest group outside of the tech company's California headquarters.

"Apple has been a vital part of the Austin community for a quarter century, and we are thrilled that they are deepening their investment in our people and the city we love," said Mayor Steve Adler in a news release. "Apple and Austin share a creative spark and a commitment to getting big things done. We share their commitment to diversity and inclusion. We're excited they are bringing more middle-skilled jobs to the area."

Apple says the new North Austin property will also feature 50 acres of preserved open space, and will be run on 100-percent renewable energy.

Austin isn't the only city receiving a windfall. Apple says that in addition to creating a new Capital City campus, it plans to add 1,000 new jobs in Seattle, San Diego, and Culver City (near Los Angeles). It's also making a dedicated push into other cities and promising to bring "hundreds" of jobs to Pittsburgh; New York; Boulder; Boston; and Portland, Oregon. The company also recently announced a new office in Nashville.

"Apple is proud to bring new investment, jobs, and opportunity to cities across the United States and to significantly deepen our quarter-century partnership with the city and people of Austin," said Apple CEO Tim Cook. "Talent, creativity, and tomorrow's breakthrough ideas aren't limited by region or zip code, and, with this new expansion, we're redoubling our commitment to cultivating the high-tech sector and workforce nationwide."

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This story originally appeared on CultureMap.

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Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”

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