New partnership chair, Amy Chonis, gave her address at the 2021 GHP Annual Meeting. Sky Noir Photography by Bill Dickinson/Getty Images

With 2020 in the rearview, the Greater Houston Partnership is looking into the new year with a new board chair. In the GHP's 2021 Annual Meeting, the organization introduced how important developing the innovation community is in Houston.

In her remarks, this year's Partnership Chair Amy Chronis, who is the Houston managing partner at Deloitte, shared what she hopes to inspire in her tenure. Her statement can be boiled down to three major points.

It's time to modernize Houston's economy

Chronis says it's time to focus on tech and innovation — and that requires support from all aspects of the city.

"Here in Houston, we must be laser-focused on building a strong, diverse, 21st century economy," she says. "Over the past few years, entrepreneurs, investors, academic institutions, local government, and the corporate sector have come together to unite, grow, and promote Houston's startup ecosystem. The progress since 2016 is staggering."

Since 2016, Chronis says, venture capital investment in Houston has increased almost 250 percent to a record $714 million dollars raised in 2020. Additionally, she calls out 30 new startup development organizations that have sprung up around town — like the East End Maker Hub, The Cannon, The Ion, Greentown Labs, and so much more.

Chronis also calls out the importance of educational institutions, such as Rice University and the University of Houston.

It's the industries that drive innovation

There is a growing need to diversify Houston's economy away from just oil and gas, Chronis says it's Houston's core industries — energy, life sciences, aerospace, along with manufacturing and global logistics — that have made transformative steps.

"We've got momentum, but we still need to double down with work to do," Chronis says, identifying energy, life sciences, and aerospace as three pillars to drive success.

Regarding energy, Chronis touts Greentown Labs opening in Houston — but warns it's increasingly important to have big corporations promote the energy transition.

"From the super majors to the service firms and the increasing presence of renewable companies, Houston is at the forefront of driving the Energy 2.0 sector," she says.

When it comes to health care, Chronis remarks on the Texas Medical Center's success with the TMC Innovation Institute and the development of TMC3, a 37-acre research commercialization campus.

"What's special about TMC3 is that it will create collaboration and innovation at scale," she adds. "It will be a catalyst that will advance Houston's position as the Third Coast for Life Sciences."

Lastly, Houston must maintain its moniker as the Space City — and the city has a lot of opportunities to do that with the development of the Houston Spaceport at Ellington Airport and the NASA Johnson Space Center.

"Houston is already home to a rich talent pool of nearly 23,000 aerospace manufacturing professionals and more than 500 aerospace and aviation companies and institutions, but the potential is so much greater," Chronis says.

Houston needs to focus on four areas to "drive a technological renaissance"

Chronis concludes her speech with some calls to action. She first acknowledges that corporations ask themselves about how they are promoting and valuing innovation.

"We must be committed to inspiring, cultivating and rewarding technological innovation," Chronis says. "How is your company partnering with startups, higher education institutions and other stakeholders to drive innovation?"

Next, Chronis calls out Houston's global diversity as a differentiator when it comes to attracting companies to Houston, and she cites HPE as an example.

"We know there are hundreds of tech companies in the Valley, and up and down the West and East coasts that are striving to build global diversity within their companies," she says. "There is no better place than Houston to do this."

Third, Chronis calls for everyone — from corporates to educations — to empower the next generation of innovators.

And, finally, she says it's time to spread the word about Houston.

"We are modern, sophisticated, and at our core, an incredibly global city. Global in a way that sets us apart from most U.S. metros," she says. "So, as we embark on this work to drive Houston's technology renaissance, we must ensure perceptions of Houston are aligned with reality."

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.