Texas bus biz plans to get on the road again

BACK ON TRACK

After a weeks-long, COVID-caused intermission, Texas-based Vonlane is hitting highways with daily routes starting July 1. Photo courtesy of Vonlane

Vonlane buses are revving their engines again. After weeks without service due to the coronavirus pandemic, the Dallas-based luxury bus operator will restart all routes serving Texas on July 1.

In a June 9 message to customers, Vonlane said daily departures resuming July 1 would include:

  • Houston-Dallas
  • Houston-Fort Worth
  • Houston-Austin
  • Houston-San Antonio
  • Dallas-Austin
  • Dallas-Oklahoma City
  • Fort Worth-Austin

Coming soon are routes to Nashville and Atlanta, with details to be announced, the company says.

As the coronavirus started to cripple travel in March, Vonlane temporarily eliminated four routes serving Texas. "While we are significantly impacted by the circumstances of the day," Vonlane founder and CEO Alex Danza said then. "Our goal is to be a solution for your urgent personal travel."

But by April 15, when most of Texas was sheltering in place, Vonlane suspended operations due to lack of demand. Limited routes between Dallas, Austin, and Houston resumed May 29.

Like many businesses, Vonlane also pivoted its operation in new directions during the shutdown.

On Memorial Day, the company announced it was expanding its services to include out-of-state charters. It now offers bespoke charter service to popular destinations across the continental U.S. like Colorado, Florida, and New Orleans, as an alternative to flying.

Passengers who book a private charter have access to up to 22 seats, can leave from a specific departure point of their choice, and travel to any destination, the company says.

Vonlane also rolled out a parcel shipping service in Texas. "Need to get something to a loved one, friend, or business associate in Austin, Dallas, or Houston today?" Danza said in the announcement. "Send it aboard the next Vonlane departure for a flat fee." More details on the service are outlined here.

In putting its luxury buses back on the road, Vonlane is adopting a number of measures designed to curb the spread of the coronavirus, such as limiting the passenger count to 13 by blocking all aisle seats through June 30; requiring passengers and employees to wear face coverings; and checking passengers' temperatures before boarding.

"As one of our core values, the safety of our passengers, crew, and fellow over-the-road travelers is our top priority," Danza said in a May 26 release announcing the charters. "In light of the current coronavirus situation, Vonlane is maximizing our efforts to make sure the Vonlane experience is as responsible, safe, and comfortable as our passengers have come to expect."

Vonlane launched its high-end bus service in 2014 with the Dallas-to-Austin route. Each bus, which holds fewer than two dozen passengers, features amenities like WiFi, satellite TV and radio, and leather seats.

Reservations can be booked online, and may be canceled and fully refunded up to 24 hours before departure.

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This article originally ran on CultureMap.

Vonlane is now driving beyond Texas. Courtesy photo

Texas travel company revs up for out-of-state expansion

ON THE ROAD AGAIN

In response to pandemic-triggered travel interruptions, Dallas-based high-end bus operator Vonlane is expanding its services to include out-of-state charters and in-state parcel shipping.

In a Memorial Day message to customers, Vonlane founder and CEO Alex Danza said the company now offers charter service to destinations across the continental U.S., citing examples like Colorado, Florida, and New Orleans. Danza says this provides long-distance travel when airline flights aren't an option.

"These bespoke trips allow you to travel privately with your friends, family, and business associates aboard your own Private Jet on Wheels," Danza wrote. "You name the pickup location, destination, and dates while we handle all of the logistics."

Vonlane has also rolled out a same-day parcel shipping service in Texas, where packages basically hitch a ride with the motor coaches.

"Need to get something to a loved one, friend, or business associate in Austin, Dallas, or Houston today?" Danza said. "Send it aboard the next Vonlane departure for a flat fee."

Amid the coronavirus pandemic, Vonlane halted its city-to-city bus service due to a lack of demand. Some routes returned on May 29, including Dallas-Austin, Dallas-Houston, and Houston-Austin.

In putting its luxury buses back on the road, Vonlane is adopting a number of measures designed to curb the spread of the coronavirus, such as limiting the passenger count to 13 by blocking all aisle seats through June 30; requiring passengers and employees to wear face coverings; and checking passengers' temperatures before boarding.

"As one of our core values, the safety of our passengers, crew, and fellow over-the-road travelers is our top priority," Danza says in a May 26 release. "In light of the current coronavirus situation, Vonlane is maximizing our efforts to make sure the Vonlane experience is as responsible, safe, and comfortable as our passengers have come to expect."

Danza says Vonlane hopes to resurrect its Fort Worth, San Antonio, and Oklahoma City routes "as soon as feasible."

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This article originally ran on CultureMap.

Some seats have been blocked to enable social distancing. Courtesy of Vonlane

Texas business-focused bus service curbs routes in response to COVID-19

bus stops

As the coronavirus cripples travel, Dallas-based luxury bus operator Vonlane LLC has temporarily eliminated four routes serving Texas.

In a March 24 email to customers, Vonlane founder and CEO Alex Danza said the four routes that have been paused are:

  • Houston-San Antonio
  • Dallas-Oklahoma City
  • Fort Worth-Austin
  • Fort Worth-Houston

As a result of these changes, no service is currently available to or from Fort Worth.

"While we are significantly impacted by the circumstances of the day," Danza wrote, "we continue to operate a minimal schedule between Austin, Dallas, and Houston as an essential public transportation provider. Our goal is to be a solution for your urgent personal travel."

Once the coronavirus pandemic has subsided, Vonlane will return to its normal schedule of 70 to 78 daily departures in Texas and Oklahoma, according to the email.

For those passengers who travel on Vonlane buses, some seats have been blocked to enable six feet of social distance, Danza wrote. Other coronavirus safety measures include disinfecting bus interiors, stocking buses with hand sanitizer, and outfitting on-board attendants with gloves to wear while serving food and beverages.

"Everyone at Vonlane is excited about the day we see you all aboard the coaches someday soon," Danza wrote.

Vonlane launched its high-end bus service in 2014 with the Dallas-to-Austin route. Each bus, which holds fewer than two dozen passengers, features amenities like WiFi, satellite TV and radio, and leather seats.

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This article originally ran on CultureMap.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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