Young professionals can dive into fun travel with this Houston-based company. Photo courtesy of Here and Now Travel

Work-life balance for a young professional is hard. There's the dream of travel but the nightmare of planning. Then there's the challenge of working with limited vacation days and finding a friend whose schedule lines up.

To the rescue comes Houston-based Here & Now Travel, which aims to create a vacation free of stress and full of memorable experiences and offers adventurous group travel specifically for young professionals.

When discussing the inspiration for starting their company, cofounder Alex Coleman tells CultureMap that he and his wife and fellow cofounder, Elise, were caught between the benefits and drawbacks of individual versus group travel.

They loved the freedom of solo traveling but not the potential feelings of isolation and vulnerability. When it came to traveling with friends, they enjoyed the bonding and security in a group but not all the work involved with navigating everyone's schedules and preferences during planning.

"We decided to create a travel company that combined the best of both worlds," Coleman says. "A company that gave people the flexibility of going to their desired destinations at their desired time, without losing the experience of traveling with a group of awesome people."

As young professionals themselves, the Colemans also wanted their company to consider the typically low number of vacation days their target clients have. That's why Here & Now trips take advantage of weekends and holidays so participants only have to take a maximum of three days off from work.

Here & Now Travel currently has six trips planned for 2020: two to Costa Rica, two to Colombia, and two to Mexico. On these trips, the itineraries lean towards adventure activities and cultural experiences.

For example, their next trip scheduled for January 9 to January 13 to Costa Rica includes exploring Juan Castro Blanco National Park, zip lining through the rainforest, learning how to make tortillas with a local family, and more.

"We shy away from crowded tourist attractions. We pride ourselves on showing travelers hidden gems of our destinations, be it the hidden Mayan cenote in Tulum where we have to be blessed by the community's Mayan Shaman before entering, or one of the region's largest waterfall in Costa Rica which sits on the land of a small farming family," says Coleman. "Through these tucked away, amazing places, we get to see things others typically don't, and have true interaction with the communities we are visiting.

Each Here & Now package includes private transportation to and from the airport and for the duration of the trip, shared three or four-star accommodation, all breakfasts and lunches, and all entrance fees and itinerary activity costs. Flights, dinners, and the required travel insurance are not included.

If you decide to join one of their trips, you can expect to be in a group of between six and 14 young professionals — with 14 being the absolute max as Here & Now Travel doesn't want to overrun the visited communities or contribute to the overuse of their resources.

"Large groups in charter buses feel clunky and seem like you are trampling or disrupting the destinations you are visiting," says Coleman. "We cap our trips at 14 people, allowing us to be good stewards of the communities we visit, and maintain our feel as a small group of travelers...and not tourists."

Each travel group is also accompanied by a Here & Now host who handles all the logistics as well as a local guide, which is a feature that Coleman believes sets their company apart from others.

"Travelers on Here & Now trips are always led by someone who calls that destination home," he explains. "Our guides have an emotional bond to the places we explore. Their passion and connection to their homes is something that can't be replicated."

Along with employing these local guides, Here & Now Travel works with local drivers, restaurants, and lodging as a way to ensure the money they spend in each community stays in that community.

As a further testament to their commitment to sustainable tourism, Here & Now Travel plans to offset their carbon footprint, which is mainly caused by airline travel, by donating to the nonprofit Trees for Houston in 2020.

The company also has plans to increase their number of trips to once per month and to eventually include European destinations.

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This article originally ran on CultureMap.

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Pharma giant considers Houston for $1B manufacturing campus

in the works

Another pharmaceutical giant is considering Houston’s Generation Park for a manufacturing hub.

According to a recent filing with the Texas Jobs, Energy, Technology and Innovation (JETI) program, Bristol Myers Squibb Co. is considering the northeast Houston management district for a new $1 billion multi-modal pharmaceutical manufacturing campus.

If approved, the campus, known as Project Argonaut, could create 489 jobs in Texas by 2031. Jobs would include operations technicians, engineering roles, administrative and management roles, production specialists, maintenance support, and quality control/assurance. The company predicts annual average wages for these positions to be around $96,000, according to the filing.

The project currently includes the 600,000-square-foot facility, but according to the filing, Bristol Myers Squibb “envisions this site growing in scale and capability well beyond its opening configuration."

The Texas JETI program offers companies temporary school property tax limitations in exchange for major capital investment and job creation. E.R. Squibb & Sons LLC applied for a 10-year tax abatement agreement in the Sheldon Independent School District.

The agreement promises a $ 1 billion investment. Construction would begin in 2027 and wrap in 2029.

“The proposed project reflects [Bristol Myers Squibb Co.’s] enduring commitment to bringing innovative medicines to patients and ensuring the long-term supply reliability they depend on,” the filing says. “The proposed project is purpose-built to support and manufacture medicines spanning multiple therapeutic areas and modalities, positioning the site as a long-term launch and commercial campus for decades to come. These medicines will provide therapies to the [Bristol Myers Squibb Co.’s] patients located in markets both nationally and internationally.”

The Fortune 100 company is considering 16 other cities for the new manufacturing facility in the Central and Eastern markets in the U.S. According to the Houston Chronicle, Bristol Myers Squibb Co is still in the “evaluation process” for its potential manufacturing site.

Last fall, Eli Lilly and Co. selected Generation Park for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.

Houston health tech co. lands NIH grant for AI cancer prediction tool

fresh funding

Houston-based CellChorus and Stanford Medicine were recently awarded a Phase I Small Business Innovation Research grant for the company's AI platform to test how certain cancer patients will respond to therapies.

The funding comes from the National Cancer Institute of the National Institutes of Health. According to a filing, the grant totaled just under $400,000.

CellChorus, which spun out from the University of Houston’s Technology Bridge, has developed TIMING (Time-lapse Imaging Microscopy In Nanowell Grids), which analyzes the behavior of thousands of individual immune cells over time and can identify early indicators of treatment success or failure.

The company will work with Stanford's Dr. David Miklos and Dr. Saurabh Dahiya, who have built the Bone Marrow Transplantation and Cell Therapy Biobank. The biobank manages and stores biological samples from patients treated at their clinic and in clinical trials.

"Predicting which patients will achieve durable responses after CAR-T therapy remains one of the most important challenges in the field,” Miklos said in a news release. “We aim to uncover functional cellular signatures that can guide treatment decisions and improve patient outcomes.”

The project will specifically profile cells from patients with relapsed/refractory large B-cell lymphoma (r/rLBCL). According to CellChorus, only about half of r/rLBCL patients who receive CAR-T therapy "achieve a durable, long-term remission." Others do not respond to therapy or experience relapse.

“The sooner we know whether a cancer therapy is working, the better. To maximize patient benefit, we need technology that can provide a robust and early prediction of response to therapy. The technology needs to be scalable, cost-efficient, and capable of rapid turnaround times,” Rebecca Berdeaux, chief scientific officer of CellChorus, added in the release. “We are excited to work with Drs. David Miklos and Saurabh Dahiya and their colleagues on this very important project.”

CellChorus has previously received SBIR grants from federal agencies, including a $2.5 million award in 2024 from its National Center for Advancing Translational Sciences (NCATS) and a $2.3 million SBIR Fast-Track award from the National Institute of General Medical Sciences in 2023.

Houston museum showcases America's founding documents in rare exhibit

Experience History

As the United States prepares to celebrate its 250th birthday, Houstonians have a chance to see rare documents from the founding of the nation. Freedom Plane National Tour: Documents That Forged a Nation, presented by the National Archives Foundation, will be on display at the Houston Museum of Natural Science through Monday, May 25.

The collection includes a rare engraving of the original Declaration of Independence; official Oaths of Allegiance signed by George Washington, Aaron Burr, and Alexander Hamilton; a draft of the Bill of Rights; the Treaty of Paris, the documented that recognized America's independence from Great Britain; and the tally of votes approving the Constitution.

The National Archives specifically chose Houston as one of only eight cities in the country to host the exhibit as a means to help the documents reach a wider audience outside of the main hub of semiquincentennial events in New England and the Washington, D.C. area.

"One of the things we decided when we put the tour together because we wanted to be off the East Coast," said Patrick Madden, CEO of the National Archives Foundation, who was onsite for the exhibit's opening in Houston. "There's a lot of 250th celebration stuff happening in the original 13 colonies. How do we get it to major markets where larger numbers of people can see it? So in the case of Houston, obviously, [is a] major market in this part of the country, but also we've partnered with the museum twice before with National Archives exhibits, so we knew that they would be up to the task of handling the exhibit and the crowds."

The star of the collection is a rare engraving of the original Declaration of Independence. Secretary of State and future president John Quincy Adams commissioned 200 exact replicas of the document from engraver William J. Stone in 1823. Less than 50 now remain. Madden joyfully pointed out that there are errors in this document, a potent reminder that the men who forged a nation made mistakes.

"There's a couple of typos in it where they had to make corrections," said Madden. "So even the founders, you know, they're all human. That resonates because here these people are making this move against the most powerful nation in the world and putting their lives on the line for a country based on ideas."

Other impressive parts of the collection include official Oaths of Allegiance signed by George Washington, Aaron Burr, and Alexander Hamilton, as well as one of the drafts of the Bill of Rights. Many states would not ratify the Constitution until certain rights were included in the document, leading to Washington going on a national tour assuring state leaders enshrining protections was first on the list. The draft copy on display specifically shows the First Amendment in progress.

Houston is the fourth stop on the exhibition's tour, which will take the documents to Denver, Miami, Dearborn, and Seattle through the summer. Freedom Plane is just one part of a larger patriotic celebration at the HMNS, which includes a film series celebrating American science and culture and general Americana decoration throughout the main hall.

Admission to Freedom Plane is free to the public, but separate from general admission to the museum. Space is limited, and passes are available on a first-come, first-serve basis. Non-members should expect long waits or the possibility that the day's passes are sold out. Only museum members can reserve passes for specific times. Flash photography is prohibited due to the fragile nature of the documents.

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This article originally appeared on CultureMap.com.