3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Loretta Williams Gurnell of the SUPERGirls SHINE Foundation, Al Ansari of FreshBrew, and Carolyn Rodz of Hello Alice. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from advocacy to coffee manufacturing — recently making headlines in Houston innovation.

Loretta Williams Gurnell, founder and executive director of the SUPERGirls SHINE Foundation

Loretta Williams Gurnell, founder and executive director of the SUPERGirls SHINE Foundation, joins the Houston Innovators Podcast to discuss how she's impacting young women in STEM. Photo courtesy of SUPERGirls SHINE Foundation

Years ago, through her own experience working with students, Loretta Williams Gurnell realized there wasn't any initiative connecting the dots for young women in terms of translating their state-mandated math and science classes into successful careers and job opportunities.

She set out to connect those dots and increase STEM opportunities for young women and launched her organization SUPERGirls SHINE Foundation in early 2016 to focus on programming to spark STEM interest and education for girls age 10 to 17. Later, amid the pandemic, she realized she needed to do more than just put on events and programming for these young women.

"We had to look at what's going to be longterm for these girls. How can we take the programatic piece that we do so well and make it a part of their lifestyle and decision making opportunities, so we had to pivot," she says on the Houston Innovators Podcast. Click here to read more.

Al Ansari, president and CEO of FreshBrew

FreshBrew has upgraded to some high-tech roasting equipment. Image courtesy of FreshBrew

Al Ansari takes coffee seriously — and he's putting his money where his mouth is. Houston-based FreshBrew, one of the largest private-label coffee and tea producers in the country, announced this month the recent investment of $10 million into its specialty roasting and production divisions.

The company, which supplies specialty blended coffee, tea and total beverage solutions to hospitality and retail business, is expanding its current roasting production and will fund extraction, bottling and canning capabilities, making FreshBrew one of only a few companies in the country to offer total end-to-end beverage solutions. The expansion, which is on the same land the company has owned since its inception in 1995, is slated to be complete in early 2023.

“Over the years, we take a myopic approach with our customers, we look at what they want to achieve and look at their market, and blend their wants and our knowledge and create custom profiles for them,” says Ansari, president and CEO of FreshBrew. Click here to read more.

Carolyn Rodz, founder and CEO of Hello Alice

In an interview with InnovationMap, Carolyn Rodz, CEO and founder of Hello Alice, explains how the partnership came about and how the program will significantly move the needle on equitable access to capital for small business owners. Photo courtesy of Hello Alice

Last month, Hello Alice — now with 1 million members in its community — announced a new program with MasterCard that provides small business owners a simpler way to unlock access to capital.

The Hello Alice Small Business Mastercard offers users expert business advice, business insights, cash back, and a rewards program that gives entrepreneurs points for completing business-advancing activities on the Hello Alice platform.

"As a small business owner myself, I've created a card that I wish I would have had," Carolyn Rodz, CEO and founder of Hello Alice, tells InnovationMap. "We really looked at where are the gaps for these business owners and the things they don't already have or are unable to access." Click here to read more.

FreshBrew has upgraded to some high-tech roasting equipment. Image courtesy of FreshBrew

Houston-based coffee company invests $10M into expansion, new state-of-the-art roasters

boom, roasted

Houston-based FreshBrew, one of the largest private-label coffee and tea producers in the country, announced this month the recent investment of $10 million into its specialty roasting and production divisions.

FreshBrew supplies specialty blended coffee, tea and total beverage solutions to companies in the food service, convenience store, hospitality and retail sectors.

The investment will expand current roasting production and will fund extraction, bottling and canning capabilities, making FreshBrew one of only a few companies in the country to offer total end-to-end beverage solutions. The expansion, which is on the same land the company has owned since its inception in 1995, is slated to be complete in early 2023.

As part of the investment, FreshBrew upgraded its existing roasters and purchased two additional roasters and added 11 packing lines for a total of 25 to accommodate increased demand. In addition, the company expanded its team lines and added sugar to its production to allow for sweet tea products.

Construction is now underway to transform the 40,000-square-feet of vending space to allow for extraction, bottling and canning production in-house. The company also acquired an additional 25,000 square-feet of space, creating a combined total of 140,000 square feet for the roasting plant and warehouse. The company plans to add up to 50 employees with the expansion and is currently at 100.

“I think COVID really changed the game for everybody in doing business, especially in the coffee market – people want innovative products, flavored coffee, cold coffee now. We believe unique items will be the wave of the future – the companies that are the most nimble will succeed and I think that’s what we do very well,” says Ansari.

Earlier this year, FreshBrew sold the vending division of the company to Compass Group North America, the owner of Canteen Vending Services, in response to rapidly increasing customer demand for production services.

Al Ansari is the president and CEO of FreshBrew. Photo courtesy of FreshBrew

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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