Overheard: Houston Innovation Awards finalists share top advice for fellow founders

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Fifteen of Houston Innovation Awards finalists share the best advice they've given or received. Photo via Getty Images

The startup journey is a long and winding road, and there's many ways to navigate it. Fifteen of this year's finalists have shared what their most valuable startup advice for their fellow Houston founders.

From the importance of mentorship to tips for female and BIPOC founders, these pearls of wisdom come directly from a selection of finalists across a handful of categories, including DEI Champion, BIPOC-Owned Business, Female-Owned Business, and Mentor of the Year.

Read these excerpts of advice from Houston's innovation community's top startup founders and supporters.

Click here to secure your tickets to the November 8 event where we'll name the 2023 Houston Innovation Awards winners.

"Be comfortable with asking for and accepting help. This journey is a marathon, not a sprint, but helping yourself with supportive people around is critical." — Cameron Carter of Rosarium Health, a BIPOC-Owned Business finalist

"Underrepresented founders often have trouble asking for what they want or deserve. ... Don't be scared to ask for what you want, or what you believe you deserve." — Pedro Silva of Milkify, a BIPOC-Owned Business finalist

"It's not 'fake it' until you make it. It's 'take it' until you make it. Be proud to be you." — Pamela Singh of CaseCTRL, a BIPOC-Owned Business finalist

"When starting a company, remember it’s a game of attrition. The best way to last longer than your nearest neighbor is to find your tribe." — Aaron Fitzgerald of Mars Materials, a BIPOC-Owned Business finalist

"Know your worth and add tax. Choose your partners wisely — at home and work. Invest in the best stock you own: YOU." — Katie Mehnert of ALLY Energy, a Female-Owned Business finalist

"Whatever battle you're fighting now that no one knows about — go ahead and WIN the war." — Shoshi Kaganovsky of Feelit Technologies, a Female-Owned Business finalist

"My advice would be to find truly effective mentors who are willing to open up their network for you. It doesn't matter if the mentors are men or women — what matters is that they genuinely care about your professional success and who you are as a person." — Tatiana Fofanova of Koda Healthcare, a Female-Owned Business finalist

"Remember...There are a BILLION ways to apply sunscreen, but no matter how you apply it, it ALL protects you from the sun. Like sunscreen, there are infinite ways to succeed in the startup world. Trust your gut, stick to your vision, and keep trying until you find what works for you. ... Your purpose and vision should be your North Star, guiding decisions in team-building, coaching, and creating a company culture. Stick to that purpose—it's what will drive you through the rollercoaster of entrepreneurship." — Emily Cisek of The Postage, a Female-Owned Business finalist

"First and foremost, embrace your uniqueness. As a woman of color, you bring a distinctive perspective to the table. Your background is not just a part of who you are; it's a strength that sets you apart in a male-dominated industry. ... Resilience is your greatest ally. Challenges will arise, and it's okay to acknowledge them. What matters most is how you respond. Each obstacle is an opportunity for growth and learning. ... Lastly, trust yourself. You are not just running a business; you are shaping a narrative of empowerment and change." — Ghazal Qureshi of UpBrainery Technologies, a Female-Owned Business finalist

"Figure out, learn, and understand your mission inside and out and use it to make all your major business (and sometimes personal) decisions." — LaGina R Harris, founder and CEO of The Us Space and Mentor of the Year finalist

"Know your value and continue advocating for inclusion." — Janice Tran of Kanin Energy, a BIPOC-Owned Business finalist

"Be your true, authentic self. There are going to be some people that like what you are doing, and there's going to be some people that don't, but the biggest thing is being true to who you are, and that's always going to flourish more than being who someone else wants you to be." — Muriel Foster, director of gBETA Houston and Mentor of the Year finalist

"Until you hire someone, you are the one wearing the product manager hat. You've got to love the problem more than the solution." — Wade Pinder, founder of Product Houston and Mentor of the Year finalist

"Be the person your younger self needed. Representation really does matter. Be a listening ear, share your lessons, and allow people to blossom under your leadership." — Michelle Ngome, founder and president of the African American Marketing Association and DEI Champion finalist

"Embrace your unique perspective as a source of strength and innovation. ... In Houston's dynamic startup scene, your presence and contributions as a traditionally marginalized founder or investor are essential for driving innovation and diversity. By staying resilient, seeking support, and advocating for inclusivity, you can navigate the entrepreneurial journey and make a lasting impact on both your business and the broader community." — Jessica Adebiyi, diversity and professional development director at Womble Bond Dickinson and DEI Champion finalist

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Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”

Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.

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