10 most promising Texas startups revealed at inaugural Houston summit

Winner, winner

Station Houston CEO Gabriella Rowe and Rice Alliance Managing Partner Brad Burke named 10 startups to watch. Photo by Natalie Harms

Texas is booming with digital startups, and Station Houston and the Rice Alliance for Technology and Entrepreneurship hosted a meeting of the minds to discuss the digital revolution at the inaugural Texas Digital Summit at Rice University on December 6.

Thirty-nine companies presented throughout the day; among the group were 26 from the Houston area. At the conclusion of the day, Gabriella Rowe, CEO of Station Houston, and Brad Burke, managing director of the Rice Alliance, announced 10 "most promising companies" that stood out to a group of investors who attended the event.

All 10 selected were Texas-based, with eight from the Houston area. Here's who the venture capitalists and investors picked for the prize.

Houston-based SafePass

Photo via safepassglobal.com

SafePass pictures a world where visitors on school or corporate campuses can be tracked. The company's technology upends the standard paper or sticker pass you get from the front office, and provides a reusable, trackable device for visitors.

"Our tracking algorithm interacts with already existing WiFi technology — so, the routers that are already at that facility," says Ronald Huff, managing director of SafePass. "We leverage that to get that real-time tracking information."

Houston-based ScribeRule

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ScribeRule operates under the assumption that your company's data has already been breached. The software protects data from both internal and external threats so that companies don't have to worry about any type of threat. The technology is scalable and easy to use.

"The problem is very simple," says Chris Melson, president and COO. "Only allow people who are authorized to see your data, see the data. And that's the problem we've solved."

"It's very difficult to protect data in a collaborative environment."

Houston-based Sensoleak

Photo via sensoleak.com

Sensoleak is making it easier for monitors in the oil and gas industry to be alerted about leaks. Using artificial intelligence, machine learning, and internet of things combined into a software, the company is providing a revolutionary solution for a longstanding problem.

"The problem right now is there is a lot of false alarms," says Shoshi Kaganovsky, founder and CEO, "and if there is a leak, it has to leak a lot before it is caught."

The company recently opened a new round of funding.

Sugar Land-based Commtrex

Photo via commtrex.com

The only open, electronic marketplace for rail shippers and asset providers is right in Houston's backyard of Sugar Land. Commtrex makes communications and connections between these transportation entities more efficient and better executed.

"Commtrex's asset management tools and market data is based on real transactions, and benefits our member companies with engagement efficiencies and financial insights," reads the website.

Houston-based Zenus

Photo via zenus-biometrics.com

Let's face it, face recognition is the future of identification, and Zenus has an award-winning technology to move the needle. Utilizing face recognition doesn't need to compromise privacy.

"We are a leading provider of face recognition software," reads the website. "Our cloud-based service can search a database of faces within a blink of an eye and it can be seamlessly integrated into any application."

Houston-based 3GiG

Photo via 3-gig.com

3GiG is a one-stop shop software company for the "oval office" needs of oil and gas companies. Energy leaders can use the services to manage projects, prospects, and more. President and CEO Kandy Lukats compares her company's services to the trending meal kits — like Blue Apron or Hello Fresh —Americans have been crazy about — all the ingredients sent right to your door.

"We believe we've found the niche between the freezer section and doing it yourself," she says.

Austin-based Towny

Photo via towny.com

This Austin company is making it more appealing to shop local. Towny looks to work in cities with under a million residents. The tool is for small, consumer-focused businesses to market their store to consumers. The small business owners pay a flat monthly rate to utilize digital marketing tools from the convenience of their phones.

Towny is already in five towns with 500 clients, says CEO Nathan Baumeister. In January, the company's monthly revenue was $17,000, but for the last two months, the tool has raked in $90,000 monthly.

"We've built a branding, mobile-first platform, where we've taken all these technologies and tactics and put it together in one package at the affordable price of $199 per month," he says.

Dallas-based CommandHound

Photo via commandhound.com

CommandHound is a B2B software that tracks employee tasks and responsibilities. It reminds users on assigned duties and keeps a record of work outcomes for later performance reviews.

"Our ultimate solution is to turn every organization into a high-performance organization through accountability," says Rene Larrave, chairman and CEO. "It's a checklist on steroids."

Houston-based SecurityGate

Photo via securitygate.io

SecurityGate is disrupting the cyber compliance and the cyber regulation market by providing cyber risk assessments at a faster rate than a human auditor could. The software analyzes data, identifies potential cyber security risks, and communicates with the company how to address the threats.

"No matter what industry vertical you're in, every single supply chain out there is worries about supply chain cyber security," says CEO Ted Gutierrez. "And the problem with that, is everyone is doing it manually."

Houston-based DeepCast.ai

Photo via deepcast.ai

Using artificial intelligence and physics, DeepCast.ai can automate operations for industrial companies.

"We simply integrate with system solutions, try to clean and facilitate the data using AI models important to the oil and gas industry," says Arturo Klie, chief technology officer and senior software engineer. "Once the data is clean, we apply our business-informed AI models to solve and provide forecasting real time and analytics.

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Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”

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