The company wants to make Texas "the home of self-driving trucks." PRNewsfoto/Kodiak Robotics

The Interstate 45 freight corridor between Houston and Dallas now serves as a testing ground for self-driving cargo trucks.

Silicon Valley startup Kodiak Robotics Inc. recently began sending its autonomous 18-wheel trucks on trips between Texas' two largest metro areas, co-founder and CEO Don Burnette says. The trucks are carrying paid cargo, but Kodiak won't identify the customer or customers. The company also won't say how many trips the trucks are making each day.

The Texas initiative represents Kodiak's first foray into commercial deliveries. Wired.com notes that pretty much every player in the autonomous truck sector has conducted tests in Texas or is carrying commercial loads in the Lone Star State, which boasts more than 2,300 miles of interstate highways.

For its part, Kodiak aims to make Texas "the home of self-driving trucks."

According to a 2016 report from the Texas Department of Transportation, nearly half of all truck freight in Texas goes through the I-45 corridor's 11 counties. In some spots, trucks make up more than one-fourth of the traffic in the corridor, which runs 276 miles from Galveston to where I-45 intersects with Interstate 20 in Dallas County, the TxDOT report says.

"The importance of the I‐45 freight corridor to the movement of goods extends beyond Texas because much of the freight originating or passing through the corridor is destined to other domestic and international markets," the report says.

For now, Burnette says, two people are aboard each Kodiak truck traveling between Houston and Dallas — a safety driver and a safety engineer.

"Dallas will be our home base for testing and operations for the foreseeable future," Burnette says. "Kodiak plans to continue refining and testing its trucks until the last truck-involved accident happens on public roads."

Kodiak's Dallas office, which opened in March, employs eight people. The company plans to relocate soon to new office space in the Dallas suburb of Lancaster, Burnette says.

At this time, Kodiak doesn't plan to hire any workers in Houston, he says.

From its base in the Dallas area, Kodiak envisions expanding its service to routes throughout Texas, but it's focusing solely on the Houston-to-Dallas route for the time being, Burnette says.

Kodiak picked Texas for its truck tests, in part, because of the "warm welcome" extended by Gov. Greg Abbott, TxDOT, the Texas Department of Public Safety, the Texas A&M Transportation Institute, and other segments of the public sector, he says.

In addition, Burnette says, Kodiak chose Texas "because of its great people, freight-rich economy, reasonable regulatory structure, and robust infrastructure."

In 2017, Texas enacted laws enabling driverless vehicles, including long-haul trucks, to operate on the state's roads.

"Texas is a leader in the testing and implementation of connected and automated vehicles, and Kodiak's willingness to partner with academia and public agencies to ensure safe deployment of new technology will add significant value to our transportation system," Christopher Poe, assistant director of the Texas A&M Transportation Institute, says in a release.

Burnette, co-founder of Otto Trucking LLC, a self-driving truck startup purchased in 2016 by Uber Technologies Inc., and fellow entrepreneur Paz Eshel established Kodiak in 2018 to "redefine" long-haul trucking through self-driving technology.

Kodiak says its autonomous technology is designed to ease pressures facing the trucking industry, including a shortage of drivers and high turnover among drivers, while improving highway safety, fostering business efficiency, reducing traffic congestion, and cutting down on harmful emissions.

"Long-haul trucking is primed for autonomous technology," Kodiak says in a post on Medium. "Highway driving is more structured and predictable than urban driving. This means there are fewer decisions for drivers to make and [it's] a better fit for autonomous vehicles."

"As hard as it is to navigate city streets, autonomous vehicles are much closer to being able to drive on more structured interstate highways, which have no jaywalking pedestrians, no aggressive cyclists, and no runaway pets," Kodiak adds. "That's why we've focused on building technology specifically for long-haul trucks driving on highway routes, often referred to as the 'middle mile.'"

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.