Self-driving semi trucks are now hauling cargo in and out of Houston

Autopilot

The company wants to make Texas "the home of self-driving trucks." PRNewsfoto/Kodiak Robotics

The Interstate 45 freight corridor between Houston and Dallas now serves as a testing ground for self-driving cargo trucks.

Silicon Valley startup Kodiak Robotics Inc. recently began sending its autonomous 18-wheel trucks on trips between Texas' two largest metro areas, co-founder and CEO Don Burnette says. The trucks are carrying paid cargo, but Kodiak won't identify the customer or customers. The company also won't say how many trips the trucks are making each day.

The Texas initiative represents Kodiak's first foray into commercial deliveries. Wired.com notes that pretty much every player in the autonomous truck sector has conducted tests in Texas or is carrying commercial loads in the Lone Star State, which boasts more than 2,300 miles of interstate highways.

For its part, Kodiak aims to make Texas "the home of self-driving trucks."

According to a 2016 report from the Texas Department of Transportation, nearly half of all truck freight in Texas goes through the I-45 corridor's 11 counties. In some spots, trucks make up more than one-fourth of the traffic in the corridor, which runs 276 miles from Galveston to where I-45 intersects with Interstate 20 in Dallas County, the TxDOT report says.

"The importance of the I‐45 freight corridor to the movement of goods extends beyond Texas because much of the freight originating or passing through the corridor is destined to other domestic and international markets," the report says.

For now, Burnette says, two people are aboard each Kodiak truck traveling between Houston and Dallas — a safety driver and a safety engineer.

"Dallas will be our home base for testing and operations for the foreseeable future," Burnette says. "Kodiak plans to continue refining and testing its trucks until the last truck-involved accident happens on public roads."

Kodiak's Dallas office, which opened in March, employs eight people. The company plans to relocate soon to new office space in the Dallas suburb of Lancaster, Burnette says.

At this time, Kodiak doesn't plan to hire any workers in Houston, he says.

From its base in the Dallas area, Kodiak envisions expanding its service to routes throughout Texas, but it's focusing solely on the Houston-to-Dallas route for the time being, Burnette says.

Kodiak picked Texas for its truck tests, in part, because of the "warm welcome" extended by Gov. Greg Abbott, TxDOT, the Texas Department of Public Safety, the Texas A&M Transportation Institute, and other segments of the public sector, he says.

In addition, Burnette says, Kodiak chose Texas "because of its great people, freight-rich economy, reasonable regulatory structure, and robust infrastructure."

In 2017, Texas enacted laws enabling driverless vehicles, including long-haul trucks, to operate on the state's roads.

"Texas is a leader in the testing and implementation of connected and automated vehicles, and Kodiak's willingness to partner with academia and public agencies to ensure safe deployment of new technology will add significant value to our transportation system," Christopher Poe, assistant director of the Texas A&M Transportation Institute, says in a release.

Burnette, co-founder of Otto Trucking LLC, a self-driving truck startup purchased in 2016 by Uber Technologies Inc., and fellow entrepreneur Paz Eshel established Kodiak in 2018 to "redefine" long-haul trucking through self-driving technology.

Kodiak says its autonomous technology is designed to ease pressures facing the trucking industry, including a shortage of drivers and high turnover among drivers, while improving highway safety, fostering business efficiency, reducing traffic congestion, and cutting down on harmful emissions.

"Long-haul trucking is primed for autonomous technology," Kodiak says in a post on Medium. "Highway driving is more structured and predictable than urban driving. This means there are fewer decisions for drivers to make and [it's] a better fit for autonomous vehicles."

"As hard as it is to navigate city streets, autonomous vehicles are much closer to being able to drive on more structured interstate highways, which have no jaywalking pedestrians, no aggressive cyclists, and no runaway pets," Kodiak adds. "That's why we've focused on building technology specifically for long-haul trucks driving on highway routes, often referred to as the 'middle mile.'"

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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