Houston hospital first in U.S. to try experimental plasma treatment

Houston Methodist is the first academic hospital in the country to use a new plasma infusion treatment against COVID-19. Photo by Getty Images

A major Houston hospital is spearheading a crucial treatment in the ongoing battle against COVID-19.

Houston Methodist is the first academic medical center in the nation to be approved by the FDA to transfuse donated plasma from a recovered COVID-19 patient into a critically ill patient.

The experimental treatment was fast-tracked as the death toll in the coronavirus pandemic soared to more than 2,000 people across the United States and more than 100,000 Americans sick from the virus, according to a statement.

The concept of the treatment centers around the idea that plasma from someone who has recovered from COVID-19 contains antibodies made by the immune system and used to kill the virus. Transfusing antibody-rich plasma into a COVID-19 patient who is still fighting the virus may transfer the power of the antibodies into a healing, possibly life-saving therapy, per the hospital.

Donating plasma is similar to donating blood and takes about an hour, according to Methodist. Plasma donors are hooked up to a small device that removes plasma while simultaneously returning red blood cells to their bodies. Unlike regular blood donation in which donors have to wait for red blood cells to replenish between donations, plasma can be donated more frequently, as often as twice a week.

Known as convalescent serum therapy, the concept dates back more than a century, when similar treatments were used during the Spanish flu pandemic of 1918, a diphtheria outbreak in the 1920s, a flesh-eating bacteria epidemic in the 1930s, and during other outbreaks of infectious diseases.

Most recently, a description of the treatment of five patients in China was published this week in the Journal of the American Medical Association, suggesting that the treatment was beneficial.

According to Methodist, scientists there recruited blood plasma donors from among approximately 250 patients who have tested positive for the COVID-19 virus at Houston Methodist hospitals. Willing donors were immediately identified; each gave a quart of blood plasma in a procedure much like donating whole blood.

The first recovered COVID-19 patient to donate plasma was an individual from the Houston metropolitan area who has been in good health for more than two weeks, according to the hospital. The plasma was then transfused into a COVID-19 patient at Houston Methodist.

Houston Methodist's convalescent serum therapy treatment is classified as an "emergency investigational new drug protocol" that requires FDA approval for each patient infused with donated convalescent serum, according to the hospital. Houston Methodist physician scientists will continue to seek additional FDA approval for follow-up studies, as time is of the essence.

"Convalescent serum therapy could be a vital treatment route, because unfortunately there is relatively little to offer many patients except supportive care, and the ongoing clinical trials are going to take a while," says Dr. Eric Salazar, principal investigator and a physician scientist in the Department of Pathology and Genomic Medicine at the Houston Methodist Hospital and Research Institute, in a statement. "We don't have that much time."

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This article originally ran on CultureMap.

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Building Houston

 
 

We could all use a little IT help right now. Photo by Maskot/Getty

Though it's been around since 2012, JPMorgan Chase's Force for Good program feels especially vital right now. The project connects Chase employee volunteers with hundreds of nonprofits around the world to build sustainable tech solutions that help advance their missions.

Even better, Houston and Dallas nonprofits have a leg up in the selection process. Organizations located in or near one of Chase's tech centers get priority, and that includes H-Town and Big D.

The government-registered nonprofits, foundations, and social enterprises (we're talking everything from food banks to theater companies) selected to participate will have access to a team of up to 10 highly skilled technologists, who will spend approximately four hours per week advising over an eight month period.

Each nonprofit is asked to propose the specific project that would benefit from technology guidance, and it needs to be something the organization can maintain when the project period is over.

"We have more than 50,000 technologists at JPMorgan Chase around the world and they're passionate about giving back," says Ed Boden, global lead of Technology for Social Good programs. "Force for Good gives our employees the opportunity to utilize their unique skills while also learning new ones, to build technology solutions for the organizations that need it most."

If you're the director, CEO, or other person in charge at a nonprofit and you still have questions about Force for Good, Chase has put together a free webinar to help explain further.

These webinars cover the overall program experience and application process, and it's highly recommended that nonprofits watch before applying. The live webinar dates (with Texas times) are June 2 from 1:30-2:30 pm and June 8 from 10:30-11:30 am.

A pre-recorded webinar will also be available for nonprofits to review after the live webinar dates.

Since 2012, Force for Good has worked with over 320 organizations in 22 cities, contributing over 190,500 hours of knowledge and skills.

"It is a great program that can provide strong impact for nonprofit organizations that need technology help," says Chris Rapp, a Dallas-based Chase executive. "As a father and husband of two Dallas artists, I am a huge believer in helping the arts grow and hopefully we can help do this through Force For Good."

The application process opened on May 28, with a deadline to submit by July 10.

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