The Ion Houston names new partner, growing startup names new CTO, and more local innovation news

short stories

In the latest round up of Houston innovation news you may have missed, a Houston startup wins an international COVID-19 innovation competition, The Ion has a new founding partner, and more. Photo courtesy of The Ion

It's been a busy week with virtual SXSW, spring break, and more. For this reason, some of Houston's innovation news may have fallen through some of the cracks.

In this roundup of short stories within Houston innovation, a Houston startup grows its C-suite, a local accelerator application deadline looms, the latest news from The Ion, and more.

Baker Botts doubles down on The Ion

The Ion has a new founding partner. Courtesy of Rice University

Houston's rising innovation hub, The Ion, has named Houston-based Baker Botts as the latest founding partner, alongside previously announced partners Microsoft and Chevron Technology Ventures.

"Today's announcement not only solidifies Baker Botts' investment in The Ion and the programs we are activating, but is a commitment to growing Houston's innovation ecosystem," says Jan E. Odegard, interim executive director of The Ion, in a news release. "Baker Botts' work with The Ion has already helped countless entrepreneurs get their work off the ground, and we are excited for their support as we continue to accelerate innovation and connect communities to build sustainable and inclusive economic growth in Houston."

Baker Botts has agreed to the following partnership opportunities with the Ion:

  • Provide in-kind services to this year's Houston Startup Showcase Winner
  • Offer on-site presence to support The Ion's various community members and provide substantive programming to startups
  • Host legal programming and workshops for The Ion's Accelerator Hub members
  • Expand gateway events including The Ion's Family Tech Night and Plaza Tec series

"Given our market-leading strengths in Houston, this is an exciting opportunity for the firm," says John Martin, managing partner of Baker Botts, in the release. "Our participation with The Ion brings together lawyers across our corporate venture capital, energy tech, IP and other practices to work closely with a range of cutting-edge companies at the heart of the Texas startup ecosystem."

GoExpedi recruits new CTO from big tech

GoExpedi has a new CTO. Photo courtesy of GoExpedi

Houston-based GoExpedi — a B2B e-commerce, supply chain and analytics company — recently hired global engineering executive Yang Tang as CTO. Tang has more than 20 years of experience leading technology and product teams at both startups and corporations, including Anheuser-Busch InBev (AB InBev) and at Walmart eCommerce's operations.

"After an extensive search to find one of the most accomplished product leaders of our time, we are excited to introduce Tang as the new head of our technical operations and state-of-the-art supply chain model," says Tim Neal, GoExpedi's CEO, in a news release. "His history of excellence in the e-commerce space is beyond reproach. He brings unparalleled expertise having managed global projects with an emphasis on e-commerce development and digital engineering for some of the world's most reputable brands. With his leadership, vision, and technical expertise, we are primed to launch into the next stage of our company's development as we expand our offering of new digital and consumer-friendly solutions."

In his position, Tang will oversee the design and execution of GoExpedi's technology, product, and data roadmaps.

"I am pleased to help the manufacturing and energy industries reimagine industrial supply chain with the brightest minds in technology, MRO procurement and oil and gas," says Tang in the release. "I was fortunate to contribute to the e-commerce renaissance that exploded in the consumer space over the last few years and am eager to apply what I have learned to the industrial sector. I look forward to collaborating with the team at GoExpedi to drive continuous improvements in all aspects of the industrial supply chain."

Last fall, GoExpedi closed a $25 million series C round with plans to hire.

Houston startup named a winner at $6M COVID-testing competition

Houston-based Steradian Technologies, Inc. was named among the winners of XPRIZE Rapid Covid Testing competition, an international innovation challenge that called for solutions for high-quality, affordable COVID-19 testing.

"We are extremely excited to create high-tech diagnostic solutions that are rapid, inexpensive, and accurate to create healthcare accessibility and equity for everyone, irrespective of any financial, geopolitical, or socioeconomic barriers. COVID-19 detection is our near-term goal, and we're looking forward to the possibilities of ubiquitous testing for all," says Asma Mirza, CEO and co-founder of Steradian Technologies, in a news release.

Steradian Technologies is "developing a product that created human super-sight via the startup's proprietary optics," according to the release, and pivoted its technology to create the RUMI diagnostic system, which uses Steradian's technology to look at photonics to detect disease biomarkers within a user's breath within 30-seconds.

"The COVID-19 pandemic has shown us that we need to be more prepared as a nation and as a global community for future viral threats. The rapid development of vaccines has been achieved through incorporating new technologies, and diagnostic tech needs to do the same. Our goal has been just that. We wanted to create a diagnostic tool that could be fast, accurate, and easy to use and could be widely deployed," says John Marino, co-founder and chief of product development, in the release. "We know that COVID-19 won't be the last threat of this kind and are developing a solution that can easily adapt to any new pathogen. We are extremely grateful to have been recognized by XPRIZE for our effort."

Houston entrepreneur to pitch with Techstars

Amanda Ducach, founder and CEO of SocialMama

Amanda Ducach, founder of SocialMama, is expecting to pitch at Techstars Austin. Photo courtesy of SocialMama

Houston-based consumer tech company, SocialMama, which connects mothers virtually via an app, was accepted into the Techstars Austin program for 2021. Founder Amanda Ducach will be presenting at the recently announced Techstars Austin virtual Demo Day on March 24.

SocialMama's Techstar Austin cohort colleagues include: BallBox, Inc (Chicago, IL), Enlightapp (Fargo, ND), Fêtefully (Dallas, TX), hampr (Lafayette, LA), Kousso (Charlotte, NC), Livo (Coral Gables, FL), Mowies (Medellin, Colombia), Nutritional Freedom (Austin, TX), and Talk Howdy (Austin, TX).

Registration is free and open online.

MassChallenge Houston's applications open for two more weeks

Photo courtesy of MassChallenge

MassChallenge Texas has opened applications for it's next cohort in Houston. The equity-free, no-cost program is seeking startups across industries that have raised less than $1 million in funding and less than $2 million in revenue to apply. The program provides startups mentorship, corporate partnerships, curriculum, and more.

The deadline to apply is March 31 by midnight. If interested, entrepreneurs can apply for free with the code "MC21INNOMAP." Click here to learn more and apply.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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