Real-time inventory software enables travelers to book a last minute flight and have their boarding passes in hand at security a few minutes later. But that technology isn't utilized in other aspects of a vacation — tour companies, for example. That's where San Francisco-based Xola comes in.

Scott Zimmerman and his co-founder Anush Ramani realized real-time technology was a glaring hole in a multi-billion-dollar business. It's why they founded Xola, a booking and marketing software system designed for tour and activity companies.

"So many smaller tour companies operate with pen and paper," Zimmerman explained. "And for many cities and countries, tourism is the number-two or number-three industry — it's a huge driver of economic growth. It's a $120 billion global market."

They created Xola as a B2B solution that created a platform for operators to promote their offerings, and allow customers to purchase tours and activities. Meanwhile, Xola's custom-design software platform managed the tour inventory and payments, providing real-time inventory management.

Since its inception in 2011, Xola has emerged as a leading B2B solution for travel industry operators. The company started in San Francisco, but opened an office in Houston in 2016 in the Heights Clock Tower. Xola's Houston operation began with six people; today, it employs 17. Zimmerman says he sees potential to grow the team with additional marketing, sales, and support staff.

"We serve customers around the world, and Houston has everything we need to continue our growth."

Zimmerman acknowledged the cost of doing business in the Bay Area is expensive, but when he went looking for cities in which to expand, price wasn't his only concern.

"We wanted a large metropolitan area, with a diverse ecosystem, good universities, a great talent pool, a high quality of life and an affordable cost of living. Houston has all these things. And the more I get to know the city, I realize just how much it has going on."

Zimmerman said that the city has "totally exceeded" his expectations in terms of Xola's growth. He said every one of the Houston employees is wonderful to work with, and loves that they come from diverse cultural and educational backgrounds.

"I can't quite describe what the office is like, but there's a great energy and enthusiasm. [The team] easy to work with. It's been fun in that regard."

Zimmerman said that Houston's talent pool is so extensive, he can't imagine "ever exhausting" the city's resources. He also sees Houston as an asset for Xola's continued growth. The company currently has offices in San Francisco, Houston, Bangalore, and Belgrade and anticipates more expansion in the coming years. Xola's ticketing and software system has received multiple five-star reviews from its customers, who praise not only its ease of operation, but also the company's stellar customer service. In fact, Xola just won a 2018 Ease of Use Award from Capterra.

"In addition to Xola's core booking system, we're building next-generation automated marketing features that help our customers maintain a competitive edge. And our Houston team will continue to grow as we do, so we can continue to serve markets around the world."

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.