Tomorrow, August 21, is World Entrepreneurs' Day, and it comes during a trying time for entrepreneurs everywhere. Here are three tips for business leaders operating during the pandemic. Photo via Getty Images

As company leaders approach the fourth quarter of 2020 and plan for 2021, many accept the fact that Houston's business landscape may look a bit different moving forward. Instead of the pandemic becoming a paralyzing force, new and eager business owners are committed to incorporating creative solutions.

These innovators have found ways to focus efforts to better serve customers in the transitioning economic landscape. The shift opens the door to new opportunity, and while the business outlook continues to evolve, some argue that times of crisis provide just as much, if not more, opportunity for entrepreneurs to find their footing. The past has shown that organizations can grow when faced with adversity and their resiliency in the earliest stages helps create a sturdy foundation.

According to the United States Bureau of Labor Statistics, twenty percent of small businesses fail within the first year, and by the tenth year, only about a third of businesses have survived. While these numbers may be intimidating to a new business owner, the measurements have proven consistent over time. This means success rates are less dependent upon the state of the economy and more dependent upon the creativity and drive of the entrepreneur leading the efforts.

Times of uncertainty and economic change bring focus to new obstacles, expose weaknesses in business structure and highlight the need for innovation. Strategic entrepreneurs can capitalize on these opportunities by introducing solutions that respond to the current reality consumers face. In honor of World Entrepreneurs' Day on August 21, below are steps to consider when launching a business during a time of crisis.

Plan for current conditions

It is always important for new business owners to plan for the future and be flexible enough to adjust them to the current environment. If a five-year plan is based on the premise of business returning to its pre-COVID-19 scale, the entrepreneur will likely face substantial challenges in the future.

Business plans should incorporate solutions to areas of weakness that have been brought to light by recent events. It may also be helpful to seek customer feedback early in the company's lifecycle to ensure audience opinion serves as a cornerstone in ongoing strategic development. Understanding if the business's premise will drive value and benefit consumers, even in difficult times, can help the organization prepare for future crises.

Identify gaps

In many ways, the pandemic identified business strategies that may no longer be relevant and provided insight into the economy's future. New entrepreneurs hold the advantage of witnessing what worked, what did not and applying the new knowledge to their plan.

The importance of flexibility, adaptable services, a strong digital brand presence and solid SEO practices all proved critical to a business's ability to remain both relevant and successful this year. When starting a company in times of economic uncertainty, identifying ways to bridge gaps and capitalize on windows of opportunity can help establish a competitive edge early on.

Seek out support

It is no surprise that, especially in the early stages, running a startup may be overwhelming. It is key for small business owners to feel comfortable asking for help and to seek out support early on. Consider joining business networks and local industry alliances to learn from others. Particularly in times of crisis and uncertainty, it can be beneficial to learn from seasoned professionals, as well as peers, and to welcome support from others who have found success during trying times.

Business support can be advantageous as well. While outsourcing may appear costly, the value of industry experts to assist with marketing strategy development, human resources and benefits, or financial management can be highly beneficial, especially in the development phase.

The early stages of an organization can make or break the success of a company, and though many questions surround the state of business during times of uncertainty, the entrepreneurial opportunity is still available for small business growth and success.

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Jill Chapman is a senior performance consultant with Houston-based Insperity, a leading provider of human resources and business performance solutions.

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.