Tomorrow, August 21, is World Entrepreneurs' Day, and it comes during a trying time for entrepreneurs everywhere. Here are three tips for business leaders operating during the pandemic. Photo via Getty Images

As company leaders approach the fourth quarter of 2020 and plan for 2021, many accept the fact that Houston's business landscape may look a bit different moving forward. Instead of the pandemic becoming a paralyzing force, new and eager business owners are committed to incorporating creative solutions.

These innovators have found ways to focus efforts to better serve customers in the transitioning economic landscape. The shift opens the door to new opportunity, and while the business outlook continues to evolve, some argue that times of crisis provide just as much, if not more, opportunity for entrepreneurs to find their footing. The past has shown that organizations can grow when faced with adversity and their resiliency in the earliest stages helps create a sturdy foundation.

According to the United States Bureau of Labor Statistics, twenty percent of small businesses fail within the first year, and by the tenth year, only about a third of businesses have survived. While these numbers may be intimidating to a new business owner, the measurements have proven consistent over time. This means success rates are less dependent upon the state of the economy and more dependent upon the creativity and drive of the entrepreneur leading the efforts.

Times of uncertainty and economic change bring focus to new obstacles, expose weaknesses in business structure and highlight the need for innovation. Strategic entrepreneurs can capitalize on these opportunities by introducing solutions that respond to the current reality consumers face. In honor of World Entrepreneurs' Day on August 21, below are steps to consider when launching a business during a time of crisis.

Plan for current conditions

It is always important for new business owners to plan for the future and be flexible enough to adjust them to the current environment. If a five-year plan is based on the premise of business returning to its pre-COVID-19 scale, the entrepreneur will likely face substantial challenges in the future.

Business plans should incorporate solutions to areas of weakness that have been brought to light by recent events. It may also be helpful to seek customer feedback early in the company's lifecycle to ensure audience opinion serves as a cornerstone in ongoing strategic development. Understanding if the business's premise will drive value and benefit consumers, even in difficult times, can help the organization prepare for future crises.

Identify gaps

In many ways, the pandemic identified business strategies that may no longer be relevant and provided insight into the economy's future. New entrepreneurs hold the advantage of witnessing what worked, what did not and applying the new knowledge to their plan.

The importance of flexibility, adaptable services, a strong digital brand presence and solid SEO practices all proved critical to a business's ability to remain both relevant and successful this year. When starting a company in times of economic uncertainty, identifying ways to bridge gaps and capitalize on windows of opportunity can help establish a competitive edge early on.

Seek out support

It is no surprise that, especially in the early stages, running a startup may be overwhelming. It is key for small business owners to feel comfortable asking for help and to seek out support early on. Consider joining business networks and local industry alliances to learn from others. Particularly in times of crisis and uncertainty, it can be beneficial to learn from seasoned professionals, as well as peers, and to welcome support from others who have found success during trying times.

Business support can be advantageous as well. While outsourcing may appear costly, the value of industry experts to assist with marketing strategy development, human resources and benefits, or financial management can be highly beneficial, especially in the development phase.

The early stages of an organization can make or break the success of a company, and though many questions surround the state of business during times of uncertainty, the entrepreneurial opportunity is still available for small business growth and success.

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Jill Chapman is a senior performance consultant with Houston-based Insperity, a leading provider of human resources and business performance solutions.

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CPRIT CEO: Houston’s $2B in funding is transforming cancer research and prevention

fighting cancer

With its plethora of prestigious health care organizations like the University of Texas MD Anderson Cancer Center, UTHealth Houston, and the Baylor College of Medicine, Houston sits at the heart of cancer research and prevention in Texas.

Of course, it takes piles of cash to support Houston’s status as the state’s hub for cancer research and prevention. Much of that money comes from the Cancer Prevention and Research Institute of Texas (CPRIT).

Data supplied by CPRIT shows organizations in Harris County gained $2.3 billion in institute funding from 2009 through 2025, or nearly $145 million per year. That represents almost 60 percent of the roughly $4 billion that CPRIT has granted to Texas institutions over a 16-year period.

“The life sciences ecosystem that has developed and changed in Houston is phenomenal,” Kristen Doyle, who became the agency’s CEO in July 2024, tells InnovationMap. “In the next decade, we will look back and see a great transformation.”

That ecosystem includes more than 1,100 life sciences and biotech companies, according to the Greater Houston Partnership.

Houston plays critical role in clinical trials

Texas voters approved the creation of CPRIT in 2007. Twelve years later, voters agreed to earmark an extra $3 billion for CPRIT, bringing the state agency’s total investment in cancer research and prevention to $6 billion.

To date, CPRIT money has gone toward recruiting 344 cancer researchers to Texas (mainly to Houston) and has supported cancer prevention services for millions of Texans in the state’s 254 counties. CPRIT funding has also helped establish, expand, or relocate 25 cancer-focused companies. In Houston, MD Anderson ranks as the No. 1 recipient of CPRIT funding.

Regarding cancer research, Doyle says Houston plays a critical role in clinical trials.

“[Clinical trials are] something that CPRIT has focused on more and more. Brilliant discoveries are crucial to this whole equation of solving the cancer problem,” Doyle says. “But if those brilliant ideas stay in the labs, then we’ve all failed.”

Researchers conduct more clinical trials in Houston than anywhere else in the U.S., the Greater Houston Partnership says.

Doyle, a 20-year survivor of leukemia, notes that a minority of eligible patients participate in clinical trials for cancer treatments, “and that’s one of the reasons that it takes so long to get a promising drug to market.”

An estimated 7 percent of cancer patients sign up for clinical trials, according to a study published in 2024 in the Journal of Clinical Oncology.

MD Anderson takes on cancer prevention

Doyle also notes that Houston is leading the charge in cancer prevention.

“We get some national recognition for programs that have been developed in Houston that then can be replicated in other parts of the country,” she says.

Much of the work in Houston focusing on cancer prevention takes place at MD Anderson. The hospital reports that it has received more than $725 million from the CPRIT since 2007, representing approximately 18 percent of CPRIT’s total awards.

“These efforts can have profound impact on the lives of patients and their families, and this funding ensures our exemplary clinicians and scientists can continue working together to drive breakthroughs that advance our mission to end cancer,” Dr. Giulio Draetta, chief scientific officer at MD Anderson, said in a November news release, following the most recent CPRIT award for the hospital totalling more than $29 million.

CPRIT funding for Houston institutions supplements the more than $4.5 billion in federal funding for health and life sciences research and innovations that the Houston area received from 2020 to 2024, according to the Greater Houston Partnership.

“We are curing cancer every single day,” Doyle says of CPRIT. “Every step that we are taking — whether that’s funding great ideas or funding the clinical trials that are bringing promising drugs to Texas and to the world — we are making a difference.”

Houston energy tech co. breaks ground on low-cost hydrogen pilot plant

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Houston’s Lummus Technology and Advanced Ionics have broken ground on their hydrogen pilot plant at Lummus’ R&D facility in Pasadena, Texas.

The plant will support Advanced Ionics’ cutting-edge electrolyzer technology, which aims to deliver high-efficiency hydrogen production with reduced energy requirements.

“By demonstrating Advanced Ionics’ technology at our state-of-the-art R&D facility, we are leveraging the expertise of our scientists and R&D team, plus our proven track record of developing breakthrough technologies,” Leon de Bruyn, president and CEO of Lummus, said in a news release. “This will help us accelerate commercialization of the technology and deliver scalable, cost-effective and sustainable green hydrogen solutions to our customers.”

Advanced Ionics is a Milwaukee-based low-cost green hydrogen technology provider. Its electrolyzer converts process and waste heat into green hydrogen for less than a dollar per kilogram, according to the company. The platform's users include industrial hydrogen producers looking to optimize sustainability at an affordable cost.

Lummus, a global energy technology company, will operate the Advanced Ionics electrolyzer and manage the balance of plant systems.

In 2024, Lummus and Advanced Ionics established their partnership to help advance the production of cost-effective and sustainable hydrogen technology. Lummus Venture Capital also invested an undisclosed amount into Advanced Ionics at the time.

“Our collaboration with Lummus demonstrates the power of partnerships in driving the energy transition forward,” Ignacio Bincaz, CEO of Advanced Ionics, added in the news release. “Lummus serves as a launchpad for technologies like ours, enabling us to validate performance and integration under real-world conditions. This milestone proves that green hydrogen can be practical and economically viable, and it marks another key step toward commercial deployment.”

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This article originally appeared on EnergyCapitalHTX.com.

TMC launches new biotech partnership with Republic of Korea

international collaboration

Houston's Texas Medical Center has launched its new TMC Republic of Korea BioBridge.

The new partnership brings together the TMC with the Osong Medical Innovation Foundation, or KBIOHealth. The Biobridge aims to support the commercialization of Korean biotech and life science startups in the U.S., foster clinical research, and boost collaboration in the public, private and academic sectors.

Through the partnership, TMC will also develop a Global Innovators Launch Pad to foster U.S. market entry for international health care companies. Founders will be selected to participate in the 10-week program at the TMC Innovation Factory in Houston.

“Gene and cell therapies are driving biotech innovation, opening possibilities for treating diseases once thought untreatable," William McKeon, president and CEO of the Texas Medical Center, said in a news release. "Expanding biomanufacturing capacity is essential to delivering the next wave of these therapies, and partnerships with leading innovators will strengthen our efforts in Houston and internationally.”

McKeon officially signed the TMC Korea BioBridge Memorandum of Understanding with Myoung Su Lee, chairman of KBIOHealth, in South Korea in October.

"This collaboration marks a significant milestone for Korea’s biohealth ecosystem, creating a powerful bridge between Osong and Houston," Lee added in the release. "By combining KBIOHealth’s strength in research infrastructure and Korea’s biotech talent with TMC’s global network and accelerator platform, we aim to accelerate innovation and bring transformative solutions to patients worldwide.”

This is the seventh international strategic partnership for the TMC. It launched its first BioBridge with the Health Informatics Society of Australia in 2016. It launched its TMC Japan BioBridge, focused on advancing cancer treatments, last year. It also has BioBridge partnerships with the Netherlands, Ireland, Denmark and the United Kingdom.