Life is much more difficult when you're stressed out. Photo via Getty Images

There is a plethora of reasons to be stressed out in 2024. Among the list of grievances are budgeting woes, lapses in addressing racial inequity, a significant amount of drunk driving, and prohibitively high healthcare costs.

So it comes as no surprise that Texas was ranked the No. 10 most stressed state of 2024, according to the latest annual report from WalletHub. Texans' stress levels are only slightly better than they were in 2023, when the Lone Star State ranked No. 9.

The personal finance website compared all 50 states across 40 unique metrics to determine every state’s worries on certain issues, such as employment, finance, health, or family-related stress.

Here's how Texas performed in the major categories in the study:

  • No. 5 – Work-related stress
  • No. 8 – Family-related stress
  • No. 11 – Health- and safety-related stress
  • No. 23 – Money-related stress

Texas employees have the second-longest workweek in the nation, the report found, placing the state right behind Alaska and tied with Wyoming. Places like Houston, Corpus Christi, and San Antonio are a few of the most stressful U.S. cities for workers in 2024 (with several other Texas cities not far behind), clearly showing that there's much more work to be done to alleviate Texans' work-related stress.

Hardships with work may have an influence on Texans' ability to rest at night, as the report additionally found Texas fell behind into No. 23 for its share of adults that get adequate sleep.

Other Texas-sized stress factors like crime rates, housing affordability, health troubles, and poverty rates also put a damper on residents' well-beings. Texans have the fourth lowest credit scores in the nation, the ninth highest share of adults with fair or poor health, and the 11th highest number of residents living in poverty.

It's not just young and middle-aged adults who experience these worries, the report claimed.

"[E]very age group except people 65 and older reported being under more stress in 2023 than they were in 2019 before the pandemic," the report's author wrote.

WalletHub analyst Cassandra Happe suggested a few ways frazzled Texans can try to improve their stress levels, such as exercising, participating in hobbies, going on vacations — of course, in whatever capacity that is most accessible — and seeking help from a mental health professional.

"What many people don’t realize, though, is that changing location can also be a big stress reducer," Happe added. "For example, states that have lower crime rates, better health care, and better economies tend to have much less stressed residents."

Texans surely aren't envious of Louisiana, which traded places with Mississippi (No. 2) in 2024 to become the nation's No. 1 most stressed out state. Louisiana residents experience the third highest work- and health-and-safety-related stress, the fourth highest money-related stress, and the 10th highest family-related stress. Louisianans may want to try some breathing exercises in their spare time.

Texas residents can, however, be filled with jealousy over Minnesota (No. 50), which was crowned the least stressed out city in America. Maybe that's where Texans need to be taking vacations.

The overall top 10 most stressed states are:

  • No. 1 – Louisiana
  • No. 2 – Mississippi
  • No. 3 – Nevada
  • No. 4 – New Mexico
  • No. 5 – Arkansas
  • No. 6 – West Virginia
  • No. 7 – Alabama
  • No. 8 – Kentucky
  • No. 9 – Oklahoma
  • No. 10 – Texas
The full report and its methodology can be found on wallethub.com.

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This article originally ran on CultureMap.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”