A COVID-19 research breakthrough out of a Texas university comes from unlikely source

have you heard the one about the llama?

COVID-19 antibody research coming out of the University of Texas stars an unlikely participant: A llama named Winter. University of Texas at Austin/Facebook

In the race to find a treatment for the novel coronavirus, researchers at the University of Texas at Austin have announced a potential breakthrough — thanks to a llama.

Scientists from Texas' flagship university who have been collaborating with the National Institutes of Health and Ghent University in Belgium identified an antibody treatment that could potentially neutralize the virus that causes COVID-19.

The researchers detail their work in the May 5 edition of Cell, a scientific journal.

"This is one of the first antibodies known to neutralize SARS-CoV-2," said Jason McLellan, associate professor of molecular biosciences at UT Austin and co-senior author of the paper, in a release. (FYI, SARS-CoV-2 is referring to the virus that causes COVID-19.)

Using a Belgian llama named Winter, scientists were able to identify two antibodies the animal produces when it comes into contact with a foreign body (such as the coronavirus). The first is similar to a human antibody and the second is much smaller, about one-quarter of the size of the other.

This is Winter. Photo courtesy of University of Texas at Austin

Researchers were able to link two copies of this special llama antibody to create a new antibody. This new antibody binds tightly to a key protein on the coronavirus germ that causes COVID-19 and could possible be nebulized and put into an inhaler.

"That makes them potentially really interesting as a drug for a respiratory pathogen because you're delivering it right to the site of infection," said Daniel Wrapp, a UT graduate student in McLellan's lab and co-first author of the paper.

Unlike vaccines, which can take up to two months to take effect, antibody treatment can be used in more vulnerable populations as a way to fight off the virus.

"Vaccines have to be given a month or two before infection to provide protection," McLellan said. "With antibody therapies, you're directly giving somebody the protective antibodies and so, immediately after treatment, they should be protected. The antibodies could also be used to treat somebody who is already sick to lessen the severity of the disease."

From here, research turns to preclinical studies, using hamsters and primates for testing. If successful, they will move onto humans.

If you're wondering just how a group of researchers living in different parts of the globe were able to make this discovery seemingly overnight, that's because they've actually been working on it since 2016, when Winter was just 9 months old.

The experiment began as a way to develop vaccinations for two earlier versions of the coronavirus: SARS-CoV-1 and MERS-CoV. Their years of research allowed the scientists to pivot in recent months to isolating the protein in COVID-19.

As for Winter, she's now 4 years old and still lives with about 130 llamas on a farm in Belgium, likely unaware of her contribution to potentially altering the course of COVID-19 forever.

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This article originally ran on CultureMap.

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Houston SaaS startup closes $12M series A funding round with support from local VC

money moves

A Houston startup with a software-as-a-service platform for the energy transition has announced it closed a funding round with participation from a local venture capital.

Molecule closed its $12 million series A, and Houston-based Mercury Fund was among the company's investors. The company has a cloud-based energy trading and risk management solution for the energy industry and supports power, natural gas, crude/refined products, chemicals, agricultural commodities, softs, metals, cryptocurrencies, and more.

"We led the seed round of Molecule upon their formation and are excited to participate in their series A," says Blair Garrou, co-founder and managing director of Mercury, in a news release. "Molecule's success in the ETRM/CTRM industry, especially in relation to electricity and renewables, positions them as the company to beat for the energy transition in the 2020s."

The company will use its new funds to further build out its product as well as introduce offerings to manage renewables credits, according to the release.

"In 2020, we realized that electricity — the growth commodity of the 2020s — represented over half of Molecule's customer base, and we decided to double down," says Sameer Soleja, founder and CEO of Molecule, in the release. "We were also rated the No. 1 SaaS ETRM/CTRM vendor. With this fundraise, we have the fuel to become No. 1 SaaS platform for power and renewables, and then the market leader overall.

"Molecule is ready to power the energy transition," Soleja continues.

Molecule's last round of funding closed in November 2014. The $1.1 million seed round was supported by Mercury Fund and the Houston Angel Network.

Houston-based afterlife planning startup launches new app

there's an app for that

The passing of a loved one is followed with grief — and paperwork. A Houston company that's simplifying the process of afterlife planning and decision making is making things even easier with a new smartphone app.

The Postage, a digital platform meant to ease with affair planning, recently launched a mobile app to make the service more accessible following a particularly deadly year. The United States recorded 3.2 million fatalities — the most deaths in its history, largely due to the coronavirus pandemic.

After losing three family members back-to-back, Emily Cisek dealt first hand with the difficulty of wrapping up a loved one's life. She saw how afterlife planning interrupted her family's grieving and caused deep frustration. Soon, she began to envision a solution to help people have a plan and walk through the process of losing someone.

The Postage, which launched in September, provides a platform for people to plan their affairs and leave behind wishes for loved ones. The website includes document storage and organization, password management, funeral and last wishes planning, and the option to create afterlife messages to posthumously share with loved ones.

"Right now, as it stands ahead of this app, end-of-life planning is really challenging. It's this daunting thing you have to sit down and do at your computer," says Cisek. Not only is it "daunting," but it's time-consuming. According to The Postage, families can expect to spend nearly 500 hours on completing end-of-life details if there is no planning done in advance.

With more than 74 percent of The Postage's web traffic coming from mobile users, an app was a natural progression. In fact, Entrepreneur reports the average person will spend nine years on their mobile device. Cisek wanted to meet users where they are at with a user-friendly app that includes the same features as the desktop website.

"What we wanted to do [with the app] is make it so easy to plan your life and the end of your life using one click — as easy as it was for posting and commenting on social media," explains Cisek. "People are so used to reflecting on those behaviors and clicking one button to add a picture ... we wanted to make it that simple," she continued.

Cisek and her team focused on providing a "seamless experience" within the app, which took approximately four months to build, which mirrors the desktop platform.

Though The Postage's website had mobile functionality, the app includes the ability to record and upload content. Whether snapping a picture of their insurance policy or recording a video to share with loved ones, The Postage app allows users to capture photos and videos directly within the app.

After snapping a picture, "the next step inherently is sharing it with your loved ones," says Cisek. Photos, family recipes and videos can easily be shared securely with loved ones who accept your invitation to The Postage so "that legacy continues on," she says.

Since The Postage's fall launch, the company has grown a steady base of paid subscribers with plans to expand.

"We're really starting to change the way people plan for the future," says Cisek.