You can search Houston's top BBQ spots by a wide range of criteria. Courtesy of Houston BBQ Guide

Anew website wants to help Houstonians eat better barbecue. Created by the founders of the Houston BBQ Festival, the Houston BBQ Guide offers readers the ability to search for restaurants based on a wide range of criteria, including location, parking, and whether a restaurant is likely to sell out of food.

The editors of the guide, led by Houston Chronicle barbecue columnist J.C. Reid, have selected the 28 initial entries with an eye on small, family-run businesses that aim "to provide a quality product and experience on a consistent basis." Entries include both historic barbecue joints like Lenox Bar-B-Q and Pizzitola's Bar-B-Que as well as spots that have earned recognition on Texas Monthly's list of the state's 50 best such as CorkScrew BBQ and The Pit Room.

Each entry includes details about a restaurant's ownership and pitmaster, noteworthy dishes, and a brief video tour. The website also includes essays about the history of Houston's barbecue restaurants and other relevant topics.

As an "about the guide" section notes, people who want to eat barbecue may not know where to find it. By breaking things does geographically, the guide offers diners the opportunity to discover new places or be prompted to visit old favorites that aren't necessarily included in media-generated lists of the "best" barbecue restaurants.

"I like to think of it as a guide for everyday barbecue fans," Reid said in a statement.

The guide also offers an alternative to crowd-sourced review websites as well as the responses one gets on social media when a request for a restaurant near Sugar Land might be met with a suggestion to drive to Tomball — well-intentioned, surely, but not very helpful.

The guide will add new entries in time. For example, Feges BBQ's original Greenway Plaza location is listed but its newly opened Spring Branch outpost isn't (yet). A separate guide to barbecue pop-ups is already in the works, and the editors also tout the possibility of expanding to other Texas cities.

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This article originally ran on CultureMap.

Kids can know their grandparents and great-grandparents a little better. Keeping Families Connected/Facebook

Sweet new Texas-based website lets you record a final goodbye for loved ones

FAMILY LEGACIES

Anew North Texas startup helps soothe the sting of losing loved ones by allowing them to leave behind an entirely different kind of heirloom. A Sweet Goodbye is a new online service that lets people record messages that can be accessed and enjoyed by family and friends after they're gone.

Fort Worth-based founder Rich Hollander, who worked for Radio Shack/Tandy Corporation in the area for more than 25 years, got the idea about a year ago during a reflective moment.

"I was sitting in synagogue, a quiet time when you contemplate things," he says. "During those times, I talk to my parents — who are both gone — and my late brother, and about 15 other people who have passed away. On this particular morning, I was talking to my mom. I knew what she was telling me, but I couldn't hear her voice. I thought, 'I wish I could just push a button and hear her voice,' but there's nothing I could do about that."

While it's too late for Hollander to hear his mother's voice, he says, he wanted to provide such a service for other people. He also says he wanted to make the process as simple and as painless as possible.

"You go to our website and click on a button that says, 'I want to make a recording.' Before that you prepare a little bit. You figure out what you want to say, and you figure out who you want to send the message to. You get their email address, and we ask you to give us two trusted advisers so they can tell us when you passed away, and then you just record your message, and that's it."

The message customers record is hosted on the cloud, and it's all audio based. Your loved one will hear it after you die, as many times as they would like. There is no video option, and messages can last a maximum of five minutes long. According to Hollander, this is by design rather than due to technical limitations.

"We thought about our target customers; Baby Boomers and their parents don't want to see themselves," he says. "They don't like the idea of recording a video. And people don't want to listen for more than five minutes. You can say a lot in that amount of time."

Some people choose to pass down secret family recipes or record tales from their youth, the company says.

Realizing that people can also use phones and other home devices to make recordings, Hollander made A Sweet Goodbye inexpensive, accessible, and convenient. He says there are other options for similar services on the market, but they are "much more complex" and "much more expensive," costing up to $8 per month, compared to his company's one-time fee.

"You can listen to it a thousand times from your computer or your phone," he says. "You can have your children listen to it. They can listen to their great grandma's voice. For $25, it's a bargain."

Hollander himself uses the service.

"I have two adult daughters in their 40s," he says. "One lives here, one lives in New Zealand. My message to them is something like, 'If you pushed this button, you are probably having a bad day, and just need my voice of reassurance. So, understand that I'm up here in heaven, and I'm looking after you guys, and tomorrow will be a better day than today.' They can push that button and hear that message whenever and wherever they want."

While A Sweet Goodbye is simple to use, there is an emotional hurdle in getting started.

"The hard part is making the first message," Hollander says. "Because it's coming to grips with the fact that you are not going to be around forever, and neither is your mom. But it is cathartic. For me, the second message was extremely easy to make."

The site has just launched and is now available for anyone to access. On Veterans Day (November 11), A Sweet Goodbye will provide one free service for active duty members in the United States military. Later, they will do another giveaway for nurses and first responders. Follow their Facebook page for updates.

"It's our way of doing something nice for the world," Hollander says.

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This article originally ran on CultureMap.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”