New tech platform allows Houstonians access to the city's top BBQ

where's the beef

You can search Houston's top BBQ spots by a wide range of criteria. Courtesy of Houston BBQ Guide

Anew website wants to help Houstonians eat better barbecue. Created by the founders of the Houston BBQ Festival, the Houston BBQ Guide offers readers the ability to search for restaurants based on a wide range of criteria, including location, parking, and whether a restaurant is likely to sell out of food.

The editors of the guide, led by Houston Chronicle barbecue columnist J.C. Reid, have selected the 28 initial entries with an eye on small, family-run businesses that aim "to provide a quality product and experience on a consistent basis." Entries include both historic barbecue joints like Lenox Bar-B-Q and Pizzitola's Bar-B-Que as well as spots that have earned recognition on Texas Monthly's list of the state's 50 best such as CorkScrew BBQ and The Pit Room.

Each entry includes details about a restaurant's ownership and pitmaster, noteworthy dishes, and a brief video tour. The website also includes essays about the history of Houston's barbecue restaurants and other relevant topics.

As an "about the guide" section notes, people who want to eat barbecue may not know where to find it. By breaking things does geographically, the guide offers diners the opportunity to discover new places or be prompted to visit old favorites that aren't necessarily included in media-generated lists of the "best" barbecue restaurants.

"I like to think of it as a guide for everyday barbecue fans," Reid said in a statement.

The guide also offers an alternative to crowd-sourced review websites as well as the responses one gets on social media when a request for a restaurant near Sugar Land might be met with a suggestion to drive to Tomball — well-intentioned, surely, but not very helpful.

The guide will add new entries in time. For example, Feges BBQ's original Greenway Plaza location is listed but its newly opened Spring Branch outpost isn't (yet). A separate guide to barbecue pop-ups is already in the works, and the editors also tout the possibility of expanding to other Texas cities.

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This article originally ran on CultureMap.

Kids can know their grandparents and great-grandparents a little better. Keeping Families Connected/Facebook

Sweet new Texas-based website lets you record a final goodbye for loved ones

FAMILY LEGACIES

Anew North Texas startup helps soothe the sting of losing loved ones by allowing them to leave behind an entirely different kind of heirloom. A Sweet Goodbye is a new online service that lets people record messages that can be accessed and enjoyed by family and friends after they're gone.

Fort Worth-based founder Rich Hollander, who worked for Radio Shack/Tandy Corporation in the area for more than 25 years, got the idea about a year ago during a reflective moment.

"I was sitting in synagogue, a quiet time when you contemplate things," he says. "During those times, I talk to my parents — who are both gone — and my late brother, and about 15 other people who have passed away. On this particular morning, I was talking to my mom. I knew what she was telling me, but I couldn't hear her voice. I thought, 'I wish I could just push a button and hear her voice,' but there's nothing I could do about that."

While it's too late for Hollander to hear his mother's voice, he says, he wanted to provide such a service for other people. He also says he wanted to make the process as simple and as painless as possible.

"You go to our website and click on a button that says, 'I want to make a recording.' Before that you prepare a little bit. You figure out what you want to say, and you figure out who you want to send the message to. You get their email address, and we ask you to give us two trusted advisers so they can tell us when you passed away, and then you just record your message, and that's it."

The message customers record is hosted on the cloud, and it's all audio based. Your loved one will hear it after you die, as many times as they would like. There is no video option, and messages can last a maximum of five minutes long. According to Hollander, this is by design rather than due to technical limitations.

"We thought about our target customers; Baby Boomers and their parents don't want to see themselves," he says. "They don't like the idea of recording a video. And people don't want to listen for more than five minutes. You can say a lot in that amount of time."

Some people choose to pass down secret family recipes or record tales from their youth, the company says.

Realizing that people can also use phones and other home devices to make recordings, Hollander made A Sweet Goodbye inexpensive, accessible, and convenient. He says there are other options for similar services on the market, but they are "much more complex" and "much more expensive," costing up to $8 per month, compared to his company's one-time fee.

"You can listen to it a thousand times from your computer or your phone," he says. "You can have your children listen to it. They can listen to their great grandma's voice. For $25, it's a bargain."

Hollander himself uses the service.

"I have two adult daughters in their 40s," he says. "One lives here, one lives in New Zealand. My message to them is something like, 'If you pushed this button, you are probably having a bad day, and just need my voice of reassurance. So, understand that I'm up here in heaven, and I'm looking after you guys, and tomorrow will be a better day than today.' They can push that button and hear that message whenever and wherever they want."

While A Sweet Goodbye is simple to use, there is an emotional hurdle in getting started.

"The hard part is making the first message," Hollander says. "Because it's coming to grips with the fact that you are not going to be around forever, and neither is your mom. But it is cathartic. For me, the second message was extremely easy to make."

The site has just launched and is now available for anyone to access. On Veterans Day (November 11), A Sweet Goodbye will provide one free service for active duty members in the United States military. Later, they will do another giveaway for nurses and first responders. Follow their Facebook page for updates.

"It's our way of doing something nice for the world," Hollander says.

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This article originally ran on CultureMap.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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