Here are 3 Houston innovators to know right now

Innovators to Know

Khaliah Guillory, founder of Nap Bar, says she hopes to expand to 30 locations in three years. Photo courtesy Khaliah Guillory

Editor's note: These Houston innovators are making big strides in the fields of neurotechnology, neurodevelopmental diagnosis, and even improving the way we rest and recharge.

For our latest roundup of Innovators to Know, we meet a researcher who is working with teams in Houston and abroad to develop an innovative brain implant; a professor who has created an AI approach to diagnosis; and a local entrepreneur whose brand is poised for major expansion in the coming years.

Jacob Robinson, CEO of Motif Neurotech

Houston startup Motif Neurotech has been selected by the United Kingdom's Advanced Research + Invention Agency (ARIA) to participate in its inaugural Precision Neurotechnologies program. The program aims to develop advanced brain-interfacing technologies for cognitive and psychiatric conditions. Three Rice labs will collaborate with Motif Neurotech to develop Brain Mesh, which is a distributed network of minimally invasive implants that can stimulate neural circuits and stream neural data in real time. The project has been awarded approximately $5.9 million.

Motif Neurotech was spun out of the Rice lab of Jacob Robinson, a professor of electrical and computer engineering and bioengineering and CEO of Motif Neurotech.

Robinson will lead the system and network integration and encapsulation efforts for Mesh Points implants. According to Rice, these implants, about the size of a grain of rice, will track and modulate brain states and be embedded in the skull through relatively low-risk surgery. Learn more.

Dr. Ryan S. Dhindsa, Dhindsa Lab

Dr. Ryan S. Dhindsa, assistant professor of pathology and immunology at Baylor and principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and his team have developed an artificial intelligence-based approach that will help doctors to identify genes tied to neurodevelopmental disorders. Their research was recently published the American Journal of Human Genetics.

Dhindsa Lab uses “human genomics, human stem cell models, and computational biology to advance precision medicine.” The diagnoses that stem from the new computational tool could include specific types of autism spectrum disorder, epilepsy and developmental delay, disorders that often don’t come with a genetic diagnosis.

“Although researchers have made major strides identifying different genes associated with neurodevelopmental disorders, many patients with these conditions still do not receive a genetic diagnosis, indicating that there are many more genes waiting to be discovered,” Dhindsa says. Learn more.

Khaliah Guillory, Founder of Nap Bar

From nap research to diversity and inclusion, this entrepreneur is making Houston workers more productiveFrom opening Nap Bar and consulting corporations on diversity and inclusion to serving the city as an LGBT adviser, Khaliah Guillory is focused on productivity. Courtesy of Khaliah Guillory

Khalia Guillory launched her white-glove, eco-friendly rest sanctuary business, Nap Bar, in Houston in 2019 to offer a unique rest experience with artificial intelligence integration for working professionals, entrepreneurs and travelers who needed a place to rest, recharge and rejuvenate.

Now she is ready to take it to the next level, with a pivot to VR and plans to expand to 30 locations in three years.

Guillory says she’s now looking to scale the business by partnering with like-minded investors with experience in the wellness space. She envisions locations at national and international airports, which she says offer ripe scenarios for patrons needing to recharge. Additionally, Guillory wants to build on her initial partnership with UT Health by going onsite to curate rest experiences for patients, caregivers, faculty, staff, nurses and doctors. Colleges also offer an opportunity for growth. Learn more.

Oculus Go is enabling users to their canceled travels with a virtual getaway. Image courtesy of Oculus Go

Virtual reality app developed in Houston allows users to escape to far away lands

there's an app for that

While rising coronavirus cases in the area have canceled so many summer vacations, not all hope of sightseeing this summer is lost. A Houston entrepreneur has created a virtual alternative.

Houston-area industrial design startup, Armstrong Innovations launched two Oculus Go app games, aptly named 'Escape'. The VR app was designed with relaxation and meditation in mind but has doubled as a new way to relax and sightsee without leaving your home during the COVID-19 pandemic.

"The sights and sounds of our new app assist with mindfulness and meditation," says CEO and founder Derek Armstrong. "It's about focusing on the sights and sounds, especially with the virus growing. It's a quick getaway without having to physically go anywhere."

The project began a year ago and was completed in March — right at the start of stay-at-home orders that paralyzed everyday life before launching this month. The company's new array of Occulus Go experiences aims at easing the mind and spirits, but with the rise of coronavirus 'Escape' can also serve to calm frayed nerves.

The app is based on popular view master toys and stereoscopes from the 1800s that are reminiscent of exploration tools used over the years. There are two different experiences to choose from one named 'Escape: Roma' for its old-world inspired poolside lounge and another named 'Escape: Utopia', which brings outer space to life in front of an Oculus user's eyes.

"The app has already gotten a lot of traction in places where people are not able to go out in the world," says Armstrong. "It's so easy just to pop on your Oculus headset, open the app, and zone out or relax for a few minutes."

The local industrial design startup was founded in 2018, and it has already released a few music packs with tracks ranging from horror titles to 8-bit retro remakes for Unreal Engine projects, an advanced real-time 3D creation tool that serves as a game engine for creators to deliver interactive experiences. The music packs are a collection of audio assets made in collaboration with Epic Games.

"Our company is focused on creating engaging gamified experiences," says Armstrong. "The inspiration for our packs and now our new app came from my interest in treating PTSD and how virtual reality can help ease the symptoms of anxiety in some cases."

Armstrong, a Houston native, describes himself as a "maker of stuff," with previous experience in music production and a passion for design. According to him, his hometown is the best place to be.

"Houston really has everything you need, when it comes to new innovations and technology," says Armstrong. "I would prefer to have my business rooted in Houston rather than moving to a design startup hotspot."

Armstrong Innovations hopes to grow into new areas of the industrial design world, especially in military-driven technologies and other video game opportunities in the next year or so. Product keys for 'Escape' can be purchased online now, available worldwide for maximum relaxation.


Derek Armstrong, a Houston native, founded his design company, Armstrong Innovations. Photo courtesy of Oculus Go

The majority of McCarthy Building Companies' projects now include some sort of virtual or augmented reality technology. Courtesy of McCarthy Building Companies

Houston-area construction team utilizes technology to solve problems

Reality real estate

In recent years, the construction industry has begun embraced advancements in reality technology like virtual reality and augmented reality. While it has yet to reach critical mass in the industry, several contracting companies in the Houston region like McCarthy Building Companies are embracing the technology and blazing the trail for the construction industry.

Chris Patton, virtual design and construction manager for McCarthy's southern region, says many construction companies are consistently looking for ways to improve processes and procedures through reality technology.

"We really saw the potential and use cases for [VR] really early on, and it was really just a matter of the hardware and the software catching up to being something usable, consumable, deployable and cost effective on our projects," Patton says. "We were sitting there waiting for it and ready to go when it was."

Patton says these visualization tools have changed the way contractors display projects and have helped the partners on these projects — such as the design team, building owner and subcontractors — make better informed decisions earlier, more quickly and sometimes at a cheaper price point.

Before AR and VR technology entered the construction industry, companies either had to work with two-dimensional construction drawings or build very expensive, three-dimensional models, or mock ups, of construction sites that allowed clients to physically walk through a building space to interact with its features. Patton says the entire mock-up building process used to cost roughly $1 million — depending on the project size.

However, now this costly and time-consuming process is a thing of the past, as construction companies have found a way to utilize AR and VR technology to bring clients into a computer-generated environment. By putting on an AR or VR helmet, clients can immerse themselves and engage in a virtual environment that shows them all of the project's details and allows them to move about a virtual construction site the same way they would in a 3D model.

McCarthy's Houston division began utilizing reality technology in early 2015, with some of its other markets integrating the technology into their practices in late 2014. Since then, the company's use of AR and VR technology has grown exponentially, Patton says.

"When we first started evaluating and looking at virtual reality and augmented reality, [we] might have [used it on] one or two projects a year, and that was probably three years ago," Patton says. "Today, I'd say almost 60-75 percent of our projects—at some point in design or construction — utilize virtual reality or augmented reality or a combination of both."

Although McCarthy has been around since 1864, the general contracting company made its Texas debut in Dallas in 1981. Since then McCarthy expanded to create a Houston office in 2011, building a portfolio of renowned Houston clients such as the Museum of Fine Arts, Houston, the Holocaust Museum Houston, Texas Children's Hospital as well as the recent completion of Houston ISD's Kinder High School for the Performing and Visual Arts.

A notable project McCarthy's Houston Division took on was phase one the MFAH's master plan that included building The Glassell School of Art. The company also continues its work on phase two, which includes new developments for the MFAH for which McCarthy's virtual design and construction group created VR and AR models for the museum.

By using software like HoloLive and Fuzor for AR technology and Fuzor for VR technology, McCarthy's VDC group can visualize and combine digital creations with the real world, Patton says. With the growing number of projects utilizing the technology, Patton says McCarthy has invested greatly in personnel who will help grow the VDC group and continue to look for advancements in the construction industry.

"Some of the folks that we have those [VDC] positions in our company, some of them come from construction technology backgrounds and construction management backgrounds but others come from graphical design and have like a gaming background, some come from architectural backgrounds," Patton says. "[Reality technology] really kind of opened the door to a new opportunity for people to get engaged with the construction industry that we hadn't seen in the past."

Lori-Lee Emshey's Future Sight AR is revolutionizing antiquated construction tools using augmented reality. Courtesy of Future Sight AR

Houston company has sight set on AR solutions for industrial construction

Visual aid

When Lori-Lee Emshey got her first oil and gas construction job in Australia, she was carrying around a backpack full of papers.

"I was really shocked at how much work they were doing with such little technology," Emshey says. "I thought, 'there's so much room for innovation here.'"

She realized that it wasn't just that site or the company she was working for — this was a problem across the industry. So, she came up with a solution. Houston-based Future Sight AR is an augmented reality technology to more efficient work on industrial construction sites. Workers can use a smart device in the field, point it at a problem on site, log the issue, and see the steps needed to fix it.

Constructing a company
Emshey realized the potential for a company in January 2016. Since then, she's partnered up with her co-founders, Sofia Lazaro and Veena Somareddy, attended accelerators and conferences across the country, completed a proof of concept, until finally incorporated this year.

It was a well-paced start for the company because they got to prove time and time again there was a need for the company. Emshey says she never wanted to start a company just to start a company. They worked tirelessly at the beginning to ensure there was no one out there already doing this in the way they were doing it.

"I feel like a lot of entrepreneurs now become an entrepreneur because it's trendy and cool, and you want to put it in your Instagram bio," she says. "The three of us aren't like that. We did this because we had to. It wasn't going to get done another way, and we couldn't let this giant opportunity float on by."

Once they got a firm footing, one of the challenges they faced was communicating the company's market need and how the technology works to individuals outside the industry. For Emshey, this was particularly annoying.

"I came from a journalism background, and it's storytelling," she says. "I thought, 'I should be able to do this.'"

Something eventually just clicked, and Emshey stopped seeing confused faces in response to her presentation, and she started seeing more head nodding. However, another challenge she says she occasionally faces is how she looks.

"It is tough. I'm pitching this industrial construction startup, and I show up and I'm a 5-foot-5 blond woman," she says. "And some people don't care, and some people would prefer I looked a different way."

Foreseeing the company's future
Raising capital has been the latest focus for Future Sight AR. Aside from some grants and accelerator money, the company hasn't raised much. They've only just started meeting with investors and have a plan to launch a round of fundraising next year. Emshey also says they are looking to partner with three companies to conduct a few pilots early next year.

It's a great time in technology for Future Sight AR as more and more people are using AR and virtual reality. People use AR or VR often — in SnapChat filters or through Pokemon Go!

Emshey says she thinks VR will grow first in gaming, while AR will take off through enterprise.

"Unlike VR when you're completely immersed, in AR, you're seeing your actual environment and one of the places you have to do that is at work," Emshey says.

Whether it's through being acquired or growing the company on its own, Emshey says she wants Future Sight AR to evolve the industry as a whole.

"If we could permanently change the way that we build projects — oil and gas or another industry — and move it toward something more efficient, safer, more productive, and a better experience for workers, and accomplish that in a permanent way in a permanent way, then we're successful," she says. "We really built this for me — I was the worker out in the field trying to do things, and it was unnecessarily difficult."

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5 Rice University-founded startups named finalists ahead of prestigious pitch competition

student founders

Five student-founded startups have been named finalists for Rice University's prestigious pitch competition, hosted by Rice University’s Liu Idea Lab for Innovation and Entrepreneurship later this month

The teams will compete for a share of $100,000 in equity-free funding at the H. Albert Napier Rice Launch Challenge (NRLC), a venture competition that features Rice University's top student-founded startups. The competition is open to undergraduate, graduate, and MBA students at Rice.

Finalists will pitch their five-minute pitch before the Rice entrepreneurship community, followed by a Q&A from a panel of judges, at Rice Memorial Center Tuesday, April 22.

The first-place team will receive $50,000 in equity-free funding, with other prizes and awards ranging from $25,000 to $1,000. Apart from first-, second- and third-place prizes, NRLC will also name winners in categories like the Outstanding Achievement in Artificial Intelligence Prize, the Outstanding Achievement in Climate Solutions Prize, and the Audience Choice Award.

Here are the five startups founded by Rice students are heading to the finals.

Haast Autonomous

Haast Autonomous is building unmanned, long-range VTOL aircraft with cold storage to revolutionize organ transport—delivering life-saving medical supplies roof-to-roof faster, safer, and more efficiently than current systems.

Founders: Jason Chen, Ege Halac, Santiago Brent

Kinnections

Kinnections' Glove is a lightweight, wearable device that uses targeted vibrations to reduce tremors and improve motor control in Parkinson’s patients.

Founders: Emmie Casey, Tomi Kuye

Labshare

Labshare is an AI-powered web app that streamlines lab inventory and resource sharing, reducing waste and improving efficiency by connecting neighboring labs through a centralized, real-time platform.

Founders: Julian Figueroa Jr, John Tian, Mingyo Kang, Arnan Bawa, Daniel Kuo

SteerBio

SteerBio’s LymphGuide is a patented, single-surgery hydrogel solution that restores lymphatic function by promoting vessel growth and reducing rejection, offering a transformative, cost-effective treatment for lymphedema.

Founders: Mor Sela Golan, Martha Fowler, Alvaro Moreno Lozano

Veloci

Veloci Running creates innovative shoes that eliminate the trade-off between foot pain and leg tightness, empowering runners to train comfortably and reduce injury risk.

Founders: Tyler Strothman

Last year, HEXASpec took home first place for its inorganic fillers that improve heat management for the semiconductor industry. The team also won this year's Energy Venture Day and Pitch Competition during CERAWeek in the TEX-E student track.

Dow aims to power Texas manufacturing complex with next-gen nuclear reactors

clean energy

Dow, a major producer of chemicals and plastics, wants to use next-generation nuclear reactors for clean power and steam at a Texas manufacturing complex instead of natural gas.

Dow's subsidiary, Long Mott Energy, applied Monday to the U.S. Nuclear Regulatory Commission for a construction permit. It said the project with X-energy, an advanced nuclear reactor and fuel company, would nearly eliminate the emissions associated with power and steam generation at its plant in Seadrift, Texas, avoiding roughly 500,000 metric tons of planet-warming greenhouse gas emissions annually.

If built and operated as planned, it would be the first U.S. commercial advanced nuclear power plant for an industrial site, according to the NRC.

For many, nuclear power is emerging as an answer to meet a soaring demand for electricity nationwide, driven by the expansion of data centers and artificial intelligence, manufacturing and electrification, and to stave off the worst effects of a warming planet. However, there are safety and security concerns, the Union of Concerned Scientists cautions. The question of how to store hazardous nuclear waste in the U.S. is unresolved, too.

Dow wants four of X-energy's advanced small modular reactors, the Xe-100. Combined, those could supply up to 320 megawatts of electricity or 800 megawatts of thermal power. X-energy CEO J. Clay Sell said the project would demonstrate how new nuclear technology can meet the massive growth in electricity demand.

The Seadrift manufacturing complex, at about 4,700 acres, has eight production plants owned by Dow and one owned by Braskem. There, Dow makes plastics for a variety of uses including food and beverage packaging and wire and cable insulation, as well as glycols for antifreeze, polyester fabrics and bottles, and oxide derivatives for health and beauty products.

Edward Stones, the business vice president of energy and climate at Dow, said submitting the permit application is an important next step in expanding access to safe, clean, reliable, cost-competitive nuclear energy in the United States. The project is supported by the Department of Energy’s Advanced Reactor Demonstration Program.

The NRC expects the review to take three years or less. If a permit is issued, construction could begin at the end of this decade, so the reactors would be ready early in the 2030s, as the natural gas-fired equipment is retired.

A total of four applicants have asked the NRC for construction permits for advanced nuclear reactors. The NRC issued a permit to Abilene Christian University for a research reactor and to Kairos Power for one reactor and two reactor test versions of that company's design. It's reviewing an application by Bill Gates and his energy company, TerraPower, to build an advanced reactor in Wyoming.

X-energy is also collaborating with Amazon to bring more than 5 gigawatts of new nuclear power projects online across the United States by 2039, beginning in Washington state. Amazon and other tech giants have committed to using renewable energy to meet the surging demand from data centers and artificial intelligence and address climate change.

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This story appeared on our sister site, EnergyCapitalHTX.com.

UH, Baylor researchers make breakthrough with new pediatric leukemia treatment device

childhood cancer

A team of Houston researchers has developed a new microfluidic device aimed at making treatments safer for children with hyperleukocytosis, a life-threatening hematologic emergency often seen in patients with leukemia.

Dr. Fong Lam, an associate professor of pediatrics at Baylor College of Medicine and a pediatric intensive care physician at Texas Children’s Hospital, partnered with Sergey Shevkoplyas, a professor of biomedical engineering at UH, on the device that uses a large number of tiny channels to quickly separate blood cells by size in a process called controlled incremental filtration, according to a news release from UH.

They tested whether performing cell separation with a high-throughput microfluidic device could alleviate the limitations of traditional conventional blood-filtering machines, which pose risks for pediatric patients due to their large extracorporeal volume (ECV), high flow rates and tendency to cause significant platelet loss in the patient. The results of their study, led by Mubasher Iqbal, a Ph.D. candidate in biomedical engineering at UH, were published recently in the journal Nature Communications.

“Continuously and efficiently separating leukocytes from recirculating undiluted whole blood — without device clogging and cell activation or damage — has long been a major challenge in microfluidic cell separation,” Shevkoplyas said in a news release. “Our study is the first to solve this problem.”

Hyperleukocytosis is a condition that develops when the body has an extremely high number of white blood cells, which in many cases is due to leukemia. According to the release, up to 20 percent to 30 percent of patients with acute leukemia develop hyperleukocytosis, and this places them at risk for potentially fatal complications.

The new device utilizes tiny channels—each about the width of a human hair—to efficiently separate blood cells through controlled incremental filtration. According to Lam, the team was excited that the new device could operate at clinically relevant flow rates.

The device successfully removed approximately 85 percent of large leukocytes and 90 percent of leukemic blasts from undiluted human whole blood without causing platelet loss or other adverse effects. It also operates with an ECV that’s about 1/70th of conventional leukapheresis machines, which makes it particularly suitable for infants and small children.

“Overall, our study suggests that microfluidics leukapheresis is safe and effective at selectively removing leukocytes from circulation, with separation performance sufficiently high to ultimately enable safe leukapheresis in children,” Shevkoplyas said in the release.

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