Here are 3 Houston innovators to know right now

Innovators to Know

Khaliah Guillory, founder of Nap Bar, says she hopes to expand to 30 locations in three years. Photo courtesy Khaliah Guillory

Editor's note: These Houston innovators are making big strides in the fields of neurotechnology, neurodevelopmental diagnosis, and even improving the way we rest and recharge.

For our latest roundup of Innovators to Know, we meet a researcher who is working with teams in Houston and abroad to develop an innovative brain implant; a professor who has created an AI approach to diagnosis; and a local entrepreneur whose brand is poised for major expansion in the coming years.

Jacob Robinson, CEO of Motif Neurotech

Houston startup Motif Neurotech has been selected by the United Kingdom's Advanced Research + Invention Agency (ARIA) to participate in its inaugural Precision Neurotechnologies program. The program aims to develop advanced brain-interfacing technologies for cognitive and psychiatric conditions. Three Rice labs will collaborate with Motif Neurotech to develop Brain Mesh, which is a distributed network of minimally invasive implants that can stimulate neural circuits and stream neural data in real time. The project has been awarded approximately $5.9 million.

Motif Neurotech was spun out of the Rice lab of Jacob Robinson, a professor of electrical and computer engineering and bioengineering and CEO of Motif Neurotech.

Robinson will lead the system and network integration and encapsulation efforts for Mesh Points implants. According to Rice, these implants, about the size of a grain of rice, will track and modulate brain states and be embedded in the skull through relatively low-risk surgery. Learn more.

Dr. Ryan S. Dhindsa, Dhindsa Lab

Dr. Ryan S. Dhindsa, assistant professor of pathology and immunology at Baylor and principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and his team have developed an artificial intelligence-based approach that will help doctors to identify genes tied to neurodevelopmental disorders. Their research was recently published the American Journal of Human Genetics.

Dhindsa Lab uses “human genomics, human stem cell models, and computational biology to advance precision medicine.” The diagnoses that stem from the new computational tool could include specific types of autism spectrum disorder, epilepsy and developmental delay, disorders that often don’t come with a genetic diagnosis.

“Although researchers have made major strides identifying different genes associated with neurodevelopmental disorders, many patients with these conditions still do not receive a genetic diagnosis, indicating that there are many more genes waiting to be discovered,” Dhindsa says. Learn more.

Khaliah Guillory, Founder of Nap Bar

From nap research to diversity and inclusion, this entrepreneur is making Houston workers more productiveFrom opening Nap Bar and consulting corporations on diversity and inclusion to serving the city as an LGBT adviser, Khaliah Guillory is focused on productivity. Courtesy of Khaliah Guillory

Khalia Guillory launched her white-glove, eco-friendly rest sanctuary business, Nap Bar, in Houston in 2019 to offer a unique rest experience with artificial intelligence integration for working professionals, entrepreneurs and travelers who needed a place to rest, recharge and rejuvenate.

Now she is ready to take it to the next level, with a pivot to VR and plans to expand to 30 locations in three years.

Guillory says she’s now looking to scale the business by partnering with like-minded investors with experience in the wellness space. She envisions locations at national and international airports, which she says offer ripe scenarios for patrons needing to recharge. Additionally, Guillory wants to build on her initial partnership with UT Health by going onsite to curate rest experiences for patients, caregivers, faculty, staff, nurses and doctors. Colleges also offer an opportunity for growth. Learn more.

Oculus Go is enabling users to their canceled travels with a virtual getaway. Image courtesy of Oculus Go

Virtual reality app developed in Houston allows users to escape to far away lands

there's an app for that

While rising coronavirus cases in the area have canceled so many summer vacations, not all hope of sightseeing this summer is lost. A Houston entrepreneur has created a virtual alternative.

Houston-area industrial design startup, Armstrong Innovations launched two Oculus Go app games, aptly named 'Escape'. The VR app was designed with relaxation and meditation in mind but has doubled as a new way to relax and sightsee without leaving your home during the COVID-19 pandemic.

"The sights and sounds of our new app assist with mindfulness and meditation," says CEO and founder Derek Armstrong. "It's about focusing on the sights and sounds, especially with the virus growing. It's a quick getaway without having to physically go anywhere."

The project began a year ago and was completed in March — right at the start of stay-at-home orders that paralyzed everyday life before launching this month. The company's new array of Occulus Go experiences aims at easing the mind and spirits, but with the rise of coronavirus 'Escape' can also serve to calm frayed nerves.

The app is based on popular view master toys and stereoscopes from the 1800s that are reminiscent of exploration tools used over the years. There are two different experiences to choose from one named 'Escape: Roma' for its old-world inspired poolside lounge and another named 'Escape: Utopia', which brings outer space to life in front of an Oculus user's eyes.

"The app has already gotten a lot of traction in places where people are not able to go out in the world," says Armstrong. "It's so easy just to pop on your Oculus headset, open the app, and zone out or relax for a few minutes."

The local industrial design startup was founded in 2018, and it has already released a few music packs with tracks ranging from horror titles to 8-bit retro remakes for Unreal Engine projects, an advanced real-time 3D creation tool that serves as a game engine for creators to deliver interactive experiences. The music packs are a collection of audio assets made in collaboration with Epic Games.

"Our company is focused on creating engaging gamified experiences," says Armstrong. "The inspiration for our packs and now our new app came from my interest in treating PTSD and how virtual reality can help ease the symptoms of anxiety in some cases."

Armstrong, a Houston native, describes himself as a "maker of stuff," with previous experience in music production and a passion for design. According to him, his hometown is the best place to be.

"Houston really has everything you need, when it comes to new innovations and technology," says Armstrong. "I would prefer to have my business rooted in Houston rather than moving to a design startup hotspot."

Armstrong Innovations hopes to grow into new areas of the industrial design world, especially in military-driven technologies and other video game opportunities in the next year or so. Product keys for 'Escape' can be purchased online now, available worldwide for maximum relaxation.


Derek Armstrong, a Houston native, founded his design company, Armstrong Innovations. Photo courtesy of Oculus Go

The majority of McCarthy Building Companies' projects now include some sort of virtual or augmented reality technology. Courtesy of McCarthy Building Companies

Houston-area construction team utilizes technology to solve problems

Reality real estate

In recent years, the construction industry has begun embraced advancements in reality technology like virtual reality and augmented reality. While it has yet to reach critical mass in the industry, several contracting companies in the Houston region like McCarthy Building Companies are embracing the technology and blazing the trail for the construction industry.

Chris Patton, virtual design and construction manager for McCarthy's southern region, says many construction companies are consistently looking for ways to improve processes and procedures through reality technology.

"We really saw the potential and use cases for [VR] really early on, and it was really just a matter of the hardware and the software catching up to being something usable, consumable, deployable and cost effective on our projects," Patton says. "We were sitting there waiting for it and ready to go when it was."

Patton says these visualization tools have changed the way contractors display projects and have helped the partners on these projects — such as the design team, building owner and subcontractors — make better informed decisions earlier, more quickly and sometimes at a cheaper price point.

Before AR and VR technology entered the construction industry, companies either had to work with two-dimensional construction drawings or build very expensive, three-dimensional models, or mock ups, of construction sites that allowed clients to physically walk through a building space to interact with its features. Patton says the entire mock-up building process used to cost roughly $1 million — depending on the project size.

However, now this costly and time-consuming process is a thing of the past, as construction companies have found a way to utilize AR and VR technology to bring clients into a computer-generated environment. By putting on an AR or VR helmet, clients can immerse themselves and engage in a virtual environment that shows them all of the project's details and allows them to move about a virtual construction site the same way they would in a 3D model.

McCarthy's Houston division began utilizing reality technology in early 2015, with some of its other markets integrating the technology into their practices in late 2014. Since then, the company's use of AR and VR technology has grown exponentially, Patton says.

"When we first started evaluating and looking at virtual reality and augmented reality, [we] might have [used it on] one or two projects a year, and that was probably three years ago," Patton says. "Today, I'd say almost 60-75 percent of our projects—at some point in design or construction — utilize virtual reality or augmented reality or a combination of both."

Although McCarthy has been around since 1864, the general contracting company made its Texas debut in Dallas in 1981. Since then McCarthy expanded to create a Houston office in 2011, building a portfolio of renowned Houston clients such as the Museum of Fine Arts, Houston, the Holocaust Museum Houston, Texas Children's Hospital as well as the recent completion of Houston ISD's Kinder High School for the Performing and Visual Arts.

A notable project McCarthy's Houston Division took on was phase one the MFAH's master plan that included building The Glassell School of Art. The company also continues its work on phase two, which includes new developments for the MFAH for which McCarthy's virtual design and construction group created VR and AR models for the museum.

By using software like HoloLive and Fuzor for AR technology and Fuzor for VR technology, McCarthy's VDC group can visualize and combine digital creations with the real world, Patton says. With the growing number of projects utilizing the technology, Patton says McCarthy has invested greatly in personnel who will help grow the VDC group and continue to look for advancements in the construction industry.

"Some of the folks that we have those [VDC] positions in our company, some of them come from construction technology backgrounds and construction management backgrounds but others come from graphical design and have like a gaming background, some come from architectural backgrounds," Patton says. "[Reality technology] really kind of opened the door to a new opportunity for people to get engaged with the construction industry that we hadn't seen in the past."

Lori-Lee Emshey's Future Sight AR is revolutionizing antiquated construction tools using augmented reality. Courtesy of Future Sight AR

Houston company has sight set on AR solutions for industrial construction

Visual aid

When Lori-Lee Emshey got her first oil and gas construction job in Australia, she was carrying around a backpack full of papers.

"I was really shocked at how much work they were doing with such little technology," Emshey says. "I thought, 'there's so much room for innovation here.'"

She realized that it wasn't just that site or the company she was working for — this was a problem across the industry. So, she came up with a solution. Houston-based Future Sight AR is an augmented reality technology to more efficient work on industrial construction sites. Workers can use a smart device in the field, point it at a problem on site, log the issue, and see the steps needed to fix it.

Constructing a company
Emshey realized the potential for a company in January 2016. Since then, she's partnered up with her co-founders, Sofia Lazaro and Veena Somareddy, attended accelerators and conferences across the country, completed a proof of concept, until finally incorporated this year.

It was a well-paced start for the company because they got to prove time and time again there was a need for the company. Emshey says she never wanted to start a company just to start a company. They worked tirelessly at the beginning to ensure there was no one out there already doing this in the way they were doing it.

"I feel like a lot of entrepreneurs now become an entrepreneur because it's trendy and cool, and you want to put it in your Instagram bio," she says. "The three of us aren't like that. We did this because we had to. It wasn't going to get done another way, and we couldn't let this giant opportunity float on by."

Once they got a firm footing, one of the challenges they faced was communicating the company's market need and how the technology works to individuals outside the industry. For Emshey, this was particularly annoying.

"I came from a journalism background, and it's storytelling," she says. "I thought, 'I should be able to do this.'"

Something eventually just clicked, and Emshey stopped seeing confused faces in response to her presentation, and she started seeing more head nodding. However, another challenge she says she occasionally faces is how she looks.

"It is tough. I'm pitching this industrial construction startup, and I show up and I'm a 5-foot-5 blond woman," she says. "And some people don't care, and some people would prefer I looked a different way."

Foreseeing the company's future
Raising capital has been the latest focus for Future Sight AR. Aside from some grants and accelerator money, the company hasn't raised much. They've only just started meeting with investors and have a plan to launch a round of fundraising next year. Emshey also says they are looking to partner with three companies to conduct a few pilots early next year.

It's a great time in technology for Future Sight AR as more and more people are using AR and virtual reality. People use AR or VR often — in SnapChat filters or through Pokemon Go!

Emshey says she thinks VR will grow first in gaming, while AR will take off through enterprise.

"Unlike VR when you're completely immersed, in AR, you're seeing your actual environment and one of the places you have to do that is at work," Emshey says.

Whether it's through being acquired or growing the company on its own, Emshey says she wants Future Sight AR to evolve the industry as a whole.

"If we could permanently change the way that we build projects — oil and gas or another industry — and move it toward something more efficient, safer, more productive, and a better experience for workers, and accomplish that in a permanent way in a permanent way, then we're successful," she says. "We really built this for me — I was the worker out in the field trying to do things, and it was unnecessarily difficult."

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Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”

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