Houston XR training company lands $5.8M contract with Air Force

taking flight

HTX Labs has been awarded a contract with the U.S. Air Force to develop a virtual AI-powered classroom for workers who maintain the Boeing KC-135’s F108 engine. Photo via Getty Images.

The U.S. Air Force’s AFWERX innovation arm has picked Houston-based HTX Labs to provide AI-enabled immersive training for workers who maintain Boeing KC-135 refueling tankers.

HTX Labs, an extended reality (XR) company and provider of immersive training programs for U.S. armed forces, will receive as much as $5.8 million in military funding for this project.

The new initiative comes on the heels of HTX Labs completing the second phase of a virtual KC-135 maintenance training program in partnership with Mildenhall, a Royal Air Force station in England. HTX Labs received Small Business Innovation Research (SBIR) funding for the second-phase project.

Under the new initiative, part of its EMPACT training platform, HTX Labs will develop a virtual AI-powered classroom for workers who maintain the KC-135’s F108 engine. In conjunction with this project, HTX Labs will collaborate with the Maine Air National Guard’s 101st Air Refueling Wing Maintenance Squadron on improving EMPACT.

Major Ryan Wing of the Maine Air National Guard says KC-135 maintenance workers “have limited opportunities to perform some of the more complex aircraft and engine repairs in a training environment. Providing immersive training to our warfighters is essential to ensuring mission readiness.”

In January, HTX Labs tapped Brian Reece as vice president of strategic accounts for the Air Force. In this role, he oversees HTX Labs’ relationship with this military branch. Reece is a retired Air Force colonel.

In 2022, Dallas-based Cypress Growth Capital invested $3.2 million in HTX Labs, which was founded in 2017.

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Khaliah Guillory, founder of Nap Bar, says she hopes to expand to 30 locations in three years. Photo courtesy Khaliah Guillory

Houston startup Nap Bar pivots with VR and big plans for growth

power nap

Houston’s Khaliah Guillory takes a 30-minute nap every day. She says this is how she’s so productive.

The habit also led to the founding of her white-glove, eco-friendly rest sanctuary business, Nap Bar.

Guillory launched the luxury sleep suites company back in 2019 to offer a unique rest experience with artificial intelligence integration for working professionals, entrepreneurs and travelers who needed a place to rest, recharge and rejuvenate. The company was named a Houston Innovation Awards finalist last year.

She says naps are backed by science. And by her professional network, too.

“Once I polled and surveyed my friends, most of them said that they also took naps during their lunch break, whether it be in their office or in their car,” says Guillory, former vice president of marketing strategy at Wells Fargo. “Once they overwhelmingly agreed that they would absolutely use a dedicated place for them to take naps if I created it, I got to work, and Nap Bar was born.”

Simply put, Guillory has effectively made it acceptable and, yes, even cool for working adults to take naps.

“I played D1 basketball at the University of Central Florida and that’s really where I learned the art of a power nap and the benefits of it,” Guillory says. “And I just continued to nap throughout my corporate career. So, in November of 2018, I retired from corporate America … I just knew I had a higher calling to do something else.”

Guillory first opened up shop in Rice Village as a beta test for her novel nap idea and it took off. She soon forged strategic partnerships with organizations like UT Health, where Nap Bar provided much-needed naps to postpartum mothers.

“Nap Bar showed what the benefits of a good nap was, specifically to postpartum moms in terms of mental stressors, productivity, and things of that nature,” Guillory says.

In November 2019, Guillory moved Nap Bar to The Galleria and says the business produced revenue from day one. However, in March 2020, she was forced to shut us down due to the COVID-19 pandemic.

“I promised myself that I was not going back to corporate America, so I pivoted. I moved forward by creating a better sleep box, with a vegan pillow mist and soy-based candle. I also became a certified sleep coach. And I just kept pivoting from there, reinventing Nap Bar as a company,” she says.

One pivot included adding a virtual reality sleep experience, MetaSnooze.

“MetaSnooze is a really cool technology that offers sleep therapy and relaxation that I curated myself,” Guillory says. “Basically, the user puts on the VR headset, and it escapes them. They're transported to places all over the country. For example, they're sitting in serene environments all the while listening to these rhythmic beats that are designed to help them release and relax. Visualizations have been scientifically proven to improve one’s mental health and mental stressors.”

Guillory initially rolled out MetaSnooze in 2020 at events like South by Southwest and kept improving the experience and building her business. By February 2024, she was curating a wellness experience at The Grammy Awards.

“That was huge for us,” Guillory says. “Being able to get feedback from the celebrities, with a handful of them even inquiring where they could purchase the headset. They were excited about the future of Nap Bar, so that was really, really cool.”

The widespread interest in Nap Bar has Guillory thinking big. She aims to expand to 30 locations in three years.

“When I say that, it sounds ambitious,” says Guillory. “It is, but I come from the school of thought that if you shoot for 30 and you get 25, no one's going to shake their finger at you for doing that, right? It's really aiming towards this big, hairy, audacious goal. I learned that in corporate America. So, what we're looking to do now is raise money like crazy.”

Guillory says she’s now looking to scale the business by partnering with like-minded investors with experience in the wellness space.

She envisions locations at national and international airports, which she says offer ripe scenarios for patrons needing to recharge. Additionally, Guillory wants to build on her initial partnership with UT Health by going onsite to curate rest experiences for patients, caregivers, faculty, staff, nurses and doctors. Colleges also offer an opportunity for growth.

“We’ve done some really cool pop-ups with the University of Houston, where we brought the rest experience on campus,” Guillory says. “That means we bring a portable, full-size, organic mattress with disposable sheets, as well as our virtual reality experience.”

Nap Bar will also serve companies, office buildings, and even sports venues, according to Guillory.

“We can literally go any and everywhere,” she says. “Our collected data suggests that we’ve just got to go where sleepy people are so that they can get restorative sleep.”

From a pricing standpoint, Nap Bar’s model is a dollar a minute. Depending on where the client is, the pop-up experience is based on a day rate or a half-day rate, starting at $4,000.

Add-ons include a full-size organic mattress or hosting a masseuse or massage therapist onsite.

With the Grammys already under her belt, Guillory would like to see Nap Bar utilized at the 2028 Olympics and build partnerships with other virtual reality companies to bring its licensed MetaSnooze software to the masses.

She also sees opportunities in athletic treatment, sleep apnea, and insomnia.

“We have done several studies with proven results that MetaSnooze has reduced mental stressors and anxiety,” Guillory says. “I'm excited about what the future holds for MetaSnooze. It definitely is a game-changer … We will continue to innovate sleep or provide sleep resources and tools in a very innovative way.”

A Houston expert shares reasons to swap screen time for extended reality. Photo via Getty Images

Extended reality will have a big impact on business, this Houston expert says

guest column

What does your reality look like? Look around you. What do you see? It would be safe to say (almost guarantee) that you are looking at a screen right now, correct? We are consumers of information and use screens to access, view, and create information.

But why are we spending so much of our time looking at screens?

One poll stated that the average adult will spend 34 years of their lives looking at screens. It almost feels that screens (TV, laptop, or phone) have become so ubiquitous in everyday life that they have blended into our reality and are just ‘there’. Do you think the inventor of the TV, John Logie Baird, ever fully grasped how much the fabric of society would revolve around his invention? Time and time again, incredible disruptions have always come from breaking the ‘norm’ and given the vast level of integration of screens into our everyday reality, this ‘norm’ feels long overdue for innovation. This is where the world of augmented reality and spatial computing comes into play.

The COVID-19 pandemic saw an unprecedented shift to even more screen time and interactions using remote video communication platforms. It was also around this time that wireless virtual reality headsets were, for the first time ever, economically accessible to the consumer due to the large push of one multinational corporation. Fast forward to 2023, there are even more companies beginning to enter the market with new extended reality (XR) headsets (i.e. virtual, mixed, and augmented reality) that offer spatial computing – the ability for computers to blend into the physical worlds (amongst other things).

Some of our innovation engineering activities at the Houston Methodist Institute for Technology, Innovation, and Education (MITIE) have focused on specific use cases of XR in surgical education and training. One of our projects, the MITIEverse, is a VR-based platform focused on creating the first-ever metaverse for medical innovation. It is a fully immersive VR environment that allows the user to view 3D-rendered patient anatomies whilst watching the actual patient procedure, even offering the ability to meet the surgeon who performed the operation. It also affords the ability to give a ‘Grand Rounds’ style presentation to an audience of 50 participants.

We have looked at using augmented reality to control robotic-assisted surgery platforms. In our proof-of-concept prototype, we successfully demonstrated the manipulation of guide wires and catheters using nothing more than an augmented reality headset, illustrating the possibility of surgeons performing surgery at a distance. Houston Methodist is dedicated to transforming healthcare using the latest innovative technology including XR. The question we now need to ask – is society ready and willing to replace screens with XR headsets?

To learn more about our XR initiatives and other Houston’s cross-industry innovation collaborations, attend Pumps & Pipes Annual Event 2023, Problem Xchange: Where Solutions Converge next month at The Ion.

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Stuart Corr is the director of Innovation Systems Engineering at Houston Methodist and executive director of Pumps & Pipes.

"We are no longer limited by the laws of physics." Photo via Getty Images

Houston expert: How extended reality and the metaverse can disrupt the business world

guest column

The year is 2012. It’s your first day of a new job. You wake up extra early to get ready and drive to the office – which takes you another half hour with Houston traffic. Once you arrive, you wait in the lobby for someone to help you with badging, sit in the same room for hours while numerous facilitators click through slides, and find out your laptop won’t be available for another week or two. Not the warmest welcome or greatest impression, right?

Fast-forward to year 2022. It’s a week before you’re set to start a new job. You receive an exciting package in the mail and unbox your new joiner start kit, complete with a virtual reality headset and other company swag. You onboard completely in the metaverse, meeting and collaborating with teammates from around the world – all from the comfort of… wherever.

Especially in a time where being physically together may not be an option, extended reality has made people feel closer than ever before.

To level set, XR is the umbrella term encompassing any immersive technology that blends digital content with the real world. It covers the full spectrum of experiences ranging from augmented reality, where digital content is superimposed and simple instructions appear directly on your phone or smart glasses, to an entirely virtual world where people, places and things co-exist and interact with one another in new, computer-generated environments – also known as the metaverse.

Although XR has been around for decades, the lack of devices and standard software platforms made implementation a challenge. Now that both are widely available and affordable, the doors for innovation have been thrown wide open.

There’s been plenty of key drivers that led to XR being a hot topic right now, including:

  • The need for digitization of our lives, accelerated by the global pandemic.
  • The recent global focus on sustainability and responsible business.
  • The cross-industry commitment to customer journey, optimized employee performance, and creating new content and services.
  • The convergence of powerful advancements in technology, such as 5G, cloud, AI and blockchain.
  • The recent investment in the metaverse by companies like Microsoft and Meta, formerly known as Facebook.

Now is the time for XR.

Every industry can benefit from using immersive technology to enhance both the enterprise and consumer experience, from retail, finance and automotive to tourism, entertainment, and real estate. XR has a proven track record of increasing revenue, collaboration, and productivity and decreasing costs, safety incidents, and our carbon footprint.

By 2027 the VR gaming market size alone is projected to reach $92.31 billion, and we’re now starting to really blur the lines between gaming and training. Compared to in-person training, VR results in a 96 percent reduction in training time, 76 percent increase in learning effectiveness, 70 percent increase in productivity, and 30 to 70 percent decrease in costs.

Engineers can leverage digital twins of manufacturing facilities for product development, performance improvement and predictive maintenance.

Science classes can teleport to outer space and use haptics to feel the ice and rock that make up the rings of Saturn.

Surgeons and patients can take a three-dimensional tour of the brain before surgery, leading to better preparation, decreased operative time and reduced risk of complications.

Those suffering from dementia can recover certain motor skills or tap into old memories to trigger positive mental stimulation, aiding in both assessment and rehabilitation.

As the new fabric of life is unfolding, the metaverse is showing promise beyond its gaming roots to offer people and brands a new place to interact, create, consume and earn.

Despite spending an average of $1,300 per employee annually on training, research proves that learners forget 70 percent of the content within 24 hours and nearly 90 percent in a month. By extending reality, we engage learners with interactive, hands-on, experiences that transform one-way training into deeper learning with heightened retention.

When high-fidelity design is mixed with low latency technology enablers, XR environments intuitively engage our senses, capturing the experience as an actual memory in our brain versus something we simply read or watched.

The future is immersive technology – not only for how we work and learn but also how we exercise and have fun. XR will touch all aspects of our lives. That’s why at Accenture, we have launched a grand experiment to make enterprise virtual reality a… well, a reality. We’re currently amid the world’s largest VR deployment in history. We are deploying over 60,000 VR headsets to our people to experiment, innovate, and learn with VR.

We as a company have over 650,000 employees and have over 200,000 new joiners annually. About one third of those people joined the company during the pandemic – over 50,000 this past quarter alone. That means a good portion of our people have never set foot in our offices, let alone met any of their teammates in person.

Through the power of VR, we now have a consistent and scalable new joiner experience that inspires our people, aligns with our purpose, and equips them to learn, live and love Accenture from day one. VR gives us the opportunity to make meaningful connections and share a sense of belonging. Our people can now head to the “Nth Floor” to meet new people from all over the world and have those natural water cooler moments – even while working remotely.

In a time where live events are facing a standstill, platforms like AltspaceVR are hosting live events for everything from Burning Man and Diplo concerts to church and AA meetings. The spatial recognition offered by VR makes it a great medium to have one-to-one, one-to-many, or many-to-many interactions.

Accessibility is key too. That’s why many applications offer experiences in both VR headset and 2D on PCs.

We are no longer limited by the laws of physics.

Extended reality creates a powerful sense of presence that we as a collective society have been missing these past two years. If we’ve learned anything from this pandemic, it’s that human connection is key to mental wellness and innovation.

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Krista L. Taylor is the immersive learning lead at Accenture.

"The Infinite" lands in Houston for the first U.S. show. Image courtesy of Infinity Productions

High-tech virtual reality experience blasts into the Space City

to infinity and beyond

From the earliest days of our circling the planet in a tiny NASA capsule — to Elon Musk's SpaceX current commercial journeys — Houston and space travel will be forever and inexorably linked.

Fitting, then, that an unprecedented new immersive experience centered on the International Space Station (ISS) is making its U.S. debut here in Space City. "The Infinite"— a multi-sensory, interactive virtual reality experience — will zoom into Sawyer Yards on December 20 for a special, and limited, run, organizers announced.

This sprawling, 12,500-square-foot exhibition shuttles viewers into a never-before-seen perspective of life on the ISS, bringing an almost-too-real feeling of being in outer space.

Tickets are on sale now for a soft open preview period beginning on December 20; admission is $29. Tickets then jump to $36 for the full-scale limited engagement beginning on January 13, 2022.

Boasting footage shot over a period of nearly three years that created some 200 hours of high-end virtual reality scenes, the four-part immersive series documents the life of eight international astronauts inside — and outside — the International Space Station. (The outside experience promises to be an especially wild ride.) The show comes to Houston off a wildly popular Canadian run in Montreal.

Specific to this Houston launch, the show boasts new footage from the first-ever cinematic spacewalk captured in 3D — 360-degree virtual reality shot outside the International Space Station on September 12, 2021 — while offering visitors a self-directed experience aboard the ISS itself, according to a press release.

Throughout the 60-minute journey, per press materials, viewers will engage with physical objects, virtual reality, multimedia art, soundscapes, light design, and even the subtle scents of a forest, meant to evoke memories of stargazing while lying on the grass.

"The Infinite" is the brainchild of Montreal-based Infinity Experiences, a joint venture of PHI Studio and Felix & Paul Studios, and is an extension of the recent Primetime Emmy Award-winning immersive series, "Space Explorers: The ISS Experience," the largest production ever filmed in space, produced by Felix & Paul Studios in association with Time Studios.

That this show will run next year is also especially timely for Houston's space saga. Next year marks the 60th anniversary of President John F. Kennedy's famous moon-shot speech given at Rice University on September 12, 1962. That speech, with its now-legendary "we choose to go to the moon" line, galvanized the nation and propelled the U.S. into a space race that found Neil Armstrong and "Buzz" Aldrin on the moon only seven years later.

"The exploration of space and the unknown is an endless source of fascination to us," said Félix Lajeunesse, co-founder of Felix & Paul Studios and creative director of The Infinite, in a statement.

"We are thrilled to bring The Infinite to Houston — the global epicenter of human space exploration — to share this massive, fully immersive exhibition, and we look forward to virtually transporting thousands of people off the Earth to enjoy the joy and wonder of space with audiences in the U.S. This unprecedented project is made possible thanks to our partners at NASA, the ISS National Lab, international space agencies and the incredible power of virtual reality."

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This article originally ran on CultureMap.

Virtual reality is a buzzword, but used correctly it can also be a pivotal business tool for external and internal uses. Photo via Getty Images

Houston expert: Is virtual reality just trendy tech or a viable business solution?

guest column

Due to the pandemic, various technologies have accelerated into the spotlight – one of which being virtual reality. As many begin to decipher the unique ways to connect with audiences, the question becomes: is virtual reality just a shiny toy to have, or is it a practical business opportunity?

The VR experience

Virtual Reality (VR), which most confuse with augmented reality (AR), is a digital, immersive environment a user can place themselves into as opposed to a digital reality that is based on a real-world environment. VR requires a wearable headset to immerse the user in a 3-D environment.

True VR is built digitally and to room scale. The environments people are placed in are constructed entirely in 3-D and are then brought into a program application. Once everything is entered into the system, the technology begins "talking to" the headset and sensors. These devices track where users are in relation to the environment – and allow them to interact with their digital surroundings. This VR programming "tells" the headset what it needs to show in order to trick the eyes and brain into believing a user is "there".

The role VR plays

Often times, my company, VISION Production Group, receives requests and interest from businesses inquiring about a VR project. These conversations involve a deeper dive into understanding the purpose behind the want for the technology, the target audience and the intended deployment strategy. People commonly mistake VR for other technologies or simply are interested in it for its curb appeal.

Yes, virtual reality is a buzzword, but used correctly it can also be a pivotal business tool for external and internal uses.

External facing VR not only allows companies to take advantage of VR's charm, but also creates a one of kind experience for customers. VISION was tasked by an offshore oil and gas company to create a VR experience that lives at the bottom of the sea floor. This would allow the oil and gas company's customer to see a part of the process that would otherwise be extremely difficult to facilitate. The experience took users into a guided submarine tour where they were accompanied by others using the headsets. The environment not only showcased a faraway destination but also incorporated important details such as textures of the submarine that allows it to feel like they are truly there.

In addition to the promising use of VR externally, VR can also be used as training tools internally. Many scenario-based onboarding tasks can be difficult to facilitate such as: active shooter trainings, offshore emergency drills, and other safety simulations. Many corporate companies are turning to VR to allow for safe, cost effective and transportable safety trainings. This is an excellent application that allows companies to create situations that would otherwise be difficult to arrange.

Understanding VR's value proposition

VR is different than most technologies. It's not something that can be shared on the web or can be downloaded on an app – it requires deployment and gear. That said, VR is a commonly misunderstood tactic that without the proper strategic thinking can be a limited investment. However, those who are able to take advantage of the distinctive characteristics of VR and apply them correctly are in an ideal position to succeed. Not only can VR create a special experience it can also be a fiscally savvy option for those not looking to take submarine trips every day to the bottom of the sea or facilitate a dangerous training scenario.

The future of VR

As mentioned, most technology has accelerated due to the pandemic, but VR has actually been limited due to the idea of sharing a headset and gathering people together for an experience. Although, the pandemic has suppressed VR's uses, the technology advancements continue to grow rapidly.

Those who can comprehend VR for what it is and see it as more than just a buzzword will have the opportunity to be on the cutting edge of a new reality.

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Dan Pratt is the creative director at Houston-based Vision Production Group.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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