Virgin Trains may be speeding into Texas. Photo courtesy of Virgin Trains

Transportation company steers talk of high-speed trains between Houston, Austin, and San Antonio

ALL ABOARD?

You've likely heard of the proposed high-speed "bullet" train that would connect Houston and Dallas, as well as the proposed transportation-in-a-tube concept that would link Houston, Austin, Dallas, San Antonio, and Laredo.

Now, another possible alternative to planes, Amtrak trains, and automobiles has chugged into the picture.

Virgin Trains USA, a transportation startup that plans to trade its shares on the Nasdaq stock exchange, is exploring two high-speed routes in Texas — one tying together Houston, Austin, and San Antonio, and the other between Houston and Dallas. All four of those cities are plagued by ever-increasing traffic tie-ups.

There's no word yet on when these routes might take shape. At this point, they're merely ideas, and ahead of the company going public, officials at Virgin Trains are staying mum.

In all, Virgin Trains has outlined seven potential routes in the U.S. beyond what it already has on the drawing board.

"Our goal is to build railroad systems in North America that connect major metropolitan areas with significant traffic and congestion," the company says in a filing with the U.S. Securities and Exchange Commission.

Virgin Trains aims to tie together heavily populated cities separated by 200- to 300-mile distances that are "too long to drive, too short to fly." It wants to run the trains along existing transportation corridors — rail, highway or a combination of the two — "to cost-effectively build our systems, as opposed to developing entirely new corridors at potentially significantly higher costs."

If the Virgin name sounds familiar, it should. British billionaire Sir Richard Branson's Virgin Group is a minority investor in Virgin Trains, which already operates a South Florida route between Miami and West Palm Beach. West Palm Beach-to-Orlando and Orlando-to-Tampa routes also are in the works in Florida, in addition to a Los Angeles-to-Las Vegas route. Virgin's other transportation investments include airlines and space travel.

Jim Mathews, president and CEO of the Rail Passengers Association, says he's on board with the Branson-backed Virgin Trains venture — not as an "anti-Amtrak" move but as an advancement in U.S. passenger rail travel.

"Speaking from the experience of someone who spent almost his entire career watching Sir Richard innovate, invest, and take risks, I firmly believe this could be a real shot in the arm for passenger rail in the United States," Mathews writes on the association's website. "Like all entrepreneurs, Sir Richard isn't afraid to fail, and he has made a few bad bets in the past. But he's also made some very good ones, and has transformed not just travel but philosophies wherever he has gone."

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This story originally ran on CultureMap.

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”