This week's roundup of Houston innovators includes Dorit Donoviel of TRISH, Nuri Firat Ince of UH, and Vanessa Wade of Connect the Dots. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from space to engineering — recently making headlines in Houston innovation.


Dorit Donoviel, director of the Translational Research Institute for Space Health

Dorit Donoviel, director of the Translational Research Institute for Space Health

The new program will work with commercial spaceflight crews to bring back crucial research to one database. Photo via Libby Neder Photography

The Translational Research Institute for Space Health, or TRISH, at Baylor College of Medicine announced a unique program that will work with commercial spaceflight providers and their passengers. The EXPAND — Enhancing eXploration Platforms and Analog Definition — Program will collect information and data from multiple space flights and organize it in one place. TRISH selected TrialX to build the centralized database.

"The space environment causes rapid body changes. This can help us understand how we humans react to and overcome stress. Ensuring that space explorers remain healthy pushes us to invent new approaches for early detection and prevention of medical conditions," says Dorit Donoviel, executive director at TRISH, in the release.

"Studying a broad range of people in space increases our knowledge of human biology. TRISH's EXPAND program will leverage opportunities with commercial spaceflight providers and their willing crew to open up new research horizons." Click here to read more.

Nuri Firat Ince, associate professor of biomedical engineering at UH

A medical device designed by a UH professor will close the loop with high frequency brain waves to prevent seizures from occurring. Photo via uh.edu

Nuri Firat Ince, an associate professor of biomedical engineering at UH, has received a federal grant aimed at helping stop epileptic seizures before they start. The BRAIN Initiative at the National Institute of Neurological Disorders and Stroke awarded the $3.7 million grant to go toward Ince's work to create a seizure-halting device based on his research.

According to UH, Ince has reduced by weeks the time it takes to locate the seizure onset zone (SOZ), the part of the brain that causes seizures in patients with epilepsy. He's done this by detecting high-frequency oscillations (HFO) forming "repetitive waveform patterns" that identify their location in the SOZ.

"If the outcomes of our research in acute settings become successful, we will execute a clinical trial and run our methods with the implanted … system in a chronic ambulatory setting," Ince says. Click here to read more.

Vanessa Wade, founder and owner of Connect the Dots

It's time for large corporations to step up to support small businesses founded by people of color. Photo courtesy

In her guest column for InnovationMap, Vanessa Wade addressed some of the challenges she faced founding a company as a person of color — specifically the lack of access to funding. In the article, she calls corporations to action to help business leaders like herself.

"The journey ahead can feel discouraging, but the good news is that now I have a much better idea of what it will take to build an equitable road back and get businesses like mine on even footing," she writes. Click here to read more.

It's time for large corporations to step up to support small businesses founded by people of color. Photo via Getty Images

Houston expert: Corporations can help level the playing field for BIPOC-owned businesses

Guest column

There were times when I wasn't sure what to do next.

When I started Connect the Dots PR in 2012, I wrote out detailed business plans, saved startup dollars, and leaned heavily on people in the PR industry to guide me in terms of pricing and feedback. Of course, we had contingency plans for unexpected hardships, but you hope not to use them.

My contingency plans went out the window when we saw we were looking at more than a year of pandemic-related shutdowns and slowdowns. I didn't have time to wait it out or say let's see what happens. It was time to move strategically.

Like most businesses, we hit a snag. A big chunk of our client base was reeling with corporate layoffs, shutdowns and revamped budgets. We've held on, but at times, it was overwhelming. I remember when the pandemic initially shut everything down, my fear was what is going to happen to my business and those that depend on me, such as employees, vendors, clients and contractors? At the onset of the pandemic, an employee came to me and said if I needed to let them go they understood. It hurt to do so, but it was a mutual decision and he landed on his feet and relocated to another state.

For a business owner of color, the hurdles are higher. When building Connect the Dots PR, the most important driver was access to startup capital. But studies have shown that white entrepreneurs are able to contribute considerably more personal equity to their new businesses than entrepreneurs of color, because white American families have nearly 10 times as much wealth as Hispanic or Black American families.

While inequities existed before the pandemic, over the last year, they've gotten worse. Beyond the physical toll of COVID-19, which affected BIPOC (Black, Indigenous, People of Color) communities, which includes Hispanic and Asian American communities among others, more severely than white ones, BIPOC-owned businesses have had less of a safety net to fall back on, have been more likely to close, and have had a harder time getting Paycheck Protection Program loans. Studies last summer showed that the pandemic shuttered Black-owned businesses at more than double the rate of white-owned businesses. It all leads to the deeply unequal recovery that we're just now embarking upon.

The journey ahead can feel discouraging, but the good news is that now I have a much better idea of what it will take to build an equitable road back and get businesses like mine on even footing.

First and foremost, there needs to be an investment in people of color-owned businesses from the public, private and nonprofit sectors. Six months ago, I applied to the Comcast RISE program which, since late last year, has invested in 2,500 BIPOC-owned businesses nationwide with monetary grants, technology makeovers and marketing services. I received the Comcast RISE Investment Fund for Connect the Dots PR, which provided relief when it was most needed. With this grant, I have been able to focus on the business and invest in my brand.

We're not the only ones. Comcast RISE plans to name 13,000 recipients by 2022. Houston was also one of five cities selected to award a $10,000 grant to 100 local businesses from the Comcast RISE Investment Fund, which is the grant I received. We need similar commitments from other corporations to level the playing field for people of color business owners.

Federal, state and local recovery programs need to target minority entrepreneurs. Too many of the existing relief efforts have had limited application windows or been first-come-first-served, which disadvantages businesses that are already starting from behind. Local organizations like the Greater Houston Black Chamber of Commerce can be useful allies in reaching businesses owned by historically disadvantaged groups.

Finally, financial institutions need better guardrails to ensure that they don't discriminate against nonwhite business owners. When accessing startup capital, barriers still exist for minority entrepreneurs, and keeping checks and balances on those with the balance sheets is the only way to make sure all businesses are starting on equal footing.

That way, when the next crisis hits, you'll have fewer businesses starting from behind, and we'll all find our way to recovery much faster. For all of us, that's a business plan worth holding onto.

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Vanessa Wade, is the founder and owner of Houston-based PR firm Connect the Dots.

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German biotech co. to relocate to Houston thanks to $4.75M CPRIT grant

money moves

Armed with a $4.75 million grant from the Cancer Prevention and Research Institute of Texas, a German biotech company will relocate to Houston to work on developing a cancer medicine that fights solid tumors.

Eisbach Bio is conducting a clinical trial of its EIS-12656 therapy at Houston’s MD Anderson Cancer Center. In September, the company announced its first patient had undergone EIS-12656 treatment. EIS-12656 works by suppressing cancer-related genome reorganization generated by DNA.

The funding from the cancer institute will support the second phase of the EIS-12656 trial, focusing on homologous recombination deficiency (HRD) tumors.

“HRD occurs when a cell loses its ability to repair double-strand DNA breaks, leading to genomic alterations and instability that can contribute to cancerous tumor growth,” says the institute.

HRD is a biomarker found in most advanced stages of ovarian cancer, according to Medical News Today. DNA constantly undergoes damage and repairs. One of the repair routes is the

homologous recombination repair (HRR) system.

Genetic mutations, specifically those in the BCRA1 and BCRA1 genes, cause an estimated 10 percent of cases of ovarian cancer, says Medical News Today.

The Cancer Prevention and Research Institute of Texas (CPRIT) says the Eisbach Bio funding will bolster the company’s “transformative approach to HRD tumor therapy, positioning Texas as a hub for innovative cancer treatments while expanding clinical options for HRD patients.”

The cancer institute also handed out grants to recruit several researchers to Houston:

  • $2 million to recruit Norihiro Goto from the Massachusetts Institute of Technology to MD Anderson.
  • $2 million to recruit Xufeng Chen from New York University to MD Anderson.
  • $2 million to recruit Xiangdong Lv from MD Anderson to the University of Texas Health Science Center at Houston.

In addition, the institute awarded:

  • $9,513,569 to Houston-based Marker Therapeutics for a first-phase study to develop T cell-based immunotherapy for treatment of metastatic pancreatic cancer.
  • $2,499,990 to Lewis Foxhall of MD Anderson for a colorectal cancer screening program.
  • $1,499,997 to Abigail Zamorano of the University of Texas Health Science Center at Houston for a cervical cancer screening program.
  • $1,497,342 to Jennifer Minnix of MD Anderson for a lung cancer screening program in Northeast Texas.
  • $449,929 to Roger Zoorob of the Baylor College of Medicine for early prevention of lung cancer.

On November 20, the Cancer Prevention and Research Institute granted funding of $89 million to an array of people and organizations involved in cancer prevention and research.

West Coast innovation organization unveils new location in Houston suburb to boost Texas tech ecosystem

plugging in

Leading innovation platform Plug and Play announced the opening of its new flagship Houston-area location in Sugar Land, which is its fourth location in Texas.

Plug and Play has accelerated over 2,700 startups globally last year with corporate partners that include Dell Technologies, Daikin, Microsoft, LG Chem, Shell, and Mercedes. The company’s portfolio includes PayPal, Dropbox, LendingClub, and Course Hero, with 8 percent of the portfolio valued at over $100 million.

The deal, which facilitated by the Sugar Land Office of Economic Development and Tourism, will bring a new office for the organization to Sugar Land Town Square with leasing and hiring between December and January. The official launch is slated for the first quarter of 2025, and will feature 15 startups announced on Selection Day.

"By expanding to Sugar Land, we’re creating a space where startups can access resources, build partnerships, and scale rapidly,” VP Growth Strategy at Plug and Play Sherif Saadawi says in a news release. “This location will help fuel Texas' innovation ecosystem, providing entrepreneurs with the tools and networks they need to drive real-world impact and contribute to the state’s technological and economic growth."

Plug and Play plans to hire four full-time equivalent employees and accelerate two startup batches per year. The focus will be on “smart cities,” which include energy, health, transportation, and mobility sectors. One Sugar Land City representative will serve as a board member.

“We are excited to welcome Plug and Play to Sugar Land,” Mayor of Sugar Land Joe Zimmerma adds. “This investment will help us connect with corporate contacts and experts in startups and businesses that would take us many years to reach on our own. It allows us to create a presence, attract investments and jobs to the city, and hopefully become a base of operations for some of these high-growth companies.”

The organization originally entered the Houston market in 2019 and now has locations in Bryan/College Station, Frisco, and Cedar Park in Texas.