Houston healthtech leader launches clinical trial for innovative anxiety-treating device

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Nexalin Technology is launching a Phase II clinical trial of its neurostimulation device for adult patients suffering from anxiety and insomnia. File image.

Houston-based Nexalin Technology’s proprietary neurostimulation device will move forward with a new clinical trial evaluating its treatment of anxiety disorders and chronic insomnia in Brazil.

The first of Nexalin’s Gen-2 15-milliamp neurostimulation devices have been shipped to São Paulo, Brazil, and the study will be conducted at the Instituto de Psiquiatria university hospital (IPq-HCFMUSP). The shipments aim to support the launch of a Phase II clinical trial in adult patients suffering from anxiety and insomnia, according to a news release.

“Brazil is an important emerging market for mental health innovation, and this collaboration marks our first IRB-approved study in the region,” Mike White, CEO of Nexalin, said in the release.

The study will be led by Dr. Andre Russowsky Brunoni, who specializes in neuromodulation and interventional psychiatry. He currently serves as director of the interventional psychiatry division at IPq-HCFMUSP and this summer will join UT Southwestern in Dallas and its Peter O’Donnell Jr. Brain Institute as a professor of psychiatry.

The Phase II study plans to enroll 30 adults in São Paulo and assess the efficacy of Nexalin’s non-invasive deep intracranial frequency stimulation (DIFS™) of the brain in reducing anxiety symptoms and improving sleep quality, according to the company. Using the Hamilton Anxiety Rating Scale (HAM-A), the trial’s goal is a reduction in anxiety symptoms, and assessments of sleep onset latency, total sleep time, overall sleep quality, depressive symptoms and clinical impression of improvement. The company plans to share results in a peer-reviewed scientific journal.

“Anxiety and insomnia are very common conditions that often occur together and cause significant distress,” Brunoni added in the news release. “In this study, we are testing a new, non-invasive brain stimulation technology that has shown promising results in recent research. Our goal is to offer a safe, painless, and accessible alternative to improve people’s well being and sleep quality.”

The Nexalin Gen-2 15-milliamp neurostimulation device has been approved in China, Brazil, and Oman.

The company also enrolled the first patients in its clinical trial at the University of California, San Diego, in collaboration with the VA San Diego Healthcare System for its Nexalin HALO, which looks to treat mild traumatic brain injury and post-traumatic stress disorder in military personnel and the civilian population. It also recently raised $5 million through a public stock offering. Read more here.

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These Houston hospitals are the best in Texas and beyond. Photo via tmc.edu

Houston hospitals soar on annual list ranking best in Texas

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Houston Methodist Hospital now shares its status as the state’s best hospital with Dallas’ UT Southwestern Medical Center.

In U.S. News & World Report’s latest ranking of Texas hospitals, Houston Methodist and UT Southwestern share the No. 1 spot. Last year, Houston Methodist was the lone holder of first-place honors in Texas.

The Houston Methodist system comprises a primary care facility within the Texas Medical Center and six community hospitals across the region. In all, Houston Methodist operates more than 2,600 patient beds and employs more than 29,700 people.

Overall, Houston hospitals fared well in this year’s Texas rankings:

  • Houston Methodist, No. 1
  • Baylor St. Luke’s Medical Center, No. 3
  • Memorial Hermann Hospital-Texas Medical Center, No. 4
  • Memorial Hermann Greater Heights Hospital, No. 6
  • Houston Medical Sugar Land Hospital, No. 9
  • Memorial Hermann Memorial Medical Center, No. 10

Specialty institutions in Houston also garnered accolades.

For instance, the University of Texas MD Anderson Cancer Center ranked first in the country for cancer care. Since the inception of the U.S. News & World Report survey in 1990, MD Anderson has been among the country’s top two institutions for cancer care.

“At MD Anderson, we remain singularly focused on eliminating cancer,” Dr. Peter WT Pisters, president of MD Anderson, says in a news release. “We are pleased to see this commitment recognized, but there is work still to be done.”

For its part, Houston Methodist nabbed national rankings in 10 specialties, including No. 4 for diabetes and endocrinology and No. 5 for gastroenterology and GI surgery.

Elsewhere in the Houston area:

  • Texas Children’s Hospital nailed down the No. 1 ranking among children’s hospitals in the state.
  • TIRR Memorial Hermann was again ranked as the Best Rehabilitation Hospital in Texas.
  • The Texas Heart Institute at Baylor St. Luke’s Medical Center claimed the No. 2 ranking among cardiovascular, heart, and vascular surgery facilities in the state.
  • The Menninger Clinic again makes the top 10 psychiatric hospitals. It ranked No. 7 in that specialty.

“A recent survey of U.S. News users revealed more than four in five (84 percent) consider a hospital’s quality metrics to be important factors when deciding where to seek treatment for a serious medical issue,” Ben Harder, chief of health analysis and managing editor at U.S. News, says in a news release. “Consumers want useful resources to help them assess which hospital can best meet their specific care needs.”

Harder adds that his publication’s hospital rankings “offer patients and the physicians with whom they consult a data-driven source for comparing performance in outcomes, patient satisfaction, and other metrics that matter to them.”

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Persona AI teams with Under Armour to protect next-gen robots

Future Fabrics

Houston-based Persona AI has cemented a partnership with sportswear manufacturer Under Armour to provide materials to protect future robots operating in dangerous conditions.

Through the partnership, Persona AI and Under Armour will launch a research initiative to explore whether advanced performance textiles can improve the durability and resilience of humanoid robots operating in harsh industrial environments.

“This is an opportunity to apply our innovation expertise in a new context,” Kyle Blakely, senior vice president of innovation, design studio, development, and testing at Under Armour, said in a news release. “Robotics presents a fascinating new design challenge, and we aim to play a leading role in shaping performance solutions for these environments. As humanoid systems take on more physically demanding roles, we see real potential to create new market opportunities, and we’re exploring how concepts like thermal management, abrasion resistance, and flexibility translate beyond sport."

Founded in June 2024 by former NASA engineer Nicolaus Radford and former Figure AI CTO Jerry Pratt, Persona AI has quickly risen to be a top name in the development of humanoid robotic systems. Radford previously was the principal investigator at NASA’s Dexterous Robotics Lab before becoming CEO of Nauticus Robotics. While at NASA, he was the chief engineer behind Robotnaut 2, the first humanoid robot on the International Space Station.

Persona AI raised $25 million in preseed funding to develop humanoid robots designed to operate in shipyards and other industrial sites. The company has inked partnerships with HD Korea Shipbuilding & Offshore Engineering, HD Hyundai Robotic, and Korean manufacturing firm Vazil Company to create and deploy humanoid robots for complex welding tasks in shipyards.

These environments often involve exposure to dangerous chemicals, harsh weather and other potential hazards. The partnership between Persona AI and Under Armour will combine the clothing manufacturer’s development of resilient but flexible materials with the humanoid design of Persona AI.

Though best known for its sportswear, Under Armour produces a wide range of specialist fabrics and clothing, including an entire line used by the U.S. military. The company’s track record of developing high-performance fabrics built to withstand war zones and desert conditions makes it a strong partner in Persona AI’s latest endeavor.

“We chose to work with Under Armour because of their track record of innovation with these types of performance materials,” Radford said. “As we develop humanoids for intense and potentially hazardous environments, this collaboration helps us understand how advanced materials can enhance long-term reliability, thereby informing solutions to better protect workers in the field.”

Waymo suspends robotaxi service in Houston due to weather concerns

Transportation news

Waymo has suspended driverless car services in Houston and other major Texas cities, and in Atlanta, after one of its vehicles was stranded by flooding during heavy rains that will likely also hinder travel in a large swath of the U.S over the holiday weekend.

Severe thunderstorms with large hail and gusty winds were possible Friday, May 22 in Texas and other parts of the Southern and Central Plains, the National Weather Service said.

Forecasters warned of possible flash flooding along the Gulf Coast of Texas and Louisiana on Saturday, when rain and thunderstorms were expected across much of the central and eastern U.S.

The Waymo vehicle got stuck during a downpour in Atlanta on Wednesday that flooded streets and even part of a downtown highway. The vehicle was not occupied and was later recovered, the company said in a statement. At least one other Waymo vehicle was waylaid during the storm.

Waymo serves only the city of Atlanta in Georgia, and services Dallas, Houston, Austin, and San Antonio in Texas.

The company paused service in Texas “out of an abundance of caution for the forecasted severe weather,” the statement said.

Global summit spotlights Houston's growing role in brain health, innovation

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The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health.

The summit, held June 9-10 at the Texas Medical Center's Helix Park, will bring together more than 500 executives, researchers, policymakers and innovators from around the world to discuss the global brain economy.

Attendees can expect to hear from leaders of global institutions, including the World Economic Forum, U.S. Chamber of Commerce, McKinsey Health Institute, Global Brain Economy Initiative, Davos Alzheimer’s Collaborative, Business Collaborative for Brain Health (UsAgainstAlzheimer’s), Rice University, Memorial Hermann, MD Anderson and many others.

Day 1 of the conference will focus on "Enabling Human Flourishing & Economic Growth." Day 2 will focus on "Scaling Innovation & AI Solutions in the Brain Economy."

Keynotes will be delivered by:

  • Lexi Branson, vice president of health policy at the U.S. Chamber of Commerce
  • Kana Enomoto, director of the McKinsey Health Institute
  • Megan Henshall, founder of Google Experience Institute (Xi)
  • Ryan Howard, co-lead of Google Experience Institute (Xi)
  • Dr. Hani Jneid, John Sealy Distinguished Centennial Chair in Cardiology and vice president of cardiovascular operations at UTMB
  • Steve Kean, president and CEO of the Greater Houston Partnership
  • Dan Patrick, Lieutenant Governor of Texas
  • Jochen Reiser, president of UTMB
  • Thomas Seitz, senior partner of the McKinsey Health Institute

Other significant speakers include:

  • Rym Ayadi, founder and president of the Euro-Mediterranean Economists Association (EMEA) and co-founder of the Brain Capital Alliance
  • Arthur Evans, CEO and executive vice president of the American Psychological Association
  • David Gow, president and CEO of the Center for Houston’s Future (Gow is the founder and chairman of Gow Media, InnovationMap's parent company)
  • Bill McKeon, president and CEO of the Texas Medical Center
  • Jeff Merritt, head of urban transformation at the World Economic Forum
  • Joanne Pike, president and CEO of the Alzheimer’s Association
  • George Vradenburg, founding chairman of Davos Alzheimer’s Collaborative and co-founder, chairman and CEO of Us Against Alzheimer’s

The event is supported through Project Metis, which was launched by the Center for Houston’s Future last year. Led by Rice Brain Institute, The University of Texas Medical Branch's Moody Brain Health Institute and Memorial Hermann’s comprehensive neurology care department, the initiative aims to advance the understanding, prevention and treatment of the brain. It was developed on the heels of Texas voters overwhelmingly approving a ballot measure to launch the $3 billion, state-funded Dementia Prevention and Research Institute of Texas (DPRIT).

“Texas voters, by approving the state-funded Dementia Prevention Institute, have shown a strong commitment to brain health, as scientific advances continue daily. [Project Metis] aims to harness the Houston region’s unique strengths: its concentration of leading medical and academic institutions, a vibrant innovation ecosystem, and a history of entrepreneurial leadership in health and life sciences,” Gow said at the time.

Learn more about The Texas Brain Economy Summit and purchase tickets here.

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