U.S. News ranks Houston hospital No. 1 in Texas for 14th year in a row

Topping the Charts

Houston Methodist is once again the top hospital in Texas. Photo via Houston Methodist

U.S. News & World Report has released its 2025 rankings of the best hospitals in Texas, and they prove that Houston is in good hands.

The esteemed Houston Methodist Hospital was rated the No. 1 best hospital in Texas for the 14th consecutive year, and the No. 1 hospital in the metro area. Eleven more Houston-area hospitals earned spots among the statewide top 35.

U.S. News annually evaluates 581 Texas hospitals to determine which meet the publication's rigorous standards and offer the best care for patients. Hospitals are also ranked among 15 specialties, including cancer, cardiology, heart and vascular surgery, obstetrics and gynecology, orthopedics, psychiatry, rehabilitation, diabetes and endocrinology, and more.

Houston Methodist also appeared on U.S. News' prestigious list of Honor Roll hospitals, consisting of 20 medical centers that are deemed the "best of the best" hospitals in the nation. No other Texas hospitals made the list, further proving that Houston Methodist takes exceptional care of its patients.

"This is a tremendous achievement for our physicians and employees who dedicate themselves every day to our patients," said Marc Boom, M.D., president and CEO of Houston Methodist, in a press release. "We take pride in these national recognitions but more importantly, these accolades reflect our unparalleled commitment to keeping our patients at the center of everything we do."

Houston Methodist earned several top-20 rankings across 11 of the 15 total specialties nationwide. It also earned national recognition for having the 7th best gastroenterology/GI surgery program, the 8th best pulmonology and lung surgery programs, and the 10th best diabetes and endocrinology programs in the country.

Elsewhere in Houston, The University of Texas MD Anderson Cancer Center ranked as the No. 1 best cancer hospital in the nation for the 11th year in a row.

"We are honored to again be ranked as the nation’s top hospital for cancer care – a recognition that reaffirms our commitment to our shared mission to end cancer," said MD Anderson president Peter WT Pisters, M.D., in a release. "We are grateful to every one of our teammates, trainees, students, donors, volunteers, advocates and patients, whose unwavering dedication make it possible for MD Anderson to deliver outstanding patient care."

Other top-performing Houston-area hospitals that ranked among the best in Texas include:

  • No. 4 – Baylor St. Luke's Medical Center
  • No. 5 – Memorial Hermann Greater Heights Hospital
  • No. 6 – Memorial Hermann Hospital
  • No. 8 – Houston Methodist Sugar Land Hospital
  • No. 9 – Houston Methodist Willowbrook Hospital
  • No. 12 – Houston Methodist The Woodlands Hospital
  • No. 13 – Memorial Hermann Memorial City Medical Center (tied with Baylor Scott and White All Saints Medical Center - Fort Worth)
  • No. 21 – Houston Methdodist Baytown Hospital (tied with Methodist Hospital - Stone Oak in San Antonio and Texas Health Harris Methodist Hospital Fort Worth)
  • No. 25 – HCA Houston Healthcare Clear Lake in Webster (tied with St. Luke's Health - The Woodlands Hospital, Baylor Scott and White Medical Center - Round Rock-Lakeway, and Texas Health Presbyterian Hospital Plano)
  • No. 29 – University of Texas Medical Branch in Galveston (tied with Medical City Plano)
---

This article originally appeared on CultureMap.com.

From Your Site Articles
Houston is home to two of the highest-ranked schools in the country. Photo via Getty Images

2 Houston high schools rank among America's top 100 in 2024, says U.S. News

best in class

Two Houston high schools are dominating U.S. News and World Report's prestigious annual list of the country's best public high schools.

The 2024 rankings from U.S. News, released April 23, put Houston ISD’s Carnegie Vanguard High School at No. 31 nationally (up from No. 35 last year and No. 40 in 2022) among the country’s best high schools. The school also ranks No. 248 nationally among the best STEM (science, technology, engineering, and math) high schools and No. 12 among the best magnet high schools.

Meanwhile, DeBakey High School for Health Professions ranks No. 70 nationally among the best high schools (down from No. 66 last year and No. 50 in 2022) and No. 19 among best magnet high schools. DeBakey ranked No. 426 nationally among best STEM high schools.

Topping the national list for 2024 is the BASIS Peoria Charter School in Peoria, Arizona.

Each year, U.S. News evaluates about 18,000 high schools on six factors: college readiness, reading and math proficiency, reading and math performance, underserved student performance, college curriculum breadth, and graduation rates.

“The 2024 Best High Schools rankings offer a starting point for parents to understand a school’s academic performance, whether it’s a prospective school or one that their child is already attending,” said LaMont Jones, Ed.D., the managing editor of education at U.S. News, in a release. “Accessible data on our high schools can empower families across the country as they navigate today’s educational environment and plan for the future.”

Elsewhere in Texas
Around the state, these Texas high schools also made it into the top 100 nationally:

  • Dallas ISD's The School for the Talented and Gifted, No. 6 (unchanged from last year). No. 21 nationally among the best STEM high schools, and No. 3 among the best magnet high schools.
  • Dallas ISD's Irma Lerma Rangel Young Women's Leadership School, No. 23 (down from No. 18 last year) and No. 10 nationally among the best magnet high schools.
  • Dallas ISD's Science and Engineering Magnet School, No. 29 nationally among the best high schools (down from No. 23 last year), No. 37 nationally among the best STEM high schools, and No. 11 nationally among the best magnet high schools.
  • Grand Prairie ISD's Collegiate Institute, No. 30 (up from No. 188 last year). No. 6 nationally among best charter high schools.
  • Austin ISD’s Liberal Arts and Science Academy, No. 38 (down from No. 32 last year and No. 34 in 2022). No. 34 nationally among the best STEM high schools.
  • BASIS San Antonio - Shavano Campus, No. 64 (up from No. 81 last year and No. 77 in 2022). No. 76 nationally among the best STEM high schools and No. 13 nationally among the best charter high schools.
  • Brownsville ISD's Early College High School, No. 71 (up from No. 229 last year).
  • Dallas ISD’s Judge Barefoot Sanders Law Magnet, No. 85 (up from No. 93 last year and No. 48 in 2022) . No. 21 nationally among the best magnet high schools.

When broken down just to Texas schools, Houston's Carnegie Vanguard High School (No. 5) and DeBakey High School for Health Professions (No. 8) are both in the top 10 best-rated public high schools in Texas this year, U.S. News says.

Other Houston-area schools that rank among Texas' 100 best are:

  • No. 24 – Kinder High School for Performing and Visual Arts, Houston ISD
  • No. 25 – Challenge Early College High School, Houston ISD
  • No. 29 – Young Women's College Prep Academy, Houston ISD
  • No. 32 – Eastwood Academy, Houston ISD
  • No. 37 – Harmony School of Innovation - Katy, Katy
  • No. 40 – Kerr High School, Alief ISD, Houston
  • No. 43 – Houston Academy for International Studies, Houston ISD
  • No. 47 – East Early College High School, Houston ISD
  • No. 59 – Clear Horizons Early College High School, Clear Creek ISD, Houston
  • No. 61 – Seven Lakes High School, Katy ISD
  • No. 63 – Early College Academy at Southridge, Spring ISD, Houston
  • No. 68 – KIPP Houston High School, Houston
  • No. 70 – North Houston Early College High School, Houston ISD
  • No. 71 – Victory Early College High School, Aldine ISD, Houston
  • No. 75 – Tompkins High School, Katy ISD
  • No. 76 – Clements High School, Fort Bend ISD, Sugar Land
  • No. 82 – Sharpstown International School, Houston ISD
  • No. 85 – Tomball Star Academy, Tomball ISD
  • No. 89 – Westchester Academy for International Studies, Spring Branch ISD, Houston
  • No. 95 – Harmony School of Innovation - Sugar Land, Sugar Land
  • No. 97 – Harmony School of Discovery - Houston, Houston
  • No. 98 – Energy Institute High School, Houston ISD

------

This article originally ran on CultureMap.

Rice University, University of Houston, and two other schools made this year's ranking of top grad schools. Photo via Rice.edu

4 Houston universities earn top spots for graduate programs in Texas

top schools

Houston's top-tier universities have done it again. U.S. News and World Report has four Houston-area universities among the best grad schools in the state, with some departments landing among the top 100 in the country.

U.S. News publishes its annual national "Best Graduate Schools" rankings, which look at several programs including business, education, engineering, fine arts, health, and many others. For the 2024 report, the publication decided to withhold its rankings for engineering and medical schools. It also changed the methodology for ranking business schools by adding a new "salary indicator" based on a graduate's profession.

U.S. News also added new rankings for doctoral and master's programs in several medical fields for the first time in four years, or even longer in some cases. New specialty program rankings include audiology, occupational therapy, physical therapy, pharmacy, nurse midwifery, speech-language pathology, nurse anesthesia, and social work.

"Depending on the job or field, earning a graduate degree may lead to higher earnings, career advancement and specialized skill development," wrote Sarah Wood, a U.S. News Education reporter. "But with several types of degrees and hundreds of graduate schools, it can be difficult to narrow down the options."

Without further ado, here's how the local schools ranked:

Rice University's Jesse H. Jones Graduate School of Business maintained its position as No. 2 in Texas, but slipped from its former No. 24 spot in the 2023 report to No. 29 overall in the nation in 2024. Its entrepreneurship program tied for No. 8 in the U.S, while its part-time MBA program ranked No. 15 overall.

Houston's University of Texas Health Science Center earned the No. 3 spots in Texas for its masters and doctorate nursing programs, with the programs earning the No. 31 and No. 45 spots overall in the nation. The school ranked No. 25 nationally in the ranking of Best Public Health schools, and No. 36 for its nursing-anesthesia program.

Prairie View A&M University's Northwest Houston Center ranked No. 5 in Texas and No. 117 in the nation for its master's nursing program. Its Doctor of Nursing Practice program ranked No. 8 statewide, and No. 139 nationally.

The University of Houston moved up one spot to claim No. 4 spot in Texas for its graduate education program, and improved by seven spots to claim No. 63 nationally. Its graduate business school also performed better than last year to claim No. 56 in the nation, according to the report. The University of Houston Law Center is the fifth best in Texas, and 68th best in the U.S. Most notably, its health care law program earned top nods for being the seventh best in the country.

Among the new specialty program rankings, UH's pharmacy school ranked No. 41 nationally, while the speech-language pathology program earned No. 44 overall. The graduate social work and public affairs programs ranked No. 67 and No. 76, respectively, in the nation.

The full list of best graduate schools can be found on usnews.com.

------

This article originally ran on CultureMap.

Houston is home to a few of the highest-ranked high schools in the nation. Getty Images

3 heroic Houston high schools rank among top 100 in America, says U.S. News

super schools

Three Houston high schools are continuing their streak of top appearances on a prestigious annual list of the country's best public high schools.

The 2023 rankings from U.S. News & World Report, released August 29, put Houston ISD’s Carnegie Vanguard High School at No. 35 nationally (up from No. 40 last year) among the country’s best high schools. The school also ranks No. 248 nationally among the best STEM (science, technology, engineering, and math) high schools and No. 12 among the best magnet high schools.

Also in the top 100 are two other Houston ISD high schools.

DeBakey High School for Health Professions ranks No. 66 nationally among the best high schools (down from No. 50 last year) and No. 18 among best magnet high schools for the second consecutive year.

Young Women's College Prep Academy comes in No. 94 nationally among the best high schools (up from No. 148 last year), and No. 26 among best magnet high schools.

Topping the national list for 2023 is the Early College at Guilford in Greensboro, North Carolina.

Each year, U.S. News evaluates about 18,000 high schools on six factors: college readiness, reading and proficiency, reading and math performance, underserved student performance, college curriculum breadth, and graduation rates.

"Having access to a strong high school program is paramount for students as they face an ever-changing world," said U.S. News' managing editor of education Liana Loewus in a release. "Making data on our high schools available helps parents ensure their child is in the educational environment that best sets them up to thrive."

Elsewhere in Texas
Around the state, these Texas high schools also made it into the top 100 nationally:

  • Dallas ISD's The School for the Talented and Gifted, No. 6 (up from No. 8 last year and No. 13 in 2021). No. 8 nationally among the best STEM high schools for the second consecutive year and No. 2 among the best magnet high schools (up from No. 4 last year).
  • Dallas ISD's Irma Lerma Rangel Young Women's Leadership School, No. 18 (up from No. 20 last year) and No. 8 nationally among the best magnet high schools for the second consecutive year.
  • Dallas ISD's Science and Engineering Magnet School, No. 23 nationally among the best high schools (down from No. 22 last year), No. 24 nationally among the best STEM high schools (down from No. 7 last year), and No. 2 nationally among the best magnet high schools (up from No. 10 in 2022).
  • Austin ISD’s Liberal Arts and Science Academy, No. 32 (up from No. 34 last year and No. 41 in 2021). No. 34 nationally among the best STEM high schools (up from No. 70 in 2022).
  • BASIS San Antonio - Shavano Campus, No. 81 (down from No. 77 last year and No. 102 in 2021). No. 41 nationally among the best STEM high schools (down from No. 25 in 2022) and No. 17 nationally among the best charter high schools.
  • Dallas ISD's Trinidad Garza Early College at Mt. View, No. 91 (up from No. 118 last year).
  • Dallas ISD’s Judge Barefoot Sanders Law Magnet, No. 93 (down from No. 48 last year and No. 59 in 2021) . No. 25 nationally among the best magnet high schools (down from No. 17 in 2022).
  • Austin ISD's Richards School for Young Women Leaders, No. 95 (up from No. 128 last year).

When broken down just to Texas schools, Houston's Carnegie Vanguard High School (No. 5), DeBakey High School for Health Professions (No. 6), and Young Women's College Prep Academy (No. 10) are all in the top 10 best-rated public high schools in Texas this year, U.S. News says.

Other Houston-area schools that rank among Texas' 100 best are:

  • No. 12 – Kinder High School for Performing and Visual Arts, Houston ISD
  • No. 21 – Challenge Early College High School, Houston ISD
  • No. 24 – Kerr High School, Alief ISD, Houston
  • No. 29 – Eastwood Academy, Houston ISD
  • No. 37 – YES Prep - Southwest, Houston
  • No. 39 – Harmony School of Innovation - Katy, Katy
  • No. 40 – North Houston Early College High School, Houston ISD
  • No. 42 – Clear Horizons Early College High School, Clear Creek ISD, Houston
  • No. 46 – Seven Lakes High School, Katy ISD
  • No. 53 – Victory Early College High School, Aldine ISD, Houston
  • No. 54 – YES Prep - Southeast, Houston
  • No. 57 – East Early College High School, Houston ISD
  • No. 58 – Houston Academy for International Studies, Houston ISD
  • No. 64 – YES Prep - East End, Houston
  • No. 69 – Tomball Star Academy, Tomball ISD
  • No. 72 – Early College Academy at Southridge, Spring ISD, Houston
  • No. 73 – Tompkins High School, Katy ISD
  • No. 75 – Clements High School, Fort Bend ISD, Sugar Land
  • No. 82 – YES Prep - North Central, Houston
  • No. 83 – Sharpstown International School, Houston ISD
  • No. 93 – YES Prep - North Forest, Houston
  • No. 95 – YES Prep - West, Houston
  • No. 97 – High School for Law and Justice, Houston ISD

------

This article originally ran on CultureMap.

Houston didn't even crack the top 100 in the new list. Photo by Alisa Matthews on Unsplash

Houston again plummets on list of best places to live in new national report

yikes

In a surprise turn of events, Houston has fallen from grace in U.S. News and World Report's "Best Places to Live" ranking for 2023-2024.

Last year, Houston ranked No. 59 on the annual report — not surprising, considering all the Newstonians. However, the Bayou City plummeted to a shocking No. 140. Two years ago, the city ranked as No. 39, so this year's report represents a series of slips for Houston.

But why? According to the report: "A paycheck goes further in Houston than it does in other major metro areas, with affordable housing and free or cheap attractions like biking along Buffalo Bayou and exploring the 7,800-acre George Bush Park. The affordability of this region, which is located in southeastern Texas and home to more than 7 million residents in the metro area, is attracting new people from across the country and around the world."

The report takes a look at several different metrics to determine their rankings, including quality of life, housing affordability, desirability, and job market strength.

Somehow, Houston scored a mere 5.6 out of 10 in the livability score. By the numbers (and out of a perfect 10), Houston scored a 6 for desirability, 6.3 for value, 5.5. for job market, a surprising 5 for quality of life, and 5.9 for net migration.

It gets worse: Houston ranks as only No. 10 on the report's Best Place to Live in Texas list for 2023.

Texas overall saw a major drop. Austin, previously the No. 1 place to live in America for three consecutive years from 2017 to 2019, lands at No. 40 overall this year. Austin managed to hang on to its title of the Best Place to Live in Texas for 2023, with San Antonio at No. 2, and Dallas-Fort Worth taking No. 3. Rounding out the top five is Killeen in No. 4, and El Paso at No. 5.

Here's how other Texas cities faired in 2023's Best Places to Live report:

  • No. 103 – San Antonio, down from No. 83 last year
  • No. 113 – Dallas-Fort Worth, down from No. 32 last year
  • No. 122 – Killeen, down from No. 108 last year
  • No. 128 – El Paso, down from No. 124 last year
  • No. 131 – Beaumont, down from No. 109 last year
  • No. 132 – Corpus Christi, up from No. 133 last year
  • No. 134 – Brownsville, unchanged from last year
  • No. 137 – McAllen, up from No. 138 last year
  • No. 140 – Houston, down from No. 59 last year

The full report can be found on U.S. News and World Report's website.

------

This article originally ran on CultureMap.

Rice University's Jones School of Business ranked No. 2 in Texas and No. 24 overall. Photo courtesy of Rice University

3 Houston universities score top spots for gra​d programs in Texas, new national report says

TOP-TIER EDUCATION

The 2023 results are in, and U.S. News and World Report has deemed three Houston universities among the best grad schools in the state, with some of its departments landing among the top 70 in the country.

Rice University's Jones School of Business ranked No. 2 in Texas and No. 24 overall in the nation, while the Brown School of Engineering earned the No. 30 spot among engineering schools, and third best program in Texas. Additionally, the university's department of psychology landed the No. 1 spot for its industrial and organizational psychology program.

Houston's University of Texas Health Science Center earned the No. 3 spots in Texas for its masters and doctorate nursing programs, with the programs earning the No. 28 and No. 33 spots overall in the nation.

The University of Houston earned the No. 5 spot in Texas for its graduate education program, and No. 70 nationally. It is the No. 63 best business school and No. 69 best engineering school in the nation, according to the report.

U.S. News publishes its national "Best Graduate Schools" rankings every year, which looks at several programs including business, education, engineering, fine arts, health, and many others. For the 2023-2024 report, the publication decided to withhold its rankings for law and medical schools, which will be published later this year. It also changed the methodology for ranking education and business schools by focusing on outcome rather than a program’s reputation and selectivity.

“When prospective students are considering their options for graduate school, the Best Graduate Schools rankings are designed to help them identify schools that excel in the program they want to study,” said LaMont Jones, senior editor of Education at U.S. News. “With many options available, U.S. News provides a wealth of data in an easy format to help each student make the best decision.”

Some category rankings have not been released for the 2023-24 school year, but the Baylor College of Medicine ranked No. 1 in Texas in the “Best Medical Schools: Research” and “Primary Care” categories for 2022. Additionally, the University of Houston Law Center, South Texas College of Law, and Texas Southern University Marshall School of Law previously ranked No. 3 (tied), No. 6, and No. 8 respectively in Texas for the 2022-2023 academic year.

------

This article originally ran on CultureMap.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston space tech co. lands $175M and more innovation news to know

Trending News

Editor's note: The top Houston innovation news for the month includes major fundraising rounds for two Houston scaleups and local inductees into the National Academy of Inventors. Here are the five most-read InnovationMap headlines from March 1-15, 2026:

1. Intuitive Machines secures $175M equity investment to fuel growth

Intuitive Machines has landed a $175 million investment as it looks secure satellite deals and develop space-based data centers. Photo courtesy Intuitive Machines.

Houston-based space infrastructure and services company Intuitive Machines has secured a $175 million equity investment from unidentified institutional investors. The investors received shares of Class A stock in exchange for their funding. Publicly held Intuitive Machines (Nasdaq: LUNR) says it plans to use the capital to help build revenue and invest in technology, including communications and data-processing networks. Continue reading.

2. Houston e-commerce giant Cart.com raises $180M, surpasses $1B in funding

Cart.com has raised $180 million to scale its logistics network, expand AI capabilities and develop workflow automation tools. Photo courtesy of Cart.com

Houston-based commerce and logistics platform Cart.com has raised $180 million in growth capital from private equity firm Springcoast Partners, pushing the startup past the $1 billion funding mark since its founding in 2020. Cart.com says it will use the capital to scale its logistics network, expand AI capabilities and develop workflow automation tools. Continue reading.

3. Houston leads Texas with 7 new National Academy of Inventors senior members

The University of Houston has more faculty named to this year’s senior member class of the National Academy of Inventors than any other Texas institution. Photos courtesy UH.

The University of Houston is now home to seven new senior members of the National Academy of Inventors. According to UH, its seven new members represent the largest group from any single Texas institution this year, bringing the university's total senior member count to 46. Continue reading.

4. Booming Houston suburb launches innovation grant to attract startups

The City of Sugar Land is putting money on the table to support startups that relocate jobs to southwest Houston. Photo via Getty Images.

Think you’ve got a burgeoning startup? Consider moving it to southwest Houston. The City of Sugar Land announced the Sugar Land Starts Innovation Fund to support companies that move jobs to the area. Continue reading.

5. 6+ can't-miss Houston business and innovation events in March

From CERAWeek to H-Town Roundup, here's what not to miss this month and how to register. Photo courtesy of CERAWeek

March brings the return of some of Houston’s signature innovation events, plus insightful talks and celebrations in honor of Women's History Month. Here’s what not to miss and how to register. Continue reading.

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”

View All Listings