Houston-to-Dallas high-speed train hires major international operator

All aboard

The high-speed train is chugging along. Rendering courtesy of Texas Central

The high-speed railroad from Houston to Dallas has acquired a key new player that will run day-to-day operations.

Renfe, an international railway company based in Spain, has been hired by Texas Central, the project developers, as the train's operating partner. The selection of Renfe as an operating partner marks another major step forward for the Houston-to-North Texas high-speed railroad.

Texas Central CEO Carlos Aguilar says in a statement that Renfe was chosen after a review of the best railroad operators in the world.

"Renfe has established a reputation for excellence in railroad operation in Spain and across the world, and we welcome them aboard," Aguilar says. "With their decades of expertise, they were a natural fit to join our other partners. Having the operator, the design build, and technology teams all on board and able to collaborate will ensure all aspects of the railroad are integrated and efficient."

A release calls Renfe "one of the world's most significant railways operators," running 5,000 trains daily on 7,500 miles of track. The company is integral to the transport system in its home base of Spain, handling more than 487 million passengers and 19.6 million tons of freight moved in 2017.

Renfe, in partnership with Adif, which manages Spanish railway infrastructure, will be responsible for running the trains; maintaining system components, such as engines, signals, and other equipment; and overseeing ticketing, passenger loyalty programs, and other services.

It will also provide technical advice on the design and construction of the Texas train and assist in the further development of Texas Central's operation and maintenance plans, preparing the railroad for passenger service.

Renfe is one of the biggest companies in Spain, employing nearly 14,000 people and recording revenues of 3.6 billion euros in 2017. Its high-speed systems were used by more than 36 million passengers in 2017. In March, Renfe announced that it had posted a net profit of 70 million euros in 2017, thanks in part to a jump in the number of its high-speed passengers, chalking up five consecutive years of growth.

Renfe president Isaías Táboas says the deal is a boon for Texas and for the Spanish railway industry.

"Texas Central represents a large high-speed train project in a country with high-growth potential, for which the Spanish experience will be of great help," he says. "Both Renfe Operadora and Adif have accumulated years and miles of high-speed railway development with professional teams, extensive experience, and specialized knowledge. We are committed to the success of Texas Central in improving the mobility of Texans and others in the U.S."

The agreement comes about a week after Texas Central engaged multinational firm Salini Impregilo ­– operating in the U.S. market with The Lane Construction Corporation – to lead the civil construction consortium that will build the passenger line, including viaducts, embankments, and drainage.

Spain's first high-speed line between Madrid and Seville was dedicated in 1986 and Renfe's first high-speed service connected the cities in 1992.

Its second high-speed line, from Madrid to Barcelona, was completed in 2007. Renfe also operates high-speed service from Barcelona to Paris, Lyon, and Toulouse in France. Among other major international projects, Renfe operates the recently opened high-speed train between Mecca and Medina, in Saudi Arabia.

The 200-mph train will link Houston and Dallas in 90 minutes, with a midway stop in the Brazos Valley.

The Texas train will be based on the latest generation of Central Japan Railway's Tokaido Shinkansen train system, the world's safest mass transportation system. It has operated for more than 54 years with a perfect record of zero passenger fatalities or injuries from operations, and an impeccable on-time performance record.

Texas Central and its partners are refining and updating construction planning and sequencing, guided by the Federal Railroad Administration's recently released draft environmental impact statement. The FRA now is working on a final environmental review that will help determine the project's timeline and final route.

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This story originally appeared on CultureMap.

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Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”

Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.

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