3 Houston innovators to know this week

who's who

This week's Houston innovators to know are Megan Eddings, Lance Black, and Todd Burke.

The city of Houston — much like most major cities in the country — is in crisis mode, with a stay-at-home mandate and rising COVID-19 case numbers.

But these three Houston innovators are emerging as leaders in making masks, discussing the importance of telemedicine at this time, and providing tips on keeping a stable supply chain.

Megan Eddings, founder of Accel Lifestyle

Photo courtesy of Accel Lifestyle

Former scientist Megan Eddings designed a fabric that doesn't hold onto bacteria, and she's launched an activewear brand of men's and women's T-shirts that don't stink. But when the coronavirus hit the country and medical professionals worried about personal protection equipment, Eddings sprung into action.

"We have enough supplies here to make 9,000 masks and I have 2,800 yards of fabric sitting at my factory in California," she says. "That's enough fabric to make more than 100,000 masks." Click here to read more about Houston fashion designers looking to help out.

Lance Black, associate director of TMCx

Photo courtesy of TMCx

Telemedicine has a unique opportunity during the coronavirus-cased shutdown. Lance Black, associate director of the Texas Medical Center's accelerator, TMCx, joined the Houston Innovators Podcast to discuss the health tech potential as well as how startups are coping in this uncertain time.

"This is going to force the health care system to take a hard look at what these platforms are capable of doing," Black says in the episode. "And it's going to stress the capabilities of these companies. To be honest, if there's a silver lining, that is one of them in my mind, that this will prove out the technology [in telehealth.]" Click here to read more and stream the episode.

Todd Burke, president at Smith and Associates

Photo courtesy of Smith and Associates

The COVID-19 outbreak has already greatly affected supply chains across industries, and companies should keep moving forward with that in mind. Todd Burke, president at Houston-based Smith and Associates gives three tips for properly managing your supply chain during the coronavirus outbreak in a guest article.

"During my 23 years at Smith, the world's largest open-market distributor of electronic components, I've witnessed various market disruptions and shifting supply chain dynamics," writes Burke. "I can confidently say that the coronavirus outbreak is heavily uncharted territory for the technology industry." Click here to read more.

Coronavirus likely will affect your supply chain — here's what to keep in mind. Getty Images

Houston expert: Here are 3 tips for a resilient supply chain during the coronavirus outbreak

Guest column

Consumers rarely consider the intricacies of managing a cohesive supply chain when the process needed to deliver product to market is free of disruptors. In short, engineering and design work is completed, a bill of materials is established, material is sourced, and product is manufactured.

Manufacturers often expect to easily purchase product off the shelves or online. When external factors come into play that have the potential to disrupt supply chains and the quick availability of product, proper management is even more critical for businesses and their customers.

During my 23 years at Smith, the world's largest open-market distributor of electronic components, I've witnessed various market disruptions and shifting supply chain dynamics. I can confidently say that the coronavirus outbreak is heavily uncharted territory for the technology industry. Mitigating supply chain disruptions during troubling times, however, is familiar to us. Even through uncertainty, I want companies to know that there are many options to keep their supply chains active.

Here are my top three tips for properly managing your supply chain during the coronavirus outbreak:

Assess inventory levels and run outages scenarios

It is important to not only assess your on-hand inventory levels but to quickly gauge the impact and availability of product from key suppliers. As a precaution and to prevent further spread of the virus, many electronic component manufacturing plants in China were shut down for weeks, and some are still running at limited capacity with prominent labor shortages.

Finding out which manufacturers have been shut down or are affected by the virus will help determine lead times and availability requirements. Surveying suppliers is an efficient way to gauge manufacturers' levels of impact and determine your own needs. Bear in mind what possible logistics delays you may encounter when assessing your material levels.

Build contingency plans with alternative sources.

With supply constraints from traditional sources being almost an inevitability, having flexible sourcing options and relationships with key suppliers is a prime strategy for contingency planning.

On top of that, make sure your sourcing partner has put stringent quality procedures in place and is certified to the highest industry standards. Expanding your AVL (approved vendor list) and qualifying other manufacturers will help keep lines running according to forecast.

Ensuring heightened supplier screenings with end-to-end evaluation transparency is even more essential during times of disruption. Trusted, multichannel sourcing capabilities are prime options in the face of the consistently evolving global situation.

Stay vigilant, and work closely with your emergency response team.

Uncertainty will continue to play a major role throughout the outbreak situation. From my experience, staying up to date with the latest news and maintaining frequent communication with both internal and external parties is one of the most proactive approaches to disruptive situations.

Smith's shipping and logistics hubs have mirrored capabilities and are located in Houston, Hong Kong, and Amsterdam, so we have been able to keep our operations running throughout the outbreak. Although Smith's business operations have continued without any shutdowns, the electronics supply chain has been significantly impacted, and disruptions will be felt for some time. The effects of the coronavirus are expected to trickle down to end consumers, as new product introductions for some consumer electronics have been delayed. Reports are even indicating that the supply and availability of technology products during the peak holiday season may be disrupted.

With the millions of components that go into everything from consumer electronics to oil and gas and medical equipment, our industry could see notable shortages in supply throughout the year. I encourage all companies and especially our friends here in Houston to thoroughly evaluate their supply chains. Utilizing these tips to implement a resilient supply chain will help build a strategic business outlook.

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Todd Burke is president at Houston-based Smith and Associates.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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