Tige Savage of Revolution Ventures and Sandy Guitar of HX Venture Fund explain how they're working together to fund Houston companies in a recent Q&A. Photos courtesy

The HX Venture Fund is a fund of funds that makes investments as a limited partner in venture capital funds across the country — VC funds that want to add Houston companies to their portfolios. HXVF is is paving the way for those investments by setting up immersive days for venture capitals visiting Houston.

One of these HXVF Engage VC days is taking place this week on Wednesday, April 27. Houston entrepreneurs can hear from partners at Revolution — a Washington, D.C.-based firm with three investment funds and strategies — at a fireside chat kicking off the visit at 8:30 am at The Ion.

Tige Savage, co-founder and managing partner of Revolution Ventures, and Sandy Guitar, managing partner of HX Venture Fund, join InnovationMap for a Q&A about how the two organizations are working together to put funding in the hands of Houston tech entrepreneurs.

InnovationMap: Tige, tell me briefly about Revolution and its family of funds. What types of companies are you looking for?

Tige Savage: We started Revolution about 17 years ago. I co-founded it with Steve Case, the founder of AOL and later the chairman of AOL Time Warner. I ran the venture capital group for that media company — that's how he and I got to know each other. AOL was based in Washington DC, so when Steve and I partnered up to launch our firm, we based it in Washington. We knew that to do the investing of the importance and scale that we had in mind, that it was an idea that was bigger than just Washington DC. So, we hopped on airplanes, and we went to where we thought the most interesting best ideas were. And as we spent our time in the market, we realized that there were a lot of opportunities in a lot of places other than New York City and Silicon Valley — we obviously have nothing against New York City or Silicon Valley, and we make investments in those places. But we realized that there was a lot going on in the country. It really gave us an opportunity to start building ecosystems and investing across the country. We looked back and realized we were generating returns in places like Florida, Washington, DC, and Portland, Oregon, et cetera — and there were great opportunities and great entrepreneurs in those places. And the barriers to building companies in those kinds of places had gotten much smaller than they'd been historically — the internet enabled talent to be in more places we've seen that amplified in a major way through the pandemic.

We started investing, and we raised capital from the outside world — and we did that in three efforts. One is something called the Rise of the Rest seed fund that is a very ecosystem focused investment vehicle. They make hundreds of investments out of their $150 million fund — small investments really to be involved in those communities. Imagine that's a very large top of funnel approach for our organization that allows us to project ourselves in a major way. David Hall is managing director of the fund and will be at this event tomorrow. He's been involved in revolution from the very early days. In fact, he was the very first person I hired.

Revolution Ventures is the fund I'm involved in. We are mostly series A investment effort with a much more concentrated portfolio. We're very focused on this same strategy of investing across the entire country. Then we have a growth fund called Revolution Growth that's sort of a later stage fund — call it series C plus, maybe series D, investor. They take larger stakes, but it's also a concentrated portfolio.

We have a few things that we think are unique about Revolution. One is what we call "place" — it's this geographic approach that we've taken from the start we're real believers that there's opportunity everywhere. We've spent a lot of time, money, capital, et cetera, working on those ecosystems and being in them. That's why places lake Houston are so exciting for us. Secondly, is policy. We're in Washington, it's in the DNA of what we do. It used to be very out of favor for tech companies to say they cared about policy, where we've always known that that's very important. If you go to some of the biggest tech companies today they'll tell you that the most important thing to them and the biggest risk they have is policy and regulatory.

We have a history of investing in billion dollar categories where technology is ripe to make the the business model, the consumer value proposition, the supply chain, the margin structure — something like that — better. That's why we called the firm Revolution, targeting places where technology can revolutionize existing categories, largely for the benefit of consumers.

IM: Sandy, what is it about Revolution that makes it a good fund for Houston companies?

Sandy Guitar: We've met with and built relationships with over 400 venture funds, but have to date have only invested in 14. So ours is a super selective process and we are just honored to be limited partners of Revolution. The reasons that make Revolution such a fit are manyfold. One is we seek investment strategies that we think will find deals in Houston. Revolution's strategy of using both the Rise of the Rest at the seed level, but a concentrated portfolio at the series A level is exactly the kind of strategy that we think works. Their generalist approach, but with specific expertise within various technologies means that they can be nimble from a technology point of view, as they look for deal flow in Houston, and they can allow for a force rank that doesn't force them in one tech bucket. We think that's a great advantage to seasoned venture capitalists.

Second of all, we're looking for investment strategies that create high growth companies, which can be innovative to our investors, such as the HEB, Shell, Chevron, Insperity, Lyondellbasell, et cetera. Those investors at HX Venture Fund rely on us to introduce them to opportunities for co-investment at the company or fund level and for opportunities to be customers to the portfolio companies of our VCs. We believe Revolution is producing the kinds companies that are going to be and are of interest to our limited partners as they try to innovate from within. And then third of all, we're looking for really strong track records that show expertise in selecting, growing and exiting companies. We want Houston entrepreneurs to benefit from that kind of acumen. That takes a lot of track record and lot of time in VC to show proof points of all three of those parts of the company formation process, and Revolution has that in spades.

IM: Tige, do you have Houston startups already in your portfolio and how is HXVF helping you grow your presence in Houston?

TS: Across our funds, between the Rise of the Rest fund and Revolution Ventures, I think there are 19 Texas investments, one in Houston. We also have a company called Big Commerce, which is in the growth fund that's a Texas and Australia-based company. Goodfair is an investment of the Rise of the Rest fund. They made an early investment — love the strategy of really trying to make fashion more affordable and more environmentally conscious and more economically achievable.

We are equally fortunate to have HX involved. Not only are they a great investor, but they're also a great facilitator of intersections for firms like ours that are actively interested in deploying capital in interesting places. We're only a handful of folks, so it takes a lot of leverage. Our Rise of the Rest strategy is an institutional effort, but having partners in the market really matters. This is why we're so excited to be partnered with Sandy and the gang there, because we really view that strategy as a unique and interesting one.

IM: Sandy, tell me about these events you’ve been putting on for your portfolio funds at HXVF.

SG: This is our second event this year already, and we've done about half a dozen of these so far of what we call VC engage days. The idea of the VC engage day is to really connect all of our communities together. In the mornings, we like to make sure that the venture capitalist coming in has an opportunity to speak with our ecosystem and that anybody for free can come and listen to these very experienced and successful venture capitalists. From there, we curate one-on-one meetings between select entrepreneurs and venture capitalists that are part of the day. We also do one-on-ones with our limited partners and the venture capitalists. And then, at the end of the day, we have a private dinner to provide more bespoke conversations either with our limited partners or with the Founder's Circle — 20-plus serial entrepreneurs here in Houston that provide a voice to us at HXVF.

TS: What was just described — that's is not a typical thing. LPs don't do that. We're obviously excited about it. It's a thing unique to Houston. HXVF is doing a lot of work to make these things happen.

IM: Tige, as someone looking in from DC into the Houston market, what do you see happening in the Houston market? What are you most excited about getting to tap into on your visit?

TS: Houston is known for a number of industries and is smart to leverage its engineering talent and try to focus that on ways to amplify it in technology. We think that the opportunities around sort of innovative manufacturing or around logistics around climate are particularly interesting to our funds, because when we talk about revolutionizing large categories in ways that make things better for consumers, those are all major elements that can have that kind of impact.

Houston's an extremely multicultural place. The engineering talent is extremely robust. The ability for large corporations to invest in and take advantage of what's going on in tech is extremely exciting. Finding a way for catalytic activity to happen within within these large businesses is sometimes a challenge. What we're most interested in is seeing where that's happening.

The ecosystem is really blooming. This is sort of the bread and butter of what we do. Collaboration, capital, and network density are what we've always thought are the three key things that are differentiators for a market. And those things are all coming together.

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This conversation has been edited for brevity and clarity.

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Rice Brain Institute awards seed grants for dementia, Alzheimer’s research

brain trust

The recently established Rice Brain Institute awarded 12 seed grants last month to support research on dementia, Alzheimer’s disease, Parkinson’s disease and other neurological disorders.

The grants are part of the Rice DPRIT Seed Grant Program, which aims to help faculty members generate preliminary data, test and teams that would be supported under the Dementia Prevention and Research Institute of Texas.

The DPRIT was approved last year to provide $3 billion in state funding over a 10-year span for research on dementia prevention and other neurological conditions. It will be modeled after the Cancer Prevention and Research Institute of Texas (CPRIT), which has awarded nearly $4 billion in grants since 2008.

“DPRIT is a historic initiative with transformative impact potential and at Rice we are very well equipped to contribute to its mission and help make Texas a leader in brain health and innovation,” Behnaam Aazhang, a Rice professor of electrical and computer engineering and director of the Neuroengineering Initiative and the RBI, said in a news release.

The Rice DPRIT Seed Grant Program is supported by the RBI and the Educational and Research Initiative for Collaborative Health (ENRICH) office at Rice. Most of the funding came from Rice's Office of Research, with a contribution from Rice's Amyloid Mechanism and Disease Center, which also launched last year.

A number of the teams include collaborators from Houston's Texas Medical Center, including Baylor College of Medicine, University of Texas Medical Branch and the McGovern Medical School at UTHealth Houston.

The 12 teams are:

  • Keya Ghonasgi, assistant professor of mechanical engineering at Rice. Ghonasgi's research addresses the high risk of falls among people with different types of dementia and aims to develop a personalized, home-based fall-prevention approach using textile-integrated wearable sensors.
  • Luz Garcini, associate professor of psychological sciences at Rice, and Hannah Ballard, associate director of community and public health at the Kinder Institute for Urban Research at Rice. Garcini and Ballard's research looks at barriers and facilitators to early detection of Alzheimer’s disease in diverse, medically underserved urban communities and focuses on populations that experience late diagnosis, including Hispanic/Latino groups.
  • Lei Li, assistant professor of electrical and computer engineering at Rice, and Pablo Valdes, assistant professor of neurosurgery at UTMB. Li and Valdes' project develops a noninvasive, bedside imaging approach to monitor brain blood flow and oxygenation in patients recovering from stroke or brain surgery using photoacoustic imaging through a specialized transparent skull implant.
  • Cameron Glasscock, assistant professor of biosciences at Rice. Glasscock's project addresses repeat expansion disorders, such as Huntington’s disease and myotonic dystrophy, and focuses on stopping DNA instability before repeats reach a disease-causing threshold.
  • Raudel Avila, assistant professor of mechanical engineering at Rice. Avila's project focuses on everyday health factors such as nutrition, hydration and brain blood flow and how they influence brain aging long before symptoms of dementia appear.
  • Isaac Hilton, associate professor of bioengineering at Rice, and Laura Lavery, assistant professor of biosciences at Rice. Hilton and Lavery's project uses precise CRISPR-based gene regulation to target multiple genetic drivers of neuronal damage in Alzheimer’s.
  • Quanbing Mou, assistant professor of chemistry at Rice, and Qing-Long Miao, assistant professor of neurology at Baylor College of Medicine. Mou and Miao's project aims to develop a gene-regulation therapy for childhood absence epilepsy by restoring activity of the CACNA1A gene.
  • Momona Yamagami, assistant professor of electrical and computer engineering at Rice, and Christopher Fagundes, professor of psychological sciences at Rice. Yamagami and Fagundes' project addresses the physical and mental health challenges faced by spouses caring for partners with Alzheimer’s disease and related dementias and aims to develop algorithms to determine the optimal timing and frequency of supportive text messages.
  • Han Xiao, professor of chemistry at Rice. Xiao's project aims to improve the delivery of antibody therapies to the brain using a noninvasive, light-based approach that temporarily opens the blood–brain barrier.
  • Lan Luan, associate professor of electrical and computer engineering at Rice. Luan's project investigates how tiny blood-vessel injuries in the brain, known as microinfarcts, contribute to dementia.
  • Natasha Kirienko, associate professor of biosciences at Rice. Kirienko's project targets a shared cause of neurodegeneration, impaired mitochondrial cleanup, and aims to identify an existing antidepressant that could be repurposed to protect neurons in diseases like Alzheimer’s and Parkinson’s.
  • Harini Iyer, assistant professor of biosciences at Rice. Iyer's project will observe zebrafish to investigate how the brain’s primary immune cells become improperly activated in neurological disorders, leading to the loss of healthy neurons and cognitive impairment.

The RBI also named the first four projects to receive research awards through the Rice and TMC Neuro Collaboration Seed Grant Program in January. Read more about those projects here.

Report: These 10 jobs earn the biggest salary premiums in Texas

A move to Texas bolsters earnings for some, and a new SmartAsset study has revealed the top professions where the median annual earnings in the Lone Star State exceed the national median.

The report, "When it Pays to Work in Texas — and When It Doesn’t," published in April, analyzed over 700 occupations to determine which have the biggest "Texas premium" — meaning jobs where the price-adjusted median annual pay in Texas most exceeds the national median for the same occupation — and which jobs have the biggest “Texas penalty,” where the statewide median annual pay falls furthest below the national median. Salaries were sourced from the U.S. Bureau of Labor Statistics (BLS) and adjusted for regional price parity.

According to the report's findings, geoscientists have the biggest "Texas premium" and make a $159,903 median annual salary. Texas' salary for geoscientists is 61 percent higher than the national median for the same position (after adjusting for regional price parity).

"Texas’s large petroleum industry helps explain why employers in the state retain so many geoscientists," the report's author wrote. "In fact, the Lone Star State is home to more geoscientists than any other state except California."

There are more than 3,600 geoscientists working in Texas, SmartAsset said.

These are the remaining top 10 occupations with the biggest "Texas premiums" (salaries are price-adjusted):

  • No. 2 – Commercial pilots: $167,727 median Texas earnings; 37 percent higher than the national median
  • No. 3 – Sailors: $67,614 median Texas earnings; 36 percent higher than the national median
  • No. 4 – Aircraft structure assemblers: $83,519 median Texas earnings; 35 percent higher than the national median
  • No. 5 – Ship captains: $108,905 median Texas earnings; 27 percent higher than the national median
  • No. 6 – Nursing instructors (postsecondary): $100,484 median Texas earnings; 26 percent higher than the national median
  • No. 7 – Tax preparers: $63,321 median Texas earnings; 25 percent higher than the national median
  • No. 8 – Chemists: $104,241 median Texas earnings; 24 percent higher than the national median
  • No. 9 – Health instructors (postsecondary): $128,680 median Texas earnings; 22 percent higher than the national median
  • No. 10 – Engineering instructors (postsecondary): $129,030 median Texas earnings; 22 percent higher than the national media

The careers where Texas workers earn less

SmartAsset said an editor is the Texas profession where workers earn the furthest below the median for the same occupation elsewhere in the U.S. Not to be confused with film and video editors, BLS defines editors as those who "plan, coordinate, revise, or edit written material" and "may review proposals and drafts for possible publication."

The study found editors make a price-adjusted median wage of $29,710, which is 61 percent lower than the national median for the same position, and there are nearly 8,200 editors in Texas.

It's worth noting that the salaries for editors may be skewed by the fact that there are not major publications in rural areas of Texas, and other professions may also have financial deviations for similar reasons.

Several healthcare jobs also appear to have the worst penalties in Texas compared to elsewhere in the country. Home health aides are the second-worst paying professions in the state, making a median wage of $24,161.

"More home health aides work in Texas than in nearly any other state, with only California and New York employing more," the report said. "However, the more than 300,000 Texans in this occupation earn median annual pay that is about 31 percent below the national median, after adjusting for regional price parity.

SmartAsset clarified that pay penalties are not consistent "across the board" for other healthcare occupations in Texas.

"For physical therapy assistants, occupational therapy assistants, and postsecondary nursing instructors, Texas may be an especially strong place to work, with these occupations offering 'Texas premiums' of between 17 percent and 26 percent," the study said.

These are the remaining top 10 occupations where median annual earnings in Texas fall furthest below the national median for the same occupation:

  • No. 3 – Cardiovascular technicians: $49,382 median Texas earnings; 27 percent lower than the national median
  • No. 4 – Semiconductor processing technicians: $38,295 median Texas earnings; 25 percent lower than the national median
  • No. 5 – Tutors: $30,060 median Texas earnings; 25 percent lower than the national median
  • No. 6 – Control and valve installers: $56,496 median Texas earnings; 24 percent lower than the national median
  • No. 7 – Mental health social workers: $46,109 median Texas earnings; 23 percent lower than the national median
  • No. 8 – Clinical psychologists: $74,449 median Texas earnings; 22 percent lower than the national median
  • No. 9 – Producers/directors: $65,267 median Texas earnings; 22 percent lower than the national median
  • No. 10 – Interpreters/translators: $46,953 median Texas earnings; 21 percent lower than the national median

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This article originally appeared on CultureMap.com.

Houston rises in 2026 ranking of best U.S. cities to start a business

Best for Biz

Houston has reaffirmed its commitment to a business-friendly environment and now ranks as the 26th best large U.S. city for starting a business in 2026. The city jumped up eight places after ranking 34th last year.

WalletHub's annual report compared 100 U.S. cities based on 19 relevant metrics across three key dimensions: business environment, access to resources, and costs. Factors that were analyzed include five-year business survival rates, job growth comparisons from 2020 and 2024, population growth of working-age individuals aged 16-64, office space affordability, and more.

Florida cities locked out the top five best places in America for starting a new business: Tampa, Orlando, Jacksonville, Hialeah, and St. Petersburg.

Houston's business environment ranked as the 19th best in the country, and the city ranked 51st in the "business costs" category. However, the city lagged behind in the "access to resources" ranking, coming in at No. 72 overall. This category examined metrics such as Houston's working-age population growth, the share of college-educated individuals, financing accessibility, the prevalence of investors, venture investment amounts per capita, and more.

"From the Gold Rush and the Industrial Revolution to the Internet Age, periods of innovation have shaped our economy and driven major societal progress," the report's author wrote. "However, the past few years have been particularly challenging for business owners in the U.S., due to factors such as the COVID-19 pandemic, the Great Resignation and high inflation."

Earlier this year, WalletHub declared Texas the third-best state for starting a business in 2026, and several Houston-area cities have seen robust growth after being recognized among the best career hotspots in the U.S. Entrepreneurial praise has also been extended to five local companies that were named the most innovative companies in the world, and six powerhouse female innovators that made Inc. Magazine's 2026 Female Founders 500 list.

Texas cities with strong environments for new businesses
Multiple cities in the Dallas-Fort Worth Metroplex can claim bragging rights as the best Texas locales for starting a new business. Dallas ranked highest overall — appearing 11th nationally — and Irving landed a few spots behind in the 16th spot. Arlington (No. 23), Fort Worth (No. 30), Plano, (No. 35), and Garland (No. 65) followed behind.

Only six other Texas cities earned spots in the report: Austin (No. 24), Lubbock (No. 36), Corpus Christi (No. 39), San Antonio (No. 64), El Paso (No. 67), and Laredo (No. 76).

Austin tied with Boise, Idaho and Fresno, California for the highest average growth in the number of small businesses nationally, while Corpus Christi and Laredo topped a separate list of the U.S. cities with the most accessible financing.

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This article originally appeared on CultureMap.com.