Tige Savage of Revolution Ventures and Sandy Guitar of HX Venture Fund explain how they're working together to fund Houston companies in a recent Q&A. Photos courtesy

The HX Venture Fund is a fund of funds that makes investments as a limited partner in venture capital funds across the country — VC funds that want to add Houston companies to their portfolios. HXVF is is paving the way for those investments by setting up immersive days for venture capitals visiting Houston.

One of these HXVF Engage VC days is taking place this week on Wednesday, April 27. Houston entrepreneurs can hear from partners at Revolution — a Washington, D.C.-based firm with three investment funds and strategies — at a fireside chat kicking off the visit at 8:30 am at The Ion.

Tige Savage, co-founder and managing partner of Revolution Ventures, and Sandy Guitar, managing partner of HX Venture Fund, join InnovationMap for a Q&A about how the two organizations are working together to put funding in the hands of Houston tech entrepreneurs.

InnovationMap: Tige, tell me briefly about Revolution and its family of funds. What types of companies are you looking for?

Tige Savage: We started Revolution about 17 years ago. I co-founded it with Steve Case, the founder of AOL and later the chairman of AOL Time Warner. I ran the venture capital group for that media company — that's how he and I got to know each other. AOL was based in Washington DC, so when Steve and I partnered up to launch our firm, we based it in Washington. We knew that to do the investing of the importance and scale that we had in mind, that it was an idea that was bigger than just Washington DC. So, we hopped on airplanes, and we went to where we thought the most interesting best ideas were. And as we spent our time in the market, we realized that there were a lot of opportunities in a lot of places other than New York City and Silicon Valley — we obviously have nothing against New York City or Silicon Valley, and we make investments in those places. But we realized that there was a lot going on in the country. It really gave us an opportunity to start building ecosystems and investing across the country. We looked back and realized we were generating returns in places like Florida, Washington, DC, and Portland, Oregon, et cetera — and there were great opportunities and great entrepreneurs in those places. And the barriers to building companies in those kinds of places had gotten much smaller than they'd been historically — the internet enabled talent to be in more places we've seen that amplified in a major way through the pandemic.

We started investing, and we raised capital from the outside world — and we did that in three efforts. One is something called the Rise of the Rest seed fund that is a very ecosystem focused investment vehicle. They make hundreds of investments out of their $150 million fund — small investments really to be involved in those communities. Imagine that's a very large top of funnel approach for our organization that allows us to project ourselves in a major way. David Hall is managing director of the fund and will be at this event tomorrow. He's been involved in revolution from the very early days. In fact, he was the very first person I hired.

Revolution Ventures is the fund I'm involved in. We are mostly series A investment effort with a much more concentrated portfolio. We're very focused on this same strategy of investing across the entire country. Then we have a growth fund called Revolution Growth that's sort of a later stage fund — call it series C plus, maybe series D, investor. They take larger stakes, but it's also a concentrated portfolio.

We have a few things that we think are unique about Revolution. One is what we call "place" — it's this geographic approach that we've taken from the start we're real believers that there's opportunity everywhere. We've spent a lot of time, money, capital, et cetera, working on those ecosystems and being in them. That's why places lake Houston are so exciting for us. Secondly, is policy. We're in Washington, it's in the DNA of what we do. It used to be very out of favor for tech companies to say they cared about policy, where we've always known that that's very important. If you go to some of the biggest tech companies today they'll tell you that the most important thing to them and the biggest risk they have is policy and regulatory.

We have a history of investing in billion dollar categories where technology is ripe to make the the business model, the consumer value proposition, the supply chain, the margin structure — something like that — better. That's why we called the firm Revolution, targeting places where technology can revolutionize existing categories, largely for the benefit of consumers.

IM: Sandy, what is it about Revolution that makes it a good fund for Houston companies?

Sandy Guitar: We've met with and built relationships with over 400 venture funds, but have to date have only invested in 14. So ours is a super selective process and we are just honored to be limited partners of Revolution. The reasons that make Revolution such a fit are manyfold. One is we seek investment strategies that we think will find deals in Houston. Revolution's strategy of using both the Rise of the Rest at the seed level, but a concentrated portfolio at the series A level is exactly the kind of strategy that we think works. Their generalist approach, but with specific expertise within various technologies means that they can be nimble from a technology point of view, as they look for deal flow in Houston, and they can allow for a force rank that doesn't force them in one tech bucket. We think that's a great advantage to seasoned venture capitalists.

Second of all, we're looking for investment strategies that create high growth companies, which can be innovative to our investors, such as the HEB, Shell, Chevron, Insperity, Lyondellbasell, et cetera. Those investors at HX Venture Fund rely on us to introduce them to opportunities for co-investment at the company or fund level and for opportunities to be customers to the portfolio companies of our VCs. We believe Revolution is producing the kinds companies that are going to be and are of interest to our limited partners as they try to innovate from within. And then third of all, we're looking for really strong track records that show expertise in selecting, growing and exiting companies. We want Houston entrepreneurs to benefit from that kind of acumen. That takes a lot of track record and lot of time in VC to show proof points of all three of those parts of the company formation process, and Revolution has that in spades.

IM: Tige, do you have Houston startups already in your portfolio and how is HXVF helping you grow your presence in Houston?

TS: Across our funds, between the Rise of the Rest fund and Revolution Ventures, I think there are 19 Texas investments, one in Houston. We also have a company called Big Commerce, which is in the growth fund that's a Texas and Australia-based company. Goodfair is an investment of the Rise of the Rest fund. They made an early investment — love the strategy of really trying to make fashion more affordable and more environmentally conscious and more economically achievable.

We are equally fortunate to have HX involved. Not only are they a great investor, but they're also a great facilitator of intersections for firms like ours that are actively interested in deploying capital in interesting places. We're only a handful of folks, so it takes a lot of leverage. Our Rise of the Rest strategy is an institutional effort, but having partners in the market really matters. This is why we're so excited to be partnered with Sandy and the gang there, because we really view that strategy as a unique and interesting one.

IM: Sandy, tell me about these events you’ve been putting on for your portfolio funds at HXVF.

SG: This is our second event this year already, and we've done about half a dozen of these so far of what we call VC engage days. The idea of the VC engage day is to really connect all of our communities together. In the mornings, we like to make sure that the venture capitalist coming in has an opportunity to speak with our ecosystem and that anybody for free can come and listen to these very experienced and successful venture capitalists. From there, we curate one-on-one meetings between select entrepreneurs and venture capitalists that are part of the day. We also do one-on-ones with our limited partners and the venture capitalists. And then, at the end of the day, we have a private dinner to provide more bespoke conversations either with our limited partners or with the Founder's Circle — 20-plus serial entrepreneurs here in Houston that provide a voice to us at HXVF.

TS: What was just described — that's is not a typical thing. LPs don't do that. We're obviously excited about it. It's a thing unique to Houston. HXVF is doing a lot of work to make these things happen.

IM: Tige, as someone looking in from DC into the Houston market, what do you see happening in the Houston market? What are you most excited about getting to tap into on your visit?

TS: Houston is known for a number of industries and is smart to leverage its engineering talent and try to focus that on ways to amplify it in technology. We think that the opportunities around sort of innovative manufacturing or around logistics around climate are particularly interesting to our funds, because when we talk about revolutionizing large categories in ways that make things better for consumers, those are all major elements that can have that kind of impact.

Houston's an extremely multicultural place. The engineering talent is extremely robust. The ability for large corporations to invest in and take advantage of what's going on in tech is extremely exciting. Finding a way for catalytic activity to happen within within these large businesses is sometimes a challenge. What we're most interested in is seeing where that's happening.

The ecosystem is really blooming. This is sort of the bread and butter of what we do. Collaboration, capital, and network density are what we've always thought are the three key things that are differentiators for a market. And those things are all coming together.

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This conversation has been edited for brevity and clarity.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.