Annual Rice student startup competition names winners, awards over $100,000 in prizes

winning teams

Here's what student-founded companies won big at this annual competition. Photo courtesy of Rice University

Five startups founded by Rice University students pitched their companies this week — and walked away with more than $100,000 in prizes.

The H. Albert Napier Rice Launch Challenge, or NRLC, is an annual competition that selects a small group of student-founded startups from Rice University. The program, which is open to undergraduate, graduate, and MBA students, concluded on April 19 and doled out several investment prizes to the finalists, which were named earlier this month.

Here's what each finalist walked away with this year:

First Place: Goldie

Goldie, founded by three Rice MBA students, won the first place — a $50,000 investment prize — as well as the Frank Liu Jr. Prize for Creative Innovations in Music, Fashion, & the Arts, which came with $2,500.

The company uses its algorithm-based fit finder technology to help online shoppers find their perfect fits digitally based on physical measurements and production size charts. On the other end of the transactions, Goldie lowers the 21 percent e-commerce rate of returns and increases customer lifetime value.

Founders: Viviane Nguyen, CEO and MBA ‘23; Stephanie Zhou, COO and MBA ‘23; Samantha Wong, CTO and Master's of science in Mechanical Engineering and MBA ‘22.

Second Place: Tierra Climate

Coming in second place — and securing a $25,000 prize, was Tierra Climate. The company is looking at a unique challenge within the grid-scale battery business. Normally not compensated for the clean storage work they do, these battery operators are able to be compensated on the Tierra Climate platform, where battery projects can sell verified Carbon Avoidance Offsets to corporate buyers.

Founders: Emma Konet, CTO and MBA ’24; Jacob Mansfield, CEO and Harvard MBA ‘23

Third Place: Separion

Separion claimed third place and a $15,000 prize. The company is addressing battery storage with its solution that uses brines already produced by geothermal energy and provides an environmentally friendly extraction process will supply lithium faster, purer, and greener.

Founders: Yuren Feng, CEO and Environmental Engineering PhD ‘24; Xiaochuan Huang, CTO and Environmental Engineering PhD ‘23; Ze He, COO and Chemical Engineering PhD ‘23

Audience Choice Award: Sygne Solutions

Sygne Solutions secured the $1,500 Audience Choice Award. The company has created a patent-pending technology that permanently destroys PFAS – thereby eliminating them from the environment. The process is scalable and sustainable, and targets the substances in water.

Founders: Bo Wang, Chemical Engineering PhD ‘23; Subash Kannan, MBA ‘24; Dana Vazquez, MBA ‘24; Kimberly Heck, Chemical and Biomolecular Engineering Research Scientist

Outstanding Undergraduate Award: Tidepay

Tidepay won the Outstanding Undergraduate Award and $5,000. The company is targeting the shipping industry with its HR and payroll solution that streamlines the onboarding process and helps transfer wages to their globally positioned employees’ bank accounts. The technology enables character reading technology to scan documents and verify eligibility and provides digital bank accounts and debit cards to unbanked seafarers. They also serve the seafarer by offering financial and logistical support services beyond remittance.

Founders: Andrew Pitigoi, CEO and Finance BBA ‘26; Devin Shah, CFO and Finance BBA ‘26

Additional prizes:

The program also awarded two prizes to two organizations not previously listed as finalists by the program:

  • The Parent Teacher Collaborative, founded by Jessica Faith Carter MBA ‘24, a school and community based nonprofit that aims to improve student outcomes by building strong collaborative partnerships between parents and teachers, received the RISE@Rice: The Sen Social Pioneer Prize for $1,000.
  • RiseWorks, an AI-driven music therapy for mental health needs, secured the Frank Liu Jr. Prize for Creative Innovations in Music, Fashion, & the Arts for $2,500. The company was founded by Jucheng Shen BS ‘26, Lai Peng BS ‘24, Yuan Chen BS ‘25, and Kaiyuan Wu BS ‘23.
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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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