An innovative, Houston-created tool instantly chills wine and spirits. Photo via thecoldcork.com

Great inventions reveal their value within due course, but there are those creations that tell their worth almost immediately, with a first look, image, or mere mention.

The Cold Cork, a malleable pouring device that instantly chills wine and spirits, falls into that category.

It seems like such a simple idea, but that’s the thing about inventions, isn’t it? Anyone can come up with an idea, but it’s the ones that can execute that idea that make it to the finish line and etch their names in the annals of creative glory.

“I had come home from the grocery store, right at the onset of COVID, and I wanted to have a glass of wine that I bought, but it was already room temperature, and I didn't want to put ice in it,” says wine-lover and former healthcare worker Michelle Kurkiewicz. “So, we started doing some research and came up with the idea for Cold Cork.”

Timing is everything, and because the nationwide pause caused by the COVID-19 pandemic offered Michelle, 33, and her husband Tyler, 30, plenty of free time, the dutiful duo was able to flesh out their labor of love.

Tyler and Michelle Kurkiewicz came up with the idea of the Cold Cork. Photo via thecoldcork.com

As it turns out, Tyler, a mechanical engineer by trade, had recently purchased a 3D printer back in January 2020, so he was able to use it to build hundreds of prototypes in-house to eventually arrive at a final design, which is based on the couple’s wedding champagne flutes.

So how does the Cold Cork work? Picture this: the wine-lover takes the Cold Cork out of the freezer (after a recommended 24 hours to thoroughly freeze), places it on top of the open bottle of wine and begins to pour.

As the liquid funnels through the stainless-steel coil, which is surrounded by a proprietary, food-grade cooling medium, the wine or spirits is chilled by 20 degrees in just 20 seconds.

To achieve the best results for red wine, pour the entire bottle through the Cold Cork into a decanter and enjoy.

And the best part? Not one part of the Cold Cork’s signature process alters the taste or composition of the drink in any way.

The device, priced at $64.95, chills liquids 20 degrees in 20 seconds. Photo via thecoldcork.com

“At first, we thought about whether the product should be inside the bottle or outside the bottle,” remembers Tyler. “But we quickly realized that there’s simply not enough room to do that amount of chilling inside a bottle. And we didn't want to have to pour any wine out. But we needed to make space to put some sort of chiller in the bottle. And so, we immediately started looking outside the bottle, and just with all the other wine gadgets, being bottle-topped and plugging in with a rubber stopper, that's immediately the direction we sort of drifted to.”

According to Tyler, the first couple of prototypes were made of a 3D filament. Initially, the idea was to focus on creating a cooling gel to compliment the coil, but that got a bit messy and, of course, there were too many wine taste-testing sessions to count.

“We definitely went through a lot of bottles of wine,” says Michelle. “But one of the first people that used our product was a sommelier and she loved it. We also gave one of our first production-level prototypes to a friend who is a manager at a restaurant. She used it on several occasions and said it was perfect for what she needed and seeing our product be used at a place that we frequented was extremely validating.”

Armed with the validation they needed to go to production, the wine-loving public could now have the product they needed to keep from having to throw all their wine in the refrigerator.

“The Cold Cork is really good for the people that maybe don't have those multi-zone fridges,” says Michelle. “We found a good niche with entry-level wine drinkers that don't have a wine fridge, but they want to drink their white wines still without being over-drank with ice cubes.

“That's really who we've been going after, and who we've seen has found a lot of value in the product. It's really the people that maybe aren't so prepared or maybe looking just for some more accessible solutions, whether it's because of the space in their apartment or financially, you know, it might be cheaper than a wine fridge. That's why we came up with the Cold Cork ourselves, because that was us, and so we kind of made a product that worked for us and found that there are a lot of people like that.”

The Cold Cork is available now and can be purchased directly from the company’s website for $64.95. In the future, more cork sizes and different colors will be offered, and more brick-and-mortar stores will carry the product. The couple pitched the idea and received investment from Trend Ventures at the 2022 Build Up Buttercup, an initiative that featured small business pitches for a select group of investors.

“We’ve gotten a lot of feedback directly from customers saying they use it a lot more than they thought,” says Michelle. “But then there are those people that are skeptical about how it works. That’s why I love to demo the Cold Cork in person.”

For a couple that met at a bar one night in downtown Houston, the Cold Cork is almost a poetic destination as a business endeavor and one that they both really relish.

“We both have our strengths, and we give each other a lot of support,” says Michelle.

“I’m very mechanically inclined, so I develop and invent, and Michelle is great with the marketing aspect and working with people to purchase the product,” adds Tyler. “In addition to the Cold Cork, we do have a couple of early projects that we are working on. I think there is a lot of opportunity with our technology to take what we have learned and fit that into different product lineups moving forward.”

Cold Cork Thermometer Test

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”