This year, seven of the 10 most-promising life science companies are based in Houston. Photo courtesy of Rice Alliance

Rice University played host this week to the 12th annual Texas Life Science Forum, where life science leaders and startup founders could network, learn and present pitches on their solutions to a wide array of health-related issues.

Hosted by Rice Alliance for Technology and Entrepreneurship and BioHouston on November 7, the event brought together more than 600 attendees for a series of keynote speakers and panels. This year, 45 early-stage therapeutic, diagnostic, medical device and digital health companies—many of which are based in Houston—also pitched their concepts.

Fort Worth-based AyuVis Research walked away from the event with the two top recognitions: The Michael E. DeBakey Memorial Life Science Award and the People's Choice Award. The company, which has developed a small molecule immunotherapy targeting bronchopulmonary dysplasia (BPD) in preterm neonates and other respiratory disorders. The company is raising a $20 million Series A round to support its clinical development and is slated to pitch at IGNITE Health’s Fire Pitch 2023 today, November 9, at the Ion.

Each year the Rice Alliance and BioHouston also name its 10 most promising life science companies, selected by investors—seven out of 10 of which are based in Houston. This year's selection included the following companies, in alphabetical order:

  • 7 Hills Pharma: This Houston-based clinical stage immunotherapy company has developed the concept of allosteric activation of integrins to facilitate cell adhesion and promote immune responses. The concept has uses in preventing infection and cancer, and increasing the effectiveness of oncology drugs and infectious disease vaccines.
  • Bairitone Health: This Houston-based company is building a scalable diagnostic system for sleep apnea anatomy utilizing home-use wearable, passive Sonar technology and AI techniques.
  • Diakonos Oncology: Also based in Houston, Diakonos' Dendritic Cell Vaccine was awarded the FDA’s Fast Track designation. The clinical-stage biotech company's immunotherapies have shown early successes for hard-to-reach, aggressive cancers like Glioblastoma Multiforme.
  • Mongoose Bio: With more than 20 years of research, Mongoose specializes in T cell-based therapies for diverse solid tumors TCR-based therapies in cancer patients. The Houston-based company has developed an immunopeptidome discovery platform for TCR-based therapies in cancer patients.
  • Nandi Life Sciences: Nandi is developing antibodies for Avastin-resistant ovarian cancer, with
  • further application in breast, colorectal and lung cancer. The company is based out of Texas Medical Center Innovation.
  • NKILT Therapeutics: This Houston-based company's seed-stage cell therapy has applications in solid tumors, such as colorectal cancer, ovarian cancer, clear cell renal carcinoma, endometrial
  • cancer and more. It is developing a novel and proprietary Chimeric ILT-Receptor.
  • NuVision Biotherapies: Based in the United Kingdom, NuVision has developed and proven a treatment for dry eye disease. It's known for its Omnigen and OmniLenz products and is raising a series A to scale, take the business to profitability and exit.
  • Panakeia Technologies: Also based in the UK, Panakeia has developed an AI-based software that can provide multi-omic biomarkers in minutes. Currently this process takes days or weeks. It's RuO platform can identify 4,500 known multi-omics cancer markers.
  • Taurus Vascular: A recent spin-out of the Texas Medical Center Innovation Biodesign program, Taurus is developing a novel, catheter-based solution for treating endoleaks, which can be related to aortic aneurysms.
  • YAP Therapeutics: The only California-based company to make the cut, this preclinical-stage biotech develops genetic medicines that leverage the company’s tissue renewal and regeneration platform to reverse and cure severe diseases, including heart failure, pulmonary diseases, retinal degeneration and hearing loss.

Last year, Bairitone Health took home the DeBakey and People's Choice awards.

Meet the latest global health tech startups to get an invite to Houston from TMC Innovation. Photo via tmc.edu

TMC names latest cohort of health tech startups for upcoming bootcamp

headed to Houston

The Texas Medical Center's innovation arm has again invited a set of health tech startups to mix and mingle with potential partners, investors, and customers in hopes to score a place in the HealthTech Accelerator.

For the 17th time, the TMC Innovation Factory is hosting its HealthTech Accelerator — starting first with announcing its bootcamp cohort, a process that includes bringing all 10 companies to Houston for valuable networking. A selection of the bootcamp will be invited into the full accelerator that will run into next spring.

The 10 selected companies with solutions from heart failure to chronic respiratory disease and more, according to TMC, include:

  • Acorai, from Stockholm, Sweden, which is developing a first-of-its-kind, hand-held, scalable medical device for non-invasive intracardiac pressure monitoring to improve heart failure management for more than 64 million patients worldwide.
  • Singapore-based Aevice Health, a connected care platform powered by the world’s smallest smart wearable stethoscope to support chronic respiratory disease patients through their continuum of care.
  • AirSeal, based in St. Louis, Missouri, which has developed a novel serum-based biomarker technology – circulating fatty acid synthase (cFAS) – that can diagnose cardiovascular and peripheral artery disease with high accuracy in both women and men.
  • Candlelit Care, a Charlotte, North Carolina-based point-of-care digital platform focused on the prevention of perinatal mental and anxiety disorders (PMADs) among Black women and birthing parents.
  • San Francisco-based Knowtex, an artificial intelligence-powered software writes medical documentation for you and assigns correct codes to ensure proper reimbursement.
  • NeuroBell, from Cork, Ireland, which is working on a novel medical device providing portable EEG monitoring with real-time and automated neonatal seizure alerts at the bedside.
  • Perth, Australia-based OncoRes Medical that's developing an intraoperative imaging technology to provide surgeons with real-time assessment of tissue microstructure.
  • From right here in Houston, Steradian Technologies, which has created RUMI, the first noninvasive, fully portable infectious disease diagnostic that costs the price of a latte. It uses novel photon-based detection to collect and diagnose infectious diseases in breath within 30 seconds.
  • Foxo, headquartered in Brisbane, Australia, serves as an interoperable tool designed to enhance clinical collaboration across the healthcare ecosystem. It enables secure, two-way communication with features such as video, voice, screen share, file sharing, and real-time messaging.
  • Thrive Health’s, from Vancouver, Canada, is a platform is a low-code framework for designing and delivering patient engagement solutions. Create tools that enable partners to close healthcare gaps quickly, strengthen care relationships, and improve patient experience and outcomes.

TMC Innovation's last bootcamp cohort was announced in May. The organization also recently named 16 digital health and medical device startups from the United Kingdom to a new accelerator formed in partnership with Innovate UK.

Earlier this fall, TMC formed a strategic partnership, or BioBridge, with the Netherlands.

A TMC-founded medical device startup has made a grand exit. Image via TMC.edu

Houston health tech startup acquired by medical device company

exit strategy

A Houston health tech business that has created a medical device to enhance and improve surgery has been acquired.

Illinois-based Northgate Technologies Inc. announced the acquisition of Allotrope Medical earlier this month. The Houston startup has designed an electrosurgical ureter identification system for optimizing surgery for both robotic and non-robotic laparoscopic surgical procedures. The StimSite technology is a hand-held device used by general and OBGYN surgeons and has received a Safer Technologies Program designation from the FDA.

“By bringing the StimSite product platform into NTI’s existing portfolio of innovative insufflation and smoke removal products, we have taken a significant step in fulfilling our vision to optimize the surgical environment for minimally invasive surgery,” says Dave McDonough, vice president and general manager at NTI.

NTI, an affiliate of the Trudell Medical Limited group of companies, develops and manufactures innovative tools for surgery that improve patient outcomes. The company has distribution in over 100 countries.

Allotrope Medical was founded in 2016 by Dr. Albert Huang and has raised over $5 million in venture capital investment, with contribution from Y Combinator, Texas Halo Fund, and more. Huang, according to his LinkedIn, is now chief medical officer for NTI.

"To have taken this from idea to exit has been a true honor," Huang writes in a post on LinkedIn. "To all those that have generously given me their time, their input, their investment, and even more importantly, those that believed in me and this technology, thank you."

Huang was a general surgery resident and innovation fellow at Houston Methodist before serving as innovation strategist at Texas Medical Center Innovation while growing his company and developing his technology. Allotrope Medical was housed out of TMC Innovation and was a member of TMC's third medical device accelerator cohort.

"For now, the focus is the transition and ensuring that the new sales team learns everything about StimSite, and gets the technology into more surgeon hands as we continue to drive it towards becoming part of the standard of care," the post reads.

Allotrope Medical was founded in 2016 by Dr. Albert Huang. Image via LinkedIn

The five finalists for Mentor of the Year in the Houston Innovation Awards sound off on their best advice. Photos courtesy

Houston's top startup mentors of 2022 share go-to advice for founders

words of wisdom

Houston is home to many great mentors — all hailing for completely different backgrounds.

At the Houston Innovation Awards Gala on November 9, InnovationMap and Houston Exponential are honoring five finalists selected by judges — and naming one winner — who have dedicated at least a portion of their lives to supporting others within the startup and tech scene in Houston.

Here are some words of wisdom from our awards honorees from the Mentor of the Year category for the 2022 Houston Innovation Awards.

"I always remind people to be open and ask for help. There is a common misconception that if you disclose your idea, someone else will quickly run with it and beat you to market! ... Don’t alienate yourself by overprotecting the idea and keeping it all to yourself. The more you open up about your idea the more feedback you’ll get, good and bad, both of which are vital in the success of the product long term."

Photo courtesy

- Alfredo Arvide, Blue People and HOUnited. Arvide, who's been an advisor for over a decade, adds, that "most markets are big enough to allow competition to thrive, so keeping your idea behind close doors until you launch may hurt you as the market may not be ready for it. Having multiple players competing in the market will help you in the long run, as long as you have a great product and a sound marketing strategy."

"Understand the problem you are trying to solve. Build a team that works well together and has the intellect, drive, and willingness to develop and bring to market a solution for that problem. Leadership is not about giving orders and making all the decisions. It is about creating the environment for your team members individually and collectively to do their best work and be most fulfilled."

Photo courtesy

- Barbara Burger, adviser and board member for several startups and organizations. With over 20 years of experience supporting startups, Burger says she is mostly focused on startups dedicated to decarbonizing the energy system.

"Don't have 'rocking chair regret.' What I mean is when you are old and in a rocking chair, you aren't going to regret the year (or less) you took away from a guaranteed salary to test if your idea worked. So, take the time and follow your dreams — you never know what could happen!"

Photo courtesy

- Craig Ceccanti, T-Minus Solutions. Ceccanti, who also co-founded Pinot's Palette and Rivalry Technologies, has been mentoring for over a decade. "I love helping people and always have so helping others achieve their dreams is a natural progression for me, he says. "I've also had incredible mentors and I like to pay it forward every chance I get. I feel that mentoring is fun, therapeutic, and mutually beneficial as I feel I learn from the smart people I get to talk to daily!

"Bring great people on your journey with you — team members, advisors, investors, mentors, consultants, etc."

Photo courtesy

- Emily Reiser, Texas Medical Center and Enventure. Reiser, who's mentored companies for several years, says it's her own mentors that inspired her. "I had excellent mentors who generously gave their time for me, especially Upendra Marathi, and it's just a given that I mentor others. It's a privilege to learn from the people I mentor and see them become successful."

"Be your own cheerleader. Stay true to yourself and don't give up."

Photo courtesy

Kara Branch, founder of Black Girls Do Engineer Corp. "I have always been the only black woman in all my roles. As a mother of three daughters, my oldest daughter inspired Black Girls Do Engineer Corp.," Branch says. "When she daughter was 9, she came to me and said she wanted to be a software engineer. ... If anyone can help her achieve her dreams is her mom and I wanted to create a space for girls who look like my daughter to come together and do the things they love and are passionate about."

Texas Medical Center Innovation announced the seven health tech startups that joined the 2022 accelerator bootcamp. Photo courtesy of TMC

7 health tech startups flock to Houston for TMC bootcamp

ready to accelerate

The Texas Medical Center's innovation arm welcomed seven companies to its 2022 health tech accelerator program bootcamp.

TMC Innovation Accelerator for HealthTech is aimed at supporting early-stage life science startups through fundraising, connecting with mentors and potential customers, and more.

“Healthtech startups who connect with our network will emerge more prepared to access their customers and grow into their markets," says Emily Reiser, associate director of TMC Innovation, in a news release. "Our advisors, members, and partners unlock insights for these entrepreneurs about how to more effectively build a strategic plan for improved market access and adoption. Bootcamp ignites these connections, providing immediate value to entrepreneurs and enabling our team to define a long term plan for continued collaboration."

If selected following the bootcamp, founders will spend six months at TMCi with strategic mentorship, clinical validation, and other customized milestone development from the organization.

“Bootcamp is an intensive period of discovery and mutual selection," says Devin Dunn, head of the Accelerator for HealthTech, in the release. "Founders get a chance better understand everything that TMCi brings to bear and our team has the opportunity to select those growing companies that will add significant value to our community.”

The bootcamp focused on several innovation areas — including surgical devices, access to care, robotics, and hospital efficiency. The participating companies include:

  • CardMedic, headquartered in Oxford, United Kingdom, aims to improve communication between staff and patients across any barrier-language, deafness, cognitive impairment or disability-with an A to Z library of pre-written scripts replicating common clinical conversations.
  • Chicago-baseed CareAdvisors is connecting health plans, hospitals, and community-based organizations to streamline high risk case management and quickly close the loop on care.
  • Endolumik, founded in Morgantown, West Virginia, has developed a fluorescence-guided device that uses near-infrared light to enhance visualization for safer, faster, and more consistent bariatric surgery.
  • Orcha, based in Daresbury, United Kingdom, rigorously reviews apps to help systems, clinicians, patients, or consumers find their way to the best health-related apps.
  • Austin-based Roboligent has created a rehabilitation robot, the Optimo Regen, that provides evidence-based therapeutic interventions for upper and lower limbs.
  • Boston-founded ScienceIO's platform transforms unstructured text into structured records in real-time. The company's core product is a HIPAA-compliant API for real-time text processing and analytics.
  • Semantic Health, founded in Toronto, Canada, uses artificial intelligence to complete secondary reviews of all coded and claims data to optimize revenue cycle management.
The application for future cohorts and more information about the program are available online. The 2022 cohort will join the ranks of TMCi's community of 305 life science startups and 221 TMC Innovation Accelerator companies and will receive access to the center's dozens of member organizations.

"Having a product that the market truly needs is critical but not enough," says Bongsu Kim, founder and CEO of Roboligent, in the release. "Especially for the medical device market, I realize that introducing a new product is a thorough and collaborative effort from a variety of stakeholders and experts. Without knowing the mechanism and the right connection, it seems almost impossible to get into the market. The TMC Innovation Accelerator is the perfect place to make it happen."

This week's roundup of Houston innovators includes John "JR" Reale of the TMC, Maria Burgos of Trendy Seconds, and Christopher Howard of Softeq. Courtesy photos

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from venture funding to startup acceleration — recently making headlines in Houston innovation.


John "JR" Reale, executive in residence at Texas Medical Center Innovation and managing director of Integr8d Capital

John "JR" Reale joined the Houston Innovators Podcast for a special two-part series. Photo courtesy of TMC

John "JR" Reale has seen the evolution of Houston's innovation ecosystem from day one. Recently, he joined InnovationMap for a two-part series on the Houston Innovators Podcast to discuss the city's evolution as a tech and startup hub as well as what he's up to nowadays — leading venture activity at the Texas Medical Center Innovation and within his own firm.

"One of the most important moments for Houston was when we got kicked in the teeth with the Amazon HQ2 bid," he says on the show. "Amazon came back with the shortlist of the 20 cities in North America — and Houston isn't on it. I remember being excited. It was arguably the most innovative company in the world saying 'no thank you.'"

Flash forward, and Houston's a different ecosystem — still with a ways to go. Click here to stream part one and part two of the series.

Maria Burgos, founder of Trendy Seconds

A Houston innovator found second-hand shopping time consuming. So, she designed a better experience. Image courtesy of Trendy Seconds

After donating her items to a local church, Maria Burgos sought to be more sustainable and decided to try secondhand shopping.

“The good news was that I had so many options, new with tags, great conditions…the bad news was that it was so much that I ended up being frustrated because I didn't find what I liked,” she tells InnovationMap. “I had to spend hours of my time scrolling thousands of items, dozens of filters, multiple platforms."

She asked herself why there wasn’t a website where she could find items in one place. “That was the genesis of Trendy Seconds,” she shares. Click here to read more.

Christopher Howard, founder and CEO of Softeq

Chris Howard, CEO and founder of SofteqA Houston software company has announced its new venture fund. Photo courtesy of Softeq

Houston-based Softeq Development Corp. announced its third group of early-stage startups to join theSofteq Venture Studio, which is geared at helping its resident startups quickly develop their technology and build their businesses. With 14 startups, the summer 2022 cohort is the largest yet and brings the total portfolio to 27 companies. Additionally, the $40 million Softeq Venture Fund welcomed Royal Eagle Capital Partners, a Houston-based investment firm, as a limited partner with its $3 million commitment.

“We are thrilled to see how much the Softeq Venture Studio has grown since 2021,” says Christopher A. Howard, founder and CEO of Softeq, in a news release. “We’re also pleased to welcome Royal Eagle Capital Partners as an investment partner in our Venture Fund, which allowed us to achieve more than 50 percent of our funding goal in just five months. We look forward to building on this partnership and growing Softeq in North America, Latin America, and beyond.”

Softeq is also celebrating a recent expansion into Latin America and staffing the new regional office with 30 engineers. The company has plans to grow to 150 employees in the region over the next year. Click here to read more.

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Houston female-focused health tech pitch competition names top 3 startup founders

A female-focused pitch competition named its top health tech startups for the fifth year running.

Ignite Healthcare Network, a Houston nonprofit founded on the mission of supporting women in health care, hosted its annual Fire Pitch Competition on November 9 at the Ion, crowning the award recipients and doling out cash prizes.

This year, Ignite accelerated 19 female health tech founders through its program that connects entrepreneurs with mentors and industry professionals. The program concludes with a select number of finalists presenting at the Fire Pitch event.

This year, eight finalists presented at the competition for judges and an audience:

  • Suchismita Acharya, CEO of Fort Worth-based AyuVis, an immunotherapy platform that's developing treatments and prevention for inflammatory and infectious diseases, specifically of the lung, kidney, skin, eye, and sepsis.
  • Piyush Modak, co-founder, vice president of research and development of New Jersey-based EndoMedix, a technology platform developing engineered biosurgery devices that address clinical needs. The first device based on this platform is PlexiClotTM Absorbable Hemostat for brain and spinal surgery.
  • Somer Baburek, co-founder and CEO of San Antonio-based HERAbiotech, which is developing a non-surgical, molecular diagnostic test for endometriosis.
  • Melissa Bowley, founder of Flourish Care, a B2B health services platform and network addressing maternal health disparities and improve outcomes. The Boston company works with health systems and insurance companies..
  • Patty Lee, co-founder and CEO of Orbit Health, a Munich-based company that uses AI and sensor technologies to develop digital health solutions for the management of Parkinson's.
  • Tawny Hammett, chief revenue officer of New York-based Paloma Health, a patient-focused technology providing holistic approach to thyroid care all from the comfort of home.
  • Meghan Doyle, CEO and co-founder of Chicago-based Partum Health, a company focused on combining specialty reproductive care, including mental health, lactation, nutrition, physical therapy, birth doula support, and more.
  • Asma Mirza, CEO and co-founder of Houston-based Steradian Technologies, creator of the RUMI, a medical device that's providing diagnostic accessibility.

Ayse McCracken, founder and board chair of Ignite, and her partners presented several prizes and awards, including naming the winners — EndoMedix won first place, Hera Biotech secured second place, and Steradian Technologies was awarded third place.

In addition to naming the three top companies, the following prizes were doled out:

  • Memorial Hermann presented AyuVis with a certificate indicating interest in a potential partnership.
  • Golden Seeds awarded a $1,000 cash prize and three hours of mentoring to Steradian Technologies.
  • Texas Children's Hospital presented Flourish Care with a certificate indicating interest in a potential partnership.
  • Southwest-Midwest National Pediatric Device Innovation Consortium awarded Hera Biotech with $20,000.
  • Houston Methodist awarded each of the three top companies with mentorship from innovation leadership.
  • JLabs presented EndoMedix with a one-year virtual residency.
  • Donna Peters, founder of The Me Suite and mentor for Ignite, presented Hera Biotech with three coaching sessions.

Last year, Joanna Nathan, CEO of Houston-based Prana Thoracic, won the top award for her company. The company went on to raise a $3 million seed round.

Earlier this year, McCracken sat down with InnovationMap to share how she's grown the program over the past five years — and why she's so passionate about what she does.

"Having an impact in the health care industry and finding solutions is important to me," McCracken says on an episode of the Houston Innovators Podcast. "The second aspect of that is there are so many women in health care, and yet you don't see them in leadership roles."

New immersive, live-action gaming venue powers up Houston debut

hi, tech

Houston is leveling up its gaming scene with the debut of a new high-tech immersive experience. Called Activate, the indoor venue combines technology and physical activity in 75-minute gaming sessions, which can be played in teams up to five people.

Simply put, the whole place is like stepping inside a live-action arcade.

Activate's first Houston-area location opened softly November 2 at 20225 Katy Frwy., Katy. Official grand opening is set for November 16-17. It is the high-tech brand's sixth location across the country, and second in Texas (behind one in Plano, which opened in spring 2023).

According to a release, the Katy facility spans 9,600 square feet, with 11 different activity rooms offering more than 500 unique games across all difficulty levels. Games include Megagrid, Hoops, Press, Hide, Laser, Strike, Portals, Control, Grid, and more. Radio Frequency Identification (RFID) wristbands track participants’ scores and progress.

"Our mission is to fuse technology, movement, and strategy to create a unique interactive gaming experience," says Activate partner Bryce Anderson in the release. "We want guests to bring their closest friends, family, or co-workers and leave with a feeling of achievement, ready to come back for more."

While gaming activities are mostly adult-focused, children aged 13 and younger can participate with adult supervision.

During Activate's soft opening phase through November 15, 10 percent of sales will be donated to Best Buddies International, a nonprofit that provides mentorships for individuals with intellectual and developmental disabilities. (Check the website for limited hours during soft opening.)

After the grand opening November 16-17, Activate will be open daily, 10 am-10 pm. Gaming sessions (75 minutes) are $24.99 Monday-Thursday, and $29.99 Friday-Sunday. Reservations are encouraged.

Activate has been creating live-action gaming experiences for adults since 2019, and has plans for further expansion, they say.

"As we continue expanding Activate across the United States, we are confident our concept will fill a void for interactive entertainment," says Anderson in the release. "We believe the Houston community will embrace this experience and find it both thrilling and challenging."

More information and reservations can be found on the website.

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This article originally ran on CultureMap.