A oil and gas CEO, a serial entrepreneur, and a retail energy exec walk into the state capital. Getty Images

The Bayou City now wields some high-profile power in the state's economic development efforts.

The Texas Senate recently endorsed Gov. Greg Abbott's appointment of three business leaders with strong ties to Houston to the board of the Texas Economic Development Corp. — including the organization's new chair and vice chair.

Robert Allen, president and CEO of Texas' nonprofit economic development arm, says the Bayou City should feel well-represented on the board with former Houston Astros owner Drayton McLane as the new chair, Houston energy executive Vicki Hollub as the new vice chair, and Houston energy executive Scott Prochazka as a new member. That means Houston-connected business leaders hold three of the board's eight seats.

Allen calls McLane "the perfect Texas ambassador."

McLane, who lives in Temple, sold the Astros to Houston businessman Jim Crane in 2011 for $680 million. Forbes estimates McLane's net worth at $2.4 billion.

Today, McLane controls a Temple-based holding company with business interests such as food distribution, car dealerships and sports marketing. In 1991, he sold grocery distributor McLane Co. to Walmart, which later sold it to Warren Buffett's Berkshire Hathaway.

"I can think of no one better to lead our efforts to market the state of Texas as the best state for business than Drayton McLane. He has achieved tremendous success in several areas of business, all while calling Texas home," Allen tells InnovationMap.

McLane also chairs the board of Texas Central Partners, the Dallas company developing high-speed rail service between Houston and Dallas-Fort Worth. In addition, he serves on the boards of the George H.W. Bush Presidential Library Foundation, Baylor Scott & White Healthcare, and the Cooper Institute.

"I am privileged to be able to give service to our great state of Texas and honored by Gov. Abbott's appointment as chair of the Texas Economic Development Corporation," McLane says in a statement provided to InnovationMap.

"The goal of the corporation is to help market Texas as a place for businesses to grow and prosper," he adds. "Texas is a great state, and we have much to offer businesses in many sectors. I care deeply for Texas and improving the economy that will carry us into the future."

Hollub, president and CEO of Houston-based oil and gas company Occidental Petroleum, is the new vice chair of the Texas Economic Development Corp. She's spent 35 years at Occidental, which just hammered out a $57 billion deal to take over Anadarko Petroleum, an oil and gas company based in The Woodlands.

In addition to the board of the Texas Economic Development Corp., Hollub sits on the boards of Lockheed Martin and the American Petroleum Institute, and she is U.S. chair of the U.S.-Colombia Business Council.

"As the first female to head a major oil and gas company in the world, Vicki defines what it means to be a Texan — hardworking, determined, and incredibly smart," Allen says.

Prochazka, president and CEO of CenterPoint Energy, a Houston-based provider of electric and natural gas service, joins McLane and Hollub on the board of the Texas Economic Development Corp. Aside from his duties at CenterPoint, Prochazka is incoming chairman of the American Gas Association, chairman of Central Houston Inc., and a board member of the Greater Houston Partnership.

Given his roles with Central Houston Inc. and the Greater Houston Partnership, Prochazka knows Houston "intimately well," Allen says.

The Texas Economic Development Corp. is an independently funded and operated nonprofit that promotes economic development, business recruitment, and job creation in Texas. For instance, the nonprofit helped pave the way for a $15 billion liquefied natural gas (LNG) export facility in Corpus Christi that recently made its first cargo shipment. Houston-based Cheniere Energy owns the facility.

With Abbott's appointment of eight members, the makeup of the economic development organization's eight-member board is entirely new. The governor appointed them in April, but the state Senate had to give its final approval, which came earlier this month.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."