Nine research projects at Rice University have been granted $25,000 to advance their innovative solutions. Photo courtesy of Rice

Over a dozen Houston researchers wrapped up 2021 with the news of fresh funding thanks to an initiative and investment fund from Rice University.

The Technology Development Fund is a part of the university’s Creative Ventures initiative, which has awarded more than $4 million in grants since its inception in 2016. Rice's Office of Technology Transfer orchestrated the $25,000 grants across nine projects. Submissions were accepted through October and the winners were announced a few weeks ago.

The 2021 winners, according to Rice's news release, were:

  • Kevin McHugh, an assistant professor of bioengineering, is working on a method to automate an encapsulation process that uses biodegradable microparticles in the timed release of drugs to treat cancer and prevent infectious disease. He suggested the process could help ramp up the manufacture of accessible multidose vaccines.
  • Daniel Preston, an assistant professor of mechanical engineering, is developing a novel filtration system that will recover water typically released by cooling towers at natural gas power plants. The inexpensive filters will result in a significant savings in water costs during power generation.
  • Geoff Wehmeyer, an assistant professor of mechanical engineering; Matteo Pasquali, the A.J. Hartsook Professor of Chemical and Biomolecular Engineering and a professor of chemistry and materials science and nanoengineering; Junichiro Kono, the Karl F. Hasselmann Chair in Engineering, a professor of electrical and computer engineering, physics and astronomy and materials science and nanoengineering and chair of the applied physics program, and Glen Irvin Jr., a research professor in chemical and biomolecular engineering, are creating a solid-state, active heat-switching device to enable the rapid charging of batteries for electric vehicles. The lightweight device will use carbon nanotube fibers to optimize battery thermal management systems not only for cars but also, eventually, for electronic devices like laptops.
  • Xia Ben Hu, an associate professor of computer science, is developing his open-source machine learning system to democratize and accelerate small businesses’ digital transformation in e-commerce.
  • Bruce Weisman, a professor of chemistry and of materials science and nanoengineering, and Satish Nagarajaiah, a professor of civil and environmental engineering and of mechanical engineering, are working to advance their strain measurement system based on the spectral properties of carbon nanotubes. The system will allow for quick measurement of strain to prevent catastrophic failures and ensure the safety of aircraft, bridges, buildings, pipelines, ships, chemical storage vessels and other infrastructure.
  • Aditya Mohite, a professor of chemical and biomolecular engineering and associate professor of materials science and nanoengineering, and Michael Wong, the Tina and Sunit Patel Professor in Molecular Nanotechnology, a professor and chair of chemical and biomolecular engineering and a professor of chemistry, materials science and nanoengineering and of civil and environmental engineering, are scaling up novel photoreactors for the environmentally friendly generation of hydrogen. Their process combines of perovskite-based solar cells and state-of-the-art catalysts.
  • Rebekah Drezek, a professor of bioengineering, and Richard Baraniuk, the C. Sidney Burrus Professor of Electrical and Computer Engineering and a professor of statistics and computer science, are developing a system to rapidly diagnose sepsis using microfluidics and compressed sensing to speed the capture and analysis of microbial biomarkers.
  • Fathi Ghorbel, a professor of mechanical engineering and of bioengineering, is working on robotic localization technology in GPS-denied environments such as aboveground storage tanks, pressure vessels and floating production storage and offloading tanks. The system would enable robots to precisely associate inspection data to specific locations leading to efficiency and high quality of inspection and maintenance operations where regular inspections are required. This will dramatically improve the environmental impact and safety of these assets.
  • Kai Fu, a research scientist, and Yuji Zhao, an associate professor of electrical and computer engineering, are working to commercialize novel power diodes and transistors for electric vehicles. They expect their devices to reduce the volume of power systems while improving integration, power density, heat dissipation, storage, and energy efficiency.
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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.