Nine research projects at Rice University have been granted $25,000 to advance their innovative solutions. Photo courtesy of Rice

Over a dozen Houston researchers wrapped up 2021 with the news of fresh funding thanks to an initiative and investment fund from Rice University.

The Technology Development Fund is a part of the university’s Creative Ventures initiative, which has awarded more than $4 million in grants since its inception in 2016. Rice's Office of Technology Transfer orchestrated the $25,000 grants across nine projects. Submissions were accepted through October and the winners were announced a few weeks ago.

The 2021 winners, according to Rice's news release, were:

  • Kevin McHugh, an assistant professor of bioengineering, is working on a method to automate an encapsulation process that uses biodegradable microparticles in the timed release of drugs to treat cancer and prevent infectious disease. He suggested the process could help ramp up the manufacture of accessible multidose vaccines.
  • Daniel Preston, an assistant professor of mechanical engineering, is developing a novel filtration system that will recover water typically released by cooling towers at natural gas power plants. The inexpensive filters will result in a significant savings in water costs during power generation.
  • Geoff Wehmeyer, an assistant professor of mechanical engineering; Matteo Pasquali, the A.J. Hartsook Professor of Chemical and Biomolecular Engineering and a professor of chemistry and materials science and nanoengineering; Junichiro Kono, the Karl F. Hasselmann Chair in Engineering, a professor of electrical and computer engineering, physics and astronomy and materials science and nanoengineering and chair of the applied physics program, and Glen Irvin Jr., a research professor in chemical and biomolecular engineering, are creating a solid-state, active heat-switching device to enable the rapid charging of batteries for electric vehicles. The lightweight device will use carbon nanotube fibers to optimize battery thermal management systems not only for cars but also, eventually, for electronic devices like laptops.
  • Xia Ben Hu, an associate professor of computer science, is developing his open-source machine learning system to democratize and accelerate small businesses’ digital transformation in e-commerce.
  • Bruce Weisman, a professor of chemistry and of materials science and nanoengineering, and Satish Nagarajaiah, a professor of civil and environmental engineering and of mechanical engineering, are working to advance their strain measurement system based on the spectral properties of carbon nanotubes. The system will allow for quick measurement of strain to prevent catastrophic failures and ensure the safety of aircraft, bridges, buildings, pipelines, ships, chemical storage vessels and other infrastructure.
  • Aditya Mohite, a professor of chemical and biomolecular engineering and associate professor of materials science and nanoengineering, and Michael Wong, the Tina and Sunit Patel Professor in Molecular Nanotechnology, a professor and chair of chemical and biomolecular engineering and a professor of chemistry, materials science and nanoengineering and of civil and environmental engineering, are scaling up novel photoreactors for the environmentally friendly generation of hydrogen. Their process combines of perovskite-based solar cells and state-of-the-art catalysts.
  • Rebekah Drezek, a professor of bioengineering, and Richard Baraniuk, the C. Sidney Burrus Professor of Electrical and Computer Engineering and a professor of statistics and computer science, are developing a system to rapidly diagnose sepsis using microfluidics and compressed sensing to speed the capture and analysis of microbial biomarkers.
  • Fathi Ghorbel, a professor of mechanical engineering and of bioengineering, is working on robotic localization technology in GPS-denied environments such as aboveground storage tanks, pressure vessels and floating production storage and offloading tanks. The system would enable robots to precisely associate inspection data to specific locations leading to efficiency and high quality of inspection and maintenance operations where regular inspections are required. This will dramatically improve the environmental impact and safety of these assets.
  • Kai Fu, a research scientist, and Yuji Zhao, an associate professor of electrical and computer engineering, are working to commercialize novel power diodes and transistors for electric vehicles. They expect their devices to reduce the volume of power systems while improving integration, power density, heat dissipation, storage, and energy efficiency.
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TMC lands $3M grant to launch cancer device accelerator

cancer funding

A new business accelerator at Houston’s Texas Medical Center has received a nearly $3 million grant from the Cancer Prevention and Research Institute of Texas.

The CPRIT grant, awarded to the Texas Medical Center Foundation, will help launch the Accelerator for Cancer Medical Devices. The accelerator will support emerging innovators in developing prototypes for cancer-related medical devices and advancing them from prototype to clinical trials.

“The translation of new cancer-focused precision medical devices, often the width of a human hair, creates the opportunity to develop novel treatments for cancer patients,” the accelerator posted on the CPRIT website.

Scientist, consultant, and entrepreneur Jason Sakamoto, associate director of the TMC Center for Device Innovation, will oversee the accelerator. TMC officials say the accelerator builds on the success of TMC Innovation’s Accelerator for Cancer Therapeutics.

Each participant in the Accelerator for Cancer Medical Devices program will graduate with a device prototype, a business plan, and a “solid foundation” in preclinical and clinical strategies, TMC says. Participants will benefit from “robust support” provided by the TMC ecosystem, according to the medical center, and “will foster innovation into impactful and life-changing cancer patient solutions in Texas and beyond.”

In all, CPRIT recently awarded $27 million in grants for cancer research. That includes $18 million to attract top cancer researchers to Texas. Houston institutions received $4 million for recruitment:

  • $2 million to the University of Texas MD Anderson Cancer Center to recruit Rodrigo Romero from Memorial Sloan Kettering Cancer Center in New York City
  • $2 million to MD Anderson to recruit Eric Gardner from Weill Cornell Medicine in New York City

A $1 million grant also went to Baylor College of Medicine researcher Dr. Akiva Diamond. He is an assistant professor at the medical college and is affiliated with Baylor’s Dan L. Duncan Comprehensive Cancer Center.

Houston students develop cost-effective glove to treat Parkinson's symptoms

smart glove

Two Rice undergraduate engineering students have developed a non-invasive vibrotactile glove that aims to alleviate the symptoms of Parkinson’s disease through therapeutic vibrations.

Emmie Casey and Tomi Kuye developed the project with support from the Oshman Engineering Design Kitchen (OEDK) and guidance from its director, Maria Oden, and Rice lecturer Heather Bisesti, according to a news release from the university.

The team based the design on research from the Peter Tass Lab at Stanford University, which explored how randomized vibratory stimuli delivered to the fingertips could help rewire misfiring neurons in the brain—a key component of Parkinson’s disease.

Clinical trials from Stanford showed that coordinated reset stimulation from the vibrations helped patients regain motor control and reduced abnormal brain activity. The effects lasted even after users removed the vibrotactile gloves.

Casey and Kuye set out to replicate the breakthrough at a lower cost. Their prototype replaced the expensive motors used in previous designs with motors found in smartphones that create similar tiny vibrations. They then embedded the motors into each fingertip of a wireless glove.

“We wanted to take this breakthrough and make it accessible to people who would never be able to afford an expensive medical device,” Casey said in the release. “We set out to design a glove that delivers the same therapeutic vibrations but at a fraction of the cost.”

Rice’s design also targets the root of the neurological disruption and attempts to retrain the brain. An early prototype was given to a family friend who had an early onset of the disease. According to anecdotal data from Rice, after six months of regularly using the gloves, the user was able to walk unaided.

“We’re not claiming it’s a cure,” Kuye said in the release. “But if it can give people just a little more control, a little more freedom, that’s life-changing.”

Casey and Kuye are working to develop a commercial version of the glove priced at $250. They are taking preorders and hope to release 500 pairs of gloves this fall. They've also published an open-source instruction manual online for others who want to try to build their own glove at home. They have also formed a nonprofit and plan to use a sliding scale price model to help users manage the cost.

“This project exemplifies what we strive for at the OEDK — empowering students to translate cutting-edge research into real-world solutions,” Oden added in the release. “Emmie and Tomi have shown extraordinary initiative and empathy in developing a device that could bring meaningful relief to people living with Parkinson’s, no matter their resources.”