The study will look at improving sustainability within George Bush Intercontinental Airport in Houston. Photo courtesy of Airbus

A few major players have teamed up to look into making air travel more sustainable — and it's all happening in Houston.

The Center for Houston’s Future, Airbus, and Houston Airports have signed a memorandum of understanding intended to study the “feasibility of a hydrogen hub at George Bush Intercontinental Airport." The study, which will conclude in March of 2025, will include the participants that will collaborate ways to rethink how their infrastructures could be designed and operated to reduce an overall environmental footprint, and lead to hydrogen-powered aircrafts like the ones Airbus plans to bring to fruition by 2035.

In 2020, Airbus debuted its ZEROe hydrogen-powered aircraft project. The “Hydrogen Hub at Airports'' concept by Airbus unites key airport ecosystem players to develop ways to decarbonize all airport-associated infrastructure with hydrogen. The study will include airport ground transportation, airport heating, end-use in aviation, and possibly ways to supply adjacent customers in transport and local industries.

The use of hydrogen to power future aircraft aims to assist in eliminating aircraft CO2 emissions in the air, and also can help decarbonize air transport on the ground. With Houston being such a large city, and a destination for some many visiting on business, the Houston airports was an easy spot to assign the study.

"Houston’s airports are experiencing tremendous growth, connecting our city to the world like never before,” Jim Szczesniak, the aviation director for the city of Houston, says in a news release. “As we continue to expand and modernize our facilities, participating in this sustainability study is crucial. Continuing to build a sustainable airport system will ensure a healthy future for Houston, attract top talent and businesses, and demonstrate our commitment to being a responsible global citizen.

"This study will provide us with valuable insights to guide our development and position Houston as a global leader in sustainable aviation innovation for generations to come.”

The CHF was a founding organizer of the HyVelocity Hydrogen Hub, which was selected by the U.S. Department of Energy as one of seven hydrogen hubs in the nation, and will work in the Houston area and the Gulf Coast. The HyVelocity Hydrogen Hub is eligible to receive up to $1.2 billion as part of a Bipartisan Infrastructure Law funding to advance domestic hydrogen production.

“The Center for Houston’s Future is pleased to have played a crucial role in bringing together the partners for this study,” Brett Perlman, the center's outgoing CEO and president, adds. “With Houston’s role as the world’s energy capital, our record of energy innovation and desire to lead in the business of low-carbon energy, Houston is the perfect place to develop our airports as North American clean hydrogen pioneers.”

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.