Learn from the mistakes of a successful Houston entrepreneur — from teamwork tips to reasons why you should network with other startups. Emilija Manevska/Getty Images

Recently, I was asked what it took to build a startup in Houston. It has taken me three attempts to create a successful startup, and there were a few things that I wish I'd known right out of the gate.

Whether your goal is to exit through a sale, an IPO, or turn your team of pirates into something that looks like a company, your business model will determine how you earn revenue and profits, and you want it to be repeatable and scalable to survive. With that in mind, here are the things I've learned along the way and what I wish I had known before I started my career as an entrepreneur.

Location does matter 

Houston is great for food, sports, and massive rainfall, but it's difficult to find a large pool of talented full-stack software engineers who speak cloud. I recruited some of the best, but it was incredibly difficult to find them compared to markets like Austin, Denver, and San Francisco.

I've seen successful companies build two separate offices, one for a headquarters, and another for development, but for us, we didn't need to build a massive team, so we remained close to customers in Houston and hired a remote team in California. If you need to build a large engineering team, consider a different city or go remote.

Startups have well-defined phases 

Your startup is not a snowflake. There have been thousands upon thousands of entrepreneurs that have succeeded and failed, and a few people have studied them to understand their histories and roadmaps. I wish I learned from them before I began, instead of spending every waking hour building a product, and competing with development time for research.

Looking back, we followed the same trail taken by many other B2B startups, like: Product-market fit, sales optimization, customer success, marketing focus, and eventually scale. It's important to know which phase you are in, who you need to hire in each phase, and most importantly, how your role changes in each one.

Partner roles need to be well understood 

One of largest factors on your probability of success is your team. When choosing your partners, I would suggest using an odd number of people to break stalemates, and to always have a CEO. One person needs to be in charge of execution, I can tell you first hand that committees do not scale well when you need a high velocity of decision making.

When choosing your team, make note of Cal Newport's research on career capital, which is the rare and valuable skills that one can leverage help your startup succeed. If your friend knows how to code or understands databases, ask yourself if he/she is the best in their class, because these are skills that you can hire for or contract out. The traits that accelerated our success were a unique blend of domain expertise, petroleum-specific software knowledge, deep business development expertise, and strong sense of diligence and commitment, which is what became our culture.

Finally, you and your partners need to know what needs to be done, and how you can individually contribute. Your contributions will change in each phase, and each of you need to understand how your roles will change, and be prepared to adapt quickly. If one of your partners writes the first line of code, doesn't mean they'll be the CTO when you have 150 people, the person that makes the first sale may not be the CRO when you have a 30 person salesforce. For those with a large ego, it's one of the hardest things to accept, but must be acknowledged in order for a team to succeed.

Your idea is probably wrong, but that is okay 

We used agile and lean philosophies to build our organization, and our approach was centered around what Steve Blank calls "customer discovery," the understanding of how to find a product-market fit. These methods subscribe to the hypothesis that successful startups are defined by their team's execution, and not the idea alone. We ditched our first idea after two weeks and pivoted to a new one, and we learned from our customers very quickly and created over 115 prototypes in 10 months before making the first sale. Each group of customers saw a different prototype, and each beta-tester used a different design, a different stack, a different user experience. We had to learn quickly. Agile and lean processes helped us iterate quickly and discover what our customers needed, but a highly skilled team was needed to figure out how to use the processes correctly.

Connect with others who have made it

Success is a multi-variate formula that compounds every good and bad decision unequally. If you don't know the answer to a key decision, your team can help, if they don't know, then find another team that has navigated your trail to provide advice.

In Houston, there are not many teams who have been through this, we leaned on help from the Austin network. I'm a big believer in helping the community of entrepreneurs, and I am more than happy to throw down the rope to help others in their ascent.

Money is your oxygen

Lastly, learning to hold your breath isn't a long-term strategy for deep sea dives. You'll need to know how many months of oxygen you have in your bank account at all times. There is no magic number of months for runway, but I can tell you from experience that three months is too little for oil and gas tech startups, especially when OilCo's take three to six months to sign and pay your invoices.

I can't emphasize how difficult starting a company can be. By reflecting on the points I mentioned here, I believe that I would have avoided some pitfalls, and maybe even made it a little farther in the journey.

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James Ruiz is the founder of Houston-based Q Engineering, a data driven solutions company for E&P professionals.

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7+ can't-miss Houston business and innovation events in June 2026

where to be

Editor's note: The FIFA World Cup comes to Houston this month, joined by major energy conferences and a lineup of fan-favorite, recurring events. Here’s what not to miss and how to register. Please note: this article may be updated to add more events.


June 1-4 — CLEANPOWER 2026 Conference and Exhibition

CLEANPOWER unites policymakers, experts, and corporate leaders to solve the challenges that none can solve alone. This must-attend, four-day conference is packed with cutting-edge discussions about wind, solar, storage, and transmission; dealmaking; networking; and fun.

This event begins June 1 at the George R. Brown Convention Center. Register here.

June 2 — Humans of Healthcare

Houston Methodist Center for Innovation will present its quarterly speaker series, Humans of Healthcare. The series will feature a panel of experts who will share about their career paths and discuss the nuances of the health care industry. This month's session will focus on today’s nursing landscape, the industry’s expectations of nurses and what career paths are possible in the field.

The event is Tuesday, June 2, from 5-6:30 p.m. at the Ion. Register here.

June 9 — Greentown Go Make Kickoff

Head to the Ion to celebrate the Greentown Go Make 2026 cohort. The open-innovation program with Shell Catalysts & Technologies and Technip Energies focuses on catalytic solutions for industrial decarbonization and the energy transition. Hear pitches from the founders and network with a select group of startups while enjoying food and drink.

This event is Tuesday, June 9, from 5:30-8 p.m. Register here.

June 9-10 — Texas Brain Economy Summit

The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health. Expect to hear from leaders of global institutions, including the World Economic Forum, U.S. Chamber of Commerce, McKinsey Health Institute, Global Brain Economy Initiative, Davos Alzheimer’s Collaborative, Business Collaborative for Brain Health (UsAgainstAlzheimer’s), Rice University, Memorial Hermann, MD Anderson and many others. Read InnovationMap's full preview of the event here.

This event begins Tuesday, June 9. Purchase tickets here.

June 10 — MIT Future of Healthcare Technology Forum

The MIT Club of South Texas will host an in-person forum to explore how innovation, government and policy are changing the healthcare industry. The event will feature MIT alumni and Houston healthcare leaders, including Dr. Tim Boone, dean of the Texas A&M School of Engineering Medicine; Cynthia Reinhart-King, chair of bioengineering at Rice University; Dr. Tony Lin, CEO and chairman emeritus of Kelsey-Seybold Clinic; and others.

This event is Wednesday, June 10, from 5:15-8:30 p.m. at the TAMU EnMed Building. Register here.

June 11 — Goals & Gigawatts: Houston Energy & Climate Week The Power of & Kickoff Party

Come watch the Mexico City FIFA opening match while celebrating energy and innovation at the Goals & Gigawatts Kickoff Party. The event will feature food, drinks, and a showcase on Houston Energy & Climate Week. Learn what to expect and how to get involved in HECW before closing the night with a DJ and karaoke.

This event is Thursday, June 11, from 1:30-6:30 p.m. Find more information here.

June 16-17 — Energy Projects Conference & Expo

The Energy Projects Conference & Expo (EPC Show) is the largest event in North America for professionals working at the heart of major energy projects. The essential event for engineering, construction, commissioning, operations and maintenance across multiple energy sectors brings together five leading conferences under one roof. Conference subjects span LNG exporting, hydrogen and ammonia, midstream, petrochem and refining, and sustainable aviation fuels.

This event begins June 16 at George R. Brown Convention Center. Register here.

June 25 – NASA Tech Talk

Every fourth Thursday of the month, NASA experts, including longtime engineer Montgomery Goforth, present on technology development challenges NASA’s Johnson Space Center and the larger aerospace community are facing, and how they can be leveraged by Houston’s innovation community. Stick around after for drinks and networking at Second Draught.

This event is Thursday, June 25, from 6-7 p.m. at the Ion. Register here.

Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”