Six-figure earners live well in Houston. Photo via Getty Images

In Houston, $100,000 per year goes much farther than many other Texas cities. A new study by personal finance website GOBankingRates.com ranked Houston No. 7 on its list of the best cities for six-figure earners in the U.S.

The annual net pay after taxes for a six-figure earner in Houston comes out to $78,089, according to the study. When factoring in major expenses like rent, groceries, healthcare, utilities, transportation costs, and miscellaneous expenses, that adds up to $43,105.46 per year, which leaves just under $35,000 leftover. Houston's continuing inflation troubles surely aren't helping, either.

Here's how GOBankingRates breaks down Houston's expenses:

  • Annual rent: $19,215.67
  • Annual groceries: $5,594.64
  • Annual healthcare: $5,563.35
  • Annual utilities: $4,389.79
  • Annual transportation costs: $7,364.29
  • Annual miscellaneous costs: $977.72
Houston appears one spot lower than its No. 6-rank in a similar 2023 study by SmartAsset. That study said Houstonians' six-figure salary was reduced to $74,515 after taxes, but was technically worth $81,350 when adjusted for the cost of living.

Houston wasn't the only Texas city to earn a spot in the top 10 where a six-figure salary goes the farthest. Higher up on the list is El Paso (No. 2) and San Antonio (No. 3).

After taxes and annual expenses, six-figure earners in El Paso have $37,685 left over, which is over $2,700 more than what a Houstonian would have with the same salary. In San Antonio, residents making $100,000 per year average about $41,008 in annual expenses, which leaves $37,081 in their pockets after paying all the bills.

For the second year in a row, the U.S. city where a $100,000 salary goes the furthest is Memphis, Tennessee. Memphis residents have nearly $40,000 leftover after taxes and annual expenses on a $100,000 salary, the study says. Like Texas, Tennessee also doesn't impose an income tax on its residents.

The top 10 U.S. cities where a $100,000 salary goes the farthest are:

  • No. 1 – Memphis, Tennessee
  • No. 2 – El Paso, Texas
  • No. 3 – San Antonio, Texas
  • No. 4 – Tulsa, Oklahoma
  • No. 5 – Oklahoma City, Oklahoma
  • No. 6 – Wichita, Kansas
  • No. 7 – Houston
  • No. 8 – Tucson, Arizona
  • No. 9 – Jacksonville, Florida
  • No. 10 – Indianapolis, Indiana

In the study's analysis of the top 10 most expensive cities for six-figure earners, New York City took the crown as the city where residents are left "in the red" by the end of the year. Following close behind is San Francisco, California (No. 2); San Jose, California (No. 3); San Diego, California (No. 4); Boston, Massachusetts (No. 5); Oakland, California (No. 6); Los Angeles, California (No. 7); Washington, D.C. (No. 8); Miami, Florida (No. 9); and Long Beach, California (No. 10).

The report analyzed the average expense costs in 50 of the most populous American cities, and subtracted those costs from each city's annual net annual pay after taxes on a $100,000 salary. Rankings were determined based on the amount of annual income leftover. Data was pulled from the U.S. Census American Community Survey, the Bureau of Labor Statistics Consumer Expenditure Survey, the Zillow Observed Rental Index, and more.The report and its methodology can be found on gobankingrates.com.

------

This article originally ran on CultureMap.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Nominations are now open for the 2025 Houston Innovation Awards

Calling All Innovators

Calling all Houston innovators: The Houston Innovation Awards return this fall to celebrate the best and brightest in the Houston innovation ecosystem right now.

Presented by InnovationMap, the fifth annual Houston Innovation Awards will take place November 5 at TMC Helix Park.

The awards program will honor the top startups and innovators in Houston across 10 categories, and we're asking you to nominate the most deserving Houston innovators and innovative companies today.

This year's categories are:

  • Minority-founded Business, honoring an innovative startup founded or co-founded by BIPOC or LGBTQ+ representation.
  • Female-founded Business, honoring an innovative startup founded or co-founded by a woman.
  • Energy Transition Business, honoring an innovative startup providing a solution within renewables, climatetech, clean energy, alternative materials, circular economy, and beyond.
  • Health Tech Business, honoring an innovative startup within the health and medical technology sectors.
  • Deep Tech Business, honoring an innovative startup providing technology solutions based on substantial scientific or engineering challenges, including those in the AI, robotics, and space sectors.
  • Startup of the Year (People's Choice), honoring a startup celebrating a recent milestone or success. The winner will be selected by the community via an interactive voting experience.
  • Scaleup of the Year, honoring an innovative later-stage startup that's recently reached a significant milestone in company growth.
  • Incubator/Accelerator of the Year, honoring a local incubator or accelerator that is championing and fueling the growth of Houston startups.
  • Mentor of the Year, honoring an individual who dedicates their time and expertise to guide and support budding entrepreneurs.
  • Trailblazer, honoring an innovator who's made a lasting impact on the Houston innovation community.

Nominations may be made on behalf of yourself, your organization, and other leaders in the local innovation scene. The nomination period closes on August 31, so don't delay — nominate today at this link, or fill out the embedded form below.

Our panel of esteemed judges will review the nominations, and determine the finalists and winners. Finalists will be unveiled on September 30, and the 2025 Houston Innovation Awards winners will be announced live at our event on November 5.

Tickets will go on sale this fall. Stay tuned for that announcement, as well as more fanfare leading up to the 2025 Houston Innovation Awards.

Nominate now:

Interested in Innovation Awards sponsorship opportunities? Please contact sales@innovationmap.com.

MD Anderson launches $10M collaboration to advance personalized cancer treatment tech

fighting cancer

The University of Texas MD Anderson Cancer Center and Japan’s TOPPAN Holdings Inc. have announced a strategic collaboration to co-develop TOPPAN Holdings’ 3D cell culture, or organoid, technology known as invivoid.

The technology will be used as a tool for personalized cancer treatments and drug screening efforts, according to a release from MD Anderson. TOPPAN has committed $10 million over five years to advance the joint research activities.

“The strategic alliance with MD Anderson paves a promising path toward personalized cancer medicine," Hiroshi Asada, head of the Business Innovation Center at TOPPAN Holdings, said in a news release.

Invivoid is capable of establishing organoid models directly from patient biopsies or other tissues in a way that is faster and more efficient. Researchers may be able to test a variety of potential treatments in the laboratory to understand which approach may work best for the patient, if validated clinically.

“Organoids allow us to model the three-dimensional complexity of human cancers in the lab, thus allowing us to engineer a powerful translational engine—one that could not only predict how patients will respond to therapy before treatment begins but also could help to reimagine how we discover and validate next-generation therapies," Dr. Donna Hansel, division head of pathology and laboratory medicine at MD Anderson, added in the news release. “Through this collaboration, we hope to make meaningful progress in modeling cancer biology for therapeutic innovation.”

The collaboration will build upon preclinical research previously conducted by MD Anderson and TOPPAN. The organizations will work collaboratively to obtain College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) certifications for the technology, which demonstrate a commitment to high-quality patient care. Once the certifications are obtained, they plan to conduct observational clinical studies and then prospective clinical studies.

“We believe our proprietary invivoid 3D cell culture technology, by enabling the rapid establishment of organoid models directly from patient biopsies, has strong potential to help identify more effective treatment options and reduce the likelihood of unnecessary therapies,” Asada added in the release. “Through collaboration on CAP/CLIA certification and clinical validation, we aim to bring this innovation closer to real-world patient care and contribute meaningfully to the advancement of cancer medicine."