Six-figure earners live well in Houston. Photo via Getty Images

In Houston, $100,000 per year goes much farther than many other Texas cities. A new study by personal finance website GOBankingRates.com ranked Houston No. 7 on its list of the best cities for six-figure earners in the U.S.

The annual net pay after taxes for a six-figure earner in Houston comes out to $78,089, according to the study. When factoring in major expenses like rent, groceries, healthcare, utilities, transportation costs, and miscellaneous expenses, that adds up to $43,105.46 per year, which leaves just under $35,000 leftover. Houston's continuing inflation troubles surely aren't helping, either.

Here's how GOBankingRates breaks down Houston's expenses:

  • Annual rent: $19,215.67
  • Annual groceries: $5,594.64
  • Annual healthcare: $5,563.35
  • Annual utilities: $4,389.79
  • Annual transportation costs: $7,364.29
  • Annual miscellaneous costs: $977.72
Houston appears one spot lower than its No. 6-rank in a similar 2023 study by SmartAsset. That study said Houstonians' six-figure salary was reduced to $74,515 after taxes, but was technically worth $81,350 when adjusted for the cost of living.

Houston wasn't the only Texas city to earn a spot in the top 10 where a six-figure salary goes the farthest. Higher up on the list is El Paso (No. 2) and San Antonio (No. 3).

After taxes and annual expenses, six-figure earners in El Paso have $37,685 left over, which is over $2,700 more than what a Houstonian would have with the same salary. In San Antonio, residents making $100,000 per year average about $41,008 in annual expenses, which leaves $37,081 in their pockets after paying all the bills.

For the second year in a row, the U.S. city where a $100,000 salary goes the furthest is Memphis, Tennessee. Memphis residents have nearly $40,000 leftover after taxes and annual expenses on a $100,000 salary, the study says. Like Texas, Tennessee also doesn't impose an income tax on its residents.

The top 10 U.S. cities where a $100,000 salary goes the farthest are:

  • No. 1 – Memphis, Tennessee
  • No. 2 – El Paso, Texas
  • No. 3 – San Antonio, Texas
  • No. 4 – Tulsa, Oklahoma
  • No. 5 – Oklahoma City, Oklahoma
  • No. 6 – Wichita, Kansas
  • No. 7 – Houston
  • No. 8 – Tucson, Arizona
  • No. 9 – Jacksonville, Florida
  • No. 10 – Indianapolis, Indiana

In the study's analysis of the top 10 most expensive cities for six-figure earners, New York City took the crown as the city where residents are left "in the red" by the end of the year. Following close behind is San Francisco, California (No. 2); San Jose, California (No. 3); San Diego, California (No. 4); Boston, Massachusetts (No. 5); Oakland, California (No. 6); Los Angeles, California (No. 7); Washington, D.C. (No. 8); Miami, Florida (No. 9); and Long Beach, California (No. 10).

The report analyzed the average expense costs in 50 of the most populous American cities, and subtracted those costs from each city's annual net annual pay after taxes on a $100,000 salary. Rankings were determined based on the amount of annual income leftover. Data was pulled from the U.S. Census American Community Survey, the Bureau of Labor Statistics Consumer Expenditure Survey, the Zillow Observed Rental Index, and more.The report and its methodology can be found on gobankingrates.com.

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This article originally ran on CultureMap.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.