Tilman Fertitta's new book, "Shut Up and Listen!" is on its way to being a bestseller. Photo by J. Thomas Ford

Tilman Fertitta can't lose. Sitting in his palatial office nestled in the towering Post Oak Hotel in Uptown, the sole owner of Fertitta Entertainment, the restaurant giant Landry's, the Golden Nugget Casinos and Hotels, and the NBA's Houston Rockets — not to mention the star of the TV reality show Billion Dollar Buyer — is taking a quick moment to bask in his success.

And why not? On top of being the world's richest restauranteur and Houston's most recognizable billionaire, Fertitta currently boasts a best seller with his new business book, Shut Up and Listen! As CultureMap reported, he just acquired Del Frisco's luxury steakhouse chain, adding to his impressive and extensive restaurant empire. And speaking of acquisitions: Soon, his Houston Rockets will unleash the powerhouse duo of James Harden and new teammate Russell Westbrook, who came to Houston in a massive trade with Oklahoma City.

Fertitta has just made the national media rounds promoting Shut Upand Listen! and looked quite comfortable doing so. "A lot of owners don't talk to the media and they don't know how to do it," he tells CultureMap, "but I've been doing it for 30 years and it just doesn't phase me."

Shut Up and Listen! is a Tilman tell-all. But rather than a life story, the book is a how-to for the business-minded. No-nonsense nuggets such as the "Tilmanisms" teach principles such as the 95/5 rule (focus on the 5 percent of the operation that isn't perfect and fix it) and offer hardcore reminders such as "when things are bad, eat the weak and grow your business." Doubters, take note: Shut Up has landed on the Publishers Weekly's and USA Today's Best Sellers lists.

CultureMap sat down with Fertitta during a rare break to talk books, business, and his beloved Bayou City.

CultureMap: You're a Texan titan of industry, a major local benefactor, you own one of the most buzzworthy teams in all of pro sports, and you're the star of your own reality TV show. Can we now say — in Houston — that you're way bigger than Mark Cuban?

Tilman Fertitta: [Laughs] Oh, I don't know about that. Mark is a special guy and we're lucky to have him in Texas.

CM: You've been actively involved with the Rockets and the University of Houston sports programs. Using your 95/5 rule, can you share any of the 5 percent of what you found wrong with the Rockets and UH?

TF: At UH, the 5 percent was we wanted to have good coaches and we wanted to improve our facilities. That's the 5 percent we realized that if we wanted to compete at the highest level of basketball and football, that's what we'd have to do.

For the Rockets, we're gonna make sure we can put the basketball team we can on the court with the best coaches every single year. I'm not a sit-on-my-hands guy — it's let's keep getting better.

CM: Why is giving back to your hometown important to you?

TF: This is where I grew up and Houston's been very good to me. I've been around a long time and I've watched people come and go in the '80s, the '90s, the 2000s, and the 2010s. It's fun to have lasted this long and been a player through so many decades.

CM: There's an old adage that says, 'Do one thing and do it well.' But you're doing a lot of things well. When do you know, as a business owner, to diversify?

TF: Systems and operations are very important. Everybody wants to do more deals. If you understand the Big Box Theory, you make more out of a bigger box. In the beginning, I knew I always wanted to be successful. Today, I know what I know and I know — and what I don't know.

CM: Are there some industries outside your wheelhouse that are on your radar?

TF: I've never done egotistical businesses; I've always had to make the numbers work — because I never use anyone else's money. A lot of times, people who do egotistical businesses are using somebody else's money.

The only egotistical business I've done is probably the Post Oak Hotel here. But I did it because I got tired of people saying, 'Houston doesn't have an unbelievable hotel.' It's truly one of the finest hotels in the country.

CM: How important is it to find a mentor for success?

TF: I never had that one mentor. I looked at a lot of different people and said, 'Gosh, I like what they're doing.' I remember seeing George Mitchell and what he was doing in Galveston and The Woodlands. I would watch different people doing different things, but I never had that one mentor. I studied a lot of different people.
I'll never win an Emmy or a Grammy, but to me, if you can get on the Forbes 400, that's very special, because that's how you're measured.

CM: You've got this new book out that will hopefully inspire a generation of entrepreneurs. Are there any books that inspired you?

TF:Outliers inspired me. I do believe that different people are blessed with different abilities and you've got to find the ability that God gave you and seize on it.

I thought that I would always write a life story book, but Harper Collins approached me and said they wanted a business management book. I can't tell you how many times we sat around with my close group and edited this book at the end and went through it five times and read it. If we found a paragraph that was boring, we got rid of it or rewrote it.

CM: What about people who may never be an entrepreneur or owner — how can they become more successful with your book?

TF: Whether you're trying to go up the corporate ladder or you want to be an entrepreneur, it just tells you that you can separate yourself from anybody else. And it's easy to separate yourself from anybody else — I was never the smartest guy in the room or the best student. But the people who want to be successful are successful.

CM: There's a Tilmanism that teaches hiring people who are stronger than you. What are some key traits of a real leader?

TF: Anybody is a good leader in great times. First off, it's somebody who everybody in the room respects. And it somebody who knows what they know and what they don't know. Work is battle and being successful is a battle, and everybody wants to go into battle with a strong leader.

I can tell you this: You could talk to everybody who works for me and they'd tell you, 'He's a really hard person to work for, but I wouldn't want to work for anybody else.'

CM: With your travel schedule and empire, do you ever feel that you have more in common with a president of a country than a CEO?

TF: You know, it's funny, I told [Bill] Clinton once, 'I'm gonna still have these jets and helicopters when you're trying to hitch a ride.' I'm a very political person — on both sides — because I'm in business and I never know who's gonna be in power.

I would have no fear of being president tomorrow because it's about making hard decisions. I think a lot of presidents have never been in business and they don't even know how to make decisions. I make a tough decision every single day.

But, you know, I'm probably too honest to be a politician — I like to tell the truth. And I don't want to be beholden to anybody.

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This article originally ran on CultureMap.

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Houston startup recognized for inclusivity on journey to commercialize next-gen therapeutics

future of medicine

A new Houston biotech company won a special award at the 16th Annual SXSW Pitch Award Ceremony earlier this month.

Phiogen, one of 45 companies that competed in nine categories, was the winner for best inclusivity, much to the surprise of the company’s CEO, Amanda Burkhardt.

Burkhardt tells InnovationMap that while she wanted to represent the heavily female patient population that Phiogen seeks to treat, really she just hires the most skilled scientists.

“The best talent was the folks that we have and it ends up being we have three green card holders on our team. As far as ethnicities, we have on our team we have Indian, African-American, Korean, Chinese Pakistani, Moroccan and Hispanic people and that just kind of just makes up the people who helped us on a day-to-day basis,” she explains.

Phiogen was selected out of 670 companies to be in the health and nutrition category at SXSW.

“We did really well, but there was another company that also did really well. And so we were not selected for the pitch competition, which we were a little bummed about because I killed the pitch,” Burkhardt recalls.

But Phiogen is worthy of note, pitch competition or not. The new company spun off from research at Dr. Anthony Maresso’s TAILOR Labs, a personalized phage therapy center at Baylor College of Medicine, last June.

“Our whole goal is to create the next generation of anti-infectives,” says Burkhardt.

That means that the company is making alternatives to antibiotics, but as Burkhardt says, “We’re hoping to be better than antibiotics.”

How does it work? Bacteriophages are viruses that infect bacteria.

“You can imagine them as the predators in the bacteria world, but they don't infect humans. They don't affect animals. They only infect bacteria,” Burkhardt explains.

Phiogen utilizes carefully honed bacteriophages to attack bacteria that include the baddies behind urinary tract infection (UTI), bacteremia (bacteria in the blood), and skin wounds.

The team’s primary focus is on treatment-resistant UTI. One example was a male patient who received Phiogen’s treatment thanks to an emergency-use authorization from the FDA. The gentleman had been suffering from an infection for 20 years. He was treated with Phiogen’s bacteriophage therapy for two weeks and completely cleared his infection with no recurrence.

Amanda Burkhardt is the CEO of Phiogen. Photo via LinkedIn

But Phiogen has its sights set well beyond the first maladies it’s treated. An oft-quoted 2016 report projected that by 2050, 10 million people a year will be dying from drug-resistant infections.

“A lot of scientists call it the silent pandemic because it's happening now, we're living in it, but there's just not as much being said about it because it normally happens to people who are already in the hospital for something else, or it's a comorbidity, but that's not always the case, especially when we're talking about urinary tract infections,” says Burkhardt.

Bacteriophages are important because they can be quickly trained to fight against resistant strains, whereas it takes years and millions of dollars to develop new antibiotics. There are 13 clinical trials that are currently taking place for bacteriophage therapy. Burkhardt estimates that the treatment method will likely gain FDA approval in the next five years.

“The FDA actually has been super flexible on progressing forward. Because they are naturally occurring, there's not really a safety risk with these products,” she says.

And Burkhardt, whose background is in life-science commercialization, says there’s no better place to build Phiogen than in Houston.

“You have Boston, you have the Bay [Area], and you have the Gulf Coast,” she says. “And Houston is cheaper, the people are friendlier, and it’s not a bad place to be in the winter.”

She also mentions the impressive shadow that Helix Park will cast over the ecosystem. Phiogen will move later this year to the new campus — one of the labs selected to join Baylor College of Medicine.

And as for that prize, chances are, it won’t be Phiogen’s last.

Houston student selected for prestigious health care research program

bright future

A Houston-area undergraduate student has been tapped for a prestigious national program that pairs early-career investigators with health research professionals.

Mielad Ziaee was selected for the National Institutes of Health’s 2023-2024 All of Us Research Scholar Program, which connects young innovators with experts "working to advance the field of precision medicine," according to a statement from UH. Ziaee – a 20-year-old majoring in psychology and minoring in biology, medicine and society who plans to graduate in 2025 — plans to research how genomics, or the studying of a person's DNA, can be used to impact health.

“I’ll be one of the ones that define what this field of personalized, precision medicine will look like in the future,” Ziaee said in a statement. “It’s exciting and it’s a big responsibility that will involve engaging diverse populations and stakeholders from different systems – from researchers to health care providers to policymakers.”

Ziaee aims to become a physician who can use an understanding of social health conditions to guide his clinical practice. At a young age, he was inspired to go into the field by his family's own experience.

According to UH, Ziaee is the oldest child of Iranian American immigrants. He saw firsthand the challenges of how language and cultural barriers can impact patients' access to and level of care.

“I think a lot of people define health as purely biological, but a lot of other factors influence our well-being, such as mental health, financial health, and even access to good food, medical care and the internet,” he said in a statement. “I am interested in seeing the relationship among all these things and how they impact our health. So far, a lot of health policies and systems have not really looked beyond biology.”

"I want everyone to have an equal chance to access health care and take charge of their well-being. We need to have the systems in place that let people do that,” he added.

Ziaee is already on his way to helping Houston-based and national health systems and organizations make headway in this area.

He was named as a student regent on the UH System Board of Regents last year, sits on the board of the Houston chapter of the American Red Cross, and is an Albert Schweitzer Fellow.

Last year he was a Centers for Disease Control and Prevention John R. Lewis scholar, for which he presented his research project about predicting food insecurity in pediatric clinical settings and recommendations to improve the assessment based off his summer research with the Johns Hopkins University School of Medicine and the Kennedy Krieger Institute.

Prior to this, he completed a 10-week guided research experience using data visualization and predictive modeling techniques to assess food insecurity in the Third Ward.

“I just took every opportunity that came to me,” Ziaee said. “All my experiences connect with my central desire to increase health access and improve health care. I am very intentional about connecting the dots to my passion.”

Earlier this year, three UH student researchers were named among 16 other early-stage research projects at U.S. colleges and universities to receive a total of $17.4 million from the DOE's Office of Fossil Energy and Carbon Management (FECM). The projects were each awarded between about $750,000 to up to $1.5 million.

Houston tech entrepreneur expands energy data co. in Europe, continues to scale

houston innovators podcast episode 229

The technology that Amperon provides its customers — a comprehensive, AI-backed data analytics platform — is majorly key to the energy industry and the transition of the sector. But CEO Sean Kelly says he doesn't run his business like an energy company.

Kelly explains on the Houston Innovators Podcast that he chooses to run Amperon as a tech company when it comes to hiring and scaling.

"There are a lot of energy companies that do tech — they'll hire a large IT department, they'll outsource a bunch of things, and they'll try to undergo a product themselves because they think it should be IP," he says on the show. "A tech company means that at your core, you're trying to build the best and brightest technology."

To Kelly, Amperon should be hiring in the same field as Google and other big tech companies that sit at the top of the market. And Kelly has done a lot of hiring recently. Recently closing the company's $20 million series B round last fall led by Energize Capital, Amperon has tripled its team in the past 14 months.

With his growing team, Kelly also speaks to the importance of partnerships as the company scales. Earlier this month, Amperon announced that it is replatforming its AI-powered energy analytics technology onto Microsoft Azure. The partnership with the tech giant allows Amperon's energy sector clients to use Microsoft's analytics stack with Amperon data.

And there are more collaborations where that comes from.

"For Amperon, 2024 is the year of partnerships," Kelly says on the podcast. "I think you'll see partnership announcements here in the next couple of quarters."

Along with more partners, Amperon is entering an era of expansion, specifically in Europe, which Kelly says has taken place at a fast pace.

"Amperon will be live in a month in 25 countries," he says.

While Amperon's technology isn't energy transition specific, Kelly shares how it's been surprising how many clean tech and climate tech lists Amperon has made it on.

"We don't brand ourselves as a clean tech company," Kelly says, "but we have four of the top six or eight wind providers who have all invested in Amperon. So, there's something there."

Amperon, which originally founded in 2018 before relocating to Houston a couple of years ago, is providing technology that helps customers move toward a lower carbon future.

"If you look at our customer base, Amperon is the heart of the energy transition. And Houston is the heart of the energy transition," he says.