Tilman Fertitta's new book, "Shut Up and Listen!" is on its way to being a bestseller. Photo by J. Thomas Ford

Tilman Fertitta can't lose. Sitting in his palatial office nestled in the towering Post Oak Hotel in Uptown, the sole owner of Fertitta Entertainment, the restaurant giant Landry's, the Golden Nugget Casinos and Hotels, and the NBA's Houston Rockets — not to mention the star of the TV reality show Billion Dollar Buyer — is taking a quick moment to bask in his success.

And why not? On top of being the world's richest restauranteur and Houston's most recognizable billionaire, Fertitta currently boasts a best seller with his new business book, Shut Up and Listen! As CultureMap reported, he just acquired Del Frisco's luxury steakhouse chain, adding to his impressive and extensive restaurant empire. And speaking of acquisitions: Soon, his Houston Rockets will unleash the powerhouse duo of James Harden and new teammate Russell Westbrook, who came to Houston in a massive trade with Oklahoma City.

Fertitta has just made the national media rounds promoting Shut Up and Listen! and looked quite comfortable doing so. "A lot of owners don't talk to the media and they don't know how to do it," he tells CultureMap, "but I've been doing it for 30 years and it just doesn't phase me."

Shut Up and Listen! is a Tilman tell-all. But rather than a life story, the book is a how-to for the business-minded. No-nonsense nuggets such as the "Tilmanisms" teach principles such as the 95/5 rule (focus on the 5 percent of the operation that isn't perfect and fix it) and offer hardcore reminders such as "when things are bad, eat the weak and grow your business." Doubters, take note: Shut Up has landed on the Publishers Weekly's and USA Today's Best Sellers lists.

CultureMap sat down with Fertitta during a rare break to talk books, business, and his beloved Bayou City.

CultureMap: You're a Texan titan of industry, a major local benefactor, you own one of the most buzzworthy teams in all of pro sports, and you're the star of your own reality TV show. Can we now say — in Houston — that you're way bigger than Mark Cuban?

Tilman Fertitta: [Laughs] Oh, I don't know about that. Mark is a special guy and we're lucky to have him in Texas.

CM: You've been actively involved with the Rockets and the University of Houston sports programs. Using your 95/5 rule, can you share any of the 5 percent of what you found wrong with the Rockets and UH?

TF: At UH, the 5 percent was we wanted to have good coaches and we wanted to improve our facilities. That's the 5 percent we realized that if we wanted to compete at the highest level of basketball and football, that's what we'd have to do.

For the Rockets, we're gonna make sure we can put the basketball team we can on the court with the best coaches every single year. I'm not a sit-on-my-hands guy — it's let's keep getting better.

CM: Why is giving back to your hometown important to you?

TF: This is where I grew up and Houston's been very good to me. I've been around a long time and I've watched people come and go in the '80s, the '90s, the 2000s, and the 2010s. It's fun to have lasted this long and been a player through so many decades.

CM: There's an old adage that says, 'Do one thing and do it well.' But you're doing a lot of things well. When do you know, as a business owner, to diversify?

TF: Systems and operations are very important. Everybody wants to do more deals. If you understand the Big Box Theory, you make more out of a bigger box. In the beginning, I knew I always wanted to be successful. Today, I know what I know and I know — and what I don't know.

CM: Are there some industries outside your wheelhouse that are on your radar?

TF: I've never done egotistical businesses; I've always had to make the numbers work — because I never use anyone else's money. A lot of times, people who do egotistical businesses are using somebody else's money.

The only egotistical business I've done is probably the Post Oak Hotel here. But I did it because I got tired of people saying, 'Houston doesn't have an unbelievable hotel.' It's truly one of the finest hotels in the country.

CM: How important is it to find a mentor for success?

TF: I never had that one mentor. I looked at a lot of different people and said, 'Gosh, I like what they're doing.' I remember seeing George Mitchell and what he was doing in Galveston and The Woodlands. I would watch different people doing different things, but I never had that one mentor. I studied a lot of different people.
I'll never win an Emmy or a Grammy, but to me, if you can get on the Forbes 400, that's very special, because that's how you're measured.

CM: You've got this new book out that will hopefully inspire a generation of entrepreneurs. Are there any books that inspired you?

TF: Outliers inspired me. I do believe that different people are blessed with different abilities and you've got to find the ability that God gave you and seize on it.

I thought that I would always write a life story book, but Harper Collins approached me and said they wanted a business management book. I can't tell you how many times we sat around with my close group and edited this book at the end and went through it five times and read it. If we found a paragraph that was boring, we got rid of it or rewrote it.

CM: What about people who may never be an entrepreneur or owner — how can they become more successful with your book?

TF: Whether you're trying to go up the corporate ladder or you want to be an entrepreneur, it just tells you that you can separate yourself from anybody else. And it's easy to separate yourself from anybody else — I was never the smartest guy in the room or the best student. But the people who want to be successful are successful.

CM: There's a Tilmanism that teaches hiring people who are stronger than you. What are some key traits of a real leader?

TF: Anybody is a good leader in great times. First off, it's somebody who everybody in the room respects. And it somebody who knows what they know and what they don't know. Work is battle and being successful is a battle, and everybody wants to go into battle with a strong leader.

I can tell you this: You could talk to everybody who works for me and they'd tell you, 'He's a really hard person to work for, but I wouldn't want to work for anybody else.'

CM: With your travel schedule and empire, do you ever feel that you have more in common with a president of a country than a CEO?

TF: You know, it's funny, I told [Bill] Clinton once, 'I'm gonna still have these jets and helicopters when you're trying to hitch a ride.' I'm a very political person — on both sides — because I'm in business and I never know who's gonna be in power.

I would have no fear of being president tomorrow because it's about making hard decisions. I think a lot of presidents have never been in business and they don't even know how to make decisions. I make a tough decision every single day.

But, you know, I'm probably too honest to be a politician — I like to tell the truth. And I don't want to be beholden to anybody.

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This article originally ran on CultureMap.

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Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”

10+ Houston innovation leaders in the spotlight at SXSW 2026

where to be

Houston's innovation scene will be well represented at South by Southwest (SXSW) this month.

The week-long, Austin-based conference and festival will spotlight some of the Bayou City's leaders in health care, energy, space and more. The event kicks off today, March 12, and runs through March 18. The SXSW Innovation Conference will feature keynotes, workshops, mentoring sessions and more throughout various venues in the city.

Here's who to see and when and where to find them:

March 12

Aileen Allen, venture partner at Mercury Fund

Mentor Session from 4-5:15 p.m. at Hilton Austin Downtown

Allen will host a mentoring session focused on funding, marketing, advertising, PR and the future of work.

March 13

Heath Butler, partner at Mercury Fund

SXSW Pitch-Smart Cities, Transportation, Manufacturing & Logistics from 2:30-3:30 p.m. at the J.W. Marriott

Butler will judge five innovative startups as they pitch their solutions to advance smart cities, enhance transportation systems, modernize manufacturing, transform logistics, and strengthen government infrastructure and civic operations.

Jonathan Cirtain, CEO and president of Axiom Space

The Clock is Ticking for Space - Replacing the ISS from 4-5 p.m. at the J.W. Marriott

Cirtain will discuss Axiom's pursuit of building the world’s first commercial space station.

March 14

Jesse Martinez, founder and CEO of LSA Global

SXSW Pitch-Intelligent Systems, Robotics, & Multisensory Technology from 10-11 a.m. at the J.W. Marriott

Martinez will judge five innovative startups as they pitch their technologies that aim to enhance the way people connect, communicate and share unique life experiences with those around them in a digital ecosystem.

Jennifer Schmitt, head of operations at Rhythm Energy

Powering Texas with Reliable Integrated High-Demand Energy from 10-11 a.m. at Marlow

Schmitt will join a panel to discuss how EirGrid, the state-owned electric power transmission operator in Ireland, is pioneering solutions as the country works toward 80 percent renewable integration by 2030.

Saki Sasagawa, director of business development for JETRO Houston

Now is Japan's Time: Leading the Future with Deep Tech from 10-11 a.m. at the J.W. Marriott

Sasagawa joins a panel that will share real-time insights from diverse perspectives on the forefront of Japan’s deep tech and IP businesses.

March 15

Bosco Lai, CEO and co-founder of Little Place Labs

SXSW Pitch Alumni: Where Are They Now? from 10-11 a.m. at the J.W. Marriott

Lai joins a panel of four former SXSW Pitch winners to share how they leveraged the platform to take their startups to the next level.

Tara Karimi, cofounder and chief science and sustainability officer at Cemvita

South by South America: The Rise of Southern Brazil Tech from 2:30-3:30. p.m. at The Line

Karimi will participate in a panel to discuss how Rio Grande do Sul, Brazil's southernmost state, is attracting elite talent and AI infrastructure and share insights on navigating the next wave of South American tech growth.

March 16

Dr. Pavitra P. Krishnamani, emergency medicine physician at The University of Texas MD Anderson Cancer Center

Viva La Revolution: How the Digital Age is Transforming Wellness from 11:30 a.m.-12:30 p.m. at Hilton Austin Downtown

Krishnamani will discuss the latest advancements and policies that can accelerate the digital age of health care, such as wearables, telehealth and artificial intelligence.

March 18

Charlie Childs, co-founder and CEO of Intero Biosystems

Spinning Out: What It Takes to Build a University Startup from 2:30-3:30 p.m. at The Line

Childs will join founders who spun their companies out of the University of Michigan to share the real story of navigating IP, early capital, team building, market validation and the “valley of death.”

Dr. James Allison, regental chair of immunology and director of The Allison Institute at The University of Texas MD Anderson Cancer Center

Dr. Padmanee Sharma, professor in the Department of Genitourinary Medical Oncology, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center

Beyond Checkpoints: Immunotherapy’s Next Act from 2:30-3:30 p.m. at the J.W. Marriott

Allison and Sharma will sit down with 21-year-old, Stage 4 cancer survivor Sharon Belvin and Time Magazine journalist Alice Park will discuss the future of immunotherapy and what challenges remain.

Last year, Houston startups Little Places Labs and Helix Earth won top prizes in their respective categories at the prestigious SXSW Pitch event, held this year from March 13-14. No Houston startups were named finalists to compete in this year's event.

NASA revamps Artemis moon landing program by modeling it after Apollo

To the moon

NASA is revamping its Artemis moon exploration program to make it more like the fast-paced Apollo program half a century ago, adding an extra practice flight before attempting a high-risk lunar landing with a crew in two years.

The overhaul in the flight lineup came just days after NASA’s new moon rocket returned to its hangar for more repairs, and a safety panel warned the space agency to scale back its overly ambitious goals for humanity’s first lunar landing since 1972.

Artemis II, a lunar fly-around by four astronauts, is off until at least April because of rocket problems.

The follow-up mission, Artemis III, had been targeting a landing near the moon’s south pole by another pair of astronauts in about three years. But with long gaps between flights and concern growing over the readiness of a lunar lander and moonwalking suits, NASA’s new administrator Jared Isaacman announced that mission would instead focus on launching a lunar lander into orbit around Earth in 2027 for docking practice by astronauts flying in an Orion capsule.

The new plan calls for a moon landing — potentially even two moon landings — by astronauts in 2028.

“Everybody agrees. This is the only way forward,” Isaacman said.

The hydrogen fuel leaks and helium flow problems that struck the Space Launch System rocket on the pad at NASA's Kennedy Space Center in February also plagued the first Artemis test flight without a crew in 2022.

Another three-year gap was looming between Artemis II and the moon landing by astronauts as originally envisioned, Isaacman said.

Isaacman stressed that “it should be incredibly obvious” that three years between flights is unacceptable. He'd like to get it down to one year or even less.

Isaacman, a tech billionaire who bought his own trips to orbit and performed the world’s first private spacewalk, took the helm at NASA in December.

During NASA’s storied Apollo program, he said, astronauts’ first flight to the moon was followed by two more missions before Neil Armstrong and Buzz Aldrin landed on the moon. What's more, he added, the Apollo moonshots followed one another in quick succession, just as the earlier Projects Mercury and Gemini had rapid flight rates, sometimes coming just a few months apart.

Twenty-four Apollo astronauts flew to the moon from 1968 through 1972, with 12 of them landing.

“No one at NASA forgot their history books. They knew how to do this," Isaacman said. “Now we're putting it in action.”

To pick up the pace and reduce risk, NASA will standardize its Space Launch System rockets moving forward, Isaacman said. These are the massive rockets that will launch astronauts to the moon aboard Orion capsules. At the same time, Elon Musk's SpaceX and Jeff Bezos' Blue Origin are speeding up their work on the landers needed to get the astronauts from lunar orbit down to the surface.

Isaacman said next year will see an Orion crew rendezvousing in orbit around Earth with SpaceX's Starship, Blue Origin's Blue Moon or both landers. It's similar to the methodical approach that worked so well during Apollo in the late 1960s, he noted. Apollo 8, astronauts' first flight to the moon, was followed by two more missions before Armstrong and Aldrin aimed for the lunar surface.

“We should be getting back to basics and doing what we know works,” he said.

The Aerospace Safety Advisory Panel recommended that NASA revise its objectives for Artemis III “given the demanding mission goals.” It’s urgent the space agency do that, the panel said, if the United States hopes to safely return astronauts to the moon. Isaacman said the revised Artemis flight plan addresses the panel's concerns and is supported by industry and the Trump administration.