$100,000 salary goes further in Houston than most cities, study shows

Cashing In

A $100,000 salary goes further in Houston than Dallas. Photo by Alexander Mils on Unsplash

Even with Houston's ever-changing cost of living, earning a six-figure salary in the city is going much further than it used to, according to an income study by fintech company SmartAsset.

An annual $100,000 salary in Houston is worth $83,343 after taxes and when adjusted for the city's cost of living, the report revealed. That's $5,254 more than what six-figure-earning Houstonians were bringing home last year, a separate report from GoBankingRates.com found.

In SmartAsset's rankings of U.S. cities where $100,000 is worth the most, Houston ranked ninth.

The report warns a six-figure salary may seem comfortable at first, but it may not stretch as far depending on where an individual lives, any applicable tax obligations, and the rate of inflation.

"Earning $100,000 places an individual tax filer at the upper limit of the 22 percent federal tax bracket," the report's author wrote. "But taxes aren’t the only factor. The cost of living varies widely across the country, affecting how much purchasing power remains after necessary expenses."

Manhattan, New York is the No. 1 place where a six-figure salary is worth the least, where a New Yorker's take-home pay is only worth $30,362 after taxes and adjusted for the cost of living.

Other U.S. cities where a $100,000 salary goes the furthest
The U.S. city where a six-figure salary goes the furthest is Oklahoma City, where residents come away with $89,989 after all expenses.

Texas cities dominated the top 10 list. Texas doesn't impose state or local income taxes, which likely boosted its statewide six-figure salary value.

Six-figure earners living in El Paso see the greatest amount in take-home pay statewide, according to SmartAsset, with residents making $89,114 annually after taxes and expenses in 2025. That's $274 more than 2024's take-home pay.

The three additional Texas cities where a $100,000 salary goes the furthest after taxes and expenses are:

  • No. 3 – Corpus Christi ($88,015)
  • No. 6 – Lubbock ($86,846)
  • No. 7 – San Antonio ($86,084)

Six-figure salaries don't stretch as far in Dallas-Fort Worth. An annual $100,000 salary in Dallas is worth only $77,197 after taxes and expenses, which is about $900 less than what six-figure-earning Dallasites brought home in 2024.

Those living in Plano are taking home even less: The study says a Plano resident's six-figure salary is only worth $71,372 in 2025.

In the report's rankings of U.S. cities where $100,000 is worth the least, Plano ranked at No. 26, while Dallas ranked 38th.

SmartAsset used its paycheck calculator to apply federal, state and local taxes to an annual salary of $100,000 in 69 of the largest American cities, which was then adjusted for the local cost of living (which included average costs for housing, groceries, utilities, transportation, and miscellaneous goods and services).

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A version of this story originally appeared on sister site, CultureMap.com.

Houstonians get to keep a good bit of cash in their pockets. Photo by Jacob Power

Houston declared one of the most affordable places to live and work in 2019

Bayou City Banks

A new study indicates it's worth it to live and work in Houston. The study, done by BusinessStudent.com, puts Houston among the country's 25 most affordable places to live and work for 2019.

Four other Texas cities appear ahead of Houston in the report: Fort Worth (No. 7), College Station (No. 18), Irving (No. 21), and Dallas (No. 22). Noticeably absent from the top 25 are Austin and San Antonio.

"Making a high salary is great," BusinessStudent.com points out, "but if rents are so high that you have very little disposable income left over, are you going to be able to put money away for a rainy day?"

"Obviously," the website adds, "a person's individual cultural and social tastes should also be considered, but from a purely financial standpoint, it would be wise to consult this list ... before you begin your next job or home search."

To come up with its list, BusinessStudent.com examined salaries for 100 business-related jobs on Indeed.com and compared them with the average rent of a two-bedroom apartment listed on Rentjungle.com. In the top three positions on BusinessStudent.com's affordability list are Tulsa, Oklahoma; Lexington, Kentucky; and Oklahoma City, Oklahoma.

The study found that in Houston, residents had 79 percent of their salary left after paying rent. That's based on an average annual salary of $79,579 and average monthly rent of $1,401.

Fort Worth residents have it the best in Texas, with 82 percent of their salary left after housing costs, with an average annual salary of $75,797 and rent of $1,108. In College Station, 80 percent of the average salary ($55,086) remained after paying rent ($906 a month).

In Irving, 79 percent of the average annual salary ($77,527) was left after paying rent ($1,327 a month). Dallas had the same share of salary remaining after paying rent (79 percent), but the average salary ($82,609) and average rent ($1,422) were considerably higher than Fort Worth or Irving — and slightly higher than Houston.

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This story originally appeared on CultureMap.

The study examined used the average annual salary for white-collar "business" jobs in Houston. Photo by Zview/Getty Images

Salaries stretch further in Houston than most metros

Bayou city banks

It truly pays to live and work in Houston. A new ranking from BusinessStudent.com puts the Bayou City — and Dallas and Fort Worth, too — among the top 10 places in the U.S. for stretching your salary.

To come up with its ranking, BusinessStudent.com examined the average annual salary for 127 white-collar "business" jobs listed on career website Indeed — such as HR director, marketing manager, and IT manager — and subtracted the average rent for a two-bedroom apartment, based on data from apartment search website Rent Jungle. According to that measure, Houston is No. 7. Dallas is tops in the Lone Star State at No. 4, while Fort Worth is No. 9.

In all, BusinessStudent.com sifted through data for 65 major U.S. markets.

"When deciding where to work and live, it is critical to look at more than just what salary you can make," BusinessStudent.com says. "Because if rents are sky high, you may net out at zero, or even worse with mounting credit card debt."

The BusinessStudent.com study calculated an average yearly salary of $79,579 in Houston and an average monthly rent of $1,401 for a two-bedroom apartment. The difference: $62,767.

BusinessStudent.com also computed an average yearly salary of $82,609 in Dallas and average monthly rent of $1,422 for a two-bedroom apartment. That resulted in a difference of $65,545, behind Palo Alto and San Jose, both in Northern California, and Detroit.

In Houston, at least, all types of workers are benefiting from stable rent growth. According to apartment search website Apartment List, the growth of rent for a two-bedroom apartment in Houston has gone up 3.6 percent over the past year, 0.8 percent in Austin, 0.4 percent in San Antonio, flat in Dallas, and 1.8 percent statewide.

For Fort Worth, the average yearly salary for a white-collar job added up to $75,797, according to BusinessStudent.com, with average monthly rent of $1,108 for a two-bedroom apartment. That left a gap of $62,501.

Aside from Houston, Dallas, and Fort Worth, Irving (No. 12) and Plano (No. 19) showed up in BusinessStudent.com's top 25.

In Irving, BusinessStudent.com discovered the average yearly salary was $77,527, with average monthly rent of $1,327 for a two-bedroom apartment. The difference was $61,603.

Plano had an average yearly salary of $75,988, with average monthly rent of $1,350 for a two-bedroom apartment. The gap: $59,788.

At the other end of the spectrum, College Station ranked No. 1 in the country for the lowest after-rent salary. There, the average yearly salary for a white-collar job was calculated at $55,086, with average monthly rent of $906 for a two-bedroom apartment. The leftover amount: $44,214.

San Antonio was the only other Texas city in the bottom 25. In the Alamo City, the average yearly salary was computed as $67,195, with average monthly rent of $1,195 for a two-bedroom apartment. The difference: $52,855. That put San Antonio at No. 12 among the bottom 25.

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This story originally appeared on CultureMap.

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Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

5+ must-know application deadlines for Houston innovators

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Editor's note: As 2026 ramps up, the Houston innovation scene is looking for the latest groups of innovative startups that'll make an impact. A number of accelerators and competitions have opened applications. Read below to see which might be a good fit for you or your venture. And take careful note of the deadlines. Please note: this article may be updated to include additional information and programs.

Did we miss an accelerator or competition accepting applications? Email innoeditor@innovationmap.com for editorial consideration.

2026 HCC Business Plan Competition

Deadline: Jan. 26

Details: HCC’s annual Business Plan Competition (BPC) is an opportunity for proposed, startup and existing entrepreneurs to develop focused plans to start or grow their businesses. Accepted teams will be announced and training will begin in late February and run through early June, with six free, three-hour training sessions. Advising will be provided to each accepted team. Applicants can apply as a team of up to five persons. Finalists will present to to gudges on May 27, 2026. Last year, $26,000 was awarded in seed money to the top five teams. In-kind prizes were also awarded to all graduating teams including free products, services and memberships, with an estimated in-kind value totaling $147,000. Find more information here.

University of Houston Technology Bridge Innov8 Hub (Spring 2026)

Deadline: Jan . 30

Details: UHTB Innov8 Hub’s immersive, 12-week startup acceleration program designed to help early-stage founders launch and scale their technology startups. Selected participants will gain access to expert mentors and advisors, collaborate with a cohort of peers, and compete for cash prizes during our final pitch event. The cohort begins Feb. 16, 2026. The program culminates in Pitch Day, where participants present their ventures to an audience of investors and partners from across the UH innovation ecosystem. Find more information here.

Rice Business Plan Competition 2026

Deadline: Jan. 31

Details: The Rice Business Plan Competition, hosted by the Rice Alliance for Technology and Entrepreneurship, gives collegiate entrepreneurs real-world experience to pitch their startups, enhance their business strategy and learn what it takes to launch a successful company. Forty-two teams will compete for more than $1 million in cash, investments and prizes on April 9-11, 2026. Find more information here.

Rice Veterans Business Battle 2026

Deadline: Jan. 31

Details: The Rice Veterans Business Battle is one of the nation’s largest pitch competitions for veteran-led startups, providing founders with mentorship, exposure to investors and the opportunity to compete for non-dilutive cash prizes. The event has led to more than $10 million of investments since it began in 2015. Teams will compete April 8-9, 2026. Find more information here.

TEX-E Fellows Application 2026-2027

Deadline: Feb. 10

Details: The TEX‑E Fellowship is a hands-on program designed for students interested in energy, climate, and entrepreneurship across Texas. It connects participants with industry mentors, startup founders, investors and academic leaders while providing practical, "real-world" experience in customer discovery, business modeling, and energy-transition innovation. Fellows gain access to workshops, real-world projects, and a statewide network shaping the future of energy and climate solutions. Participants must be a student at PVAMU, UH, UT Austin, Rice University, MIT or Texas A&M. Find more information here.

2026 Energy Venture Day & Pitch Competition

Deadline: Feb. 13

Details: The Rice Alliance, the Houston Energy Transition Initiative (HETI) and TEX-E will present the annual Energy Venture Day and Pitch Competition during CERAWeek on March 24-25, 2026. Energy Venture Day features two days of presentations by energy tech ventures driving efficiency and advancements toward the energy transition. On March 24, the Pitch Preview at the Ion will feature over 50 companies presenting in front of Rice Alliance's robust network of investors and industry partners. On March 25, the Energy Venture Day and Pitch Competition during CERAWeek will showcase 36 ventures at the George R Brown Convention Center. The pitch competition is divided up into the TEX-E university track, in which Texas student-led energy startups compete for $50,000 in cash prizes, and the industry ventures track. The industry track is subdivided into three additional tracks, spanning materials to clean energy. The top three companies from each industry track will be named. The winner of the CERAWeek competition will also have the chance to advance and compete for the $1 million investment prize at the Startup World Cup. Find more information here.

Greentown Go Make 2026

Deadline: March 10

Details: Greentown Go Make 2026 is an open-innovation program with Shell and Technip Energies. The six-month program is advancing industrial decarbonization by accelerating catalytic innovations. Selected startups will gain access to a structured platform to engage leadership from Shell and Technip Energies and explore potential partnership outcomes, including pilots and demonstrations. They’ll also receive networking opportunities, partnership-focused programming, and marketing visibility throughout the program. The cohort will be selected in May. Find more information here.

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