3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Ryan Sitton of Pinnacle, Julia P. Clarke of Raba Kistner Inc., and Phillip Yates of Equiliberty. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from data analysis to fintech — recently making headlines in Houston innovation.

Ryan Sitton, CEO of Pinnacle

Ryan Sitton joins the Houston Innovators Podcast to discuss his career in data and reliability. Photo courtesy of Ryan Sitton

Data analysis for big industry came first — before the technology that can support this analysis even entered the scene. Ryan Sitton, CEO and founder of Pinnacle, a Houston company that offers its clients streamline data management, joined the Houston Innovators Podcast to discuss his passion is using data to drive better decision making to drive more sustainable and reliable operations.

"I was basically doing data analytics in the mid 2000s before it was sexy. I was pulling together data in chemical plants and refineries and trying to predict how these plants would behave with the data I had," Sitton says. "I realized early on how there was so much opportunity here — but we don't have the technologies or the methodology to do it."

But over the years, the technology has caught up and now Sitton is able to provide clients with even more data-driven solutions. Click here to read more.

Julia P. Clarke, senior geotechnical manager in Houston at Raba Kistner Inc.

Julia P. Clarke knows what it's like to be the only woman in a room. Photo courtesy of Raba Kistner

Women in STEM are in Houston, writes Julia P. Clarke, an engineer at a local firm in town, but there's work to be done to making them stay. Supporting women across the science, technology, engineering, and mathematics fields begins in the classroom, she writes in a guest column for InnovationMap.

"I grew up in Jamaica and then immigrated to the United States. It wasn't until I was recognized by my high school teacher, Mrs. Owens, for my natural ability to excel in subjects like science and math that I fell in love with the basis of engineering," she explains. "Without the mentorship and investment of teachers and professionals throughout my career, I would not be where I am today." Click here to read more.

Phillip Yates, founder of Equiliberty

This founder is bridging the wealth gap for Black Houstonians. Photo courtesy of Equiliberty

Phillip Yates, a Houston-area attorney, envisioned a company that could solve the societal problems that perpetuate poverty. He started Equiliberty, a technology company that's part financial resource and part social network, to help provide underrepresented individuals with educational resources to secure financial success and a space to use their talents to create community-driven wealth.

The platform provides business development services, educational resources, access to capital, and mentorship to help users find financial independence.

"When I created Equiliberty, I envisioned a world where everybody has access to mentors," said Yates in a press release. "I know firsthand the importance of having a supportive network and community dedicated to your success." Click here to read more.

Ryan Sitton joins the Houston Innovators Podcast to discuss his career in data and reliability. Photo courtesy of Ryan Sitton

This Houston innovator is using data to power industrial reliability and sustainability

HOUSTON INNOVATORS PODCAST EPISODE 92

Ryan Sitton has had a varied career so far. Formerly working in oil and gas, he started his own company in 2006 to help companies to better utilize their data. Now, still leading Houston-based Pinnacle as CEO, Sitton works with the world's largest companies to solve their problems with data. He also served as Texas Railroad Commissioner and has written two books about decision-making and leadership.

Sitton joined the Houston Innovators Podcast to discuss how, despite the multiple hats he wears, at the core of his passion is using data to drive better decision making to drive more sustainable and reliable operations.

"I was basically doing data analytics in the mid 2000s before it was sexy. I was pulling together data in chemical plants and refineries and trying to predict how these plants would behave with the data I had," Sitton says. "I realized early on how there was so much opportunity here — but we don't have the technologies or the methodology to do it."

But over the years, the technology has caught up and now Sitton is able to provide clients with even more data-driven solutions.

"We go into the biggest companies of the world that are trying to have more reliability at the same time as lowering cost," Sitton explains. "We build models that pull together literally millions of pieces of data and we do a combination of engineering analysis and data analysis and data science to give them better predictions — better ways to run their facilities so that they are more sustainable and more profitable."

Sitton's two books — Crucial Decisions, which is out now, and the Myth of Status, which is coming later this year — also center around decision making and leadership.

He shares more about his time at the Texas Railroad Commision and shares how COVID-19 affected business — as well as shares his advice for startups tapping into data-driven solutions — on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


Ryan Sitton's new book, "Crucial Decisions," touches on an array of topics and how data is the key to making the positive and impactful decisions. Photo via Getty Images

Houston energy expert on how big data yields more reliable results

Guest column

Abraham Maslow's hierarchy of need tells us that at our core, humans crave safety and sustenance. When you turn on the light each morning while getting ready for work, or when you check your bank account and see your paycheck arrived on schedule, we expect every aspect of our daily lives to work.

In today's world, we often take these things for granted, until reliability is threatened. Our dependency is revealed in the frenzy over a potential toilet paper shortage and in the panic buying of gasoline in a hurricane. When things in society are consistent, economies thrive. However, when you introduce fear and uncertainty, things begin to spiral. It is in these times that the decisions we make can have the biggest impact on the world around us.

The link between impactful decisions and reliability has brought our society to a pivotal moment in history. We have created a society so reliable and developed that even during the coronavirus lockdown, the basic needs of Americans could be met with only 25 percent of our workforce actively working. By increasing productivity using machines and systems, we have been able to improve our overall quality of life, but not without a price. As a result of such high improvement, we as a society have come to not only expect, but demand, reliability at all times.

When dependability waivers and anxiety rises, those in key decision-making positions are faced with unprecedented situations. Due to distress and a lack of understanding of certain situations, those in decision making positions are often times forced to make decisions based on rapid response and emotion. Because of this, consistency and reliability suffer.

A prime example of an emotional response is the coronavirus shutdown that occurred earlier this year. As a response to the growing fear and panic over the virus, major portions of our economy were shut down; schools were closed; and citizens were confined to their homes.

What followed was the bankruptcy of thousands of businesses, an unprecedented wave of fear throughout society and a disruption to the consistency of our daily lives. We have yet to know what lasting impacts this decision will have on our future economy or livelihood, but we now understand that rapid decision making is often met with long-term consequences.

While there will continue to be disagreements on all sides regarding the handling of the shutdown, what is undisputable is that we as a society have gained an opportunity to learn. We now have the unique advantage of using data in ways that has never been used before in order to make consistently better decisions, allowing us the opportunity to perform at levels we have never thought possible.

Whether it be data advancements in sports (think Billy Beane and the Oakland Athletics), or the progression of technology (continuous iPhone updates), we are able to study the improvements of data on society in order to make more reliable decisions. With more powerful data analytics and innovations in data sciences, we are able to positively impact the most vital components of our society in order to make decisions that will drive evolution and reliability.

As the world continues to progress, the decisions we are forced to make have become more complex. With each complicated decision comes the potential for lasting positive or negative impact on society. In shifting from emotional, rapid reactions towards more data and quantitative focused methods, we have the unique and unprecedented opportunity to make our world a more reliable, stable and creative place.

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Ryan Sitton is the founder of Pinnacle and the author of "Crucial Decisions."

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.

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