Daniel Barvin has a neurodegenerative disease in his near future. He joined Houston-based Coya Therapeutics to help fight for a cure to the aggressively deadly ALS. Photo via Getty Images

We can never predict how our lives will turn out, but then maybe some of us can. Genetic testing showed that I, like my grandfather, aunt, uncle and father before me, would most likely die of amyotrophic lateral sclerosis, more commonly known as ALS, and/or frontotemporal degeneration (FTD) in my 40s.

Being 36, it’s possible that fear could have overtaken my life, but instead I chose to fight for every chance to change not only my life, but the lives of millions who are suffering or may one day suffer from neurodegenerative disease.

ALS is a rare disease that robs one of their ability to control their muscles, leading them to lose their ability to walk, talk and eventually breathe. Eighty percent of cases are sporadic (of unknown origin) and 20 percent have known genetic causes.

When I learned that I carried the C9ORF72 genetic variant, a causative genetic variant for ALS/FTD) my first instincts were to help others understand their status and where they could turn for help. I saw a vacuum for resources and understanding in the genetic ALS space and I knew that thousands were suffering in darkness.

Through the efforts of many, we created the first ever nonprofit – Genetic ALS & FTD: End the Legacy – focused on fighting for the genetic ALS and FTD communities. After making great strides to fight for our rights and access to care, I was asked if I could help my current CEO, Howard Berman, commercialize Dr. Stanley Appel’s regulatory T Cell (Treg) therapy for ALS.

I joined Coya Therapeutics in 2021 as the first employee, working to build a company that would one day bring life changing therapies to patients. Coya’s therapies are based on Dr. Appel’s discovery that neurodegenerative diseases drive an inflammatory response. As inflammation rises, it damages regulatory T cells, and when Tregs are damaged, inflammation becomes a persistent condition driving degeneration and eventually death.

It was at that point that my life changed from the advocacy world to the therapeutic world. Now over three years later, we are closer than ever to making a paradigm change for how patients with ALS and other neurodegenerative diseases are treated.

At Coya, we believe that combination biologics are the future of treating neurodegenerative diseases. COYA 302 is our lead asset, which has shown promising results in a proof-of-concept study released in March of 2023. We are currently working towards a double-blind, placebo-controlled trial for COYA 302 in ALS set to kick off later this year.

I never wanted to live a life so damned by disease, but when put between a rock and a hard place, the only choice is to fight. I don’t know how my life will end, but I hope that my children will know that I faced a great challenge head on with pride and resilience.

In the end, it is the combination of both the worlds I work in that lead to better outcomes for patients, raising awareness and lifesaving research. This ALS Awareness Month, please join us and our partners like the ALS Association, End the Legacy, and I AM ALS in raising awareness about these conditions, their risks, and treatment options.

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Daniel Barvin is the vice president of operations and patient advocacy at Coya Therapeutics.

A Rice University study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding." Photo courtesy of Kinder Institute

Rice University secures NSF support to look into Houston flooding

troubled waters

Houston will be the setting of a new three-year National Science Foundation-funded study that focuses on a phenomenon the city is quite familiar with: flooding.

Conducted by Rice University, the study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding," according to a statement.

The team will begin its research in the Trinity/Houston Gardens neighborhood and will implement field research, participatory design work and hydrological impact analyses.

Rice professor of anthropology Dominic Boyer and Rice's Gus Sessions Wortham Professor of Architecture Albert Pope are co-principal investigators on the study. They'll be joined by Phil Bedient, director of the Severe Storm Prediction, Education and Evacuation from Disasters Center at Rice, and Jessica Eisma, a civil engineer at the University of Texas at Arlington.

According to Boyer, the study will bring tougher researchers from across disciplines as well as community members and even elementary-aged students.

"Our particular focus will be on green stormwater infrastructure—techniques like bioswale, green roofs and rain gardens—that are more affordable than conventional concrete infrastructure and ones where community members can be more directly involved in the design and implementation phases,” Boyer said. “We envision helping students and other community members design and complete projects like community rain gardens that offer a variety of beneficial amenities and can also mitigate flooding.”

Rice's Severe Storm Prediction, Education and Evacuation from Disasters Center, or SSPEED Center, is a leader in flood mitigation research and innovation.

In 2021, the center developed its FIRST radar-based flood assessment, mapping, and early-warning system based on more than 350 maps that simulate different combinations of rainfall over various areas of the watershed. The system was derived from the Rice/Texas Medical Center Flood Alert System (FAS), which Bedient created 20 years ago.

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This article originally ran on EnergyCapital.

Houston Community College and its partner received funding that will go toward creating a certificate program that will launch in the fall 2022 semester as part of The Resilient Workforce Collaborative. Photo via HCC

Houston college system snags part of $3.3M investment in resiliency innovation

impact investment

Houston Community College and partners received a $1.8 million grant from JP Morgan Chase this month with the goal of training underserved Houstonians in jobs that will help boost the city's preparedness for the aftermath of natural disasters.

The funds will go toward creating a certificate program that will launch in the fall 2022 semester as part of The Resilient Workforce Collaborative.

“The Resilient Workforce Collaborative brings together the public sector, private sector, higher education institutions, and our nonprofit partners to make transformational change in our most underserved neighborhoods,” Mayor Sylvester Turner says in a statement. “The collaborative complements our efforts within the Complete Communities to prepare low-to-moderate income Houstonians for high-demand jobs and increase the diversity of candidates in the talent pipelines for green careers that will advance our city’s resilience. This resourceful partnership is a welcomed addition to Houston’s workforce development landscape.”

The collaborative will operate out of HCC's Resiliency Center of Excellence, which was first announced in May and is slated to open its $35 million Resiliency Operations Center at HCC's Northeast College in 2024. Other members of the collaborative include City of Houston, Harris County, Workforce Solutions Gulf Coast, Resilience Innovation Hub, American Youth Works, WorkTexas, TRIO Electric, TRIO Education, Memorial Assistance Ministries, South Union CDC, Impact Hub Houston, Neuhaus Education Center, TXRX Labs, Volunteers of America-TX, Wesley Community Center, and JPMorgan Chase.

The program will aim to help residents who come from some of Houston’s most underserved and under-resourced neighborhoods find career opportunities in the clean energy, disaster response, utilities, trades and manufacturing fields. According to HCC, "an important element of the collaborative is employers changing some of their hiring practices to emphasize specialized training certificates over traditional 4-year degrees."

So far, partnering employers include The City of Houston, Harris County and TRIO Electric—and the collaborative is looking for more employers and funders to support its mission.

“This collaborative provides a ‘go-to place’ for Houstonians to learn skills that will lead to good paying jobs. It is a better system because it’s set up to fulfill needs that already exist in the workplace,” HCC Chancellor Cesar Maldonado said in a statement.

HCC and the City of Houston signed a memorandum of understanding in August, on the five-year anniversary of Hurricane Harvey, that the organizations would train 500,000 citizens, employees, small businesses, volunteers, and first responders in new resiliency training programs starting this fall.

At the time, seven courses in resiliency were announced, with an additional 30 courses slated to be added in 2023. The program will be offered at 22 HCC locations.

A Rice University professor has developed a new early warning system and planning tool for the city of Houston. Photo courtesy of Kinder Institute

Rice University debuts new flood alert system for Houston

water feature

It's no secret: certain areas around Houston are at a high risk of flooding. And risks associated with such natural disasters become even more substantial in the middle of a pandemic.

"What if first responders have to go to a shelter, a nursing home, or another facility where there's COVID, right in the middle of a flood," Phil Bedient, director of Rice University's Severe Storm Prediction, Education and Evacuation from Disasters (SSPEED) Center, asks in a statement.

His solution? To develop a new early warning system and planning tool for the city of Houston to help hospitals and other critical facilities on the watersheds of Brays, Sims, Hunting and White Oak bayous respond.

"The idea is to provide a tool that can help emergency managers better deal with situations with multiple risks," he says.

Dubbed the Flood Information and Response System (FIRST), the tool is a radar-based flood assessment, mapping, and early-warning system based on more than 350 maps that simulate different combinations of rainfall over various areas of the watershed. The maps are compared to a weather radar and stream gauges on the bayous to alert users of likely scenarios during a weather event.

FIRST was derived from the Rice/Texas Medical Center Flood Alert System (FAS), which Bedient created 20 years ago. The latest iteration, FAS5, debuted in 2020. Since the product's creation it has accurately alerted users in more that 60 storms and has warned hospital officials in the TMC of the threat of rising water in the area more than two hours before it would eventually occur, according to a statement.

FIRST was funded by federal CARES Act dollars and commissioned by the Houston Health Department, following concerns that overflows at wastewater treatment plants could potentially expose communities to the COVID-19, Loren Hopkins, chief environmental science officer for the Houston Health Department and professor in the practice of statistics at Rice, says in a statement.

"The FIRST model assessed what areas and facilities are at highest risk of overflows that could spread SARS-CoV-2 and other pathogens during flooding and similar events," Hopkins added. "During a flood, the information gained through this system will inform the public health response to control the spread of pathogens that could make people sick."

CARES funds for FIRST's development were approved in the fall and Rice University undergraduates jumped at the opportunity to build out the product by the December 31 deadline, using hydrologic software and maps they had created with training from Bedient about a year prior.

"They performed herculean tasks," Bedient says. "Our deadline was hard and fast, and they helped us deliver the operational project and report on time."

FIRST was reported to have worked well during May's deluge, and will continue to be refined as more data, storms, and floodwaters arise. A demo is available to test online.

Houston has proven to be resilient time and time again. In a guest column, Amy Chronis explores if 2020 has the potential to be Clutch City's breaking point. Photo via Pexels

Clutch City: Is 2020 a time of devastation or doubling down for Houston?

guest column

"Clutch City" may be Houston's most befitting nickname — and it has proven to stand the test of time. Whoever coined the term likely had no idea in how many ways this moniker would be tested and upheld over the next 20-plus years.

Time and time again the fourth largest city in America has proven to be resilient, whether it be a natural catastrophe, tough economic times or the global pandemic. But, will the multi-dimensional stresses of 2020 break the city's winning streak?

Houston is also well known for being The Energy Capital of the World, a qualifier that has meant record revenue and jobs growth, as well as weathering several oil and gas economic down cycles. While the city has taken many hits from previous downturns, it has always been able to recover. The oil, gas and chemicals downturn of 2020, however, is unlike anything we've ever seen before — and could fundamentally transform the energy industry, as well as Houston's economy.

This year, the industry has been grappling with the energy transition while it is also is facing the "Great Compression," sustained low oil prices on top of diminished oil demand from the global pandemic, and the "Great Crew Change." The confluence of these simultaneous challenges could have profound impacts on the workforce and future of work in the oil, gas and chemicals industry. According to Deloitte's latest report, 70 percent of jobs in the industry lost during the pandemic may not return by the end of 2021.

The silver lining "clutch" play may be that Houston already has been on the path and is continuing to diversify its businesses, even within the energy and industrial sectors. The Greater Houston Partnership touts Houston's key industries beyond energy, including advanced manufacturing, aerospace and aviation, life sciences and biotechnology, digital technology and transportation and logistics. Notably, the common thread linking these industries is the need for greater digitalization of and within business models.

The encouraging news is that Houston has anticipated this need and factored it into its future planning. For example, the development of Ion Houston is designed to be the anchor of a 16-plus acre Innovation District in Houston dedicated to innovation, entrepreneurship and technology. This could be the type of investment the city needs to focus on as we grapple with a hard-hit economy. At this point, it is beyond choosing to prioritize moving to what's been called Industry 4.0 — digitalization should be a priority for companies wanting to survive and stay competitive.

According to an analysis conducted by the Greater Houston Partnership of the largest Texas cities, the following sectors had the most VC deals in technology over the last 20 years: life science, oil and gas, oncology, B2B payments, infrastructure and FemTech. The analysis also showcased the top niche tech specialties outside of oil and gas spanned multiple industries including life sciences, legal, space, environmental and FinTech. Houston's dual effort of industry diversification and focus on digitalization has been prescient.

COVID-19 has further accelerated the importance for companies across sectors to get on the fast track to Industry 4.0. The time for transformation is now. The oil, gas and chemicals sector, as well as all sectors, should start building a workforce for the future in order to survive and break the barriers to entry to Industry 4.0. This effort typically includes attracting people across generations by promoting sustainability, offering new digital ways of working, making flexible/remote working a permanent reality while building a sense of pride amongst the workforce toward the work product and organization itself.

Organizational agility is one way through this downturn. Challenging traditional ways of thinking and functioning will likely be required for companies to remain competitive.

The advance work and planning Houston has undertaken to diversify its economy by expanding its industries and focusing on digitalization and the future of workforce, together may ensure that we keep Houston strong and that the "Clutch City" lives up to its name.

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Amy Chronis is the Houston managing partner at Deloitte.

Mayor Sylvester Turner was just named chairman of the Resilient Cities Network. Photo courtesy of The Ion

Mayor Turner recognized nationally for progress of moving Houston toward resiliency

Turner's plans

In the past five years, six federally declared flooding disasters have wreaked havoc in Houston — most notably Hurricane Harvey in 2017. Now, you might say Houston stands tall as a hub of resilience when it comes to disaster preparedness and myriad other pressing issues.

The Texas chapter of the American Planning Association recently honored Mayor Sylvester Turner's Resilient Houston initiative as the top entry in the resilience category of the chapter's annual awards program. In addition, Turner was just named chairman of the Resilient Cities Network.

With backing from Shell Oil Co., the City of Houston hired its first chief resilience officer, Marissa Aho, in 2019 and developed a multibillion-dollar resilience strategy to address threats from hurricanes, tropical storms, floods, and climate change. The plan also seeks to boost the resilience of Houston's economy, neighborhoods and natural resources.

"Our efforts need to be bold, transformative, and aligned to achieve the outcomes Houstonians deserve," Turner said in unveiling the resilience plan in February. "Resilient Houston is a framework for transformative change that comes from thinking and acting together to build and grow Houston's long-term resilience. We will need our partners and every Houstonian at the table to achieve this vision."

Dallas and El Paso also have resilience plans in place.

Houston's resilience effort outlines a number of ambitious goals, such as:

  • Updating city building codes and standards by 2030 to reduce damage from disasters.
  • Attracting or incubating 50 Energy 2.0 companies in the Houston area by 2025.
  • Planting 4.6 million new native trees by 2030.
  • Building at least 375,000 homes in Houston for all income levels by 2050.
  • Providing all Houstonians with easy access to high-frequency public transportation by 2050.

As explained by Rice University's Kinder Institute for Urban Research, hurricanes and floods are examples of "acute shocks" in terms of resilience. These are sudden, large-scale events that disrupt and endanger life. Other shocks include economic crisis, cyberattacks, terrorism, chemical disasters, and extreme heat.

The Kinder Institute points out that Houston's resilience strategy not only addresses these shocks but also takes on "chronic stresses" that hamper recovery from these shocks. Those stresses include poor air quality, health disparities, crime, economic inequality, urban sprawl, and limited access to education.

"Stresses do not impact every Houstonian the same way," says the institute, which helped develop the Resilient Houston project.

Startups participating in Houston's Ion Smart and Resilient Cities Accelerator are tackling many of the same challenges that Resilient Houston is. The accelerator's second cohort launched in April with six startups.

Funded by Microsoft Corp. and Intel Corp., the accelerator "is committed to solving challenges Houstonians face every day," Christine Galib, director of the accelerator, said in an April release. "We connect participating startups with mentors, partners, and stakeholders so they gain access to the resources they need to build, validate, and scale their technologies. Together, we are building a safer, smarter, and more accessible city for all Houstonians."

Houston's push for resilience meshes with Turner's new role as chairman of the Resilient Cities Network. The network is a global city-led nonprofit that aims to "empower cities to help them build a safe, equitable, and sustainable future for all."

"The reach, achievements, and vision of the Resilient Cities Network are impressive. I'm honored to be part of an organization that supports the critical needs of vulnerable communities by implementing projects that address multiple shocks and stresses and are improving the lives of people," Turner says in a release.

Among other goals, the network strives to strengthen local economies and bolster local campaigns to combat climate change.

Supported by $1.8 million from Shell, the City of Houston joined the Resilient Cities Network in August 2018. Houston is the U.S. headquarters for Shell.

"A year after Hurricane Harvey, Houstonians can clearly say we didn't let the storm get the best of us. Nevertheless, there's still work to be done across a wide range of challenges that we share as a community," Bruce Culpepper, who then was president and U.S. chairman of Shell, said in a 2018 release about his company's backing of Resilient Houston.

"Building long-term resiliency is much more than disaster response," Culpepper added. "It's about enabling the people of our city to thrive."

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Houston VC funding surged in Q1 2025 to highest level in years, report says

by the numbers

First-quarter funding for Houston-area startups just hit its highest level since 2022, according to the latest PitchBook-NVCA Venture Monitor. But fundraising in subsequent quarters might not be as robust thanks to ongoing economic turmoil, the report warns.

In the first quarter of 2025, Houston-area startups raised $544.2 million in venture capital from investors, PitchBook-NVCA data shows. That compares with $263.5 million in Q1 2024 and $344.5 million in Q1 2023. For the first quarter of 2022, local startups nabbed $745.5 million in venture capital.

The Houston-area total for first-quarter VC funding this year fell well short of the sum for the Austin area (more than $3.3 billion) and Dallas-Fort Worth ($696.8 million), according to PitchBook-NVCA data.

While first-quarter 2025 funding for Houston-area startups got a boost, the number of VC deals declined versus the first quarters of 2024, 2023 and 2022. The PitchBook-NVCA Monitor reported 37 local VC deals in this year’s first quarter, compared with 45 during the same period in 2024, 53 in 2023, and 57 in 2022.

The PitchBook-NVCA report indicates fundraising figures for the Houston area, the Austin area, Dallas-Fort Worth and other markets might shrink in upcoming quarters.

“Should the latest iteration of tariffs stand, we expect significant pressure on fundraising and dealmaking in the near term as investors sit on the sidelines and wait for signs of market stabilization,” the report says.

Due to new trade tariffs and policy shifts, the chances of an upcoming rebound in the VC market have likely faded, says Nizar Tarhuni, executive vice president of research and market intelligence at PitchBook.

“These impacts amplify economic uncertainty and could further disrupt the private markets by complicating investment decisions, supply chains, exit windows, and portfolio strategies,” Tarhuni says. “While this may eventually lead to new domestic investment and create opportunities, the overall environment is facing volatility, hesitation, and structural change.”

Expert: Texas is building a cybersecurity wall — but it needs more bricklayers

Guest Column

Texas has always been a state that thinks in terms of scale. Big energy, big ambitions and now, big action in cybersecurity.

With the creation of the Texas Cyber Command under the Department of Information Resources, the state is recognizing what many of us in the industry have long understood: cybersecurity is not just an IT issue, it's a matter of public safety and economic resilience. Protecting municipal systems, schools, and critical energy infrastructure from cyber threats is no longer optional. It is essential.

For these efforts to succeed, Texas must invest as much in people as it does in technology. Without a capable, well-trained workforce to carry out the mission, even the strongest cyber strategies will struggle to hold the line.

The scope of the threat

Cyberattacks are not theoretical. In the last year alone, several cities in Texas experienced major ransomware attacks. One incident in Fort Worth took down core city systems, affecting everything from email access to permitting operations. The ripple effects were significant.

The energy sector is also under constant pressure. As a cornerstone of both the Texas and national economy, the it is a high-value target. Hackers are probing systems that manage oil, gas, and renewable energy infrastructure, looking for weaknesses that could be exploited to steal data or disrupt operations.

Texas has responded by centralizing its cyber incident response capabilities. The Texas Cyber Command is a smart step forward. It brings coordination and focus to an increasingly complex landscape. But its effectiveness will depend entirely on the professionals tasked with doing the work. And that’s where the challenge lies.

The workforce gap

Across the U.S., there are an estimated 400,000 unfilled cybersecurity positions. In Texas, more than 40,000 roles remain vacant, according to CyberSeek. These are not just numbers in a report. They represent a growing vulnerability with gaps in frontline defenses against real and persistent threats.

We cannot afford to rely solely on traditional pathways to fill this gap. Four-year degree programs are important, but they are not designed to scale fast enough or flexibly enough to meet today’s needs. Instead, we need to broaden our view of what a cybersecurity talent pipeline looks like and who it includes.

There needs to be an expanded focus on practical, skills-based training that takes high-aptitude individuals, including those from non-traditional backgrounds, and prepares them for success in cybersecurity careers through rigorous hands-on training that reflects the demands of real-world cyber roles. With the right structure and support, people from all walks of life are already proving they can become capable defenders of our digital infrastructure.

The same entrepreneurial spirit that drives innovation in other sectors can be applied to cybersecurity workforce development. We don’t have to wait years to grow the next generation of defenders. We can do it now, with the right focus and investment.

Texas has taken a critical first step by creating the Cyber Command, but if we want to build lasting resilience, we need to address the workforce bottleneck head-on. Cybersecurity needs more than tech…it needs talent.

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Dean Gefen is theCEO, NukuDo, a San Antonio-based cybersecurity workforce development and staffing company.