How this Houston innovator is using his personal connection to ALS fuel his fight for a cure

guest column

Daniel Barvin has a neurodegenerative disease in his near future. He joined Houston-based Coya Therapeutics to help fight for a cure to the aggressively deadly ALS. Photo via Getty Images

We can never predict how our lives will turn out, but then maybe some of us can. Genetic testing showed that I, like my grandfather, aunt, uncle and father before me, would most likely die of amyotrophic lateral sclerosis, more commonly known as ALS, and/or frontotemporal degeneration (FTD) in my 40s.

Being 36, it’s possible that fear could have overtaken my life, but instead I chose to fight for every chance to change not only my life, but the lives of millions who are suffering or may one day suffer from neurodegenerative disease.

ALS is a rare disease that robs one of their ability to control their muscles, leading them to lose their ability to walk, talk and eventually breathe. Eighty percent of cases are sporadic (of unknown origin) and 20 percent have known genetic causes.

When I learned that I carried the C9ORF72 genetic variant, a causative genetic variant for ALS/FTD) my first instincts were to help others understand their status and where they could turn for help. I saw a vacuum for resources and understanding in the genetic ALS space and I knew that thousands were suffering in darkness.

Through the efforts of many, we created the first ever nonprofit – Genetic ALS & FTD: End the Legacy – focused on fighting for the genetic ALS and FTD communities. After making great strides to fight for our rights and access to care, I was asked if I could help my current CEO, Howard Berman, commercialize Dr. Stanley Appel’s regulatory T Cell (Treg) therapy for ALS.

I joined Coya Therapeutics in 2021 as the first employee, working to build a company that would one day bring life changing therapies to patients. Coya’s therapies are based on Dr. Appel’s discovery that neurodegenerative diseases drive an inflammatory response. As inflammation rises, it damages regulatory T cells, and when Tregs are damaged, inflammation becomes a persistent condition driving degeneration and eventually death.

It was at that point that my life changed from the advocacy world to the therapeutic world. Now over three years later, we are closer than ever to making a paradigm change for how patients with ALS and other neurodegenerative diseases are treated.

At Coya, we believe that combination biologics are the future of treating neurodegenerative diseases. COYA 302 is our lead asset, which has shown promising results in a proof-of-concept study released in March of 2023. We are currently working towards a double-blind, placebo-controlled trial for COYA 302 in ALS set to kick off later this year.

I never wanted to live a life so damned by disease, but when put between a rock and a hard place, the only choice is to fight. I don’t know how my life will end, but I hope that my children will know that I faced a great challenge head on with pride and resilience.

In the end, it is the combination of both the worlds I work in that lead to better outcomes for patients, raising awareness and lifesaving research. This ALS Awareness Month, please join us and our partners like the ALS Association, End the Legacy, and I AM ALS in raising awareness about these conditions, their risks, and treatment options.

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Daniel Barvin is the vice president of operations and patient advocacy at Coya Therapeutics.

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A Rice University study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding." Photo courtesy of Kinder Institute

Rice University secures NSF support to look into Houston flooding

troubled waters

Houston will be the setting of a new three-year National Science Foundation-funded study that focuses on a phenomenon the city is quite familiar with: flooding.

Conducted by Rice University, the study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding," according to a statement.

The team will begin its research in the Trinity/Houston Gardens neighborhood and will implement field research, participatory design work and hydrological impact analyses.

Rice professor of anthropology Dominic Boyer and Rice's Gus Sessions Wortham Professor of Architecture Albert Pope are co-principal investigators on the study. They'll be joined by Phil Bedient, director of the Severe Storm Prediction, Education and Evacuation from Disasters Center at Rice, and Jessica Eisma, a civil engineer at the University of Texas at Arlington.

According to Boyer, the study will bring tougher researchers from across disciplines as well as community members and even elementary-aged students.

"Our particular focus will be on green stormwater infrastructure—techniques like bioswale, green roofs and rain gardens—that are more affordable than conventional concrete infrastructure and ones where community members can be more directly involved in the design and implementation phases,” Boyer said. “We envision helping students and other community members design and complete projects like community rain gardens that offer a variety of beneficial amenities and can also mitigate flooding.”

Rice's Severe Storm Prediction, Education and Evacuation from Disasters Center, or SSPEED Center, is a leader in flood mitigation research and innovation.

In 2021, the center developed its FIRST radar-based flood assessment, mapping, and early-warning system based on more than 350 maps that simulate different combinations of rainfall over various areas of the watershed. The system was derived from the Rice/Texas Medical Center Flood Alert System (FAS), which Bedient created 20 years ago.

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This article originally ran on EnergyCapital.

Houston Community College and its partner received funding that will go toward creating a certificate program that will launch in the fall 2022 semester as part of The Resilient Workforce Collaborative. Photo via HCC

Houston college system snags part of $3.3M investment in resiliency innovation

impact investment

Houston Community College and partners received a $1.8 million grant from JP Morgan Chase this month with the goal of training underserved Houstonians in jobs that will help boost the city's preparedness for the aftermath of natural disasters.

The funds will go toward creating a certificate program that will launch in the fall 2022 semester as part of The Resilient Workforce Collaborative.

“The Resilient Workforce Collaborative brings together the public sector, private sector, higher education institutions, and our nonprofit partners to make transformational change in our most underserved neighborhoods,” Mayor Sylvester Turner says in a statement. “The collaborative complements our efforts within the Complete Communities to prepare low-to-moderate income Houstonians for high-demand jobs and increase the diversity of candidates in the talent pipelines for green careers that will advance our city’s resilience. This resourceful partnership is a welcomed addition to Houston’s workforce development landscape.”

The collaborative will operate out of HCC's Resiliency Center of Excellence, which was first announced in May and is slated to open its $35 million Resiliency Operations Center at HCC's Northeast College in 2024. Other members of the collaborative include City of Houston, Harris County, Workforce Solutions Gulf Coast, Resilience Innovation Hub, American Youth Works, WorkTexas, TRIO Electric, TRIO Education, Memorial Assistance Ministries, South Union CDC, Impact Hub Houston, Neuhaus Education Center, TXRX Labs, Volunteers of America-TX, Wesley Community Center, and JPMorgan Chase.

The program will aim to help residents who come from some of Houston’s most underserved and under-resourced neighborhoods find career opportunities in the clean energy, disaster response, utilities, trades and manufacturing fields. According to HCC, "an important element of the collaborative is employers changing some of their hiring practices to emphasize specialized training certificates over traditional 4-year degrees."

So far, partnering employers include The City of Houston, Harris County and TRIO Electric—and the collaborative is looking for more employers and funders to support its mission.

“This collaborative provides a ‘go-to place’ for Houstonians to learn skills that will lead to good paying jobs. It is a better system because it’s set up to fulfill needs that already exist in the workplace,” HCC Chancellor Cesar Maldonado said in a statement.

HCC and the City of Houston signed a memorandum of understanding in August, on the five-year anniversary of Hurricane Harvey, that the organizations would train 500,000 citizens, employees, small businesses, volunteers, and first responders in new resiliency training programs starting this fall.

At the time, seven courses in resiliency were announced, with an additional 30 courses slated to be added in 2023. The program will be offered at 22 HCC locations.

A Rice University professor has developed a new early warning system and planning tool for the city of Houston. Photo courtesy of Kinder Institute

Rice University debuts new flood alert system for Houston

water feature

It's no secret: certain areas around Houston are at a high risk of flooding. And risks associated with such natural disasters become even more substantial in the middle of a pandemic.

"What if first responders have to go to a shelter, a nursing home, or another facility where there's COVID, right in the middle of a flood," Phil Bedient, director of Rice University's Severe Storm Prediction, Education and Evacuation from Disasters (SSPEED) Center, asks in a statement.

His solution? To develop a new early warning system and planning tool for the city of Houston to help hospitals and other critical facilities on the watersheds of Brays, Sims, Hunting and White Oak bayous respond.

"The idea is to provide a tool that can help emergency managers better deal with situations with multiple risks," he says.

Dubbed the Flood Information and Response System (FIRST), the tool is a radar-based flood assessment, mapping, and early-warning system based on more than 350 maps that simulate different combinations of rainfall over various areas of the watershed. The maps are compared to a weather radar and stream gauges on the bayous to alert users of likely scenarios during a weather event.

FIRST was derived from the Rice/Texas Medical Center Flood Alert System (FAS), which Bedient created 20 years ago. The latest iteration, FAS5, debuted in 2020. Since the product's creation it has accurately alerted users in more that 60 storms and has warned hospital officials in the TMC of the threat of rising water in the area more than two hours before it would eventually occur, according to a statement.

FIRST was funded by federal CARES Act dollars and commissioned by the Houston Health Department, following concerns that overflows at wastewater treatment plants could potentially expose communities to the COVID-19, Loren Hopkins, chief environmental science officer for the Houston Health Department and professor in the practice of statistics at Rice, says in a statement.

"The FIRST model assessed what areas and facilities are at highest risk of overflows that could spread SARS-CoV-2 and other pathogens during flooding and similar events," Hopkins added. "During a flood, the information gained through this system will inform the public health response to control the spread of pathogens that could make people sick."

CARES funds for FIRST's development were approved in the fall and Rice University undergraduates jumped at the opportunity to build out the product by the December 31 deadline, using hydrologic software and maps they had created with training from Bedient about a year prior.

"They performed herculean tasks," Bedient says. "Our deadline was hard and fast, and they helped us deliver the operational project and report on time."

FIRST was reported to have worked well during May's deluge, and will continue to be refined as more data, storms, and floodwaters arise. A demo is available to test online.

Houston has proven to be resilient time and time again. In a guest column, Amy Chronis explores if 2020 has the potential to be Clutch City's breaking point. Photo via Pexels

Clutch City: Is 2020 a time of devastation or doubling down for Houston?

guest column

"Clutch City" may be Houston's most befitting nickname — and it has proven to stand the test of time. Whoever coined the term likely had no idea in how many ways this moniker would be tested and upheld over the next 20-plus years.

Time and time again the fourth largest city in America has proven to be resilient, whether it be a natural catastrophe, tough economic times or the global pandemic. But, will the multi-dimensional stresses of 2020 break the city's winning streak?

Houston is also well known for being The Energy Capital of the World, a qualifier that has meant record revenue and jobs growth, as well as weathering several oil and gas economic down cycles. While the city has taken many hits from previous downturns, it has always been able to recover. The oil, gas and chemicals downturn of 2020, however, is unlike anything we've ever seen before — and could fundamentally transform the energy industry, as well as Houston's economy.

This year, the industry has been grappling with the energy transition while it is also is facing the "Great Compression," sustained low oil prices on top of diminished oil demand from the global pandemic, and the "Great Crew Change." The confluence of these simultaneous challenges could have profound impacts on the workforce and future of work in the oil, gas and chemicals industry. According to Deloitte's latest report, 70 percent of jobs in the industry lost during the pandemic may not return by the end of 2021.

The silver lining "clutch" play may be that Houston already has been on the path and is continuing to diversify its businesses, even within the energy and industrial sectors. The Greater Houston Partnership touts Houston's key industries beyond energy, including advanced manufacturing, aerospace and aviation, life sciences and biotechnology, digital technology and transportation and logistics. Notably, the common thread linking these industries is the need for greater digitalization of and within business models.

The encouraging news is that Houston has anticipated this need and factored it into its future planning. For example, the development of Ion Houston is designed to be the anchor of a 16-plus acre Innovation District in Houston dedicated to innovation, entrepreneurship and technology. This could be the type of investment the city needs to focus on as we grapple with a hard-hit economy. At this point, it is beyond choosing to prioritize moving to what's been called Industry 4.0 — digitalization should be a priority for companies wanting to survive and stay competitive.

According to an analysis conducted by the Greater Houston Partnership of the largest Texas cities, the following sectors had the most VC deals in technology over the last 20 years: life science, oil and gas, oncology, B2B payments, infrastructure and FemTech. The analysis also showcased the top niche tech specialties outside of oil and gas spanned multiple industries including life sciences, legal, space, environmental and FinTech. Houston's dual effort of industry diversification and focus on digitalization has been prescient.

COVID-19 has further accelerated the importance for companies across sectors to get on the fast track to Industry 4.0. The time for transformation is now. The oil, gas and chemicals sector, as well as all sectors, should start building a workforce for the future in order to survive and break the barriers to entry to Industry 4.0. This effort typically includes attracting people across generations by promoting sustainability, offering new digital ways of working, making flexible/remote working a permanent reality while building a sense of pride amongst the workforce toward the work product and organization itself.

Organizational agility is one way through this downturn. Challenging traditional ways of thinking and functioning will likely be required for companies to remain competitive.

The advance work and planning Houston has undertaken to diversify its economy by expanding its industries and focusing on digitalization and the future of workforce, together may ensure that we keep Houston strong and that the "Clutch City" lives up to its name.

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Amy Chronis is the Houston managing partner at Deloitte.

Mayor Sylvester Turner was just named chairman of the Resilient Cities Network. Photo courtesy of The Ion

Mayor Turner recognized nationally for progress of moving Houston toward resiliency

Turner's plans

In the past five years, six federally declared flooding disasters have wreaked havoc in Houston — most notably Hurricane Harvey in 2017. Now, you might say Houston stands tall as a hub of resilience when it comes to disaster preparedness and myriad other pressing issues.

The Texas chapter of the American Planning Association recently honored Mayor Sylvester Turner's Resilient Houston initiative as the top entry in the resilience category of the chapter's annual awards program. In addition, Turner was just named chairman of the Resilient Cities Network.

With backing from Shell Oil Co., the City of Houston hired its first chief resilience officer, Marissa Aho, in 2019 and developed a multibillion-dollar resilience strategy to address threats from hurricanes, tropical storms, floods, and climate change. The plan also seeks to boost the resilience of Houston's economy, neighborhoods and natural resources.

"Our efforts need to be bold, transformative, and aligned to achieve the outcomes Houstonians deserve," Turner said in unveiling the resilience plan in February. "Resilient Houston is a framework for transformative change that comes from thinking and acting together to build and grow Houston's long-term resilience. We will need our partners and every Houstonian at the table to achieve this vision."

Dallas and El Paso also have resilience plans in place.

Houston's resilience effort outlines a number of ambitious goals, such as:

  • Updating city building codes and standards by 2030 to reduce damage from disasters.
  • Attracting or incubating 50 Energy 2.0 companies in the Houston area by 2025.
  • Planting 4.6 million new native trees by 2030.
  • Building at least 375,000 homes in Houston for all income levels by 2050.
  • Providing all Houstonians with easy access to high-frequency public transportation by 2050.

As explained by Rice University's Kinder Institute for Urban Research, hurricanes and floods are examples of "acute shocks" in terms of resilience. These are sudden, large-scale events that disrupt and endanger life. Other shocks include economic crisis, cyberattacks, terrorism, chemical disasters, and extreme heat.

The Kinder Institute points out that Houston's resilience strategy not only addresses these shocks but also takes on "chronic stresses" that hamper recovery from these shocks. Those stresses include poor air quality, health disparities, crime, economic inequality, urban sprawl, and limited access to education.

"Stresses do not impact every Houstonian the same way," says the institute, which helped develop the Resilient Houston project.

Startups participating in Houston's Ion Smart and Resilient Cities Accelerator are tackling many of the same challenges that Resilient Houston is. The accelerator's second cohort launched in April with six startups.

Funded by Microsoft Corp. and Intel Corp., the accelerator "is committed to solving challenges Houstonians face every day," Christine Galib, director of the accelerator, said in an April release. "We connect participating startups with mentors, partners, and stakeholders so they gain access to the resources they need to build, validate, and scale their technologies. Together, we are building a safer, smarter, and more accessible city for all Houstonians."

Houston's push for resilience meshes with Turner's new role as chairman of the Resilient Cities Network. The network is a global city-led nonprofit that aims to "empower cities to help them build a safe, equitable, and sustainable future for all."

"The reach, achievements, and vision of the Resilient Cities Network are impressive. I'm honored to be part of an organization that supports the critical needs of vulnerable communities by implementing projects that address multiple shocks and stresses and are improving the lives of people," Turner says in a release.

Among other goals, the network strives to strengthen local economies and bolster local campaigns to combat climate change.

Supported by $1.8 million from Shell, the City of Houston joined the Resilient Cities Network in August 2018. Houston is the U.S. headquarters for Shell.

"A year after Hurricane Harvey, Houstonians can clearly say we didn't let the storm get the best of us. Nevertheless, there's still work to be done across a wide range of challenges that we share as a community," Bruce Culpepper, who then was president and U.S. chairman of Shell, said in a 2018 release about his company's backing of Resilient Houston.

"Building long-term resiliency is much more than disaster response," Culpepper added. "It's about enabling the people of our city to thrive."

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Houston team develops innovative soft skeleton for kids with cerebral palsy

health tech

A team from the NSF University of Houston Building Reliable Advances and Innovation in Neurotechnology (UH BRAIN) Center and TIRR Memorial Hermann has introduced the MyoStep soft exoskeleton for children with cerebral palsy, according to a news release from UH.

The soft skeleton aims to address motor impairments caused by cerebral palsy that impact children’s ability to participate in physical activities, self-care and academics.

“The MyoStep project represents a significant advancement in the field of pediatric mobility aids, particularly for children with cerebral palsy,” Jose Luis Contreras-Vidal, director of UH BRAIN and the Hugh Roy and Lillie Cranz Cullen Distinguished Professor of Electrical and Computer Engineering, said in a news release.

The next-generation lightweight, soft exoskeleton was funded by the IEEE Electron Devices Society (EDS) Award.

The MyoStep is made to be lightweight and discreetly fit under clothes. It includes a wireless sensor network embedded inside the smart and flexible fabrics that is the backbone of the suit and collects and sends real-time data about the user’s movements It also includes safety features with temperature monitoring and emergency shut-off mechanisms.

“By integrating cutting-edge technologies such as artificial muscles, smart fabrics, and a comprehensive sensor network, MyoStep offers a promising solution to the challenges faced by existing exoskeletons,” Contreras-Vidal said in a news release.

Cerebral palsy is a neurological disorder that impacts motor skills. It occurs in one to four out of every 1,000 births worldwide.

“What makes the MyoStep project so compelling is that it’s not just about the technology: it’s about restoring confidence, function, and hope,” Dr. Gerard Francisco, a clinical partner on the technology, The Wulfe Family Chair of Physical Medicine and Rehabilitation at UTHealth Houston and medical officer at TIRR Memorial Hermann, said in a news release. “This kind of innovation has the potential to dramatically improve quality of life, helping children move through the world with greater ease and dignity.”

Houston's 11 best places to work and more innovation news to know

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Editor's note: It's time to look back at the top business and innovation news for the first half of June 2025. Get the details on InnovationMap's most-read stories from June 1-13 below.

1. 11 Houston companies named best places to work by U.S. News

Chevron is one of the best places to work. Courtesy photo

Nearly a dozen public and private Houston-based companies have been hailed among the best places to work in 2025 by U.S. News and World Report.

The annual report examines thousands of companies around the world to determine the best employers based on six metrics including work-life balance and flexibility; quality of pay and benefits; job and company stability; career opportunities and professional development; and more. U.S. News included seven publicly-traded companies and four privately owned companies in Houston on the lists. Continue reading.

2. 2 Houston suburbs named among 10 best places to live by U.S. News & World Report

Pearland is the No. 2 best place to live in the U.S. Photo via pearlandedc.com

The Houston suburbs of Pearland and League City have landed among the top 10 best places to live in 2025, according to U.S. News & World Report.

Pearland ranked No. 3 nationwide, earning a 7.0 score alongside No. 1-winning Johns Creek, Georgia and No. 2 winner Carmel, Indiana. Pearland also landed on top of U.S. News separate rankings of the best places to live in Texas for 2025-2026. Continue reading.

3. Texas Space Commission doles out $5.8 million to Houston companies

Axiom Space and FluxWorks are the latest Houston-area companies to receive funding from the Texas Space Commission. Photo via Getty Images.

Two Houston-area companies have landed more than $5.8 million in funding from the Texas Space Commission. The commission granted up to $5.5 million to Houston-based Axiom Space and up to $347,196 to Conroe-based FluxWorks.

Axiom Space, a commercial spaceflight company, said the new funding will go toward the development of its orbital data center capabilities. Continue reading.

4. 3 Houston startups named most innovative in Texas by LexisNexis

Sage Geosystems is the No. 3 most innovative startup in Texas. Photo via sagegeosystems.com

Three Houston companies claimed spots on LexisNexis's 10 Most Innovative Startups in Texas report, with two working in the geothermal energy space.

Sage Geosystems claimed the No. 3 spot on the list, and Fervo Energy followed closely behind at No. 5. Fintech unicorn HighRadius rounded out the list of Houston companies at No. 8. Continue reading.

5. 9 can't-miss Houston business and innovation events for June

Don't miss these June events—from lightning pitches to a female-focused AI summit. Photo by Scott Halleran/Getty Images

From lightning pitches to a female-focused AI summit and energy conferences, there's still plenty to do as Houston settles into the summer. Here are the Houston business and innovation events you can't miss in June and how to register. Continue reading.

Houston universities launch summer 2025 accelerators for student ventures

summer session

OwlSpark, a startup and small business accelerator for Rice University-affiliated ventures, has named the latest 11 companies to its program that focus on challenges across technology, health care, consumer products and other sectors. The program is hosted in tandem with the University of Houston’s RED Labs and will take place at the Ion.

The early-stage accelerator runs for 12 weeks and culminates at The Bayou Startup Showcase on July 31.

According to a news release from Rice, “the accelerator cultivates a vibrant environment where founders are empowered to build, test, and scale their ideas in a setting built for entrepreneurship.”

The program is divided into two tracks: one for high-growth tech startups and another for small businesses.

The latest OwlSpark class includes:

  • Web and mobile platform EasilyBEE, which boosts family and community engagement in K-12 schools
  • Diagnos, a wearable-integrated wellness platform that monitors health and prevents injuries in college athletes
  • Johnnie, an AI-powered records management software for rural and midsize first responder agencies
  • JustKindHumility, which offers faith-based travel journals
  • Klix, whichautomates early-stage clinical trial management from document screening to AI-driven patient outreach and eligibility checks
  • Lizzy’s Gourmet Gains, which offers high-protein, flavor-forward dips and dressings
  • NextStep, an AI-powered multilingual assistant helping underserved communities navigate resources for health care
  • A catheter-integrated sensor device PeriShield, which detects early infection in peritoneal dialysis patients
  • Right Design, which connects creatives with vetted employers, mentors and projects via job matching and commissions
  • UCoreAlly, which provides business support for biotech startups in marketing, business development, customer support, human resources and accounting
  • Ultrasound-based ablation system VentriTech that treats ventricular arrhythmias

The Owl Spark accelerator has supported 229 founders and launched 104 ventures with participants raising more than $116 million in funding since 2013, according to Rice.

UH also shared the 9 teams that will participate in RED Labs' latest cohort.

The latest RED Labs class includes:

  • BLEED, an art agency that helps artists commercialize their work by connecting art collectors to original artwork and artists
  • Brain Haven, which is developing nasal inhalers designed to stimulate the emotional and memory processing centers to preserve neuroplasticity and delay cognitive decline
  • Candi Wands Automated Cotton Candy, which has developed a continuously operating cotton candy machine to help entertainment venues boost passive revenue
  • ChériCollectible, a series of in-person events where Gen Z and collectors can buy, sell, and trade modern collectibles
  • JobRadar, a job board that uses AI to analyze and categorize positions in real-time and then apply candidates instantly
  • Stage Select LLC, a supplementary talent booking service that partners with multi-stage venues to help fill gaps in programming and increase profitability by finding and booking local talent for their "second stage."
  • P-LEGS, a pediatric lower-limb exoskeleton that reduces physical strain on therapists while delivering customizable gait training.
  • Roll ‘N’ Reel Photo Booth, an interactive event-based equipment rental business
  • Stayzy, which automates guest communication and handles maintenance issues with an AI-powered software for short-term rental companies that manage 20-plus rentals
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