Rice researchers score $45M from NIH for cancer-fighting tech

freshly funded

A research team housed out of the newly launched Rice Biotech Launch Pad received funding to scale tech that could slash cancer deaths in half. Photo via Rice University

A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

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The 250,000-square-foot building is the new home for four key research areas at Rice: advanced materials, quantum science and computing, urban research and innovation, and the energy transition. Photo courtesy of Rice

University opens its newest, largest campus research facility in Houston

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As the academic year officially kicks off, professors have started moving in and Rice University has opened its largest core campus research facility, The Ralph S. O’Connor Building for Engineering and Science.

"To me it really speaks to where Rice wants to go as we grow our research endeavors on campus," Michael Wong, Chair of the Department of Chemical and Biomolecular Engineering, whose lab is located in the new facility, said in a video from Rice. "It has to be a mix of engineering and science to do great things. We don’t want to do good things, we want to do great things. And this building will allow us to do that."

At $152 million, the state-of-the-art facility features five floors of labs, classrooms and seminar rooms. Common spaces and a cafe encourage communication between departments, and the top level is home to a reception suite and outdoor terrace with views of the Houston skyline.

It replaces 1940s-era Abercrombie Engineering Laboratory on campus, which was demolished in 2021 to make way for the new facilities. The iconic sculpture "Energy" by Rice alumnus William McVey that was part of the original building was preserved with plans to incorporate it into the new space.

The new building will be dedicated to its namesake Ralph O'Connor on Sept. 14 in Rice's engineering quad at 3 p.m. O'Connor, a Johns Hopkins University grad, became a fan Rice when he moved to Houston to work in the energy industry in the 1950s.

The former president and CEO of the Highland Oil Company and founder of Ralph S. O’Connor & Associates left the university $57 million from his estate after he died in 2018. The gift was the largest donation from an estate in Rice's history and brought his donations to the university, including those to many buildings on campus and endowments and scholarships, to a total of $85 million.

“How fitting that this building will be named after Ralph O’Connor,” Rice President Reginald DesRoches said in a statement last summer. “He was a man who always looked to the future, and the future is what this new engineering and science building is all about. Discoveries made within those walls could transform the world. Anybody who knew Ralph O’Connor knows he would have loved that.”

The dedication event will be open to the public. It will feature remarks from DesRoches, as well as Rice Provost Amy Dittmar, Dean of the Wiess School of Natural Sciences Thomas Killian, Chair of the Rice Board of Trustees Robert Ladd and Dean of the George R. Brown School of Engineering Luay Nakhleh. A reception and tours of the new building will follow.

An annual ranking recognized Rice University again — but the Houston school ranked a tad lower this year. Photo courtesy of Rice

Report: Rice University again ranks among the top schools in nation

hooting in Houston

Rice University has earned yet another accolade worth hooting about.

Niche, an education review and ranking website, has named Rice the ninth best college in the U.S., down from No. 6 last year. The Houston university receives an A+ in nine of the 12 ranking categories, including academics, diversity, and value. It gets an A for the party scene, a B+ for athletics, and a B for safety.

“We’re proud that Niche once again rates Rice not only one of the nation’s top universities, but also one of the nation’s best college values,” university President Reginald DesRoches said in 2022. “This is especially gratifying because Niche reflects the opinions of students and parents who know firsthand what outstanding education opportunities Rice continues to offer.”

Rice regularly ranks highly on lists of the best colleges and universities in the country, including those published by Niche, Forbes, and U.S. News & World Report.

“Rice is an awesome place. I went to Rice because I wanted professors who actually wanted to see their students succeed, and I can confidently say that’s what I found at Rice,” a student wrote in a Niche review. “The classes are thorough but the tests are very reasonable and focus on the material we learned in class.”

Topping Niche’s national list is Yale University, followed by Stanford University, the Massachusetts Institute of Technology, Harvard University, Princeton University, Columbia University, the University of Pennsylvania, and Dartmouth College.

Rice comes in at No. 12 on Niche’s list of the “best value colleges” in the U.S. and ranks first among the best colleges in Texas. Here are the top 10 Texas schools, including the eighth-ranked University of Houston:

1. Rice University
2. University of Texas at Austin
3. Texas A&M University (College Station)
4. Trinity University (San Antonio)
5. Southern Methodist University (University Park)
6. Texas Christian University (Fort Worth)
7. Texas Tech University (Lubbock)
8. University of Houston
9. University of Texas Permian Basin (Odessa)
10. Baylor University (Waco)

Other Houston-area schools in the Texas ranking are:

University of Houston – Clear Lake (No. 13)
University of St. Thomas (No. 26)
University of Houston – Downtown (No. 39)
Prairie View A&M University (No. 43)

“Choosing where to go to college is easily one of the most significant — and expensive — decisions of a person’s life. Niche’s mission is to ensure that every college-bound student has access to easy, transparent and free resources … to help them find their best fit,” Luke Skurman, founder and CEO of Niche, says in a news release.

In his new role, Adrian Trömel will oversee the creation of the Rice Nexus, an innovation hub within the Ion that aims to bridge the gap between the university and Houston's innovation ecosystem. Photo courtesy of Rice

University names Houston founder to leadership role to oversee new innovation hub

next up for the rice nexus

Rice University’s Office of Innovation has named Houston materials scientist-turned-entrepreneur Adrian Trömel as its new assistant vice president for strategy and investments.

Trömel founded non-invasive neurostimulation medical device company CNX Medical at the Texas Medical Innovation Institute in 2019 and most recently served as chief growth officer for Hamilton Health Box, which brings an on-site care team to company offices.

In his new role, Trömel will oversee the creation of the Rice Nexus, an innovation hub within the Ion that aims to bridge the gap between the university and Houston's innovation ecosystem. He will also lead the creation of a translational research grant fund and a university-affiliated venture fund for Rice-affiliated entrepreneurs, according to the release.

“Adrian brings a broad, multidisciplinary background to the team at the Office of Innovation,” Paul Cherukuri, chief innovation officer at Rice, says in a statement. “As a materials scientist and entrepreneur, his experience can be brought to bear to help faculty and students spin out new technologies and start new ventures.”

Trömel holds a bachelor’s and master’s in materials sciences from the École polytechnique fédérale de Lausanne (EPFL) and the Netherlands and an MBA from Rice. He is also an angel investor and a lead lecturer for Rice's New Enterprise MBA ELab.

In addition to his professional work, he serves as the foreign trade advisor to the Ministry of Economy of Luxembourg.

Rice has been building up its Office of Innovation in the last few years. In August 2022, the university named Cherukuri as the inaugural vice president for innovation. According to Rice President Reginald DesRoches, the Office of Innovation and the Cherukuri's position were created to ensure Rice is a leader within Houston and the global innovation ecosystem.

This past March, Cherukuri announced plans to develop the Rice Nexus.

"We've got so much technology in our labs that we've never shared with the world," he said at the time. "We're going to demonstrate that in the Ion."

Click here to listen to a full interview with Cherukuri about thought leadership in Houston, Rice University, and the challenges of advancing research and technology to address society's greatest needs on the Houston Innovators Podcast.

Ten individuals from Rice University have been named to the second cohort of the Innovation Fellowship program. Photos via Rice.edu

10 Houston researchers named to fellowship to advance innovation

owls taking flight

A program with a mission to translate research into innovative startups has named its 2023 cohort of fellows.

Rice University's Innovation Fellows program, which is run by the Liu Idea Lab for Innovation and Entrepreneurship and the Office of Innovation, has announced the 10 innovators that will be joining the program this year. The program, open to Rice faculty and doctoral and postdoctoral students, provides support — funding, mentorship, and more — to move innovation out of labs and into commercialization.

“The Rice Innovation Fellows program is a critical part of our efforts to support innovation and entrepreneurship,” Rice President Reginald DesRoches says in a news release. “These exceptional individuals represent some of the most innovative and promising research being conducted at Rice, and we’re thrilled to support them as they work to bring their ideas to the world.”

According to the release, the 10 members of the 2023 cohort are:

Martha Fowler, a doctoral student from the bioengineering lab of Omid Veiseh
Carson Cole, a doctoral student from the chemistry lab of Jeff Hartgerink
Fatima Ahsan, a doctoral student from the electrical and computer engineering lab of Behnaam Aazhang
Siraj Sidhik, a doctoral student from the materials science and nanoengineering lab of Aditya Mohite
Roman Zhuravel, a postdoctoral student from the physics and astronomy lab of Guido Pagano
Samira Aghlara-Fotovat, a doctoral student from the bioengineering lab of Veiseh
Clarke Wilkirson, a doctoral student from the mechanical engineering lab of Peter Lillehoj
Yuren Feng, a doctoral student from the civil and environmental engineering lab of Qilin Li
Yang Xia, a doctoral student from the chemical and molecular engineering lab of Haotian Wang
Thao Vy Nguyen, a doctoral student from the chemical engineering lab of Sibani Lisa Biswal

Each of Rice's Innovation Fellows will receive up to $20,000 in funding, as well as access to the university's network for mentorship and training.

“We're incredibly excited to welcome this exceptional group of researchers into the Innovation Fellows program,” says Yael Hochberg, head of the Rice Entrepreneurship Initiative and faculty director for Lilie, in the release. “We look forward to working with them as they bring their groundbreaking research to market and make a real impact on the world.”

Last year's inaugural cohort in raised more than $1 million in venture capital funding and over $3 million in additional nondilutive funding, as well as earning more than $500,000 in revenue.

Some of the 2022 cohort's accomplishments included Helix Earth Technologies winning the inaugural TEX-E Prize and Sygne Solutions securing second place and $200,000 at the 2023 Rice Business Plan Competition.

Paul Cherukuri, Rice’s vice president for innovation, who recently joined the Houston Innovators Podcast, explains how this is one avenue Rice has for getting innovation off campus and into industry.

“With commercialization of research at the forefront of what Rice University wants to do,” says Cherukuri, "the Innovation Fellows program is the first in a constellation of programs and resources developed by the Office of Innovation to help impactful new ventures overcome the hard tech ‘valley of death’ and transition from the campus to the community, so we can help create the next generation of game-changing company for Houston, Texas and the world,."

Pack your bags, Owls. Photo via Rice.edu

Houston university goes global with Parisian outpost announcement

Rice U in France

Rice University owls are flapping their wings across the Atlantic Ocean in order to open some doors to global education and research opportunities in Europe.

The university announced in a press release that the Rice University Paris Center is holding its ceremonial launch on Wednesday, June 29. The new facility will be housed in a historic 16th-century building in Paris and will be home to Rice-organized student programs, independent researchers, and international conferences, as well as a satellite and hub for other European research activity.

“The ambitions of our university and the needs of the future leaders we are educating require global engagement and perspective,” says outgoing Rice President David Leebron in the release. “The opening of this dedicated overseas facility represents the next step in the long-standing plan we have been pursuing to internationalize Rice and the Rice experience in every dimension.

"This has included welcoming more international students to our campus in Houston, fostering international travel and programs by our students and faculty, and building strong relationships with the best universities across the globe," he continues. "The Paris location offers an incredible range of opportunities, in fields ranging from art and architecture to international business and global relations and politics.”

The Rice University Paris Center will be located in Le Marais in the Hotel de La Faye, a 1500s hôtel particulierthat was listed as a historic monument in 1966.

Caroline Levander, currently Rice’s vice president for global and digital strategy, was key in making the new center a reality and will oversee the Rice University Paris Center in her new role as vice president global.

“For our purposes, this building is an ideal educational space conveniently situated in one of the most historically significant areas of Paris,” Levander says in the release. “It looks and feels like a private university campus in the heart of a European capital city, and it reflects how Rice plans to expand its international impact in the coming years.”

Sylvester Turner and a delegation of civic and business leaders from the Greater Houston Partnership will attend the announcement in Paris this week. Per the release, the center, which will have six classroom spaces of various sizes that can accommodate around 125 students, is expected to be ready in January.

“Rice University’s mission statement commits us not only to pathbreaking research and unsurpassed teaching, but also to the betterment of our world,” says Provost Reginald DesRoches, who will transition to Rice’s president in July, in the release. “We’re eager to extend that mission internationally, and the opening of the Rice University Paris Center demonstrates that commitment.”

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Real estate giant taps downtown Houston tower for new smart building tech

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Houston-based real estate giant Hines is rolling out a new smart building platform with the goal of better serving workers and workplaces at its buildings across the country, including one building in Houston that's aiming to be an office building of the future.

From the employee perspective, the new Hines app will allow employees and employers to book spaces within buildings, order food from on-site cafes and restaurants, book on-site fitness classes and access the building via their smartphone or smartwatch. For employers and tenants, the app will help them gain insights into building performance, occupancy data, ESG targets and employee satisfaction, according to a statement from Hines.

“We’re committed to a people-centric experience and this investment takes that commitment to the next level,” Ilene Goldfine, chief digital strategy officer at Hines, says in a statement. “The traditional systems were managed building by building and made it difficult or impossible to track performance across a portfolio. This new digital ecosystem, which unites back-end technology with front-end experiences, will deliver long-term cost savings to our investors and clients.

"Our clients will also be able to track employee satisfaction, make informed decisions about their space needs and ensure they’re monitoring their carbon targets,” Goldfine continues.

The new digital platform will be launched at eight Hines buildings across five cities, including 717 Texas Ave., a 33-story Class A office tower in Downtown Houston.

The other buildings where Hines will roll out the app include:

Salesforce Tower in Chicago
1144 15th Street in Denver
The Kearns Building in Salt Lake City
CIBC Square in Toronto
T3 Bayside in Toronto
Two buildings at T3 Sterling Road in Toronto

The company plans to add more locations across its global portfolio.

Hines' opened its first location of The Square coworking space at 717 Texas Ave. in 2020 as part of its coworking concept Hines². The company, in collaboration with Montreal-based Ivanhoé Cambridge, opened a second Houston location of The Square recently and has a coworking space in The Kearns Building in Salt Lake City where it will roll out the new app.

Earlier this year, Hines also launched a sustainability-focused business unit, known as EXP by Hines. The unit, led by Hines veteran Doug Holte, aims to address “the disruptive changes in the built environment.”

Houston expert encourages energy industry to bridge its generational divides

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What’s the biggest obstacle between us and net-zero? Is it policy? Technology? Financing? All of these are important, yes, but none of them is what is really holding us back from our energy transition goals.

The biggest obstacle is a lack of open-mindedness and an unwillingness of people across the industry and across generations to work together.

In October of 2022, I was invited to speak at Energy Dialogues’s North American Gas Forum, a conference that brings together executives from across the energy industry. Over the two days of the conference, I was amazed by the forward-thinking conversations we were having on decarbonization, the future of clean energy, emissions reduction, and much more. I returned back to campus at Duke University, energized by these conversations and excited to share them. But rather than seeing the same sense of excitement, I was met with doubt, disbelief, even scorn.

There’s a fundamental distrust between generations in this industry, and it goes both ways. Experienced energy professionals often see the younger generation as irrational idealists who are too politicized to be pragmatic, while the younger generation often paints the older generation as uncaring climate denialists who want nothing to do with clean energy. Neither is true.

Over the past two years since founding Energy Terminal, I’ve met hundreds (maybe thousands) of people all across the energy industry, from CEOs of major energy companies to students just getting started on their career journey. Despite being so different on the surface, their goals are strikingly similar. Almost all can agree on three things: we want to reduce emissions, we want to expand energy access, and we want to do so while encouraging economic prosperity. The perceived barrier between generations in the energy industry is exponentially larger than the actual barrier.

For experienced professionals — take a chance to engage in conversations with young energy leaders. Understand their priorities, listen to their concerns, and find the middle ground. We are a generation passionate about impact and growth, and enabled with the right resources, we can do incredible things. The changing energy world presents unbelievable opportunities for both progress and profit, but without the next generation on board, it will never be sustainable.

For the young energy leaders of the future–listen to the experiences of the leaders that have come before us. Understand the balance between energy that is clean with energy that is secure, reliable, and affordable. We have brilliant ideas and an insatiable appetite for progress, but we won’t do it alone. Every person and every company has a valuable role to play in the energy transition, so consider how we can amplify our strengths rather than attack each other’s weaknesses.

If my co-founder, a climate activist from New York, and myself, the son of an oil and gas family from south Texas, can do it, so can you. This is a call to find the middle ground, to open up your mind to new possibilities, and to make real progress by working with each other rather than against each other.

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Michael Wood III is co-founder of Energy Terminal, a platform that aims to build the next generation of energy leaders and to bridge the gap between youth and the energy industry.

This article originally ran on EnergyCapital.

TMC again expands global impact with new Netherlands partnership

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The Texas Medical Center may be based in Houston, but the organization has again grown its global impact.

Since 2016, TMC’s BioBridges have worked with 88 startup companies. Those include strategic alliances with four other countries. Australia, the United Kingdom, Denmark and Ireland are all among TMC’s BioBridges partners. As of today, add the Netherlands to that list.

On September 27, TMC president and CEO, William F. McKeon, and Carmen van Vilsteren, chair of Health~Holland, Top Sector Life Sciences & Health (LSH), signed an agreement in Rotterdam. The TMC Netherlands BioBridge Memorandum of Understanding codifies the innovative goals of the partnership. Essentially, the BioBridge program provides a means for entrepreneurs, researchers, clinicians and industry partners from other countries to access the US market, as well as TMC experts.

“The TMC Netherlands BioBridge represents an unparalleled opportunity for collaboration and growth,” Ashley McPhail, chief external affairs & administration officer at Texas Medical Center said in a press release. “The Netherlands has solidified its position as a global leader in the field of life sciences and health, with a thriving ecosystem of research institutions, innovative companies, and highly skilled professionals. This strategic partnership will bring positive benefits to patients, clinicians and industry partners on a global scale.”

This lifeline for international healthcare companies makes expansion into the United States far smoother. The Global Innovators Launch Pad allows for startup founders to take part in a 10-week residency at the TMC Innovation Factory that will teach them about foundational infrastructure, clinical evidence and funding in the US.

“Since Texas is an important hub for innovation in the MedTech and digital health sectors, the collaboration with Texas Medical Center creates opportunities for Dutch companies looking to expand their international reach. Vice versa, it gives companies in Texas access to the vibrant Dutch Life Sciences & Health sector,” said van Vilsteren.

That exchange includes members of the TMC gaining the opportunity to participate in the Health~Holland Visitors Programme (HVP), “Shaping the Healthcare of the Future.”

The annual event invites high-level representatives from the private sector, NGOs, knowledge institutions, healthcare providers and different tiers of government to share their expertise.

It's the fifth partnership of its kind for TMC, with the last one being with Ireland, announced last year. TMC's other global initiatives include accelerators with Denmark and the United Kingdom, both announced earlier this year.

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