A Houston-based biotech company has completed early testing for its groundbreaking insulin alternative and is headed toward clinical trials. Photo via Getty Images

A Houston biotech startup is one step closer to releasing its marquee drug for the global insulin market, which is projected to break the $90 billion threshold by 2029.

rBIO says it recently completed testing of the properties of R-biolin, an insulin drug that’s biologically identical to Novo Nordisk’s Novolin drug. The patent for Novolin about two decades ago. In March 2023, the Dutch drugmaker announced it was slashing the list price of Novolin by 65 percent to $48.20 per vial and $91.09 per FlexPen.

Executives at rBIO are now pursuing a partnership with a contract research organization to manage clinical trials of R-biolin. If those trials go well, R-biolin will seek approval to supply its insulin therapy to diabetes patients around the world.

Washington University in St. Louis is rBIO’s academic partner for the R-biolin project.

The rBIO platform produces insulin at greater yields that traditional manufacturing techniques do. The company is striving to drive down the cost of insulin by 30 percent.

About 38 million Americans have diabetes, with the vast majority being treated for type 2 diabetes, according to the U.S. Centers for Disease Control and Prevention (CDC). Many people with diabetes must take insulin to control their blood sugar levels.

Research company iHealthcareAnalyst predicts the global market for insulin will surpass the $90 billion mark in 2029.

“There has been a lot of talk in the media about reducing the cost of insulin for diabetic patients, but what is often overlooked is that the domestic demand for insulin will soon outpace the supply, leading to a new host of issues,” Cameron Owen, co-founder and CEO of rBIO, says in a news release.

“We’re dedicated to addressing the growing demand for accessible insulin therapies, and … we’re thrilled to announce the viability of our highly scalable manufacturing process.”

Professionals from the University of California San Diego and Johns Hopkins University established rBIO in 2020. The startup moved its headquarters from San Diego to Houston in 2022.

CEO Cameron Owen and Chief Scientific Officer Deenadayalan Bakthavatsalam work on insulin purification in the Houston lab. Photo courtesy

This week's roundup of Houston innovators includes Gaurab Chakrabarti of Solugen, Sandy Guitar of HX Venture Fund, and Cameron Owen of rBIO. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from synthetic biology to venture capital — recently making headlines in Houston innovation.

Gaurab Chakrabarti, the CEO and co-founder of Solugen

Gaurab Chakrabarti shared his entrepreneurial journey on the SXSW stage this year. Photo courtesy of the Greater Houston Partnership

Houston doesn't have too many unicorns — startups valued at $1 billion or more — in its innovation ecosystem, but Solugen, a sustainable chemicals company, is among the elite group. Gaurab Chakrabarti, the CEO and co-founder of the company, joined Houston House by the Greater Houston Partnership, to share his story on the SXSW stage.

“You do make your own luck, but you have to be putting in the work to do it," Chakrabarti says, adding that it's not an easy thing to accomplish. “There are things you can be doing to increase your luck surface area."

He shared several lessons he learned on his founder journey in the discussion. Read more.

Sandy Guitar, managing director of HX Venture Fund

Sandy Guitar shares some lessons learned from the fallout of Silicon Valley Bank. Photo via HXVF

Following the failure of Silicon Valley Bank, there's one thing Sandy Guitar can say has changed for Houston innovators: Bank diversification is going to be a must.

“We didn't think we needed one last week, but this week we know we need a resilience plan," she says, explaining that bank diversification is going to be added to "the operational due diligence playbook." Read more.

Cameron Owen, co-founder and CEO of rBIO

San Diego-based rBIO moved to Houston to take advantage of the growing ecosystem of biomanufacturing and synthetic biology. Photo courtesy of rBIO

Founded in San Diego, rBIO recently relocated to Houston and has big plans for settling in the city, says Cameron Owen, the company's co-founder and CEO.

“Companies from California like us and the coastal areas were converging here in Houston and creating this new type of bioeconomy,” he tells InnovationMap.

He shares that Houston wasn't originally on his radar, until it was. A visit turned into a relocation, and it's just the beginning for the biotech startup that's focused on using synthetic biology for pharmaceuticals. Read more.

San Diego-based rBIO moved to Houston to take advantage of the growing ecosystem of biomanufacturing and synthetic biology. Photo via Getty Images

California-founded biotech startup relocates to join Houston's emerging bioeconomy

new to hou

Cameron Owen had an idea for a synthetic biology application, and he pitched it to a handful of postdoctoral programs. When he received the feedback that he didn't have enough research experience, he decided to launch a startup based in San Diego around his idea. He figured that he'd either get the experience he needed to re-apply, or he'd create a viable company.

After three years of research and development, Owen's path seems to have taken him down the latter of those two options, and he moved his viable company, rBIO, to Houston — a twist he didn't see coming.

“Houston was not on my radar until about a year and a half ago,” Owen says, explaining that he thought of Houston as a leading health care hub, but the coasts still had an edge when it came to what he was doing. “San Diego and the Boston area are the two big biotech and life science hubs.”

But when he visited the Bayou City in December of 2021, he says he saw first hand that something new was happening.

“Companies from California like us and the coastal areas were converging here in Houston and creating this new type of bioeconomy,” he tells InnovationMap.

Owen moved to Houston last year, but rBIO still has an academic partner in Washington University in St. Louis and a clinical research organization it's working with too, so he admits rBIO's local footprint is relatively small — but not for long.

"When we look to want to get into manufacturing, we definitely want to build something here in Houston," he says. "We’re just not to that point as a company."

In terms of the stage rBIO is in now, Owen says the company is coming out of R&D and into clinical studies. He says rBIO has plans to fundraise and is meeting with potential partners that will help his company scale and build out a facility.

With the help of its CRO partner, rBIO has two ongoing clinical projects — with a third coming next month. Owen says right now rBIO is targeting the pharmaceutical industry’s biologics sector — these are drugs our bodies make naturally, like insulin. About 12 percent of the population in the United States has diabetes, which translates to almost 40 million people. The demand for insulin is high, and rBIO has a way to create it — and at 30 percent less cost.

This is just the tip of the iceberg — the world of synthetic biology application is endless.

“Now that we can design and manipulate biology in ways we’ve never been able to before,” Owen says, "we’re really only limited by our own imagination.”

Synthetic biology is a field of science that involves programing biology to create and redesign natural elements. While it sounds like science fiction, Owen compares it to any other type of technology.

“Biology really is a type of software,” he says. “Phones and computers at their core run on 1s and 0s. In biology, it’s kind of the same thing, but instead of two letters, it’s four — A, C, T, and G.”

“The cool thing about biology is the software builds the hardware,” he continues. “You put that code in there and the biology builds in and of itself.”

Owen says the industry of synthetic biology has been rising in popularity for years, but the technology has only recently caught up.

“We’re exploring a brave new world — there’s no doubt about that,” Owen says.

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Top innovators: 2024 Houston Innovation Awards finalists revealed

best of the rest

After nearly 300 nominations, InnovationMap and its group of judges are ready to reveal the finalists for this year's Houston Innovation Awards.

Taking place on Thursday, November 14, the Houston Innovation Awards celebrates all of Houston's innovation ecosystem — startups, entrepreneurs, investors, mentors, and more. Over 50 finalists will be recognized in particular for their achievements across 13 categories, which includes the 2024 Trailblazer Legacy Awards that were announced earlier this month.

Scroll down to see the 2024 Houston Innovation Awards finalists.

This year, 35 startups, 14 individuals, and six organizations will all be recognized, and winners will be named at the event. The finalists were decided by this year's judges after they reviewed over 130 applications.

If you are interested in sponsorship opportunities, please reach out to sales@innovationmap.com. If you have questions about the Houston Innovation Awards, email awards@innovationmap.com.

Minority-founded business, honoring an innovative startup founded or co-founded by BIPOC or LGBTQ+ representation

  • CLS Wind, a self-erection wind turbine tower system provider for the wind energy industry
  • Corrolytics, a technology startup founded to solve microbiologically influenced corrosion problems for Industrial assets
  • Gold H2, a startup that's transforming depleted oil fields into hydrogen-producing assets utilizing existing infrastructure
  • Nap Bar, a white-glove rest sanctuary, with an integration of artificial intelligence for professionals, entrepreneurs, and travelers to rest, recharge, and rejuvenate
  • Speakerbox Media, a B2B video agency that turns experts into thought leaders with engaging webinars and video podcasts, providing end-to-end content strategy and production.

Female-founded business, honoring an innovative startup founded or co-founded by a woman

  • Dauntless XR, a developer of extended reality software
  • EveryDopeGirl, a community building an interracial and intergenerational culture of support amongst women globally
  • Koda Health, provider of a tech-enabled care coordination service for improving serious illness care planning
  • March Biosciences, a clinical-stage cell therapy company with a mission to transform patient care in the most challenging hematological malignancies
  • nVenue, machine learning and AI technology provider that generates and delivers real-time odds and predictive analytics to sportsbooks and media

Energy transition business, honoring an innovative startup providing a solution within renewables, climatetech, clean energy, alternative materials, circular economy, and beyond

  • Amperon, an AI platform powering the smart grid of the future
  • ARIX Technologies, an integrated robotics and data analytics company that delivers inspection services through its robotics platforms
  • Elementium Innovations, a battery technology with liquid electrolyte solutions
  • InnoVent Renewables, a startup with proprietary continuous pyrolysis technology that converts waste tires, plastics, and biomass into valuable fuels and chemicals
  • Sage Geosystems, an energy company focused on developing and deploying advanced geothermal technologies to provide reliable power and sustainable energy storage solutions regardless of geography
  • Tierra Climate, a software provider that helps grid-scale batteries reduce carbon emissions

Health tech business, honoring an innovative startup within the health and medical technology

  • Allterum Therapeutics, a biopharmaceutical company creating a treatment for cancer
  • Bairitone Health, an AI-driven, sonar-based diagnostic imaging technology platform
  • Ictero Medical, a medical device company developing the first minimally-invasive cryoablation solution to treat gallstone disease
  • InformAI, a technology company dedicated to advancing healthcare through the development of AI-driven solutions in radiology, oncology and transplant surgery
  • Koda Health, provider of a tech-enabled care coordination service for improving serious illness care planning
  • March Biosciences, a clinical-stage cell therapy company with a mission to transform patient care in the most challenging hematological malignancies

AI/data science business, honoring an innovative startup utilizing artificial intelligence and data science within a tech solution

  • ARIX Technologies, an integrated robotics and data analytics company that delivers inspection services through its robotics platforms
  • Cognitive Space, an automated satellite operations provider that enables constellations to scale
  • Enovate Ai, a provider of business and operational process optimization for decarbonization and energy independence
  • nVenue, machine learning and AI technology provider that generates and delivers real-time odds and predictive analytics to sportsbooks and media
  • Voyager Portal, a software plaform that helps commodity traders and manufacturers in the O&G, chemicals, agriculture, mining, and project cargo sectors optimize the voyage management lifecycle

Deep tech business, honoring an innovative startup providing technology solutions based on substantial scientific or engineering challenges

  • FluxWorks, developer and manufacturer of magnetic gears and magnetic gear-integrated motors
  • Gold H2, a startup that's transforming depleted oil fields into hydrogen-producing assets utilizing existing infrastructure
  • Hertha Metals, developer of a technology that cost-effectively produces steel with fewer carbon emissions
  • Venus Aerospace, a deep tech company developing reusable hypersonic technology for aviation, defense, and beyond

Scaleup of the year, honoring an innovative later stage startup that's recently reached a significant milestone in company growth

  • Cart.com, a unified commerce and logistics solutions provider for B2C and B2B companies
  • Coya Therapeutics, a clinical-stage company developing therapies for neurodegenerative, autoimmune, and metabolic diseases
  • NanoTech Materials, a chemical manufacturer that integrates novel heat-control technology with thermal insulation, fireproofing, and cool roof coatings to drastically improve efficiency and safety
  • Square Robot, an advanced robotics company serving the energy industry and beyond by providing submersible robots for storage tank inspections
  • Syzygy Plasmonics, a company that's decarbonizing chemical production with a light-powered reactor platform that electrifies the production of hydrogen, syngas, and fuel with reliable, low-cost solutions

People’s choice: Startup of the Year, a startup celebrating a recent milestone or success and the winner will be selected by the community via online portal and announced at the event

  • Corrolytics, a technology startup founded to solve microbiologically influenced corrosion problems for Industrial assets
  • FlowCare, a startup advocating for free menstruation products in business and academic settings
  • InnoVent Renewables, a startup with proprietary continuous pyrolysis technology that converts waste tires, plastics, and biomass into valuable fuels and chemicals
  • MendIt, an app that quickly and easily connects users to professionals who specialize in mending and repairing clothing
  • Passport Journeys, an app connects mother-daughter pairs with licensed therapists
  • TrueLeap, an education technology company on a mission to accelerate access to quality education for emerging markets by integrating e-learning software, content, training, analytics, and community

Community champion organization, honoring a corporation, nonprofit, university, or other organization that plays a major role in the Houston innovation community

  • Energy Tech Nexus, a new global energy and carbon tech hub focusing on hard tech solutions that provides mentor, accelerator and educational programs for entrepreneurs and underserved communities.
  • Greentown Houston, a climatetech incubator and convener for the energy transition community that provides community engagement and programming in partnership with corporations and other organizations.
  • Houston Angel Network, supports Houston startups with capital, connections, and counsel and provides accredited investors access to startup deals in which they can invest, both locally and nationally.
  • Impact Hub Houston, a nonprofit that serves as a pivotal hub within the city's innovation ecosystem, fostering a dynamic environment where changemakers, entrepreneurs, and community leaders converge to drive social impact and innovation forward.
  • Microsoft, a global tech company that supports the local innovation ecosystem with mentorship and opportunities in underserved communities.
  • University of Houston, a Tier One research institution that fosters entrepreneurship, innovation, and commercialization of new technologies and leverages its research capabilities and diverse student body.

Ecosystem builder, honoring an individual who has acted as a leader in developing Houston’s startup ecosystem

Investor of the year, honoring an individual who is leading venture capital or angel investing

Mentor of the year, honoring an individual who dedicates their time and expertise to guide and support to budding entrepreneurs

Houston startup expands DOD partnership to provide clean energy at Texas site

seeing green

Expanding on its partnership with the United States Department of Defense's Defense Innovation Unit, Sage Geosystems has been selected to conduct geothermal project development initiatives at Naval Air Station in Corpus Christi.

Along with the Environmental Security Technology Certification Program, Sage will provide its proprietary Geopressured Geothermal Systems technology, will be able to evaluate the potential for geothermal baseload power generation to provide clean and consistent energy at the Naval Air Station base.

“We’re pleased to expand our partnership with the DOD at NAS Corpus Christi to demonstrate the advantages of geothermal technology for military energy independence,” Cindy Taff, CEO of Sage Geosystems, says in a news release.

Sage is also conducting initiatives at Fort Bliss and has completed an analysis at the Ellington Field Joint Reserve Base. The analyses could “pave the way for expanding geothermal energy solutions across additional U.S. military installations,” according to Sage.

The company’s proprietary technology works by leveraging hot dry rock, which is a more abundant geothermal resource compared to traditional hydrothermal formations, and it provides energy resilience for infrastructures. In addition, Sage is building a 3 megawatt commercial EarthStore geothermal energy storage facility in Christine, Texas, which is expected to be completed by December. Sage also announced a partnership with Meta Platforms. With Meta Platforms, Sage will deliver up to 150 megawatt of geothermal power generation east of the Rocky Mountains.

The Naval Air Station Corpus Christi is considered a critical training and operations hub for the U.S. Navy, and the partnership with Sage shows the Navy's commitment to achieving net-zero carbon emissions by 2045. Sage’s technology will be assessed for its ability to create a microgrid, which can reduce reliance on the utility grid and ensure power supply during outages.

“As we advance our Geopressured Geothermal Systems, we see tremendous potential to not only provide carbon-free power, but also strengthen the operational capabilities of U.S. military installations in an increasingly digital and electric world,” Taff adds.

In September, the Air Force awarded Sage a grant of $1.9 million in a first-of-its kind contract to determine whether a power plant using Geopressured Geothermal Systems is able to generate clean energy needed for a base to achieve energy resilience.

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This article originally ran on EnergyCapital.

3 Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes three Houston startup founders celebrating big wins.

Shreyans Chopra, founder of Mstack

Shreyans Chopra, founder of Mstack, is celebrating the close of his company's $40 million series A. Photo courtesy of Mstack

Houston-based Mstack, whose platform helps manufacturers source specialty chemicals, has raised $40 million in a series A funding round. The company says the infusion of cash will enable it to “double down on its mission to disrupt a historically flawed supply chain for specialty chemicals.”

“This new funding affirms investor confidence in our vision and technology to transform global markets. It enables us to expand geographically and intensify our R&D efforts,” Mstack founder Shreyans Chopra says. Read more.

Scott Deans, co-founder and CEO of BeOne Sports

Rice University's athletic programs will be supported by Houston startup BeOne Sports' technology. Photo via LinkedIn

Rice University — in an effort to enhance athletics and research-driven innovation — has formed a partnership with a startup founded by its alumni.

BeOne Sports, a sports performance technology company developed a platform for mobile motion-capture AI and advanced data analytics, will integrate its technology within Rice's sports medicine and rehabilitation programs.

“BeOne Sports was born from the collaborative environment at Rice, where business leaders and engineers work together to solve real-world problems” Scott Deans, co-founder and CEO of BeOne Sports, says. “Our mission is to provide cutting-edge technology to maximize potential in the simplest, fastest and most versatile ways possible. This partnership with Rice is an exciting step toward democratizing access to sports technology for athletes and coaches at all levels.” Read more.

Henal Patel, founder and CEO of DocJuris

Henal Patel, CEO of DocJurisDocJuris has raised its first round of venture funding to grow its team to keep up with demand for its legal software platform. Photo courtesy of DocJuris

Houston-based DocJuris, a leader in AI contract review, announced the successful closure of its series A funding round by raising $8 million in new capital. This brings the total capital raised to date to $11.2 million.

"DocJuris AI has become an industry-leading platform that empowers enterprise legal, procurement, and sales teams to close deals faster while reducing risk," DocJuris CEO and Founder Henal Patel says in a news release. "With this funding, we will continue scaffolding our platform around generative AI, expand our customer success team, and grow our user base." Read more.