Houston House at SXSW 2024 featured conversations about startup scaling, tips from CEOs, and more. Photo via Allie Danziger/LinkedIn

Houston innovators talked big topics at SXSW 2024 — from the startup scaling and converging industries to the future of work.

Houston House, which was put on by the Greater Houston Partnership on March 11, hosted four panels full of experts from Houston. If you missed the day-long activation, here are some highlights from the experts who each commented on the future of the Bayou City when it comes to startups, technology, innovation, and the next generation's workforce.

"When we think about Houston, we think about access to at-scale infrastructure, amenities, and workforce and talent pools."

— Remington Tonar, co-founder and chief growth officer at Cart.com, says about why the company chose to return its headquarters back to Houston last year. One of these amenities, Tonar explained, is Houston's global airports.

"If New York and Austin had a baby, it would be Houston, because you have friendly people with a big-city culture."

— Mitra Miller, vice president and board member of Houston Angel Network, says, adding that Houston has a cost efficiency to it, which should be at the forefront of founders' minds when considering where to locate.

"We are not only attracting global talents, we are also attracting global wealth and foreign investments because we are the rising city of the future. We are the global launch pad where you can scale internationally very quickly."

— Sunny Zhang, founder of TrueLeap, says adding how there's a redistribution of global workforce happening when you consider ongoing global affairs.

"We overwhelmingly as a company, and my co-founder would agree, knew we had to go the Houston path. And we started funneling a lot more resources here."

— Carolyn Rodz, co-founder and CEO of Hello Alice, says, explaining that the pandemic helped equalize the talent across the country, and this has been to the benefit of cities like Houston.

"Houston is here with arms open, welcoming people and actively recruiting."

— Sean Kelly, co-founder and CEO of Amperon, says, emphasizing how Texas has made moves to being business friendly. Amperon was founded in New York, before moving to Houston a couple years ago.

"There is a revolution starting to happen in Houston right now."

— Trevor Best, co-founder and CEO of Syzygy Plasmonics, says, first commenting on the momentum from Rice University, where his company's technology originates from. But, as he adds, when you compare the ecosystem when the startup was founded in 2019 to where it's at now, "there is so much more happening."

"Houston has a critical mass in terms of aerospace."

— Stephanie Munez Murphy of Aegus Aerospace says, saying specifically that NASA's Johnson Space Center holds some responsibility for that. "JSC is the home of opening up space commercialization."

"There's diversity in industries people are coming from, but also in terms of experience and expertise that (Houstonians) have."

— Robyn Cardwell of Omniscience says, adding that Houston's diversity goes further than just where people originate from. "Houston has all these pieces put together ... for growing and scaling organizations," she adds.

"I've worked with thousands of students in Houston who are actively looking to better themselves and grow their career post college or post high school and go into the workforce."

— Allie Danziger of Ascent Funding says, adding that Gen Z, which is already entering the workforce, is entrepreneurial and ready to change the world. "Seeing the energy of Houstonians is just thrilling," she adds.

"We're working together in the Houston community. ... There are so many opportunities to collaborate but we need conveners." 

— Stacy Putman of INEOS says, adding that within industry there has been a lack of discussion and collaboration because of competition. But, as she's observing, that's changing thanks to conveners at colleges or at the Greater Houston Partnership.

"The opportunity for Houston is that everybody has to step up to be in some way, shape, or form helping us with this."

— Raj Salhotra of Momentum Education says about supporting the future workforce of Houston, including low-income household students.

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Houston startup’s brain implant for depression advances to clinical trial

moving forward

Houston-based Motif Neurotech has received FDA approval to move forward with its first clinical trial for its innovative way to fight treatment-resistant depression and other mental health disorders.

The company has developed a brain-computer interface technology based on research from Rice University. The blueberry-sized, wirelessly powered implantable device known as the Digitally-programmable Over-brain Therapeutic (DOT) stimulator delivers electrical stimulation to brain circuits linked to depression. The DOT stimulator sits in the skull above the dura without touching the brain and is considered an alternative to transcranial magnetic stimulation, which requires multiple treatment sessions and can cause headaches.

“The goal for this technology is that it would be the mental health equivalent of a continuous glucose monitor for diabetes,” Jacob Robinson, a Rice University professor of electrical computer engineering and bioengineering and CEO of Motif Neurotech, said in a news release. “What has been really special for me personally on this journey is to be able to work all the way from a concept through the process of research and development funded by the federal government at Rice, and take that into a product that is going to affect people’s lives for the better.”

Eligible adults whose depression has not improved after trying multiple therapies can take part in the study. The clinical trial will be conducted in collaboration with Baylor College of Medicine, Brain Health Consultants (Houston), UT Health Houston, Massachusetts General Brigham, Emory Healthcare, University of Iowa, University of Utah Health and New York University, according to Rice.

Motif also announced that it was one of the first teams selected for ARPA-H’s EVIDENT initiative, which recently awarded up to $139.4 million to spur new, effective therapies for behavioral health. Through the initiative, Motif will collect additional data alongside its clinical trial.

“The idea with this funding is to support a number of teams who have rapid-acting interventions for a mental health condition and to collect additional data to help determine with greater precision whether a treatment is working, how it is working and which patients are benefitting most from which course of treatment,” Robinson added in the release.

Motif Neurotech was spun out of Robinson’s and Professor Kaiyuan Yang’s labs at Rice, along with collaborators and co-founders Dr. Sameer Sheth at Baylor College of Medicine and Dr. Sunil Sheth at the University of Texas Health Science Center at Houston. It was founded through the Rice Biotech Launch Pad. The company closed its Series A round with an oversubscribed $18.75 million last year.

New immersive experience Time Mission clocks into Houston this summer

It's Time

Time for a new immersive experience to come to Houston: Time Mission, a kid-friendly, team-based adventure, is scheduled to land at the Marq-E Entertainment District in summer 2026.

Created by LOL Entertainment, a location-based entertainment company specializing in immersive attractions, Time Mission blends physical and mental challenges in a fast-paced experience, a release says. Players take on real-world tasks like cracking codes, dodging lasers, solving riddles, and exploring hidden tunnels to earn points for their team.

Racing through 25-plus unique portals, teams of two to five players embark on a time-travel journey across the past, present, and future, all while collecting points and battling the clock. The website says the attraction is appropriate for "players age 6 to 106."

“We’ve seen a shift in how people seek entertainment, choosing immersive adventures that foster connection and excitement," says Rob Cooper, CEO of LOL Entertainment, in the release. "We’re excited to introduce [Texas] to an experience where strategy, innovation, and teamwork collide."

There are currently Time Mission locations in Pennsylvania, New York, Rhode Island, Virginia, Illinois, and Belgium. Dallas will be the first Texas location, followed by Houston.

Immersive attractions have been popular in Houston for several years, from Meow Wolf just north of downtown to interactive experiences dedicated to balloons and more.

Time Mission will be located in a 10,000-square-foot space at the Marq-E Entertainment District (7620 Katy Fwy., Ste. 355). The exact opening date will be announced at a later time.

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This article originally appeared on CultureMap.com.

7+ can't-miss Houston business and innovation events in May

where to be

Editor’s note: Houston is living up to its nicknames as Space City and the Energy Capital of the World this month with a lineup of insightful talks, pitch days and industry conferences. Plus, there are opportunities to network over crawfish, learn about brain health and more. Here’s what not to miss and how to register. Please note: this article may be updated to add more events.

May 7 – Ion Block Party and Crawfish Boil

Head to this special edition Block Party, featuring a crawfish cook-off competition among the Ion’s businesses. Competing teams include Transwestern, Microsoft, Rice Alliance, Rice Nexus, South Main Baptist, Per Scholas, Industrious and many others. Taste test crawfish while supplies last, and sip a complimentary drink from Second Draught.

This event is Thursday, May 7, from 4-7 p.m. at the Ion. Register here.

May 12 – Why the Next Decade of Breakthrough Brain Tech Matters For You, and What to Do About It

Hear from Matias Serebrinsky, co-founder and general partner of San Francisco-based PsyMed Ventures, at this talk presented by EO Houston. Serebrinsky will discuss why founders are disproportionately affected by brain health issues and look at breakthrough brain and mental health tech.

This event is Tuesday, May 12, from 11:20 a.m.-1 p.m. at Tony's on Richmond Avenue. Register here.

May 18-19 — Geothermal Transition Summit North America

This two-day summit serves as the meeting point for the geothermal and oil and gas industries and will focus on geothermal energy, including scaling plants and navigating state regulations. The event promises 40 expert speakers, 15 exhibition spaces, and networking opportunities with 250 industry decision makers.

This event begins May 18 at Norris Conference Center. Register here.

May 19 – IOT Innovation Day

IoT Innovation Day will present a series of fast‑paced, 15‑minute tech talks focused on the future of connected devices. These sessions feature insights from founders, engineers, product innovators and industry leaders. Attendees are also invited to sign up to present their own tech talk showcasing their expertise, startup or solution.

This event is Tuesday, May 19, from 10 a.m.-6 p.m. Register here.

May 20-21 — ESF North America

ESF North America returns for its 5th edition, under the theme of “innovation and adaptation.” Attendees will explore how technology, innovation, and collaboration can drive a resilient, competitive refining and chemicals industry.

This event begins May 20 at The Westin Oaks Houston at the Galleria. Register here.

May 21 – AI + Energy Sector Pitch Day

Hear from startups powering the AI boom or using AI to support the energy transition at Greentown's latest installment of its Sector Pitch Day series. Brian Walker, program manager for emerging technologies in the U.S. Department of Energy’s Building Technologies Office, will present the keynote address. Six Greentown startups will present pitches, as well as others from IMPEL, a DOE tech-to-market program, and more. Stick around for a networking happy hour.

This event is Thursday, May 21, from 1:30-6:30 p.m. at the Ion. Register here.

May 28 – NASA Stories at the Ion: A Conversation with NASA’s Artemis II Orion Vehicle Manager Branelle Rodriguez

NASA’s Artemis II Orion Vehicle Manager Branelle Rodriguez will discuss what it took to ready the spacecraft for its mission and return to Earth at this special installment of NASA Stories. Rodriguez will share insights on Orion’s high-speed reentry, the views of the Moon and Earth witnessed by the crew, and what’s next for Orion on NASA’s upcoming Artemis missions in 2027 and 2028. Complimentary breakfast and networking take place before each talk.

This event Thursday, May 28, from 8:30-10 a.m. at the Ion. Register here.

May 28 – NASA Tech Talks: Texas-France Space Hub Business Accelerator Initiative

NASA Tech Talks is partnering with the Rice Space Institute (RSI) this month to host the second cohort of the Texas-France Space Hub in Houston. The hub aims to unite academic institutions and private enterprises to expand commercial space presence in both countries. Startups from the hub will present during the event, followed by drinks and networking at Second Draught.

This event Thursday, May 28, from 6-7 p.m. at the Ion. Register here.