After the floods from Hurricane Harvey totaled her car, Rahel Abraham wanted to find a solution. ClimaGuard/Facebook

Floodwaters from Hurricane Harvey seriously damaged about 600,000 vehicles in the Houston area, driving millions upon millions of dollars in auto insurance claims. Rahel Abraham's 2008 Infiniti G35 was among them.

Rather than merely moving on from the hurricane, though, Abraham — drawing upon her experience as an engineer in Houston's petrochemical industry — invented something that she foresaw shielding cars from the economic wrath of flooding.

Now, Abraham's brainchild forms the backbone of her Houston-based startup, ClimaGuard LLC. The next several weeks promise to be momentous for the business — Abraham will enter the 12-week DivInc business accelerator program in Austin in late August, and the company's first product is set to hit the market in early September.

ClimaGuard's waterproof, temperature-resistant, portable Temporary Protective Enclosure (TPE) can entirely cover a compact car, sedan, or midsize SUV. It comes in three sizes; the cost ranges from $349 to $499.

To protect a vehicle, someone sets a TPE on the ground, a driveway, or another flat surface, then drives the vehicle onto the bottom part of the product, and connects the bottom and top parts with the zipper. Abraham likens it to a clamshell preserving a pearl.

Once the vehicle is inside the TPE, it can be anchored with straps to a sturdy fixture. It's designed to withstand up to three feet of water and keep the vehicle from floating away.

One person can set up a TPE in less than five minutes, Abraham says.

She hopes to team up with auto insurers to offer discounts for policyholders that have a TPE. This, Abraham says, would spur more people to buy the product.

"My goal is not to make it to where it's an exclusive product — available only to those who can afford it — but I want to be able to help those who it would make even more of an economic impact for," Abraham says.

Among potential customers for the TPE are car owners, homeowners, small businesses, first-responder organizations, and nonprofit agencies, Abraham says. Other than vehicles, the product could protect valuables like antique pianos and restaurant gear, according to Abraham.

The sense of "helplessness and vulnerability" Abraham felt after her car was lost in Hurricane Harvey propelled her to devise ClimaGuard's TPE, she says, so that others might avoid enduring the sort of "stressful and traumatic" ordeal that she did.

Another catalyst: After hatching the idea for the TPE, Abraham learned that more than 41 million Americans live in federally designated flood zones, and that flooding is the costliest type of natural disaster in the U.S. and is forecast to occur more frequently. That research "validated my gut feeling," she says.

Abraham, a first-time entrepreneur, founded the bootstrapped startup in 2018, just a year after Harvey. Today, she's the only full-time employee of ClimaGuard. She holds a bachelor's in chemical engineering from the University of Texas at Austin and a master's degree in environmental engineering from the University of Houston.

Abraham says she hopes participating in the 12-week DivInc accelerator program in Austin will broaden her business network and hone her marketing skills. ClimaGuard was among 13 companies selected for this fall's DivInc group, which is sponsored by JPMorgan Chase.

DivInc aims to diversify the startup environment by offering workshops, mentoring, and business-strategy assistance to underrepresented entrepreneurs — people of color and women. The Austin-based nonprofit organization chooses participants through an application process that its program director, Brooke Turner, describes as being "extremely competitive" this year.

"It's tough being a developer or entrepreneur when no one looks like you when you walk into a room of other developers or entrepreneurs," DivInc co-founder Ashley Jennings told Crunchbase in 2017. "How can they feel that they fit in? So what we have now is an opportunity to create role models with this generation."
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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.