The Welch Foundation has announced a $100 million gift to Rice University to establish The Welch Institute focused on materials science. Photo courtesy of Rice

A private foundation that funds chemical research within the state of Texas is dedicating funds to a new venture — an institute focused on advanced materials at Rice University.

The Welch Foundation announced today a $100 million gift to Rice University to establish The Welch Institute. The institute will foster the study of matter, the design and discovery of new materials, and nanotechnology, and it will be led by an independent board of directors and scientific advisory board.

"The Welch Institute will focus on the development of advanced materials for the good of society and to advance the vision of Robert A. Welch, who believed in basic chemical research as a powerful force for transformative breakthroughs and improving the quality of life," says Welch Foundation Chair and Director Carin Barth in a news release. "It will bring together top minds across all disciplines to catalyze innovation and center leadership in the field right here in the Houston area."

Material science has an impact across industries — from energy, water, space, telecommunications, manufacturing, transportation, and more.

"Innovation is the foundation of progress. More than ever, the discovery of new knowledge is in turn the precursor of innovation. That is why universities and the work we do are key components of the innovation ecosystem," said Rice University President David Leebron at the press conference. "We expect the Welch Institute to serve the needs of all mankind, but we also expect it will secure a stronger future for the people of Houston."

The institute has a huge opportunity to lead the way in material science in the United States — as most of the current research and innovation within this field is happening on foreign land.

"While [material science] is fundamental to every conceivable aspect of our lives, the United States may be falling behind in terms of advancement in this field," says Gina Luna, board member of The Welch Foundation and acting president of The Welch Institute, at the press conference. "Of the top 10 material science institutes in the world today, not one of them is in the U.S. We believe the Welch Institute can change that."

Luna adds that the organization will bring together experts together in Houston, "where we just know how to get things done," she adds.

Rice is an ideal home for the initiative, says Pulickel M. Ajayan, chair of Rice's department of materials science and nanoengineering, and Houston stands to benefit from the program as well.

"This new institute will serve as an international hub for materials research, so that people from all around the world can come here and spend time and see Houston and Rice as a destination for materials research," he adds.The Welch Foundation has granted over $1 billion in funds and has endowed 48 chairs at 21 Texas universities, says Peter Dervan, chairman of the Scientific Advisory Board of The Welch Foundation and Bren Professor of Chemistry at the California Institute of Technology.

"We want to develop the Institute while maintaining all of our legacy grant programs and awards, which have served Texas scientists so well over the years," he adds,

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.