3 Houston innovators to know this week

who's who

This week's innovators to know roundup includes Patrick Jankowski of the Greater Houston Partnership, Deanea LeFlore of The Ion, and Dr. Mehdi Razavi of the Texas Heart Institute. Photos courtesy

Editor's note: In this week's Monday roundup of Houston innovators, I'm introducing you to three innovators across the city — from the Greater Houston Partnership, The Ion, and Texas Heart Institute.

Patrick Jankowski, senior vice president of research

The Greater Houston Partnership hosted its annual economic outlook event online this week. Photo courtesy of the GHP

At the GHP's annual economic outlook, Patrick Jankowski, senior vice president of research, predicts that 2021 will be a "bipolar year." The first and second halves of the year are going to look different, Jankowski says, it's just a matter of how different at this point. In addition to the vaccine and COVID case numbers, the things the GHP as well as Houston businesses are watching is the new Biden Administration.

"We won't see any significant growth in the economy until we get to the second half of the year," he says. Read more.

Deanea LeFlore, director of partnerships at The Ion

Deanea LeFlore, director of partnerships at The Ion, joins this week's episode of the Houston Innovators Podcast. Photo courtesy of Station Houston

Houston is just a few months away from being able to walk into The Ion, and the organization's director of partnerships, Deanea LeFlore, hopes that when that happens, they are entering a innovation hub reflective of the city.

"I think that when people walk into The Ion, what's personally important to me, is that it looks like Houston so that you see yourself reflected in the people in the building as well as the programming," LeFlore says. "That's my biggest hope and aspiration, and I believe we are well on track to be able to deliver on exactly that."

LeFlore shares more on what she's been working on — from online programming to growing partnerships at The Ion. Listen to the podcast and read more.

Dr. Mehdi Razavi, director of Electrophysiology Clinical Research & Innovations at the Texas Heart Institute

A medical device coming out of the Texas Heart Institute has been recognized for its innovation. Photo via THI

A new technology out of Houston's Texas Heart Institute's was named the top future medical product design worldwide last month as part of the annual Create the Future Design contest. The med device, which allows for pain-free defibrillation, is being developed by THI's Electrophysiology Clinical Research & Innovations team in conjunction with scientists at Rice University and UCLA, the technology allows doctors to place up to 12 tiny nodes around the heart to pace and defibrillate the heart without using a shock.

The technology will be most useful for atrial fibrillation and ventricular fibrillation, which can lead to sudden death, stroke, and congestive heart failure, according to Dr. Mehdi Razavi, the head investigator on this project and leader of the THI team.

"It's extremely painful. It's like someone takes a two by four and just pounds you from the inside in the chest, or a horse kicking you in the chest," Razavi says. He went on to add: "I have actually one patient who was a Vietnam veteran. He said nothing that he faced in battle was as disconcerting—not just because of the pain, but the fact that you don't know when the pain is when the shock is about to happen. That anxiety is just overwhelming." Read more.

The Greater Houston Partnership hosted its annual economic outlook event online — here's what the numbers indicate for Houston business in the new year. Photo via Getty Images

2021 will be a 'bipolar year' and other key takeaways from the Greater Houston Partnership's economic outlook

looking forward

As much of the world is ready to celebrate a new year — one likely to be drastically less affected by COVID-19 — the Greater Houston Partnership released an annual report about what Houston's economy will look like in 2021.

Senior vice president of research Patrick Jankowski and his team put the Houston Region Economic Outlook report together and shared some its highlights at a virtual event hosted by Bob Harvey, president and CEO of GHP.

Of course, much of the study focused on how the coronavirus — as well as the impending vaccine — will affect the region's economy.

"At this point last year, neither Patrick nor any of us could have predicted the arrival of COVID-19 and its devastating impact on the global economy," Harvey says at the event. "Here in Houston COVID wreaked havoc on industries across the spectrum from energy to hospitality."

In the early weeks, the Houston region lost 350,000 jobs, according to the report, and in the months since, the region added back about half with 176,000 jobs.

Below are some more key takeaways from the report — and in most cases, the outcome depends on how COVID-19 case numbers are affected by the holidays and the accessibility of the vaccine.

"The weeks and months ahead are likely to be some of the most difficult of the pandemic," Harvey cautions. "We cannot afford to let our guard down now as we approach the finish line."

Energy will continue to struggle

Photo via Getty Images

The past six years have been rough for oil and gas, and in Houston specifically, Houston has lost nearly 100,000 upstream energy jobs, and the energy industry's share of Houston's GDP has fallen from 35 to 40 percent (a GHP '14 estimate) to 20 to 25 percent (a GHP '19 estimate).

The Russia-Saudi Oil Feud in March brought this decline to its head and it's not looking like it's getting back to normal any time soon. "Next year won't be any easier for the industry. While global demand has improved, it will remain three to five million barrels per day below pre-COVID levels," reads the report.

The new administration is expected to have several goals that will affect the industry, such as bringing the U.S. back into the Paris Agreement, negotiating new mileage and emission rules for autos and trucks, slowing or halting oil leasing on federal lands and in the Gulf of Mexico, increasing environmental scrutiny during the pipeline permitting process, and more.

Jobs in some industries will come back

Chart via GHP

According to the report, Houston's unemployment rate, at 3.9 percent in February, jumped to 5.5 percent in March, then 14.3 percent in April — the highest on record.

"Unemployment has improved — we're at 7.9 percent now," Jankowski says at the event.

But recovery depends on the industry. Jankowski predicts that retail and energy are both expected to continue to lose jobs, and other industry sectors — such as government, arts and entertainment, and educational services — aren't expected to grow by much.

However, some of the sectors hardest hit in 2020 — construction, manufacturing, support services, and restaurants — are expected to bounce back with thousands of new jobs.

The chart gives a range of job growth — there's a lower and a higher outlook. Jankowski says it depends on how well the vaccine is doing.

If by mid-year, we don't have much of the population inoculated, it's going to be closer to that lower number," he says.

2021 will be a "bipolar year"

Patrick Jankowski of the GHP. Photo via Houston.org

The first and second halves of the year are going to look different, Jankowski says, it's just a matter of how different at this point. In addition to the vaccine and COVID case numbers, the things the GHP as well as Houston businesses are watching is the new Biden Administration

"We won't see any significant growth in the economy until we get to the second half of the year," he says

The first quarter of 2021 will be especially tough for Houston, according to the report, since the region always experiences job losses in January as retail, restaurant, and transportation workers hired for the holiday season are rolled off. Additionally, contract workers employed to meet year-end deadlines are released and plans for reorganization are implemented.

"No one should be surprised when Houston loses 40,000 or more jobs this January," the report reads. "Houston's recovery will likely lag the U.S.'s by a few months, but growth will resume in the second half of '21."

Out of the largest 100 cities in the country, Houston ranks high up on the list that evaluated personal financial distress of citizens. Photo by Scott Halleran/Getty Images

Houston ranks No. 3 on list of cities with the most people in financial distress amid COVID-19

money problems

During the pandemic-produced recession, debt and loans are weighing heavily on the hearts and minds of Houstonians.

A study released this week by personal finance website WalletHub found Houston ranks first among the country's 100 largest United States cities for online searches about debt and first for online searches about loans. Overall, Houston ranks third for financial distress, behind first-place Las Vegas and second-place Chicago.

To examine where Americans are struggling the most financially, WalletHub compared the 100 largest cities across nine key metrics. Factors taken into consideration include average credit score, number of bankruptcy filings between June 2020 and June 2019, and online searches regarding debt and loans.

Aside from sitting at No. 1 for interest in debt and loans, Houston ranks:

  • No. 9 for share of people with accounts in distress in September
  • No. 9 for average number of accounts in distress in September
  • No. 12 for average credit score in September

WalletHub defines a distressed account as one for which payments have been reduced, skipped or delayed.

Among Texas cities, Houston has a lot of company in WalletHub's top 10. San Antonio appears at No. 4, Dallas at No. 5, Austin at No. 8, and Fort Worth at No. 10. In all, the ranking includes 13 Texas cities. Irving demonstrates the most financial stability of the 13 cities, according to WalletHub, with its financial stress ranking at No. 72.

As with almost every U.S. city, Houston has been whacked by the recession. In September, the metro area's unemployment rate stood at 9.6 percent, up from 8.1 percent the previous month. Compared with the state's three other major metro areas, Houston's September unemployment rate was the highest. The September jobless rate was 6.4 percent in Austin, 7.4 percent in Dallas, 7.6 percent in Fort Worth, and 7.8 percent in San Antonio. The statewide unemployment rate was 8.3 percent, while the nationwide unemployment rate was 7.7 percent.

One of the main drivers of Houston's high unemployment rate is the ongoing slump in the U.S. oil, gas, and chemical industry. A report released October 5 by consulting giant Deloitte showed the nationwide sector shed 107,000 jobs from March to August.

"We will never see oil and gas employment get back to where it was in December 2014. Employment in the industry today is pretty much where it was in 2006," Patrick Jankowski, senior vice president of research at the Houston Partnership, said in June. "Energy has been real good to Houston. It's still a big part of our economy, but we cannot rely on it like we have in the past."

A September report from the Federal Reserve Bank of Dallas noted that the Houston area is in recovery mode, but the pace has slowed, mostly due to weakness in the energy sector. The report says "that while Houston's recovery is likely to continue, it will lag the state."

The report adds that the Houston area had recovered 33 percent of pandemic-era job losses as of August, compared with 42 percent across Texas and 48 percent nationwide.

Of course, the pandemic recession also has hammered the hospitality industry.

During his State of the City address on October 22, Houston Mayor Sylvester Turner said said 196 meetings, conferences, and conventions in the city had been canceled or rescheduled since March. The result: an estimated economic loss of $332 million. The city's hotel occupancy rate stands at a meager 44 percent, according to Turner, with the rate for downtown hotels at only 17 percent.

The pandemic's impact during the rest of 2020 and into 2020 "will be significant for our hospitality community," the mayor said.

Despite the downturn in the energy and hospitality sectors, Turner and others feel optimistic about what's ahead for Houston.

"As we gradually take steps to reopen, we recognize that the full recovery will take several years, but when we work together, we put ourselves in the best position to manage the virus and rebound from it," Turner said. "As we move forward through these unprecedented times, the city's foundation is strong, the city itself is resilient, and the city's future is bright."

According to a new study, Houston is among the cities most vulnerable to job loss due to the recession caused by COVID-19. Getty Images

COVID-19 could cost Houston 44,000 jobs by the end of the year, says local economist

hits keep coming

No matter whether the outlook leans more toward optimism or pessimism, Houston stands to lose a head-spinning number of jobs in the grips of a coronavirus-induced recession.

Economist Bill Gilmer, director of the Institute for Regional Forecasting at the University of Houston's Bauer College of Business, says a moderate recession could drain as many as 44,000 jobs from the regional economy by the end of 2020. That's out of nearly 3.2 million workers in the Houston metro area.

The job figures might look "much worse" through the second and third quarters of this year, Gilmer says. However, he adds, Houston's job losses should be followed by a "quick recovery" in 2021.

A study published March 27 by personal finance website SmartAsset predicts an even greater impact on employment in Houston.

SmartAsset forecasts 56,469 full-time and part-time jobs in just the city of Houston, or nearly 5 percent of the local workforce, could be lost in a coronavirus recession. In all, more than 282,000 jobs, or 24.6 percent of the city's workforce, could be in jeopardy, according to the study.

John Diamond, director of the Center for Public Finance at Rice University's Baker Institute for Public Policy, says he thinks Smart Asset's job-loss estimate is "decent" but might be too low.

In light of the federal government's extension of social-distancing guidelines to April 30 and perhaps further extensions, Diamond believes Houston will suffer "substantial" job losses in the next two to four months. After the social-distancing rules are relaxed, Diamond expects an employment bounce-back later in the year.

"The recovery could be rapid if business supply chains and networks remain intact," Diamond says, "and if oil prices rebound by the end of the year."

For his part, Ed Hirs, an economics lecturer at the University of Houston, pessimistically envisions about 300,000 people in the Houston metro area will lose their jobs, at least in the short term, due to the coronavirus recession and the recent plunge in oil prices. (By comparison, the Economic Policy Institute projects the entire state of Texas will lose 442,717 private-sector jobs as a result of the coronavirus pandemic.)

"COVID-19 is going to be kind of a catch-all spring cleaning excuse for a lot of the oil and gas companies as they try to reduce their payroll," Hirs says.

For now, though, concerns about the oil war between Russia and Saudi Arabia must "take a back seat" to concerns about COVID-19, he says.

Aside from the energy industry, the escalating economic slump promises to hit several other prominent business sectors in Houston, including hospitality and manufacturing. Hirs thinks a recession could shrink Houston's 2020 economic output by 10 percent.

"This is across the board," he says, "and has the potential to be extraordinarily devastating."

ThinkWhy, a labor analysis firm, believes the impact of the COVID-outbreak on the Houston job market will be more evident in the blow it delivers to international trade than in any boost it provides to the health care sector. "But the pandemic will no doubt have an impact on both," the firm says.

It's already having a tremendous impact on small and midsize businesses in the Houston area. A March 23-28 survey by the Greater Houston Partnership found 34 percent of those businesses already had reduced their headcounts in response to the COVID-19 slowdown. And 55 percent said they're unsure whether they'll wind up carrying out permanent layoffs in the next six months.

"Houstonians like to embrace the notion that their metro was among the last to enter the Great Recession and was among the first to exit. That's not going to be the case this time," economist Patrick Jankowski, senior vice president of research at the Greater Houston Partnership, wrote in an unvarnished economic assessment published March 20. "All three pillars of Houston's economy — energy, global trade, and the U.S. economy — are tottering. The next 12 to 18 months will likely be very rough for Houston."
From entrepreneur networking opportunities to thought-provoking panels, here's where you need to be in December. Getty Images

10+ can't-miss Houston business and innovation events for December

Where to be

Before everyone checks out of 2019, Houston has a couple more weeks filled with exciting entrepreneurial networking opportunities. Scroll through the curated list of innovation events you can't miss.

For a full calendar of Houston innovation events, head to Houston Exponential's page.

If you know of innovation-focused events for this month or next, email me at natalie@innovationmap.com with the details andsubscribe to our daily newsletterthat sends fresh stories straight to your inboxes every morning.

December 3 — Intro to the Houston Startup Scene & Ask Me Anything with Omair Tariq and Dr. Brittany Barreto

Are you new to the Houston tech startup community? Thinking about moving here? Trying to figure out how to plug in? Come hear a comprehensive overview from local community leaders and get a chance to introduce yourself and ask questions at the Intro to the Houston Startup Scene & Ask Me Anything. Tickets are $10.

Details: The event is from 4 to 7 pm on Tuesday, December 3, at The Cannon (1334 Brittmoore Road). Learn more.

December 3 — Houston Coalition for Equitable Development without Displacement community forum

The Houston Coalition for Equitable Development without Displacement is gathering for a second time to discuss securing a Community Benefits Agreement with Rice Management Company as they develop the 16-acre Innovation District around the old Sears building and Fiesta at the edge of Third Ward.

Details: The event is from 6 to 8 pm on Tuesday, December 3, at Wesley Chapel AME Church (2209 Emancipation Ave.). Learn more.

December 3-4 — InvestH2O 2019 Forum: Investing in Resiliency

With nearly $1 trillion in losses over the past 5-7 years for FEMA and other federal agencies, states-counties-cities, private insurance and reinsurance companies, industry and business operations from water- and weather-related incidents, the need for alternative investment and resource allocation could not be more obvious. The event's programming will be focused on innovating solutions.

InnovationMap readers can attend for free through this link.

Details: The event is from Tuesday, December 3, to Wednesday, December 4, at various locations. Learn more.

December 4 — The Cannon & EPIcenter - Jumpstart your innovation Happy Hour

In partnership with The Cannon, EPIcenter's Incubator and Accelerator will be hosting a six-week seminar using the Wendy Kennedy curriculum, "So what? Who cares? Why you?" for innovators in any industry. Director of the EPIcenter Energy Incubator and Accelerator and certified Business Coach Andi Littlejohn will lead participants through a proven methodology to discover, define and describe the commercial opportunities of innovations.

Details: The event is from 4 to 6 pm on Wednesday, December 4, at The Cannon (1334 Brittmoore Road). Learn more.

December 4 — The Ion Smart Cities Accelerator Demo Day

The Ion Smart Cities Accelerator will present its inaugural cohort of companies that are addressing the needs of Houston's people by deploying technology into the infrastructure and civic fabric that makes Houston so strong.

Details: The event is from 5 to 8 pm on Wednesday, December 4, at ion Accelerator and Prototyping Lab (1301 Fannin Street, Suite 2100). Learn more.

December 5 — Houston Region Economic Outlook

The Greater Houston Partnership's Annual Houston Region Economic Outlook event will feature Partnership Senior Vice President of Research Patrick Jankowski who will deliver the 2020 employment forecast for the region. ConocoPhillips Chief Economist Helen Currie will follow with a presentation on the national economy.

Details: The event is from 9:30 am to 1:30 pm on Thursday, December 5, at the Royal Sonesta (2222 West Loop S.). Learn more.

December 5 — Evening of Pediatric Device Innovation

Please join JLABS @ TMC for the 5th Annual Evening of Pediatric Device Innovation as top experts from Houston and across the country will discuss the latest in pediatric medical device innovation and updates on bringing a pediatric medical device to market.

Details: The event is from 3 to 6:30 pm on Thursday, December 5, at the TMC Innovation Institute (2450 Holcombe Blvd). Learn more.

December 5 — Meet & Greet with Flyover Capital

Meet Flyover Capital's Dan Kerr on his last night in town and learn how they are working to creating the next generation of technology success stories outside the coastal tech hubs.

Details: The event is from 6 to 7:30 pm on Thursday, December 5, at WeWork (708 Main Street, 3rd Floor). Learn more.

December 11 — ENRICH/LEAP Information Session

ENRICH and LEAP are 6-8 week fellowship programs where you and a team of your peers will work directly with established companies on one of a wide scope of projects. These invaluable programs allow people the ability to gain skills and insights that only professional work can offer. Come hear Enventure leadership discuss these programs and learn how you can get involved.

Details: The event is from 5:30 to 8 pm on Wednesday, December 11, at the TMC Innovation Institute (2450 Holcombe Blvd). Learn more.

December 12 — WeWork Labs x NextSeed Launch Event

WeWork Labs, a global acceleration program with a location in downtown Houston, and NextSeed, a Houston-based online investment platform, have announced a partnership set to begin in December. Together, the two entities will build a support system for Houston-based food entrepreneurs to provide workshops, programming, events, and more.

Details: The event is from 6 to 8:30 pm on Thursday, December 12, at WeWork (708 Main Street). Learn more.

December 14 — Smart Infrastructure Hackathon

On Saturday, December 14, join Microsoft and The Cannon for a smart infrastructure hackathon. Bring your own ideas and team, or join a team when you arrive. Everyone is welcome, regardless of skill level.

Details: The event is from to 9 am to 7 pm on Saturday, December 14, at The Cannon (1334 Brittmoore Road). Learn more.

December 14 — TEDxHoustonWomen 2019 : BOLD + Brilliant!

Connect with a locally rooted, globally connected community of people interested in leading the change they wish to see in the world; and sow the seeds to collaborate with innovative thinkers who catalyze ideas toward action.

Details: The event is from 10:30 am to 4 pm on Saturday, December 14, at Unity of Houston (2929 Unity Dr). Learn more.

December 17 — The Future of Work: Closing the Skills Gap

GA gathers Houston industry leaders to share how they approach the challenge of upskilling the workforce. In this discussion, we'll cover how to bridge the gap between current team capabilities and the skills needed to stay competitive. Whether radically reskilling existing teams or onboarding new talent, the companies who adapt fastest will stand the test of time.

Details: The event is from 8:30 to 11 am on Tuesday, December 17, at Station Houston (1301 Fannin Street, 21st Floor). Learn more.

A new report from the Greater Houston Partnership found that Houston saw over $33 billion in foreign investments over the past 10 years. Photo by Scott Halleran/Getty Images

Houston sees boom of foreign investment and exports over the past decade

Global city

Throughout the past decade, over 500 foreign-owned companies from 36 countries have planned investments in Houston. The investments are spread across more than 600 deals within 63 industries in Houston. Adding up the amount of disclosed valuations, the total exceeds $33 billion.

The city has a lot to offer these companies from all over the world, says Greater Houston Partnership's senior vice president of research, Patrick Jankowski, in a release.

"These foreign-owned companies came to Houston for a variety of reasons, from being closer to their clients to establishing a beachhead for entering the U.S. market," Jankowski says in the release.

The information is compiled in the new Global Houston report from the GHP that analyzes data on foreign investment over the past decade. The research shows that now

The foreign investment movement greatly impacts the local economy, Jankowski adds.

"It infuses new capital into the region, expands the manufacturing base, helps underpin jobs, facilitates the exchange of ideas and best practices, increases trade, adds to the tax base and stimulates growth," he says.

Aside from the investments, the report found that locally, more than 2,500 Houston manufacturing firms have their hands in global trade. Around 17.3 percent of Houston's economy is related to exports, which amounts to double than what was recorded in 2003, according to the Brookings Institution. The Bayou City regularly leads the nation in exports, such as oil field services, refined products, chemicals, and fabricated metals.

The report also took into account Houston's diversity, which has also evolved over the past 10 years. About one in four residents are born outside the country, and a third of the population growth is attributed to immigrants — who account for 390,000 of the city's new residents. In 2017 alone, foreign-born Houstonians made up almost a third of the total GDP of Houston, or $142.1 billion.

"Over the last couple of decades, Houston's economy has become more diversified," says Bob Harvey, GHP president and CEO, in a news release. "We've surged beyond traditional oil and gas to include a burgeoning energy tech and renewables industry, a thriving life sciences and healthcare sector, and a robust advanced manufacturing ecosystem. And in that time, as this report shows, Houston's trade and investment ties with the rest of the world have grown as well. These global connections are essential to our long-term success."

In 2018, Houston's top five trade partners all increased activity. The top countries are, Mexico ($24.6 billion in 2018, compared to $20.1 billion in 2017), China ($20.3 billion, compared to $18.8 billion in 2017), Brazil ($12.9 billion, compared to $12.6 billion in 2017), The Netherlands ($10.4 billion, compared to $8.6 billion in 2017), and South Korea ($10.3 billion, compared to $6.8 billion in 2017).

By the numbers

Here are some key findings from the report.

  • The Houston/Galveston Customs District handled 289.2 million tons of cargo in 2018, or 33,000 metric tons every hour.
  • The Houston/Galveston Customs District ranked first in the nation in foreign tonnage handled and 7th in the nation by dollar value in 2018.
  • The three ports of Houston, Galveston and Freeport support 343,525 jobs, according to a report from Martin & Associates and Texas A&M University
  • Of Houston's 1.6 million foreign-born residents, 39.8 percent are naturalized (i.e. U.S. citizens). That's up from 32.3 percent a decade ago.
  • Latin America leads among regions of origin for Houston's foreign-born population with 1.02 million people in 2017, up 42 percent from 2008. Asia follows at 409,395, up 37 percent and Africa with 95,017, a 14 percent increase.
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Play it back: Houston home tech startup begins 2025 with fresh funding

HOUSTON INNOVATORS PODCAST EPISODE 272

One of the dozen or so Houston startups kicking of the new year with fresh funding is SmartAC.com, a company that's designed a platform that enables contractors in the HVAC and plumbing industries to monitor, manage, and optimize their maintenance memberships through advanced sensors, AI-driven diagnostics, and proactive alerts.

Last month, the SmartAC.com raised a follow-on round with support from local investor Mercury to continue growth and expansion of the product, which has evolved on many ways since the company launched in 2020, emerging from stealth with $10 million raised in a series A. In a May 2023 interview for the Houston Innovators Podcast, Founder and CEO Josh Teekell explained how he embraced the power of a pivot.

The company's sensors can monitor all aspects of air conditioning units and report back any issues, meaning homeowners have quicker and less costly repairs. While SmartAC.com started with providing the service and tech to homeowners directly, Teekell says he's had a greater interest in working with plumbers and HVAC companies who then deploy the technology to their customers.

"It became quite evident that homeowners don't care about air conditioning really at all until their system breaks," Teekell says on the show. "The technology is really built around giving those contractors as another way to gain a customer relationship and keep it."

Revisit the podcast episode below where Teekell talks about SmartAC.com's last raise.

SmartAC.com's previous round in 2023 — a $22 million series B — was used grow its team that goes out to deploy the technology and train the contractors on the platform.

"We've been very fortunate to get some of the biggest names in Houston on our cap table," Teekell says in the May 2023 conversation. "Since we're raising a bunch of money locally, everyone understands what a pain air conditioning can be."

Houston biotech company tests hard-to-fight cancer therapeutics

fighting cancer

A Houston-based, female-founded biotech company has developed a treatment that could prove to be an effective therapy for a rare blood cancer.

Cellenkos Therapeutics has completed promising Phase 1b testing of its Treg cell therapy, CK0804, in the fight against myelofibrosis. According to a news release from the Cellenkos team, the use of its cord-blood-derived therapeutics could signal a paradigm shift for the treatment of this hard-to-fight cancer.

Cellenkos was founded by MD Anderson Cancer Center physician and professor Simrit Parmar. Her research at the hospital displayed the ability of a unique subset of T cells’ capability to home in on a patient’s bone marrow, restoring immune balance, and potentially halting disease progression.

Myelofibrosis has long been treated primarily with JAK (Janus Kinase) inhibitors, medications that help to block inflammatory enzymes. They work by suppressing the immune response to the blood cancer, but don’t slow the progression of the malady. And they’re not effective for every patient.

“There is a significant need for new therapeutic options for patients living with myelofibrosis who have suboptimal responses to approved JAK inhibitors,” Parmar says. “We are greatly encouraged by the safety profile and early signs of efficacy observed in this patient cohort and look forward to continuing our evaluation of the clinical potential of CK0804 in our planned expansion cohort.”

The expansion cohort is currently enrolling patients with myelofibrosis. What exactly are sufferers dealing with? Myelofibrosis is a chronic disease that causes bone marrow to form scar tissue. This makes it difficult for the body to produce normal blood cells, leaving patients with fatigue, spleen enlargement and night sweats.

Myelofibrosis is rare, with just 16,000 to 18,500 people affected in the United States. But for patients who don’t respond well to JAKs, the prognosis could mean a shorter span than the six-year median survival rate outlined for the disease by Cleveland Clinic.

Helping myelofibrosis patients to thrive isn’t the only goal for Cellenkos right now.

The company seeks to aid people with rare conditions, particularly inflammatory and autoimmune disorders, with the use of CK0804, but also other candidates including one known as CK0801. The latter drug has shown promising efficacy in aplastic anemia, including transfusion independence in treated patients.

The company closed its $15 million series A round led by BVCF Management, based in Shanghai, in 2021. Read more here.

Pioneering Houston biotech startup expands to Brazil for next phase

On the Move

Houston biotech company Cemvita has expanded into Brazil. The company officially established a new subsidiary in the country under the same name.

According to an announcement made earlier this month, the expansion aims to capitalize on Brazil’s progressive regulatory framework, including Brazil’s Fuel of the Future Law, which was enacted in 2024. The company said the expansion also aims to coincide with the 2025 COP30, the UN’s climate change conference, which will be hosted in Brazil in November.

Cemvita utilizes synthetic biology to transform carbon emissions into valuable bio-based chemicals.

“For decades Brazil has pioneered the bioeconomy, and now the time has come to create the future of the circular bioeconomy,” Moji Karimi, CEO of Cemvita, said in a news release. “Our vision is to combine the innovation Cemvita is known for with Brazil’s expertise and resources to create an ecosystem where waste becomes opportunity and sustainability drives growth. By joining forces with Brazilian partners, Cemvita aims to build on Brazil’s storied history in the bioeconomy while laying the groundwork for a circular and sustainable future.”

The Fuel of the Future Law mandates an increase in the biodiesel content of diesel fuel, starting from 15 percent in March and increasing to 20 percent by 2030. It also requires the adoption of Sustainable Aviation Fuel (SAF) and for domestic flights to reduce greenhouse gas emissions by 1 percent starting in 2027, growing to 10 percent reduction by 2037.

Cemvita agreed to a 20-year contract that specified it would supply up to 50 million gallons of SAF annually to United Airlines in 2023.

"This is all made possible by our innovative technology, which transforms carbon waste into value,” Marcio Da Silva, VP of Innovation, said in a news release. “Unlike traditional methods, it requires neither a large land footprint nor clean freshwater, ensuring minimal environmental impact. At the same time, it produces high-value green chemicals—such as sustainable oils and biofuels—without competing with the critical resources needed for food production."

In 2024, Cemvita became capable of generating 500 barrels per day of sustainable oil from carbon waste at its first commercial plant. As a result, Cemvita quadrupled output at its Houston plant. The company had originally planned to reach this milestone in 2029.

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This story originally appeared on our sister site, EnergyCapitalHTX.

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