3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Youngro Lee of Brassica, Anu Puvvada of KPMG Studio, and Brock Murphy of Parent ProTech. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from corporate innovation to fintech — recently making headlines in Houston innovation.

Youngro Lee, founder of Brassica

Youngro Lee joins the Houston Innovators Podcast to discuss his latest endeavor on his mission to democratize investing. Photo courtesy

Brassica Technologies, a fintech infrastructure company that's providing a platform for alternative assets, is just the next step in his career in using tech to democratize finance. The idea came from Lee's experience as a startup founder and fintech exec — first at NextSeed and then at Republic, which acquired NextSeed two years ago.

"The reason why I thought this was what I wanted to focus on next was exactly because it was an issue I struggled with as a founder of NextSeed," Lee says on the show. "The backend was always an issue. There's not one single vendor that we felt really understood our business, was doing it efficiently, or enabled us to deliver those services to our end clients."

Lee shares more about the future of Brassica, including the challenges he's facing within regulation and the state of fintech as a whole, on the podcast. He also weighs in on how he's seen the Houston innovation ecosystem grow and develop alongside his own entrepreneurial journey. Read more.

Anu Puvvada, KPMG Studio leader

Anu Puvvada, KPMG Studio leader, shares how her team is advancing software solutions while navigating hype cycles and solving billion-dollar-problems. Photo courtesy of KPMG

In 2021, KPMG, a New York-based global audit, accounting, and advisory service provider, formed a new entity to play in the innovation space. The Houston-based team finds innovative software that benefit KPMG's clients across industries.

In an interview with InnovationMap, Anu Puvvada, leader of KPMG Studio, shares more about the program, its first spin out, and why she's passionate about leading this initiative from Houston.

"When you think about innovation as a whole, it's mired with risk and uncertainty," she says. "You never know if something's going to work or not. And part of what we have to do with any idea that we're building in the studio or anything that our clients are doing around innovation, we have to do as much as we can to mitigate that risk and uncertainty. And that's kind of what KPMG's wheelhouse is." Read more.

Brock Murphy, Parent ProTech co-founder

Brock Murphy launched Parent ProTech last fall. Photo via parentprotech.com

Houston-based Parent ProTech is a one-stop shop for parental education on technology and applications that their kids use.

“Our goal is to make everyone the best digital parent possible,” Brock Murphy, Parent ProTech co-founder, tells InnovationMap. “We understand technology and the role it plays in influencing the next generation. So we help parents when it comes to understanding the platforms, how to use them and how to unlock the parental controls that can be hidden, deeper into these platforms.”

Murphy — with co-founder Drew Wooten and creative director Joshua Adams — launched the platform in September 2022. Since then, Parent ProTech has made its mark through partnerships with schools in Texas. Read more.

Parent ProTech allows for parents to learn about the platforms their kids are active on — and how to protect them from potential danger. Photo via Canva and ParentProTech.com

Houston startup develops tech to protect children from online threats

imapct-driven innovation

Worry is an unavoidable part of the job description for any parent with children that continuously explore social media and other online applications and networks.

It seems as if with each passing day, a litany of horror stories centered around online bullying and online predators come to light replete with children who were approached and violated online and parents that had virtually no idea what their kids were up against.

But imagine a world where parents are able to not only monitor a child’s online activity, but are able to finally understand it, control it, and restrict it.

It’s a lofty task, but the team behind Parent ProTech, the one-stop shop for parental education on technology and applications that their kids use, are not only equipped to tackle it, they are passionate about finally giving parents the guide to parenting in the digital age.

Growing the tech platform

“Currently we’re at over 20,000 users and last week I closed a big deal with a national charter school, so they’re looking to launch in their Texas schools starting in August, which will pull us to 56,000 users signed up,” says Murphy. “The easiest way to get this important research into as many hands as possible was going to the schools.

“In Texas they have the Texas Essential Knowledge and Skills, or TEKS, requirement, and so we’re filling some of the void when it comes to social and emotional learning when it comes to interacting with technology and others online, preventing violence and cyberbullying and different computer applications requirements that the state passes down to schools to teach to children.”

Brock Murphy launched Parent ProTech last fall. Photo via parentprotech.com

Murphy realized that there was a dearth in online protection when it comes to children when he first started looking at the data coming out of the COVID-19 pandemic.

Based on the data, it was evident that children from ages 11 to 14 years old spent over nine hours in front of a screen per day and, according to FBI reports, have the potential to encounter some 500,000 online predators during that time.

“We’re highlighting the good, the bad and the ugly,” says Murphy. “And then we’re monitoring the different platforms, so when Snapchat added a new feature, for example, and inappropriate content was popping up on my entire teams’ Snapchat, we definitely wanted to flag the families.

“We alerted them about the new feature and the inappropriate content popping up and informed them about what to look out for and how they can do to combat it. These platforms are constantly changing, and parents are busy, so we’re taking this off their plate. We’ll monitor it and let them know when there’s something major that happens that could put their child at risk.”

For convenience, Parent ProTech is web-based and mobile compatible, but with an update planned in the next few months, it will be more personalized based on the age of the child and the parent’s philosophy on social media and screen time.

Mission-driven origin with constant updates

Murphy founded the company without an application development background. Before creating Parent ProTech, Murphy took a very interesting path that brought him to the Houston area. First, he interned at the White House, then worked for SpaceX in Brownsville, Texas. After that, he was lured away to a company headquartered in Paris, France. That company, eventually sent him to Houston to open up a local branch office.

Murphy says he's routinely been asked by parents, teachers, administrators, and families about technology and how to keep their family safe online. That curiosity was the seed planted in early 2021 that sprouted into Parent ProTech and laid the foundation for the team’s mission to help parents understand technology and the role it plays in influencing the next generation.

So for those parents that have no idea what Discord or YikYak is or are still shaking their heads at the popularity of TikTok, with all of its sometimes disturbing viral challenges, Parent ProTech has it covered.

“Essentially what we’ve built is a database for families and schools to dive into the different platforms and understand them,” says Murphy. “We’re diving deep into these platforms so parents can quickly get what they need to put parental controls in place. This way, they can rest a little easier knowing that their children will see the content they want them to see and not be exposed to inappropriate content.”

Additionally, Parent ProTech wants to be able to equip parents with the tools to keep their children from talking to strangers online.

Parents, of course, love the idea for Parent ProTech, but it wasn’t as attractive to the kids on the business end of the restrictions and monitoring.

“It’s not an easy conversation because parents are scared of pushing their children away,” says the Texas A&M alum. “Kids don’t want their mom to know when they’re posting on TikTok. And that push/pull can sometimes put parents in a position where they are overwhelmed and can cause a paralysis state where they don’t do anything at all.

“I met with some sophomores in high school, and they weren’t keen on what we do, but then I told them the story about the family in San Diego where the oldest of three sons was approached by a pill pusher on Snapchat because the Snapchat map was turned on and there was Xanax delivered to the mailbox and it was laced with fentanyl and the son passed away," he continues. "Those are the kinds of stories that get the kids to listen to what we’re saying and the importance of monitoring the activity on these platforms.”

Involving the experts

The Parent ProTech team doesn’t just rely on real news fodder, though, it also regularly consults with therapists and developmental professionals for the best results.

“We talk to child psychologists and therapists on how we would recommend parents talk about the restrictions and the changes they make when they deep dive into these platforms,” says Murphy. “And what we’ve found is the education of the parents on what the platforms actually are is really important. That helps with conversation starters and plans like if a parent wants to limit their child’s screentime to 15 minutes a day.”

Parent ProTech isn’t just providing technology knowledge and parental controls, it’s also helping families monitor their digital footprint.

“What you post today could come back and haunt you when you apply to medical school or that dream job,” says Murphy. “So we focus on that and how we can promote safety and well-being of our interactions with each other online.”

Moving forward, one of Parent ProTech’s biggest goals, outside of being that one stop shop for families/parents when it comes to safely navigating technology, is also being pro technology and promoting the tools and excitement that all of this advancement has on kids and the positive activity that can come out of it.

“We also want parents and kids to realize the potential there is with all of this advancement and continue pushing that message,” says Murphy. “We’d also like to develop some AI tools to help with bullying and inappropriate content to help prevent scammers from taking advantage of kids and elderly.”

Murphy also wants to put his time on Capitol Hill to good use by helping to advocate for various policy changes in Washington D.C. and state capitals that will help protect children online.

“We have to build this army of parents that want more priority of safety when it comes to children online and part of that is parents being more engaged in what their kids are doing and we’re here to help foster that.”

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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