3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Remington Tonar of Cart.com, Joey Sanchez of The Ion, and P.J. Popovic of Rhythm. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from e-commerce to energy — recently making headlines in Houston innovation.

Remington Tonar, chief commercial officer of Cart.com

With $150M in VC raise, this Houston company is re-envisioning the future of e-commerce operationsRemington Tonar of Cart.com joins the Houston Innovators Podcast this week. Photo via Cart.com

In a world where Amazon dominated the e-commerce world, Cart.com is offering merchants but an alternative and a supplemental tool.

As Remington Tonar, chief commercial officer of Cart.com, explains on the most recent episode of the Houston Innovators Podcast, Cart.com connects the dots for e-commerce companies, and, in fact, works alongside Amazon, too. While Cart.com clients can use the suite of software services to create their own shop, ship out of Cart.com's distribution centers, etc., they can also list their products on Amazon too.

"I like to view Amazon as co-op-etition. We can coexist with Amazon," Tonar says on the show. "We're not antithetical to Amazon. We're not mutually exclusive. We can work with folks who are selling on Amazon to build their direct-to-consumer business, and we are doing that today." Click here to read more and stream the episode.

Joey Sanchez, senior director of ecosystems at The Ion

Joey Sanchez is now the senior director of ecosystems at The Ion. Photo via HX.com

Joey Sanchez, who's worked in corporate partnerships for Houston Exponential for a few years, has hopped over and into a new role at The Ion.

In his new role, he will work with the Houston early-stage investing and startup community, including founders, early-stage startups, scaled startups, early-stage angel investors, venture capital investors, and corporate partners, to grow the Ion's presence in Houston.

"Houston and Texas are seeing unprecedented growth in tech and innovation. I am excited for the opportunity to continue building and supporting the Houston innovation ecosystem," says Sanchez the release. "An ecosystem needs harmony among all aspects involved, and I have always enjoyed connecting people. The overarching goal remains to build a vibrant ecosystem that supports a high frequency of connections between critical stakeholders to realize outsized success." Click here to read more.

​P.J. Popovic, CEO of Houston-based Rhythm

P.J. Popovic, CEO of Houston-based Rhythm, explains Renewable Energy Certificates work and their impact on Texas. Photo courtesy of Rhythm

What are RECs and what difference do they make? P.J. Popovic, CEO of Houston-based Rhythm, shares his expertise on Renewable Energy Certificates in a guest column for InnovationMap.

"Through PPAs, various risks, credit needs, and long-term commitments create challenges for many organizations to meet their sustainability goals. So, while RECs do not provide as material of a market signal as PPAs, with the recent changes in market prices, RECs can now be considered a meaningful, profitable market signal for renewable projects." Click here to read the article.

P.J. Popovic, CEO of Houston-based Rhythm, explains Renewable Energy Certificates work and their impact on Texas. Photo courtesy of Rhythm

Houston expert: Why higher REC prices are good for the future of renewables

guest column

We all know what renewable energy is — wind, solar, biomass, geothermal, hydropower — but how do you purchase it? It's invisible. Not to mention when energy from any source enters the electricity grid, there's no way to track all those electrons.

Renewable Energy Certificates have made it possible

Renewable Energy Certificates, or RECs, allow us to track your clean energy. Each individual REC represents one megawatt-hour of clean energy generated. And while a REC isn't technically electricity, it represents the clean energy going into the electricity grid—meaning homes and businesses claim their commitment to renewable energy if their electricity is supported by RECs.

It's also important to understand what a renewable energy certificate is not: an offset. An offset represents a metric ton of emissions avoided and a REC represents 1 MWh of clean energy generated. While each have similar goals, they are not quite the same thing.

Not all RECs are created equally

The market for RECs is fluid. Due to the growth of the renewable energy market, RECs have been oversupplied for years. This has created low prices and little-to-no financial advantage for the facilities that generate clean electricity (e.g., wind facilities, solar farms, hydro plants).

In Texas, the retail electricity market is inundated with renewable electricity claims said to be supported by RECs. The energy plan you sign up for might come from solar, wind, biomass, or even trash incineration, but the renewable energy facilities likely are coming from outside Texas, located in places like California, Canada, or elsewhere. While there's no wrong way to switch to renewable energy, supporting renewable energy sources inside Texas helps Texans move closer to being a more sustainable state.

Choosing Texas renewable energy plans and your actions do have a true, real-world impact more than ever before

Some critics have argued that REC-supported renewable energy plans don't meet the highest standard of sustainability arguing RECs are not foundational to the existence of renewable energy assets. In other words, they argue that RECs don't provide a material revenue source for renewable projects because they don't incentivize new developments of renewable facilities to be built.

When RECs were trading for less than a dollar, this was a valid argument. But that was then, and this is now.

In the last year alone, voluntary renewable energy certificate prices have skyrocketed and are now between $7 and $10 per MWh. This means RECs can now contribute up to 30 percent of a renewable facility's revenue. Naturally, this encourages more and more clean-energy facilities and clean-energy jobs to be created. A win-win.

What about Power Purchase Agreements?

A Power Purchase Agreement, or PPA, is a tad different than a REC. In a PPA, the developer of a renewable project (solar arrays at a solar farm, or turbines at a wind farm) can sell the actual energy it produces over a 10-to-20-year contract.

While the sale of this renewable energy still contributes to a larger portion of project revenues, the revenue mix has clearly shifted, and RECs cannot be considered an immaterial incentive anymore. Sure, PPAs are a stronger market signal for renewable project development, but only a couple of hundred organizations globally utilize PPAs. This makes them very challenging for businesses to access.

Through PPAs, various risks, credit needs, and long-term commitments create challenges for many organizations to meet their sustainability goals. So, while RECs do not provide as material of a market signal as PPAs, with the recent changes in market prices, RECs can now be considered a meaningful, profitable market signal for renewable projects.

Making the future of renewable energy in Texas even brighter.

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P.J. Popovic is the CEO of Houston-based Rhythm.

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Rice researchers score $45M from NIH for cancer-fighting tech

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A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

TMC again expands global impact with new Netherlands partnership

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The Texas Medical Center may be based in Houston, but the organization has again grown its global impact.

Since 2016, TMC’s BioBridges have worked with 88 startup companies. Those include strategic alliances with four other countries. Australia, the United Kingdom, Denmark and Ireland are all among TMC’s BioBridges partners. As of today, add the Netherlands to that list.

On September 27, TMC president and CEO, William F. McKeon, and Carmen van Vilsteren, chair of Health~Holland, Top Sector Life Sciences & Health (LSH), signed an agreement in Rotterdam. The TMC Netherlands BioBridge Memorandum of Understanding codifies the innovative goals of the partnership. Essentially, the BioBridge program provides a means for entrepreneurs, researchers, clinicians and industry partners from other countries to access the US market, as well as TMC experts.

“The TMC Netherlands BioBridge represents an unparalleled opportunity for collaboration and growth,” Ashley McPhail, chief external affairs & administration officer at Texas Medical Center said in a press release. “The Netherlands has solidified its position as a global leader in the field of life sciences and health, with a thriving ecosystem of research institutions, innovative companies, and highly skilled professionals. This strategic partnership will bring positive benefits to patients, clinicians and industry partners on a global scale.”

This lifeline for international healthcare companies makes expansion into the United States far smoother. The Global Innovators Launch Pad allows for startup founders to take part in a 10-week residency at the TMC Innovation Factory that will teach them about foundational infrastructure, clinical evidence and funding in the US.

“Since Texas is an important hub for innovation in the MedTech and digital health sectors, the collaboration with Texas Medical Center creates opportunities for Dutch companies looking to expand their international reach. Vice versa, it gives companies in Texas access to the vibrant Dutch Life Sciences & Health sector,” said van Vilsteren.

That exchange includes members of the TMC gaining the opportunity to participate in the Health~Holland Visitors Programme (HVP), “Shaping the Healthcare of the Future.”

The annual event invites high-level representatives from the private sector, NGOs, knowledge institutions, healthcare providers and different tiers of government to share their expertise.

It's the fifth partnership of its kind for TMC, with the last one being with Ireland, announced last year. TMC's other global initiatives include accelerators with Denmark and the United Kingdom, both announced earlier this year.

Houston startup founders prepare to scale globally following Shark Tank success

HOUSTON INNOVATORS PODCAST EPISODE 205

While Milkify's founders — husband and wife team Pedro Silva and Berkley Luck — secured partners on a popular business pitch and investment show, the entire experience almost didn't happen.

Silva and Luck, who got her PhD in molecular and biomedical s at Baylor College of Medicine, founded the company to provide breast milk freeze drying as a service to Houston-area families. Now, Milkify has customers across the country, but the duo didn't know if going through the process would be worth the investment and publicity, or if it would just be a distraction.

"The competitor in me wanted to be the first breast milk company to go on the show and to tell our story to the world — to show the world what my wife came up with that we thought was so great," Silva says on the Houston Innovators Podcast. "It was probably the scariest 45 minutes of my life."

But the sharks bit. Milkify's episode aired in April, and two investors — Gwyneth Paltrow and Lori Greiner — agreed to a $400,000 convertible note for 20 percent equity in the company. Paltrow even said on the show that she would have used the service when she was breastfeeding.

"It was empowering," Luck says of getting to wear her white coat on TV and share the story of how she came up with the idea of Milkify. "It was important to me when we went on the show to express that this had a scientific basis, that we didn't start this lightly, and that we've made huge strides in doing this in the absolute safest way possible."

Silva says they can't talk about some of the details of the show or the deal, but since then, Milkify has reached new customers, received additional investment interest, grown its team, and built out its plan to scale, the founders shared on the podcast. The team also shares its big-picture scale plans, which include tapping international partners to potentially take Milkify's tech global.

"Our vision is for every family to have access to breast milk formula, but instead of re-creating breast milk in a lab, we're doing it with mom's own milk," Silva says, mentioning a partnership with a breast milk bank that will convert its operation from freezing to freeze drying donated milk. "We're also working with groups in the UK and Australia to launch similar services using our patented technology."

"By the end of the year, we hope to see some announcements with those partnerships across the globe."

From the beginning, the importance of Milkify's team has been on supporting working parents to give them the best way to care for their families, Silva says. And for Luck — who says she's proud of the integrity Milkify has at its core despite competitors offering lower-quality and, in some cases, dangerous alternatives — she sees a lot of research benefits for the company.

"It's amazing to be at this leading edge, not just of innovation but of research, and to be able to still put out meaningful advances as an industry partner, not just as an academic," Luck says, adding that she hopes to be able to continue to contribute to the ongoing research into breast milk.

Luck and Silva share more about their Shark Tank experience, their co-founder strengths, and the future of Milkify on the podcast. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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