Here are the most promising energy tech startups in the market today. Natalie Harms/InnovationMap

This week, 39 energy startup companies from all over the world pitched in Houston — and nine were recognized as being the most promising of the batch.

The Rice Alliance for Technology and Entrepreneurship returned its Offshore Technology Conference pitch event to its in-person capacity and host the annual event at the Ion Houston for the first time. The event featured three-minute pitches from the companies, and a select group of corporate and venture investors decided on the top nine to honor.

"We asked investors and corporates to look at the companies here today and help us determine the companies most promising — based on those that have an innovative technology that is solving a large problem, has customers willing to pay for it, and has the right team to build and grow their company," Brad Burke, managing director of the Rice Alliance says to the crowd at the event on May 3.

Here's which energy tech companies stood out to investors.

EarthEn

EarthEn, a Chandler, Arizona-based company, is a grid-scale energy storage solution. The technology can provide short-term — 6 to 8 hours — and long-term — over 100 hours — storage. The EarthEn pods provide a cheaper alternative and are built using 3D printing.

Echogen Power Systems

Based in Akron, Ohio, Echogen Power Systems has created a technology that captures heat that would otherwise be lost and converts it to a useable power source. The solution allows for any customer that operates at significant levels of heat to have a cost-effective energy option.

FuelX Innovation

Based in Aiken, South Carolina, FuelX Innovation is manufacturing solid-state hydrogen products and power systems, impacting mobile hydrogen fuel cell-powered applications. The company is focused on producing the lowest cost Alane, or aluminum hydride, for the fuel cell.

Lillianah Technologies

Lillianah Technologies, based in the Houston area in Spring, uses algae to remove carbon dioxide from the atmosphere. The company sells carbon offsets to corporations.

oPRO.ai

oPRO.ai — which is based in Los Altos, California — is providing its customers with deep learning optimization software for process and responsible operations for oil and gas, petrochemical, chemicals, and metal industries.

Proteum Energy

Phoenix, Arizona-based Proteum Energy provides its customers low-cost, clean hydrogen by reforming renewable ethanol into renewable hydrogen.

Sync Power Solutions

Embracing a clean sheet approach, Sync Power Solutions, based in Abilene, Texas, created a solution involving a redesign of electric motors and generators to increase energy efficiency, save on costs, and more.

Utility Global

Houston-based Utility Global is using high temperature electrolysis without the use of electricity to produce hydrogen from waste gases.

ZL Innovations

Based in Portland, Oregon, ZL Innovations is focused on eliminating greenhouse gas emissions from failed industrial valves. The company's solution is a magnetic actuation assembly that can be better sealed to prevent emissions.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.