Houston-based investment platform expands capabilities for local deals

Nextseed's next phase

Houston-based NextSeed has been approved as a broker-dealer platform, allowing for larger investments. Getty Images

NextSeed, which launched in Houston four years ago as a crowdfunding online investment platform, has expanded its services to become a broker-dealer. The platform also rolled out a new website.

Now that NextSeed Securities LLC is a SEC-registered broker-dealer, NextSeed campaigns aren't limited to the $1 million cap instated by crowdfunding rules, according to a news release. The new function also means that, rather than just debt securities (where investors are paid back based on revenue of the company), investors can also engage in equity investing (where money can be exchanged for ownership of the company).

"We previously focused only on debt securities, in part because we wanted to facilitate the right type of capital to the local small business community," says CFO Tae Mi Lee in the release. "With the launch of our broker-dealer practice, we are able to expand our services to offer both debt and equity offerings for different types of issuers and investors."

In the past, NextSeed deals have focused on local brick-and-mortar companies. However, this new capability opens doors to other types of deals.

"We have always wanted investors on the platform to have the ability to diversify their investment portfolios across multiple industries and asset classes, while providing the right investment structure for our business clients through a broader range of options," Tae Mi Lee continues. "We are excited about what this expansion means for our NextSeed community."

The broker-dealer model shifts more responsibility on NextSeed as the vehicle for trading securities, but also represents a growth in investing in Houston.

"The standards of review and compliance obligations for both issuers and investors become stricter and more comprehensive for offerings made via our broker-dealer, but we wanted to be able to offer a more extensive and flexible service to our community," says CEO and Co-Founder Youngro Lee in the release. "Since day one of our funding portal operations, we tried to adhere to certain standards above and beyond the minimal legal requirements. We're now just taking another leap forward into a new phase of NextSeed."

Since its launch in 2015, NextSeed has raised $11 million for companies on its platform. While not all in Houston, NextSeed focuses on funding its portfolio by locals who want to support nearby establishments. Here are some examples of deals made on the platform:

Buffalo Bayou Brewery in Houston raised $1,000,000.
Alkalign Studio in Menlo Park, California, raised $100,000.
The Native Hostel Bar & Kitchen in Austin raised $396,500.
Fair Isle Brewing in Seattle raised $327,800.

Earlier this year, NextSeed announced another new capability for its portfolio of companies. NextSeed Space launched to help provide local entities turnkey retail space with short-term leases. The space is located in Greenway Plaza, and the first tenant was announced as The Waffle Bus, however NextSeed moved in traditional Mexican restaurant, Tlahuac, which will reside in the food court until the end of June.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

New accelerator joins the Ion and more Houston innovation news to know

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Editor's note: The Houston innovation scene is buzzing with big news this month, from a new accelerator joining the fold at the Ion to pre-IPO funding and national expansion plans. Below are the five most-read InnovationMap stories from Feb. 1-15, 2026:

New accelerator for AI startups to launch at Houston's Ion this spring

The new AI Native Dual-Use Sports, Health & Wellness Accelerator is expected to launch in March. Photo courtesy of the Ion

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform. The AI Native Dual-Use Sports, Health & Wellness Accelerator is scheduled to formally launch in March. Continue reading.

10+ can't-miss Houston business and innovation events in February

From recurring monthly favorites to the return of annual celebrations and summits, here's what not to miss in February. Photo courtesy the Ion.

February may be a short month, but its event calendar isn’t. From recurring monthly favorites to the return of annual celebrations and summits, here are the Houston business and innovation events not to miss — and how to register. Continue reading.

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