AI and automation are coming for Texas jobs, according to ChatGPT. Image via Getty Images

ChatGPT seems to have its eyes set on at least 200,000 Texas jobs, according to a new study.

The report by UK-based affiliate marketing site NetVoucherCodes compiled data on nearly 200 U.S. job types and then asked ChatGPT for each job’s relative risk from AI, automation, and also the likelihood of AI increasing that job’s productivity.

The query found that 237,000 jobs in Texas have a high risk of being replaced by AI, and 1.07 million jobs are considered at a medium risk of being replaced by AI.

Similarly 1.8 million Texas jobs were considered at a high risk of being replaced by automation. More than 3 million jobs were considered at a medium risk of being replaced by automation.

In both the AI and automation queries, Texas had the second-most at risk jobs among the states. California had the most jobs at risk in both categories. New York fell behind Texas in the No. 3 spot for most jobs being at risk of being replaced by AI, and Florida had the third most jobs at risk of being replaced by automation.

Maine had the highest number of low-risk jobs, followed by Hawaii and Montana.

Texas jobs that were both at high risk and made up a large portion of Texas's workforce include fast food and counter workers, cashiers, customer service representatives, and stockers and order fillers.

“The data we’ve pulled together shows that a lot of lower income jobs are the ones that are at a higher risk of being replaced. When we break this down, we realize it’s because these jobs often involve a lot of the same repetitive tasks. This can be inputted into a computer and can be done automatically," John Strizaker from NetVoucherCodes said in a statement.

“The jobs that aren’t at risk are ones that really require human thinking and decision making, like nurses, doctors along with creative roles such as fashion designers and hairdressers," he continued.

At the same time, the study found that more than 1.4 million Texas jobs have a high likelihood of being able to use AI and automation to boost productivity. This was the second highest number of jobs in this category behind California.

“Although this might be a concern in the near future, there’s a lot of benefits to AI and automation," Strizaker said in the statement. "It will increase productivity, especially in creative fields and it will be able to take over repetitive tasks and free up workers for other things that require thinking.”

Some Houston companies are already using GPT, or generative pre-trained transformer, technology to their advantage. Femtech company ema pivoted to use the powerful tool to provide access to women's health information 24/7 to its users about 16 months ago.

And at the start of this year the University of Houston and Intel launched a new artificial intelligence program to help bridge the AI knowledge gap and fill hundreds of AI-related jobs that are open in the Houston area.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.