Houston researcher scores prestigious NSF award for machine learning, power grid tech

grant funding

The UH team is developing ways to use machine learning to ensure that power systems can continue to run efficiently when pulling their energy from wind and solar sources. Photo via Getty Images

An associate professor at the University of Houston received the highly competitive National Science Foundation CAREER Award earlier this month for a proposal focused on integrating renewable resources to improve power grids.

The award grants more than $500,000 to Xingpeng Li, assistant professor of electrical and computer engineering and leader of the Renewable Power Grid Lab at UH, to continue his work on developing ways to use machine learning to ensure that power systems can continue to run efficiently when pulling their energy from wind and solar sources, according to a statement from UH. This work has applications in the events of large disturbances to the grid.

Li explains that currently, power grids run off of converted, stored kinetic energy during grid disturbances.

"For example, when the grid experiences sudden large generation losses or increased electrical loads, the stored kinetic energy immediately converted to electrical energy and addressed the temporary shortfall in generation,” Li said in a statement. “However, as the proportion of wind and solar power increases in the grid, we want to maximize their use since their marginal costs are zero and they provide clean energy. Since we reduce the use of those traditional generators, we also reduce the power system inertia (or stored kinetic energy) substantially.”

Li plans to use machine learning to create more streamlined models that can be implemented into day-ahead scheduling applications that grid operators currently use.

“With the proposed new modeling and computational approaches, we can better manage grids and ensure it can supply continuous quality power to all the consumers," he said.

In addition to supporting Li's research and model creations, the funds will also go toward Li and his team's creation of a free, open-source tool for students from kindergarten up through their graduate studies. They are also developing an “Applied Machine Learning in Power Systems” course. Li says the course will help meet workforce needs.

The CAREER Award recognizes early-career faculty members who “have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization,” according to the NSF. It's given to about 500 researchers each year.

Earlier this year, Rice assistant professor Amanda Marciel was also

granted an NSF CAREER Award to continue her research in designing branch elastomers that return to their original shape after being stretched. The research has applications in stretchable electronics and biomimetic tissues.

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This article originally ran on EnergyCapital.

The NIH grant goes toward TransplantAI's work developing more precise models for heart and lung transplantation. Photo via Getty Images

Houston health tech company scores $2.2M grant to use AI to make organ transplants smarter, more successful

future of medicine

The National Institute of Health has bestowed a Houston medtech company with a $2.2 million Fast-Track to Phase 2 award. InformAI will use the money for the product development and commercialization of its AI-enabled organ transplant informatics platform.

Last year, InformAI CEO Jim Havelka told InnovationMap, “A lot of organs are harvested and discarded.”

TransplantAI solves that problem, as well as organ scarcity and inefficiency in allocation of the precious resource.

How does it work? Machine learning and deep learning from a million donor transplants informs the AI, which determines who is the best recipient for each available organ using more than 500 clinical parameters. Organ transplant centers and organ procurement organizations (OPOs) will be able to use the product to make a decision on how to allocate each organ in real time. Ultimately, the tool will service 250 transplant centers and 56 OPOs around the United States.

The NIH grant goes toward developing more precise models for heart and lung transplantation (kidney and liver algorithms are further along in development thanks to a previous award from the National Science Foundation), as well as Phase 2 efforts to fully commercialize TransplantAI.

"There is an urgent need for improved and integrated predictive clinical insights in solid organ transplantation, such as for real-time assessment of waitlist mortality and the likelihood of successful post-transplantation outcomes," according to the grant’s lead clinical investigator, Abbas Rana, associate professor of surgery at Baylor College of Medicine.

“This information is essential for healthcare teams and patients to make informed decisions, particularly in complex cases where expanded criteria allocation decisions are being considered," Rana continues. "Currently, the separation of donor and recipient data into different systems requires clinical teams to conduct manual, parallel reviews for pairing assessments. Our team, along with those at other leading transplant centers nationwide, receives hundreds of organ-recipient match offers weekly.”

Organ transplantation is moving into the future, and Transplant AI is at the forefront.

A team from the University of Houston received a grant to continue its work on using AI and digital twin technology to better evaluate bridges in Texas. Photo via uh.edu

Houston professor earned $500,000 grant to tap into digital twin tech for bridge safety

transportation innovation

A University of Houston professor has received a grant from the Texas Department of Transportation (TxDOT) to improve the efficiency and effectiveness of how bridges are inspected in the state.

The $505,286 grant will support the project of Vedhus Hoskere, assistant professor in the Civil and Environmental Engineering Department, over three years. The project, “Development of Digital Twins for Texas Bridges,” will look at how to use drones, cameras, sensors and AI to support Texas' bridge maintenance programs.

“To put this data in context, we create a 3D digital representation of these bridges, called digital twins,” Hoskere said in a statement. “Then, we use artificial intelligence methods to help us find and quantify problems to be concerned about. We’re particularly interested in any structural problems that we can identify - these digital twins help us monitor changes over time and keep a close eye on the bridge. The digital twins can be tremendously useful for the planning and management of our aging bridge infrastructure so that limited taxpayer resources are properly utilized.”

The project began in September and will continue through August 2026. Hoskere is joined on the project by Craig Glennie, the Hugh Roy and Lillie Cranz Cullen Distinguished Chair at Cullen College and director of the National Center for Airborne Laser Mapping, as the project’s co-principal investigator.

According to Hoskere, the project will have implications for Texas's 55,000 bridges (more than twice as many as any other state in the country), which need to be inspected every two years.

Outside of Texas, Hoskere says the project will have international impact on digital twin research. Hoskere chairs a sub-task group of the International Association for Bridge and Structural Engineering (IABSE).

“Our international efforts align closely with this project’s goals and the insights gained globally will enhance our work in Texas while our research at UH contributes to advancing bridge digitization worldwide,” he said. “We have been researching developing digital twins for inspections and management of various infrastructure assets over the past 8 years. This project provides us an opportunity to leverage our expertise to help TxDOT achieve their goals while also advancing the science and practice of better developing these digital twins.”

Last year another UH team earned a $750,000 grant from the National Science Foundation for a practical, Texas-focused project that uses AI. The team was backed by the NSF's Convergence Accelerator for its project to help food-insecure Texans and eliminate inefficiencies within the food charity system.

UH Professor Vedhus Hoskere received a three-year, $505,286 grant from TxDOT for a bridge digitization project. Photo via uh.edu

This Houstonian is celebrating a major win for the prosthesis device he created while at the University of Houston. Photo via UH.edu

Groundbreaking prosthesis device designed at UH earns international ‘luminary’ award

give him a hand

A recent University of Houston graduate is receiving international recognition for his 3D-printable finger prosthesis.

David Edquilang, the creator of a low-cost prosthesis known as Lunet, was awarded the 2023 Red Dot: Luminary award last month at the Red Dot Award: Design Concept ceremony in Singapore. The luminary award is the highest recognition given at the international event, according to a release from UH.

Edquilang, who graduated from UH in 2022, developed Lunet while he was a student at the Gerald D. Hines College of Architecture and Design and under the mentorship of UH associate professor and co-director of the Industrial Design program Jeff Feng.

The prosthesis is made up of polylactic acid and thermoplastic polyurethane, two common types of 3D-printed plastics, and designed to be simple but essentially indestructible.

Lunet's "fingers" are made of four parts held together by plastic pins, compared to other prosthetics that feature many different parts and require metal fasteners, adhesives or tools.

“The problem with higher mechanical complexity is that these designs are less durable,” Edquilang says in the statement. “The more parts you have, the more points of failure. You need to make prosthetic fingers robust and as strong as possible, so it doesn’t break under normal use, yet you want the design to be simple. This was one of the greatest challenges in making Lunet.”

Lunet is also unique in that it includes a linkage mechanism that allows the fingers' distal knuckle (closest to the fingertip) to be more flexible, and even partially hyperextend backward to be more durable and realistic.

What's perhaps the rarest component of Lunet is that Edquilang has made it open access on the internet.

“Not every good idea needs to be turned into a business. Sometimes, the best ideas just need to be put out there,” Edquilang adds. “Medical insurance will often not cover the cost of a finger prosthesis, since it is not considered vital enough compared to an arm or leg. Making Lunet available online for free will allow it to help the greatest number of people."

The concept was born after Edquilang worked on an upper limb prosthesis with fellow UH student Niell Gorman. After that project wrapped, Edquilang, in partnership with Harris Health System, began designing a prosthetic hand for a woman who had lost three fingers due to frostbite. Edquilang and Feng continued to refine the product, and after conceptualizing the breakthrough idea for the flexible linkage for the distal knuckle, Lunet became what it is today.

The product has also won a 2023 Red Dot: Best of the Best award, two 2023 DNA Paris Design Awards, Gold for the 2023 Spark Design Award, and is currently a U.S. National Runner Up for the 2023 James Dyson Award.

“It feels great knowing you have the capability to positively impact people’s lives and give them help they otherwise wouldn’t be able to get,” Edquilang says.

This summer UH researchers also published their work on a wearable human-machine interface device that can track and record important health information but is less noticeable and lighter than a Band-Aid. The device could be attached to a robotic hand or prosthetic, as well as other robotic devices that can collect and report information to the wearer.

Also this summer, a team from Rice published their work on a new system of haptic accessories that rely heavily on fluidic control over electrical inputs to signal or simulate touch to a wearer. The technology, which was backed by the National Science Foundation, has uses for those with visual and auditory impairments and offers a slimmed-down design compared to other bulky complex haptic wearables.

A Rice University study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding." Photo courtesy of Kinder Institute

Rice University secures NSF support to look into Houston flooding

troubled waters

Houston will be the setting of a new three-year National Science Foundation-funded study that focuses on a phenomenon the city is quite familiar with: flooding.

Conducted by Rice University, the study will consider how "design strategies aimed at improving civic engagement in stormwater infrastructure could help reduce catastrophic flooding," according to a statement.

The team will begin its research in the Trinity/Houston Gardens neighborhood and will implement field research, participatory design work and hydrological impact analyses.

Rice professor of anthropology Dominic Boyer and Rice's Gus Sessions Wortham Professor of Architecture Albert Pope are co-principal investigators on the study. They'll be joined by Phil Bedient, director of the Severe Storm Prediction, Education and Evacuation from Disasters Center at Rice, and Jessica Eisma, a civil engineer at the University of Texas at Arlington.

According to Boyer, the study will bring tougher researchers from across disciplines as well as community members and even elementary-aged students.

"Our particular focus will be on green stormwater infrastructure—techniques like bioswale, green roofs and rain gardens—that are more affordable than conventional concrete infrastructure and ones where community members can be more directly involved in the design and implementation phases,” Boyer said. “We envision helping students and other community members design and complete projects like community rain gardens that offer a variety of beneficial amenities and can also mitigate flooding.”

Rice's Severe Storm Prediction, Education and Evacuation from Disasters Center, or SSPEED Center, is a leader in flood mitigation research and innovation.

In 2021, the center developed its FIRST radar-based flood assessment, mapping, and early-warning system based on more than 350 maps that simulate different combinations of rainfall over various areas of the watershed. The system was derived from the Rice/Texas Medical Center Flood Alert System (FAS), which Bedient created 20 years ago.

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This article originally ran on EnergyCapital.

A Houston startup based out of the TMC Innovation Factory has announced funding and upcoming trials. Photo courtesy of TMC

Houston health tech startup secures $16M series A, prepares for first U.S. clinical trials

money moves

Fueled by fresh funding in the bank, a medical device startup has announced upcoming trials.

VenoStent, Inc., a company developing an innovative tool to improve outcomes for hemodialysis patients, has closed $16 million in a series A round of financing. Two Charleston, South Carolina-based firms — Good Growth Capital and IAG Capital Partners — led the round.

The company also announced it received Investigational Device Exemption from the FDA for its United States clinical trial, SAVE-FistulaS.

“Our mission at VenoStent is to improve the quality and length of life of dialysis patients. On the heels of our very promising results in several preclinical studies and a 20-patient feasibility study that led to our Breakthrough Designation last year, this recent IDE approval is perhaps our biggest milestone to date," Tim Boire, CEO of VenoStent, says in a news release. "We now enter an exciting new epoch in our company’s development that we believe will ultimately result in FDA Approval and vastly improve the quality and length of life for patients."

VenoStent's novel therapeutic medical device is a bioabsorbable wrap. Image courtesy of VenoStent

VenoStent's series A will fund the trial, expand manufacturing capabilities, and more. The company is targeting the more than 800,000 people in the U.S. with end-stage renal disease. Currently, more than half of the surgeries performed to initiate hemodialysis fail within a year. VenoStent's novel therapeutic medical device is a bioabsorbable wrap that reduces vein collapse by providing mechanical support and promoting outward vein growth.

“This trial is designed to provide the highest level of clinical evidence. We’re excited to be in this position to treat the first patients in the United States with this technology, and demonstrate the safety and efficacy of our device,” continues Boire in the release.

Per the release, the company is aiming for FDA Approval and be the first-to-market device to improve hemodialysis access surgery.

“We’re extremely pleased to be partnering with VenoStent on this critical mission. This company and technology are poised for commercial success to address a critical, unmet need,” says Bob Crutchfield, operating partner at Good Growth Capital, in the release.

The TMC Venture Fund also contributed to the series A investment round, along with SNR, Baylor Angel Network / Affinity Fund, Creative Ventures, Cowtown Angels, Alumni Ventures, and other notable angel investors. Past investors in VenoStent include KidneyX, National Science Foundation, National Institute of Health, Y Combinator, Health Wildcatters, and the Texas Halo Fund.

“VenoStent’s data and traction to date is impressive and gives us a lot of confidence in their continued success. We look forward to helping them get this Breakthrough product to market and help patients that are in dire need of this innovative technology,” says Joel Whitley, partner at IAG Capital Partners, in the release.

Tim Boire is the CEO of VenoStent. Photo via LinkedIn

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Unique cell therapy developed in Houston doses inaugural patient

cancer-fighting innovation

Replay, a genome-writing company headquartered in San Diego, has announced that its first patient has been dosed with an engineered T-Cell Receptor Natural Killer (TCR-NK) cell therapy for relapsed or refractory multiple myeloma.

What does that have to do with Houston? Last year, Replay incorporated a first-in-class engineered TCR-NK cell therapy product company, Syena, using technology developed by Dr. Katy Rezvani at The University of Texas MD Anderson Cancer Center.

Rezvani, a professor of stem cell transplantation and cellular therapy, is the force behind MD Anderson’s Rezvani Lab, a group of 55 people, all focused on harnessing natural killer cells to combat cancer.

“Everybody thinks that the immune system is fighting viruses and infections, but I feel our immune system is capable of recognizing and killing abnormal cells or cells that are becoming cancerous and they're very powerful. This whole field of immunotherapy really refers to the power of the immune system,” Rezvani tells InnovationMap.

Dr. Katy Rezvani is a professor of stem cell transplantation and cellular therapy and the force behind MD Anderson’s Rezvani Lab, which is focused on harnessing natural killer cells to combat cancer. Photo via mdanderson.org

At Rezvani Lab, scientists train immune cells to fight cancer. While cancer drugs like chemotherapy are still the norm, immunotherapy has gained ground, led by Houston research, including the work of Nobel laureate Jim Allison. The harnessed cells are taught to attack cancerous cells, while ignoring healthy ones, says Rezvani. “We’re turning them into heat-seeking missiles,” she explains.

However, there must be a beacon to signal to those “missiles” that there is something to attack. Much of the field has used chimeric antigen receptors (CARs) to achieve that. But they have limitations.

“CARs can only recognize beacons that sit on the surface of the tumor cells,” Rezvani says. “So basically, it's like the tumor cell has to have a hat on it.”

She says that this usually means that the targets that send off a signal are relatively limited, mostly blood cancers. Using T cell receptors (TCRs) may be able to open up the field to look beyond the “hat.” In other words, TCRs can peer inside cells and see what differentiates a tumor cell from healthy cells. With Replay, Rezvani Lab has developed a first-in-class and first-in-human approach of engineering natural killer cells to express the TCR.

There are six different FDA-approved products that use CAR-T cells, but Rezvani says that her TCR-NK-based technology, though still in its early phases, shows great promise.

“We could use it to target many different types of antigens, many different types of cancers, especially solid tumors," she explains. "These cell therapies have a lot of potential — we call them living drugs… It's not like chemotherapy where you have to keep giving different multiple cycles, these cells are very long lived.”

Rezvani, who started her career in London, says that Houston has been instrumental in the success of her lab.

“There are so many opportunities because we have access to some of the most brilliant minds in research,” Rezvani says. “We have some of the best clinicians in the world. We have patients who come to us who are willing to participate in our clinical trials — really put their trust in us — and are committed and want to participate in these clinical studies.”

The role of funding also plays a part. As Rezvani admitted, bringing a new technology to the market is expensive. The philanthropists who help support trials can’t be forgotten among Houston’s finest.

Whether or not Syena produces the first TCR-NK product on the market, Rezvani is enthusiastic and hopeful for the future of her patients.

“The field of immunotherapy is really expanding, the field of cell therapies is expanding, and there is so much promise,” she says. “The promise of AI, big data, all the engineering tools that we have available, the promise of CRISPR — all of that is going to bring what we've learned from biology, from basic science, together to help us make the cell therapies that are going to be safe and and also very effective for our patients.”

Dallas law firm targets Texas innovation hubs with expansion to Houston, Austin

new to hou

A Dallas-based law firm has announced two new Texas offices in Houston and Austin.

Founded in Dallas in 2003, Wilson Whitaker Rynell has expanded in the Lone Star State, strategically targeting Austin for its tech scene and Houston for its innovative startup culture, per the firm's news release.

Wilson Whitaker Rynell provides legal services across civil litigation, patents, trademarks, copyrights, and business law and litigation.

"Whether it's navigating complex legal issues in Austin's tech sector or addressing startup legal needs in Houston, Wilson Whitaker Rynell is committed to providing personalized and effective legal counsel both in Texas and throughout the country," reads the release.

The two new offices bring the firm up to three locations in Texas's major innovation hubs. The Houston office is located in downtown at 1201 Fannin Street (Suite 262).

"An expansion into Austin and Houston marks a significant step in the firm's mission to deliver top-tier legal services tailored to the unique business environments and challenges in Texas," Jennifer Rynell, a partner at Wilson Whitaker Rynell, says in the release.

"We are a firm recognized by Super Lawyers poised to make a lasting impact, reinforcing its position as a leader in the legal field across the Lone Star State," she continues.

How corporations can implement meaningful innovation, according to this Houston expert

guest column

I vividly remember, it was a typical Tuesday at Houston Exponential, and I’m sipping maybe my third coffee of the morning when the phone rings.

On the line is yet another hopeful voice from a newly minted innovation group at a "big company." They lay out their vision: “We’ve got this new innovation group! It’s me — a tech enthusiast who’s been yelling into the corporate void about needing to shake things up for the last two decades — plus a data scientist who loves numbers more than people, and a procurement guy who… well, procures stuff. And here’s the kicker: they’ve handed us $60 million to put to work. But here’s the catch — this treasure needs to be turned into a groundbreaking innovation that will dazzle the C-Suite, in about six months.”

I chuckle then sigh, because I’ve heard this story not once or twice, but about a dozen times over. And unfortunately, each of those grand plans crashed faster than a shooting star burning out over the Texas night sky — brilliant, swift, and leaving us wondering what might have been. Why? Well, let’s dig into some observations from my time working with institutional innovators from around the world and uncover just why throwing money at innovation like confetti at a wedding isn’t the quick fix big companies hope it will be.

The big miss here is a deep understanding of and ability to articulate the challenges. Innovation isn’t a highway where you can just press the gas and speed straight to Mt. Scale. It’s more like a winding country road with breathtaking views, unexpected potholes, and the occasional bewildered chicken crossing your path. For institutional innovators — the brave souls charting the course through this ever-changing landscape — the journey is filled with excitement, challenges, and the promise of discovery.

In my first hand experience mentoring over 500 startups and corporations, I’ve seen that the magic of innovation doesn’t come from a deep-pocketed budget but from a deep understanding of the problems we aim to solve. If you can view challenges through a kaleidoscope of perspectives, not just through the monochrome lens of one industry, you find the alternate routes that, while not exactly shortcuts, do keep you from turning down dark alleys and dead ends. A key observation here is that solutions to hard problems often lie in adjacent industries.

For example, consider how biomimicry has led to inventions like Velcro, inspired by burrs' ability to stick to animal fur, or how bullet trains in Japan were designed to mimic the kingfisher's beak for better aerodynamics. These are just a few examples of how solutions to complex problems often reside right in front of us or in the industry next door. Right here in Houston, Pumps & Pipes is a glowing example of how experts from Energy, Life Science and Space converge on similar problem sets with wildly different perspectives and applications.

Imagine if the engineers at NASA sat down for tacos with teachers from the local high school, or if doctors brainstormed with video game designers over a game of pickleball. Sounds fun, right? But it’s also where the magic happens. When we step out of our industry bubbles, we find that the solutions to our biggest problems often come from the most unexpected places.

So how do we begin to find these solutions? It all starts with a clear and clearly articulated challenge statement.

A crucial factor in encouraging organizations to look beyond traditional industry boundaries is to foster a deep understanding of problem-solution fit (you can read more about Problem - Solution fit in my last article here) and that means a deep understanding of the Problem. By guiding problem holders to dig deep into the nuances of the problems they aim to address, we expand their perspective. Once a comprehensive grasp of the problems are established, new pathways for solutions organically emerge. To do this you must broaden the collective thinking to the point where solutions from other industries become not just viable but often the most effective approach. My favorite quote on this subject is that “people don’t need a ¼ inch drill bit, they need a ¼ inch hole, and really they don’t need a ¼ hole, they need to hang a picture and when framed in that context, a command strip is more effective at solving the problem.”

So how do we do this? It’s easy, just continuously ask "why" or “why does this matter to your customer” to peel back the layers of the initial problem statements to reveal underlying causes or first principles. Ok this is actually much harder than it sounds but when organizations are guided through exercises to distill their challenges into first principles and more universal problem statements, a transformation occurs, resulting in several benefits:

  1. Expanding Solution Horizons: By elevating the problem discussion beyond industry-specific issues, the range of potential solutions widens remarkably.
  2. Universal Problem Statements: Restating the issues into more universal terms unlocks innovative approaches and solutions previously unseen.
  3. Enhanced Solution Fit and Success Probability: This reframing leads to solutions that are not only more fitting but also stand a higher chance of successfully being adopted and integrated and thus resolving the underlying issues.
  4. Increased Buy-In: These solutions are and are perceived as more novel and thus receive increased buy-in across the organization when moving towards adoption.

The critical lesson here is the power of abstracting the problem. By pulling back from the immediate and specific issues and reinterpreting them into broader, more universally applicable challenges, we can tap into a richer vein of solutions. This approach not only broadens the scope of potential innovations but also increases the alignment and effectiveness of the solutions we pursue.

The art of crafting challenge statements that are both broad enough to inspire innovative thinking and specific enough to be actionable is crucial. These statements serve as beacons, guiding both internal and external innovation efforts towards solutions that are not bound by conventional industry norms. By framing challenges in a way that invites diverse perspectives, organizations unlock innovative solutions that transcend traditional boundaries, fostering a more expansive and inclusive approach to problem-solving.

Turning lofty ambitions into tangible results begins with understanding that innovation isn’t just about flashy gadgets or the latest buzzwords. It’s about solving real problems for real people. This means rolling up our sleeves, listening intently, and sometimes realizing that the solution isn’t a high-tech wonder but perhaps something as simple and elegant as a command strip instead of a hole in the wall.

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Jon Nordby is managing partner at Anthropy Partners, a Houston-based investment firm, and professor of entrepreneurship at the University of Houston.

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